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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00395


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PURL: https://purl.expasy.org/prosite/signature/PS00395

Direct ScanProsite submission
General information about the entry

Entry name [info] ALANINE_RACEMASE
Accession [info] PS00395
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-FEB-2002 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00332

Name and characterization of the entry

Description [info] Alanine racemase pyridoxal-phosphate attachment site.
Pattern [info] 
[SACVLG]-[AIPTV]-x(0,1)-K-[ADGS]-[DEN]-[GA]-Y-G-[HACILN]-[GD].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 331 in 331 different sequences
Number of true positive hits 331 in 331 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 44
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 88.27 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] pyridoxal_phosphate at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 331 sequences 

ALR1_AGRFC  (P58736), ALR1_BACSU  (P10725), ALR1_CALS4  (Q8RAK6), 

ALR1_CLOAB  (Q97LR2), ALR1_ECO57  (Q8X5V2), ALR1_ECOL6  (Q8FB20), 
ALR1_ECOLI  (P0A6B4), ALR1_OCEIH  (Q8ELR9), ALR1_PSEAE  (Q9HUN4), 
ALR1_RHILO  (Q98A05), ALR1_SALTI  (P0A1A4), ALR1_SALTY  (P0A1A3), 
ALR1_SCHPO  (O59828), ALR1_SHIBO  (P0A6B6), ALR1_SHIDY  (Q932V0), 
ALR1_SHIFL  (P0A6B5), ALR1_SHISO  (Q93HP9), ALR1_STAA8  (Q9ZAH5), 
ALR1_STAAC  (Q5HED1), ALR1_STAAM  (P63479), ALR1_STAAN  (P63480), 
ALR1_STAAR  (Q6GF03), ALR1_STAAS  (Q6G7N9), ALR1_STAAW  (P63481), 
ALR2_AGRFC  (P58737), ALR2_BACSU  (P94494), ALR2_CALS4  (Q8R860), 
ALR2_CLOAB  (Q97DY9), ALR2_ECO57  (Q8X4I9), ALR2_ECOL6  (P59237), 
ALR2_ECOLI  (P29012), ALR2_KLEAE  (O30746), ALR2_OCEIH  (Q8ELK1), 
ALR2_PSEAE  (Q9HTQ2), ALR2_RHIJ3  (Q9RAE7), ALR2_RHILO  (Q98F05), 
ALR2_SALTI  (Q8Z688), ALR2_SALTY  (P06191), ALR2_SCHPO  (Q9P5N3), 
ALR3_RHILO  (Q981H7), ALR3_SALTI  (Q8Z300), ALRX_PSEPU  (P17916), 
ALR_ACIBS   (B0VNF6), ALR_ACICJ   (A5G2H9), ALR_ACIET   (B9MAN2), 
ALR_ACIF2   (B7J911), ALR_ACIF5   (B5EP95), ALR_ACISJ   (A1W2F6), 
ALR_ACTSZ   (A6VP88), ALR_AERHH   (A0KH11), ALR_ALBFT   (Q221R3), 
ALR_ALIB4   (A8ESX7), ALR_ALISL   (B6ELK6), ALR_ALTMD   (B4S1A6), 
ALR_ANOFW   (B7GFP5), ALR_AQUAE   (O67687), ALR_AQUPY   (Q9RER4), 
ALR_AROAE   (Q5P3K0), ALR_AZOSB   (A1KCI5), ALR_BEUC1   (C5BZY7), 
ALR_BORA1   (Q2KXU7), ALR_BORBU   (O51182), ALR_BORBZ   (B7J192), 
ALR_BORPD   (A9IU63), ALR_BRUA2   (Q2YIU9), ALR_BRUC2   (A9MCK3), 
ALR_BRUME   (Q8YD03), ALR_BRUO2   (A5VVI9), ALR_BRUSI   (A9WVT5), 
ALR_BRUSU   (Q8FVC1), ALR_BURM7   (A3MKW5), ALR_BURM9   (A2SB51), 
ALR_BURMA   (Q62JA4), ALR_BURMS   (A1V591), ALR_CAMC1   (A7ZCL1), 
ALR_CAMC5   (A7GZM8), ALR_CAMJ8   (A8FLV4), ALR_CAMJD   (A7H3E3), 
