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PROSITE entry PS00367


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00367
Entry name [info] BH4_AAA_HYDROXYL_1
Accession [info] PS00367
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2002 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00316

Name and characterization of the entry

Description [info] Biopterin-dependent aromatic amino acid hydroxylases signature.
Pattern [info] 
P-D-x(2)-H-[DE]-[LIVF]-[LIVMFY]-G-H-[LIVMC]-[PA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 39 in 39 different sequences
Number of true positive hits 39 in 39 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 95.12 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] iron_copper at position 4
Site [info] iron_copper at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 39 sequences 

AAAH_CHLPN  (Q9Z6L3), PH4H_BOVIN  (Q2KIH7), PH4H_CAEEL  (P90925), 

PH4H_CAUVC  (Q9A7V7), PH4H_CHLRE  (A8HQD7), PH4H_CHRVO  (P30967), 
PH4H_DICDI  (Q54XS1), PH4H_DROME  (P17276), PH4H_HUMAN  (P00439), 
PH4H_MOUSE  (P16331), PH4H_PHYPA  (E5KBU4), PH4H_PINTA  (E5KBU3), 
PH4H_PSEAE  (P43334), PH4H_RALN1  (Q8XU39), PH4H_RAT(P04176), 
PH4H_RHILO  (Q98D72), PH4H_VIBCH  (Q9KLB8), TPH1_CHICK  (P70080), 
TPH1_HUMAN  (P17752), TPH1_MOUSE  (P17532), TPH1_RABIT  (P17290), 
TPH1_RAT(P09810), TPH1_XENLA  (Q92142), TPH2_HORSE  (Q0EAB8), 
TPH2_HUMAN  (Q8IWU9), TPH2_MACMU  (Q2HZ26), TPH2_MOUSE  (Q8CGV2), 
TPH2_RAT(Q8CGU9), TY3H_ANGAN  (O42091), TY3H_CAEBR  (A8X3V8), 
TY3H_CAEEL  (P90986), TY3H_CANLF  (Q76IQ3), TY3H_DROME  (P18459), 
TY3H_HUMAN  (P07101), TY3H_MOUSE  (P24529), TY3H_ONCMY  (A0A060X6Z0), 
TY3H_PHASP  (P11982), TY3H_RAT(P04177), TY3H_SCHMA  (O17446)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

PH3H_STRC4  (F5BFC8), TY3H_BOVIN  (P17289)


				
	

	

		PDB
[Detailed view]		
		
			69 PDB
			


			1DMW; 1J8T; 1J8U; 1KW0; 1LRM; 1LTU; 1LTV; 1LTZ; 1MLW; 1MMK; 1MMT; 1PAH; 
			
				1PHZ; 1TDW; 1TG2; 1TOH; 2PAH; 2PHM; 2TOH; 2XSN; 3E2T; 3HF6; 3HF8; 3HFB; 
				3PAH; 3TCY; 3TK2; 3TK4; 4ANP; 4ESM; 4ETL; 4JPX; 4JPY; 4PAH; 4Q3W; 4V06; 
				5DEN; 5EGQ; 5FGJ; 5J6D; 5JK5; 5JK6; 5JK8; 5L01; 5PAH; 5TPG; 6HPO; 6HYC; 
				6N1K; 6PAH; 6ZN2; 6ZVP; 6ZZU; 7A2G; 7PIM; 7WIY; 7ZIF; 7ZIG; 7ZIH; 7ZII; 
				7ZIJ; 7ZIK; 8CJI; 8CJJ; 8CJK; 8CJL; 8CJM; 8CJN; 8CJO
			
			

			» more