PROSITE entry PS00407

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PURL: https://purl.expasy.org/prosite/signature/PS00407

Direct ScanProsite submission

General information about the entry

Entry name [info]	CONNEXINS_1
Accession [info]	PS00407
Entry type [info]	PATTERN
Date [info]	01-NOV-1990 CREATED; 01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00341

Name and characterization of the entry

Description [info]	Connexins signature 1.
Pattern [info]	C-[DNH]-[TL]-x-[QT]-P-G-C-x(2)-[VAIL]-C-[FY]-D.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	104 in 104 different sequences
Number of true positive hits	104 in 104 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	5
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	95.41 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Site [info]	disulfide at position 1
Site [info]	disulfide at position 8
Site [info]	disulfide at position 11
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

104 sequences

CX32_DANRE  (Q7T047), CX32_MICUN  (P51915), CX33_MICUN  (P51916),

CXA10_HUMAN (Q969M2), CXA10_MOUSE (Q9WUS4), CXA1_BOVIN  (P18246), 
CXA1_CANLF  (Q6S9C0), CXA1_CHICK  (P14154), CXA1_CHLAE  (Q6TYA9), 
CXA1_DANRE  (O57474), CXA1_ERIEU  (Q6TYA8), CXA1_HUMAN  (P17302), 
CXA1_MACFA  (Q4R4S7), CXA1_MOUSE  (P23242), CXA1_PIG(Q29101), 
CXA1_RABIT  (Q6TYA7), CXA1_RAT(P08050), CXA1_URSAM  (A6XKM2), 
CXA1_XENLA  (P16863), CXA2_XENLA  (P16864), CXA3_BOVIN  (P41987), 
CXA3_CHICK  (P29415), CXA3_HUMAN  (Q9Y6H8), CXA3_MOUSE  (Q64448), 
CXA3_RAT(P29414), CXA3_SHEEP  (Q9TU17), CXA4_BOVIN  (A4IFL1), 
CXA4_HUMAN  (P35212), CXA4_MOUSE  (P28235), CXA4_PIG(Q29559), 
CXA4_RAT(Q03190), CXA4_XENLA  (P51914), CXA4_XENTR  (Q0V990), 
CXA5_BOVIN  (Q0VCR2), CXA5_CANLF  (P33725), CXA5_CHICK  (P18860), 
CXA5_HUMAN  (P36382), CXA5_MOUSE  (Q01231), CXA5_RAT(P28234), 
CXA6_MOUSE  (Q6S5G4), CXA6_RAT(P28233), CXA8_CHICK  (P36381), 
CXA8_HUMAN  (P48165), CXA8_MOUSE  (P28236), CXA8_RAT(Q8K4Q9), 
CXA8_SHEEP  (P55917), CXA9_HUMAN  (P57773), CXB1_BOVIN  (O18968), 
CXB1_HORSE  (Q6WGK6), CXB1_HUMAN  (P08034), CXB1_MACFA  (Q60HF7), 
CXB1_MOUSE  (P28230), CXB1_RAT(P08033), CXB1_XENLA  (P08983), 
CXB2_BOVIN  (A2VE67), CXB2_GORGO  (Q8MHW5), CXB2_HUMAN  (P29033), 
CXB2_HYLLA  (Q7JGL3), CXB2_MACMU  (Q8MIT8), CXB2_MOUSE  (Q00977), 
CXB2_PONPY  (Q8MIT9), CXB2_RAT(P21994), CXB2_SHEEP  (P46691), 
CXB3_BOVIN  (Q58D78), CXB3_HUMAN  (O75712), CXB3_MOUSE  (P28231), 
CXB3_RAT(P25305), CXB4_HUMAN  (Q9NTQ9), CXB4_MOUSE  (Q02738), 
CXB4_RAT(P36380), CXB5_HUMAN  (O95377), CXB5_MOUSE  (Q02739), 
CXB5_RAT(P28232), CXB6_BOVIN  (Q5E9Z5), CXB6_CHICK  (O93533), 
CXB6_HUMAN  (O95452), CXB6_MOUSE  (P70689), CXD2_BOVIN  (Q866T7), 
CXD2_HUMAN  (Q9UKL4), CXD2_LEUER  (P69998), CXD2_LEUOC  (P69999), 
CXD2_MOUSE  (O54851), CXD2_RAT(O70610), CXD4_HUMAN  (Q96KN9), 
CXD4_MACFA  (Q9N0B3), CXD4_MOUSE  (Q8BSD4), CXG1_BOVIN  (Q2HJ66), 
CXG1_CANLF  (P28228), CXG1_CHICK  (P18861), CXG1_CRIGR  (Q6R4A8), 
CXG1_DANRE  (Q92052), CXG1_HUMAN  (P36383), CXG1_MESAU  (Q6PYT3), 
CXG1_MOUSE  (P28229), CXG1_PIG(A4GVD1), CXG1_RAT(A4GG66), 
CXG1_XENLA  (Q7ZXS7), CXG1_XENTR  (Q6NZH5), CXG2_BOVIN  (Q29RK8), 
CXG2_HUMAN  (Q5T442), CXG2_MOUSE  (Q8BQU6), CXG2_RAT(Q80XF7), 
CXG3_HUMAN  (Q8NFK1), CXG3_MOUSE  (Q921C1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

5 sequences

CXB7_HUMAN  (Q6PEY0), CXE1_DANRE  (U3JA75), CXE1_HUMAN  (A6NN92),

CXE1_MOUSE  (Q9CX92), CXG3_BOVIN  (A3KN25)

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PDB
[Detailed view]

82 PDB

pdb_00002zw3; pdb_00003iz1; pdb_00003iz2; pdb_00005er7; pdb_00005era; pdb_00006l3t; pdb_00006l3u; pdb_00006l3v; pdb_00006mhq; pdb_00006mhy; pdb_00006uvr; pdb_00006uvs; pdb_00006uvt; pdb_00007f92; pdb_00007f93; pdb_00007f94; pdb_00007jjp; pdb_00007jkc; pdb_00007jlw; pdb_00007jm9; pdb_00007jmc; pdb_00007jmd; pdb_00007jn0; pdb_00007jn1; pdb_00007qeo; pdb_00007qeq; pdb_00007qer; pdb_00007qes; pdb_00007qet; pdb_00007qeu; pdb_00007qev; pdb_00007qew; pdb_00007qey; pdb_00007xki; pdb_00007xkk; pdb_00007xkt; pdb_00007xl8; pdb_00007xnh; pdb_00007xnv; pdb_00007xq9; pdb_00007xqb; pdb_00007xqd; pdb_00007xqf; pdb_00007xqg; pdb_00007xqh; pdb_00007xqi; pdb_00007xqj; pdb_00007z1t; pdb_00007z22; pdb_00007z23; pdb_00007zxm; pdb_00007zxn; pdb_00007zxo; pdb_00007zxp; pdb_00007zxq; pdb_00007zxt; pdb_00008gn7; pdb_00008gn8; pdb_00008gnb; pdb_00008hkp; pdb_00008iyg; pdb_00008q9z; pdb_00008qa0; pdb_00008qa1; pdb_00008qa2; pdb_00008qa3; pdb_00008qjf; pdb_00008qjh; pdb_00008qk6; pdb_00008qki; pdb_00008qko; pdb_00008qoj; pdb_00008r7p; pdb_00008r7q; pdb_00008r7r; pdb_00008xgd; pdb_00008xge; pdb_00008xgf; pdb_00008xgg; pdb_00008xgj; pdb_00008xh8; pdb_00008xh9
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