ALR_CAMJE   (Q9PP26), ALR_CAMJJ   (A1VZN9), ALR_CAMJR   (Q5HUQ3), 
ALR_CARHZ   (Q9F8I0), ALR_CAUVC   (Q9A7Q9), ALR_CERS5   (A4WRF5), 
ALR_CHLTE   (Q8KB67), ALR_CHRSD   (Q1QU82), ALR_CITBB   (B5EBG2), 
ALR_CLOK5   (A5N376), ALR_CLONN   (A0PY95), ALR_CLOP1   (Q0TSS9), 
ALR_CLOPE   (Q8XM22), ALR_CLOPS   (Q0SUN0), ALR_CLOTE   (Q890X1), 
ALR_COPPD   (B5Y9T8), ALR_CUPMC   (Q1LNJ3), ALR_CUPNH   (Q0K9V9), 
ALR_CUPTR   (B3R2F9), ALR_CUTAK   (Q6A5H2), ALR_DEIDV   (C1CVP5), 
ALR_DEIGD   (Q1IYK9), ALR_DEIRA   (Q9RVE3), ALR_DELAS   (A9BR02), 
ALR_DESOH   (A8ZRV0), ALR_DESRM   (A4J8G6), ALR_DICNV   (A5EW54), 
ALR_DINSH   (A8LRT3), ALR_EDWI9   (C5BCC5), ALR_ERWT9   (B2VJ52), 
ALR_FRACC   (Q2JFD6), ALR_FUSNN   (Q8RGA2), ALR_GEOKA   (Q5L3G4), 
ALR_GEOMG   (Q39RJ8), ALR_GEOSE   (P10724), ALR_GEOSL   (Q74FK2), 
ALR_GEOSM   (C6E5Z6), ALR_HAEIN   (P45257), ALR_HAHCH   (Q2SLB1), 
ALR_HALH5   (Q9KFF9), ALR_HALHL   (A1WUS2), ALR_HALOH   (B8D0W1), 
ALR_HAMD5   (C4K4C4), ALR_HELP2   (B6JMG2), ALR_HELPG   (B5Z7U5), 
ALR_HELPH   (Q1CST1), ALR_HELPJ   (Q9ZKQ9), ALR_HELPY   (O25595), 
ALR_JANMA   (A6SY68), ALR_JANSC   (Q28RK6), ALR_LACAC   (Q5FMB2), 
ALR_LACCB   (B3WAR0), ALR_LACDA   (Q1GBP6), ALR_LACDB   (Q04C45), 
ALR_LACGA   (Q046E7), ALR_LACH4   (A8YXI3), ALR_LACLA   (Q9CH94), 
ALR_LACLM   (Q9RLU5), ALR_LACLS   (Q030B4), ALR_LACP3   (Q034T9), 
ALR_LACPL   (O08445), ALR_LARHH   (C1DBE8), ALR_LAWIP   (Q1MSD5), 
ALR_LEPCP   (B1Y2H6), ALR_LEPIC   (Q75FF2), ALR_LEPIN   (Q8EX97), 
ALR_LEVBA   (Q03T06), ALR_LIGS1   (Q1WV14), ALR_LIMF3   (B2GA65), 
ALR_LIMRD   (A5VI51), ALR_LIMRJ   (B2G5M9), ALR_LIMRT   (Q9FCV2), 
ALR_LISIN   (Q92DC9), ALR_LISM4   (G2K4Q7), ALR_LISMC   (C1L1F6), 
ALR_LISMF   (Q721S9), ALR_LISMH   (B8DG73), ALR_LISMO   (P0DJL8), 
ALR_LISW6   (A0AH04), ALR_MACCJ   (B9E8C3), ALR_MANSM   (Q65TC1), 
ALR_MARMS   (A6W1F2), ALR_MARN8   (A1U388), ALR_METCA   (Q607M5), 
ALR_METFK   (Q1H1N8), ALR_METI4   (B3DWZ0), ALR_METMP   (Q6LX41), 
ALR_METNO   (B8IEC7), ALR_MYCA1   (A0QKR9), ALR_MYCAV   (Q9L888), 
ALR_MYCBO   (P0A4X3), ALR_MYCLE   (P38056), ALR_MYCS2   (A0QSR6), 
ALR_MYCSM   (P94967), ALR_MYCTO   (P9WQA8), ALR_MYCTU   (P9WQA9), 
ALR_MYCUA   (A0PME2), ALR_MYCVP   (A1T566), ALR_NEIG1   (Q5F788), 
ALR_NEIMA   (Q9JTA6), ALR_NEIMB   (Q9JYC4), ALR_NEIMF   (A1KV59), 
ALR_NITEC   (Q0AFV7), ALR_NITEU   (Q82UR4), ALR_NITMU   (Q2Y763), 
ALR_NITOC   (Q3JEJ2), ALR_NITSB   (A6Q1W0), ALR_NITV2   (Q72DH4), 
ALR_NITV4   (A1VF31), ALR_NITV9   (B8DRL1), ALR_NOSS1   (Q8YU96), 
ALR_PARC0   (A1TIS2), ALR_PARPJ   (B2T5L6), ALR_PASMU   (Q9CNL5), 
ALR_PECAS   (Q3V7N2), ALR_PECCP   (C6DE79), ALR_PEDPA   (Q03DZ2), 
ALR_PELTS   (A5D4I1), ALR_PERPY   (Q9S5V6), ALR_PHOPR   (Q3V7I5), 
ALR_POLNA   (A1VIH8), ALR_POLSJ   (Q12H34), ALR_PROMA   (Q7V9Z2), 
ALR_PSE14   (Q48PY9), ALR_PSEA6   (Q15NL4), ALR_PSEE4   (Q1I2V7), 
