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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00427


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PURL: https://purl.expasy.org/prosite/signature/PS00427

Direct ScanProsite submission
General information about the entry

Entry name [info] DISINTEGRIN_1
Accession [info] PS00427
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00351

Name and characterization of the entry

Description [info] Disintegrins signature.
Pattern [info] 
C-x(2)-[GS]-x-C-C-x(1,2)-[NQRSEKD]-C-x-[FMYLVI]-x(6)-C-[RKNQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 246 in 246 different sequences
Number of true positive hits 246 in 246 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 103
Number of 'partial' sequences 13
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 70.49 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 6
Site [info] disulfide at position 9
Site [info] disulfide at position 13
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 246 sequences 

AD26A_MOUSE (Q9R158), ADA11_HUMAN (O75078), ADA11_MOUSE (Q9R1V4), 

ADA12_HUMAN (O43184), ADA12_MOUSE (Q61824), ADA18_HUMAN (Q9Y3Q7), 
ADA18_MACFA (Q95194), ADA18_RAT   (P97776), ADA19_HUMAN (Q9H013), 
ADA19_MOUSE (O35674), ADA20_HUMAN (O43506), ADA21_HUMAN (Q9UKJ8), 
ADA21_MOUSE (Q9JI76), ADA22_HUMAN (Q9P0K1), ADA22_MOUSE (Q9R1V6), 
ADA22_XENLA (O42596), ADA24_MOUSE (Q9R160), ADA28_HUMAN (Q9UKQ2), 
ADA28_MACFA (Q9XSL6), ADA28_MOUSE (Q9JLN6), ADA29_HUMAN (Q9UKF5), 
ADA29_MOUSE (Q811Q4), ADA30_HUMAN (Q9UKF2), ADA32_HUMAN (Q8TC27), 
ADA33_HUMAN (Q9BZ11), ADA33_MOUSE (Q923W9), ADAM1_RAT   (P70505), 
ADAM2_BOVIN (O77780), ADAM2_CAVPO (Q60411), ADAM2_HUMAN (Q99965), 
ADAM2_MACFA (Q28478), ADAM2_MOUSE (Q60718), ADAM2_RABIT (Q28660), 
ADAM2_RAT   (Q63202), ADAM5_CAVPO (Q60472), ADAM5_MACFA (Q28483), 
ADAM5_MOUSE (Q3TTE0), ADAM5_RAT   (Q5BK84), ADAM7_HUMAN (Q9H2U9), 
ADAM7_MACFA (Q28475), ADAM7_MOUSE (O35227), ADAM7_RAT   (Q63180), 
ADAM8_HUMAN (P78325), ADAM8_MOUSE (Q05910), ADAM9_HUMAN (Q13443), 
ADAM9_MOUSE (Q61072), ADM1A_MOUSE (Q60813), DID1A_MACLB (P83253), 
DID1_BITGA  (Q6T6T3), DID1_ECHOC  (Q3BER2), DID2A_MACLB (Q3BK13), 
DID2_BITGA  (Q6T6T2), DID4A_ECHOC (Q3BER3), DID4_MACLO  (P0C6A8), 
DID5A_ECHOC (Q3BER4), DID5B_ECHOC (P0C6A4), DID5B_MACLO (P0C6B0), 
DID5_CERCE  (P83041), DID6A_ECHCS (P82465), DID7A_VIPBB (P0C6A6), 
DID8A_CERCE (P83043), DIDAA_ERIMA (P81742), DIDA_AGKCO  (Q805F7), 
DIDA_AGKPI  (Q805F5), DIDA_AGKPL  (C9E1S2), DIDA_CERVI  (Q3BK16), 
DIDBA_ECHML (P0C6A3), DIDB_CERVI  (Q3BK15), DIDLA_ECHCA (P0C6B4), 
