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PROSITE entry PS00392


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00392
Entry name [info] DDC_GAD_HDC_YDC
Accession [info] PS00392
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00329

Name and characterization of the entry

Description [info] DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site.
Pattern [info] 
S-[LIVMFYW]-x-{KG}-x(3)-K-[LIVMFYWGH]-[LIVMFYWG]-x-{R}-x-[LIVMFYW]-{V}-
[CA]-x(2)-[LIVMFYWQ]-{K}-x-[RK].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 118 in 118 different sequences
Number of true positive hits 108 in 108 different sequences
Number of 'unknown' hits 0
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 47
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 91.53 %
Recall (true positives / (true positives + false negatives)) 69.68 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] pyridoxal_phosphate at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 108 sequences 

CNSB_PENEN  (A0A0A2IDH4), CSAD_MOUSE  (Q9DBE0), CSAD_RAT(Q64611), 

DCE1_BOVIN  (Q0VCA1), DCE1_CANLF  (A0PA85), DCE1_FELCA  (P14748), 
DCE1_HUMAN  (Q99259), DCE1_MOUSE  (P48318), DCE1_PANTR  (Q5IS68), 
DCE1_PIG(P48319), DCE1_PONAB  (Q5R7S7), DCE1_RAT(P18088), 
DCE2_CANLF  (Q4PRC2), DCE2_HUMAN  (Q05329), DCE2_MOUSE  (P48320), 
DCE2_PIG(P48321), DCE2_RAT(Q05683), DCEA_ECO57  (P58228), 
DCEA_ECOL6  (P69909), DCEA_ECOLI  (P69908), DCEA_SHIFL  (Q83PR1), 
DCEB_ECO57  (P69911), DCEB_ECOL6  (Q8FHG5), DCEB_ECOLI  (P69910), 
DCEB_SHIFL  (P69912), DCE_DROME   (P20228), DCHS_ACIB3  (B7GZJ8), 
DCHS_ACIB5  (B7I459), DCHS_ACIBC  (B2HVG6), DCHS_ACIBT  (A3M7A4), 
DCHS_ACIBY  (B0VBU8), DCHS_BOVIN  (Q5EA83), DCHS_DROME  (Q05733), 
DCHS_HUMAN  (P19113), DCHS_KLEAE  (P28577), DCHS_MORMO  (P05034), 
DCHS_MOUSE  (P23738), DCHS_PSEE4  (Q1IAK7), DCHS_PSEFL  (P95477), 
DCHS_RAOOR  (Q8L0Z4), DCHS_RAOPL  (P28578), DCHS_RAT(P16453), 
DCHS_SOLLC  (P54772), DCHS_VIBA7  (Q56581), DCHS_VIBC1  (A7MVI6), 
DDC_ACIBA   (Q43908), DDC_BOVIN   (P27718), DDC_CAVPO   (P22781), 
DDC_DROLE   (O96571), DDC_DROME   (P05031), DDC_DROSI   (O96567), 
DDC_HAEIN   (P71362), DDC_HUMAN   (P20711), DDC_MANSE   (P48861), 
DDC_MOUSE   (O88533), DDC_PIG (P80041), DDC_RAT (P14173), 
DHAPP_DROLE (O96569), DHAPP_DROME (P18486), DHAPP_DROSI (P81893), 
DHPAA_AEDAE (Q16S21), GADL1_BOVIN (A6QM00), GADL1_HUMAN (Q6ZQY3), 
GADL1_MOUSE (Q80WP8), GADL1_XENTR (Q28D99), HPAAS_PETCR (Q06086), 
MFNA_ARCFU  (O28275), MFNA_META3  (A6UVR4), MFNA_METLZ  (A2STQ3), 
MFNA_METM5  (A4G060), MFNA_METM7  (A6VIC0), MFNA_METMJ  (A3CWM4), 
MFNA_METMP  (Q6M0Y7), MFNA_METPE  (B8GDM7), MFNA_METS3  (A5ULW4), 
MFNA_METTP  (A0B9M9), MFNA_METVS  (A6URB4), MFNA_PYRAB  (Q9UZD5), 
MFNA_PYRFU  (Q8U1P6), MFNA_PYRHO  (O58679), MFNA_THEGJ  (C5A2X8), 
MFNA_THEKO  (Q5JJ82), PAAS_ARATH  (Q8RY79), PAAS_PETHY  (Q0ZQX0), 
PAAS_ROSHC  (Q0ZS27), RHBB_RHIME  (Q9Z3R1), SDC1_ARATH  (Q9MA74), 
SDC1_ORYSJ  (Q6ESZ9), SDC2_ORYSJ  (Q8RV06), SDC3_ORYSJ  (Q7X8D4), 
TDC1_CAEEL  (Q95ZS2), TDC1_CAMAC  (P93082), TDC1_ORYSJ  (Q6ZJK7), 
TDC2_CAMAC  (P93083), TDC2_ORYSJ  (Q7XHL3), TDC_CATRO   (P17770), 
TRPDC_MEDG7 (A7B1V0), TYDC1_NARPS (A0A2H5AIY0), TYDC1_PAPSO (P54768), 
TYDC1_PETCR (Q06085), TYDC2_NARPS (A0A2H5AIY2), TYDC2_PAPSO (P54769), 
TYDC3_PAPSO (P54770), TYDC3_PETCR (Q06087), TYDC4_PETCR (Q06088), 
TYDC5_PAPSO (P54771), TYDC_PAPSO  (O82415), TYRDC_ENTFC (A0A481NV25)
» more