ALR_PSEF5   (Q4K3T9), ALR_PSETA   (B9WZ64), ALR_PSEU2   (Q4ZZW2), 
ALR_RALN1   (Q8XZM4), ALR_RALPJ   (B2UAX2), ALR_RHIME   (Q92R07), 
ALR_RHORT   (Q2RXD1), ALR_RICAE   (C3PMD1), ALR_RICAH   (A8GM54), 
ALR_RICCK   (A8EXF8), ALR_RICCN   (Q92JD9), ALR_RICFE   (Q4UNC8), 
ALR_RICPR   (Q9ZE52), ALR_RICPU   (C4K1B0), ALR_RICRO   (B0BW55), 
ALR_RICRS   (A8GQR1), ALR_RICTY   (Q68XW3), ALR_ROSDO   (Q163V1), 
ALR_SALAI   (A8M4B3), ALR_SALTO   (A4XBI0), ALR_SHEAM   (A1SA53), 
ALR_SHEB2   (B8E9P2), ALR_SHEB5   (A3D8P9), ALR_SHEB8   (A6WJ85), 
ALR_SHEB9   (A9L126), ALR_SHEDO   (Q12RW2), ALR_SHEFN   (Q07XT3), 
ALR_SHELP   (A3QI45), ALR_SHEON   (Q8EAI6), ALR_SHEPA   (A8H8K6), 
ALR_SHEPC   (A4Y3F6), ALR_SHEPW   (B8CIQ9), ALR_SHESA   (A0KT33), 
ALR_SHESH   (A8FRA1), ALR_SHESM   (Q0HF52), ALR_SHESR   (Q0HYW0), 
ALR_SHESW   (A1RNI3), ALR_SHEWM   (B1KHY4), ALR_SHIB3   (B2TX62), 
ALR_SHIBS   (Q31TW1), ALR_SHIDS   (Q327W0), ALR_SODGM   (Q2NTA8), 
ALR_SORC5   (A9ESU7), ALR_STAA3   (Q2FF55), ALR_STAAE   (A6QIR5), 
ALR_STAEQ   (Q5HME5), ALR_STAES   (Q8CNK7), ALR_STAS1   (Q49Z24), 
ALR_STRA1   (Q3JZK5), ALR_STRA3   (Q8E3M9), ALR_STRA5   (Q8DY10), 
ALR_STRCO   (O86786), ALR_STRE4   (C0M6I5), ALR_STREM   (B4U178), 
ALR_STRGC   (A8AVC4), ALR_STRMU   (Q8DSF4), ALR_STRP1   (Q99Y98), 
ALR_STRP2   (Q04J74), ALR_STRP3   (P0CZ56), ALR_STRP4   (B5E745), 
ALR_STRP6   (Q5XAA4), ALR_STRP7   (C1C8T6), ALR_STRP8   (Q8NZK4), 
ALR_STRPB   (Q1JA50), ALR_STRPC   (Q1JKA0), ALR_STRPD   (Q1JF94), 
ALR_STRPF   (Q1J545), ALR_STRPG   (A2RCT3), ALR_STRPI   (B1I755), 
ALR_STRPJ   (B8ZMG1), ALR_STRPM   (Q48RM8), ALR_STRPN   (P0A2W8), 
ALR_STRPQ   (P0CZ57), ALR_STRPZ   (B5XI21), ALR_STRR6   (P0A2W9), 
ALR_STRS2   (A4W3N5), ALR_STRS7   (C0MEB7), ALR_STRSY   (A4VXD9), 
ALR_STRT1   (Q5LY71), ALR_STRT2   (Q5M2S7), ALR_STRTD   (Q03IX8), 
ALR_STRU0   (B9DVI3), ALR_STRZJ   (C1CFR7), ALR_STRZP   (C1CM34), 
ALR_STRZT   (C1CSV9), ALR_STUS1   (A4VQM5), ALR_SYMTH   (Q67K79), 
ALR_SYNFM   (A0LFQ9), ALR_SYNY3   (P54918), ALR_THEFY   (Q47LN3), 
ALR_THEYD   (B5YIM9), ALR_THIDA   (Q3SH36), ALR_THISH   (B8GNS7), 
ALR_TREDE   (Q73NQ7), ALR_TREPA   (Q56346), ALR_TREPS   (B2S3S0), 
ALR_VARPS   (C5CX88), ALR_VEREI   (A1WQY3), ALR_VIBA3   (B7VI70), 
ALR_VIBCH   (Q9KUY6), ALR_VIBPA   (Q87L78), ALR_VIBVU   (Q8DCL0), 
ALR_VIBVY   (Q7MH94), ALR_XANAC   (Q8PGD0), ALR_XANC8   (Q4UQB5), 
ALR_XANCP   (Q8P4R0), ALR_XANE5   (Q3BNX4), ALR_XANOM   (Q2P7U1), 
ALR_XANOR   (Q5H522), ALR_XYLFA   (Q9PF26), ALR_XYLFT   (Q87AK1), 
ALR_YERPE   (Q8ZJ10), ALR_YERPG   (A9QYT2), BSR_AERHH   (A0KLG5), 
BSR_PSEPK   (Q88GJ9), BSR_PSEPU   (I6LNY0), BSR_PSETA   (I0J1I6), 
BSR_VIBCH   (Q9KSE5), BSR_VIBPA   (Q87HG4), BSR_VIBVU   (Q8D6Q0), 
BSR_YERPE   (Q8ZFL4), DADX_PSEPK  (Q88CB2), LYR_PROMI   (M4GGR9), 
LYSR_OENOB  (Q04HB7), VANTC_ENTGA (Q9X3P3), VANTE_ENTFL (Q93A44), 
VANTG_ENTFL (Q9KHL7)
» more

