PROSITE entry PS00378

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00378
Entry name [info]	HEXOKINASE_1
Accession [info]	PS00378
Entry type [info]	PATTERN
Date [info]	01-NOV-1990 CREATED; 01-NOV-1997 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00370

Name and characterization of the entry

Description [info]	Hexokinase domain signature.
Pattern [info]	[LIVM]-G-F-[TN]-F-S-[FY]-P-x(5)-[LIVM]-[DNST]-x(3)-[LIVM]-x(2)-W-T-K-x- [LF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	59 in 45 different sequences
Number of true positive hits	59 in 45 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	9
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	86.76 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

45 sequences

EMI2_YEAST  (Q04409), HKDC1_HUMAN (Q2TB90), HKDC1_MOUSE (Q91W97),

HXK10_ORYSJ (Q2KNB5), HXK1_ARATH  (Q42525), HXK1_BOVIN  (P27595), 
HXK1_HUMAN  (P19367), HXK1_MOUSE  (P17710), HXK1_PONAB  (Q5RC71), 
HXK1_RAT(P05708), HXK1_SCHPO  (Q09756), HXK1_TOBAC  (Q9SEK2), 
HXK2_ARATH  (P93834), HXK2_DROME  (Q9NFT7), HXK2_EQUGR  (A2PYL8), 
HXK2_EQUZE  (A2PYL7), HXK2_HORSE  (A2PYL6), HXK2_HUMAN  (P52789), 
HXK2_MOUSE  (O08528), HXK2_PIG(Q1W674), HXK2_RAT(P27881), 
HXK2_SCHPO  (P50521), HXK2_SOLTU  (Q9SQ76), HXK3_HUMAN  (P52790), 
HXK3_MOUSE  (Q3TRM8), HXK3_ORYSJ  (Q2KNB4), HXK3_RAT(P27926), 
HXK4_HUMAN  (P35557), HXK4_MOUSE  (P52792), HXK4_ORYSJ  (Q6Z398), 
HXK4_RAT(P17712), HXK5_ORYSJ  (Q5W676), HXK6_ORYSJ  (Q8LQ68), 
HXKA_YEAST  (P04806), HXKB_YEAST  (P04807), HXKG_ASPNG  (Q92407), 
HXKG_KLULA  (Q6CUZ3), HXKG_YEAST  (P17709), HXKL1_ARATH (Q9FZG4), 
HXK_EMENI   (P80581), HXK_KLULA   (P33284), HXK_PLAFA   (Q02155), 
HXK_SCHMA   (Q26609), HXK_SCHOC   (P50506), HXK_TOXGO   (Q969A8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

9 sequences

HXK1_ASPFU  (Q4U3Y2), HXK1_ORYSJ  (Q8LH82), HXK1_SOLTU  (O64390),

HXK2_ORYSJ  (Q2KNB9), HXK2_TOBAC  (Q6Q8A5), HXK7_ORYSJ  (Q1WM16), 
HXK8_ORYSJ  (Q1WM15), HXK9_ORYSJ  (Q2KNB7), NGK1_YEAST  (Q06204)

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PDB
[Detailed view]

73 PDB

1BDG; 1BG3; 1CZA; 1DGK; 1HKB; 1HKC; 1IG8; 1QHA; 1V4S; 1V4T; 2NZT; 3A0I; 3B8A; 3F9M; 3FGU; 3FR0; 3GOI; 3H1V; 3HM8; 3ID8; 3IDH; 3IMX; 3O08; 3O1B; 3O1W; 3O4W; 3O5B; 3O6W; 3O80; 3O8M; 3QIC; 3S41; 3VEV; 3VEY; 3VF6; 4DCH; 4DHY; 4F9O; 4FOE; 4FOI; 4FPA; 4FPB; 4ISE; 4ISF; 4ISG; 4IWV; 4IXC; 4JAX; 4L3Q; 4LC9; 4MLE; 4MLH; 4NO7; 4QS7; 4QS8; 4RCH; 5HEX; 5HFU; 5HG1; 5V4W; 5V4X; 5ZQT; 6E0E; 6E0I; 6JJ4; 6JJ7; 6JJ8; 6JJ9; 6P4X; 6PDT; 6R2N; 7T78; 7T79
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