UniProtKB/Swiss-Prot
False negative sequences		 47 sequences 

AADC_BACAT  (I0DFJ0), CSAD_HUMAN  (Q9Y600), DCE1_ARATH  (Q42521), 

DCE2_ARATH  (Q42472), DCEA_LISMO  (Q9F5P3), DCEB_LISIN  (Q928R9), 
DCEB_LISMO  (Q9EYW9), DCEC_LISIN  (Q928K4), DCEC_LISMO  (Q8Y4K4), 
DCE_LACLA   (Q9CG20), DCE_LACLM   (O30418), DCE_PETHY   (Q07346), 
DCE_SOLLC   (P54767), DCE_YEAST   (Q04792), DCHS_RHILO  (Q98A07), 
DDC_CAEEL   (P34751), GADA_DICDI  (Q54VQ5), GADB_DICDI  (Q54IJ3), 
MFNA_HALMA  (Q5V1B4), MFNA_HALS3  (B0R349), MFNA_HALSA  (Q9HSA3), 
MFNA_METAC  (Q8TUQ9), MFNA_METAR  (Q0W498), MFNA_METB6  (A7IAB9), 
MFNA_METBF  (Q46DU3), MFNA_METBU  (Q12VA2), MFNA_METHJ  (Q2FSD2), 
MFNA_METJA  (Q60358), MFNA_METKA  (Q8TV92), MFNA_METMA  (Q8PXA5), 
MFNA_METST  (Q2NHY7), MFNA_METTH  (O27188), MFNA_NATPD  (Q3IT46), 
PDXD1_HUMAN (Q6P996), PDXD1_MOUSE (Q99K01), PDXD1_XENLA (Q6DF78), 
PDXD2_HUMAN (Q6P474), SGPL1_HUMAN (O95470), SGPL1_MOUSE (Q8R0X7), 
SGPL1_PONAB (Q5R4G0), SGPL1_RAT   (Q8CHN6), SGPL_ARATH  (Q9C509), 
SGPL_CAEEL  (Q9Y194), SGPL_DROME  (Q9V7Y2), SGPL_YEAST  (Q05567), 
TRPDC_CLOS1 (J7SZ64), TYDC2_ARATH (Q9M0G4)
» more

UniProtKB/Swiss-Prot
False positive sequences		 10 sequences 

ATG1B_ARATH (F4JBP3), CCME_EHRCJ  (Q3YSH2), CCME_EHRCR  (Q2GG46), 

CCME_EHRRG  (Q5FHG0), CCME_EHRRW  (Q5HBM4), CH101_VIBCH (Q9KNR6), 
HS7C4_DICDI (Q54BD8), MMS1_YEAST  (Q06211), NUOD_SPHAL  (Q1GTK0), 
RMT2_YARLI  (Q6CBX2)
» more

PDB
[Detailed view]		 40 PDB

1JS3; 1JS6; 1PMM; 1PMO; 1XEY; 2DGK; 2DGL; 2DGM; 2OKJ; 2OKK; 3FZ6; 3FZ7; 3FZ8; 3K40; 3RBF; 3RBL; 3RCH; 3VP6; 4E1O; 4OBU; 4OBV; 6EEI; 6EEM; 6EEW; 6ENZ; 6JRL; 6KHN; 6KHO; 6KHP; 6LIU; 6LIV; 6ZEK; 7A0A; 7EIW; 7EIX; 7EIY; 7LZ6; 8JG7; 8OR9; 8ORA
» more