UniProtKB/Swiss-Prot
False negative sequences		 44 sequences 

ALR2_STAA8  (Q9EZ08), ALR2_STAAC  (Q5HG21), ALR2_STAAM  (P63482), 

ALR2_STAAN  (P63483), ALR_ACTP2   (A3MYX4), ALR_ALCBS   (Q0VMG4), 
ALR_CERS1   (A3PIR7), ALR_CERS4   (Q3J3L4), ALR_CERSK   (B9KQC8), 
ALR_COREF   (Q8FS13), ALR_CORGB   (A4QBT0), ALR_CORGL   (Q8RSU9), 
ALR_COXB1   (B6J6U2), ALR_COXB2   (B6J0J1), ALR_COXBN   (A9KFM0), 
ALR_COXBR   (A9ND48), ALR_COXBU   (Q83D71), ALR_DESDA   (B8J2K3), 
ALR_FRAP2   (B0TYB0), ALR_FRAT1   (Q14IP6), ALR_FRATF   (A7ND36), 
ALR_FRATH   (Q2A2P9), ALR_FRATM   (B2SHB9), ALR_FRATN   (A0Q5X2), 
ALR_FRATO   (Q0BL88), ALR_FRATT   (Q5NH94), ALR_FRATW   (A4IZ25), 
ALR_HAEDU   (Q7VNC9), ALR_HELAH   (Q17WC4), ALR_HELPS   (B2UU89), 
ALR_LATSS   (Q38V64), ALR_LEGPA   (Q5X709), ALR_LEGPC   (A5IGG9), 
ALR_LEGPH   (Q5ZXJ2), ALR_LEGPL   (Q5WYG1), ALR_METPP   (A2SLS6), 
ALR_METS4   (B0UL34), ALR_PSYWF   (A5WDJ3), ALR_RICBR   (Q1RGU4), 
ALR_RUEST   (Q1GFQ4), ALR_STACT   (B9DMI9), ALR_SULNB   (A6QC54), 
ALR_VESOH   (A5CWE3), ALR_WIGBR   (Q8D2H8)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

ALR_PISSA   (Q9F9L1), ALR_PSEFL   (P33162)


				
	

	

		PDB
[Detailed view]		
		
			52 PDB
			


			pdb_00001bd0; pdb_00001epv; pdb_00001ftx; pdb_00001l6f; pdb_00001l6g; pdb_00001niu; pdb_00001rcq; pdb_00001sft; pdb_00001xfc; pdb_00001xqk; pdb_00001xql; pdb_00002rjg; 
			
				pdb_00002rjh; pdb_00002sfp; pdb_00003b8t; pdb_00003b8u; pdb_00003b8v; pdb_00003b8w; pdb_00003co8; pdb_00003oo2; pdb_00003s46; pdb_00004a3q; pdb_00004beq; pdb_00004beu; 
				pdb_00004bf5; pdb_00004bhy; pdb_00004dyj; pdb_00004dza; pdb_00004fs9; pdb_00004wr3; pdb_00004xbj; pdb_00004y2w; pdb_00005fac; pdb_00005fag; pdb_00005faj; pdb_00005irp; 
				pdb_00006a2f; pdb_00006g56; pdb_00006g58; pdb_00006g59; pdb_00006q70; pdb_00006q71; pdb_00006q72; pdb_00006scz; pdb_00007agz; pdb_00008ahw; pdb_00008b8h; pdb_00008zpe; 
				pdb_00008zpf; pdb_00008zpg; pdb_00008zph; pdb_00009jt7
			
			

			» more