DIDLB_ECHCA (P0C6B5), DIDS_ECHCA  (P83658), DID_ATHCH   (M5BGY5), 
DID_ATHNI   (M5BHN0), DID_ATHSQ   (M5BGS2), DID_ECHCA   (Q5EE07), 
DIS_ECHOC   (Q3BER1), VM212_CROHD (P0C7X6), VM212_CROSS (P0C7X7), 
VM23A_ECHCA (P81630), VM23B_ECHCA (P81631), VM25A_BITAR (P0DM97), 
VM25A_MACLO (P0C6A9), VM26B_ECHCS (P82466), VM28_CROAD  (J3SBP9), 
VM2A6_VIPAA (P0C6A5), VM2AB_AGKCO (Q805F6), VM2AE_CROAT (P34182), 
VM2AG_GLOHA (Q8AWX7), VM2AL_TRIAB (P0C6B6), VM2B1_AGKBI (P0C6E3), 
VM2BI_BITGA (Q6T271), VM2B_CRAGM  (P17495), VM2C1_CRODO (C0L2T8), 
VM2CO_AGKCO (Q9IAB0), VM2C_PROFL  (P23323), VM2D2_BITAR (Q4JCS1), 
VM2D3_BITAR (Q4JCS0), VM2DI_GLOHA (Q1PBD1), VM2E1_PROEL (P17349), 
VM2E2_PROEL (Q90YA6), VM2EA_ECHCS (P17347), VM2EB_ECHPL (Q7LZK1), 
VM2EG_ECHPL (Q7LZK0), VM2FL_PROFL (P18619), VM2G_CRAGM  (P62383), 
VM2G_TRIAB  (P62384), VM2H1_BOTLA (U5PZ28), VM2H1_GLOHA (Q90220), 
VM2H2_GLOHA (Q90221), VM2HA_PROFL (P14530), VM2HS_GLOBR (Q90WC0), 
VM2I1_GLOUS (Q7LZI5), VM2I2_GLOUS (Q7LZT4), VM2IA_BOTIN (Q5XUW8), 
VM2IA_CROAT (A2CJE5), VM2IC_CROAT (P68520), VM2IV_CROVV (A2CJE6), 
VM2I_CROBA  (P31981), VM2I_CROCC  (P31982), VM2I_CROCE  (P31985), 
VM2I_CRODD  (P68521), VM2I_CROLT  (P31986), VM2I_CROMM  (P31984), 
VM2I_CROVV  (P31987), VM2I_LACMU  (P31990), VM2I_SISMB  (P22827), 
VM2I_SISTE  (P22828), VM2J2_BOTJA (Q98SP2), VM2JA_BOTJA (Q0NZX5), 
VM2JC_BOTJA (P31989), VM2JN_PROJR (P0C6E4), VM2JR_BOTJA (Q0NZX6), 
VM2JT_PROJR (P83912), VM2J_PROJR  (Q7ZZS9), VM2L2_MACLB (Q98995), 
VM2L4_GLOBR (Q698K8), VM2LA_ECHLE (P0C7A7), VM2LB_ECHLE (P0C7A8), 
VM2MB_GLOBR (O73795), VM2MC_GLOBR (Q9YI19), VM2MD_GLOBR (Q9PVK9), 
VM2MU_ECHML (P0C6R5), VM2OC_ECHOC (Q14FJ4), VM2OI_ECHOC (P0C6R6), 
VM2P1_PROMU (E9NW26), VM2P2_PROMU (E9NW27), VM2PA_ECHPL (P0C6R7), 
VM2PB_ECHPL (P0C6R8), VM2RH_CALRH (P30403), VM2S2_GLOBR (O93516), 
VM2S3_GLOBR (O93515), VM2SA_GLOIT (Q7SZE0), VM2T3_PROMU (O57413), 
VM2TA_CRAGM (P15503), VM2TI_ERIMA (P22826), VM2TO_ERIMA (P0C6S4), 
VM2T_PROFL  (P21859), VM2US_GLOUS (Q7SZD9), VM2V2_CROAT (C9E1R7), 
VM2V2_CROVV (C9E1R9), VM2_AGKPI   (P16338), VM2_BITAR   (P17497), 
VM2_BOTAL   (Q801Z4), VM2_BOTAS   (Q072L5), VM2_BOTAT   (P18618), 
VM2_BOTCO   (P31988), VM2_CROAD   (J9Z332), VM2_CRORU   (H9M5U4), 
VM2_CROSM   (C0HJM4), VM2_CROTA   (C0HK50), VM2_GLOBL   (P21858), 
VM2_GLOHA   (Q9DGH6), VM2_TRIST   (P0DM87), VM31_BOTAT  (C5H5D2), 
VM31_CRODC  (C5H5D1), VM31_CRODU  (Q076D1), VM31_LACMR  (C5H5D5), 
VM32A_CROAD (J3S829), VM32A_GLOBR (P0DM89), VM32B_GLOBR (P0DM90), 
VM32D_CROAD (J3SDW6), VM32_BOTAT  (C5H5D3), VM32_LACMR  (C5H5D6), 
VM33_BOTAT  (C5H5D4), VM33_CROAD  (J3S830), VM34_CROAD  (F8S108), 
VM34_DRYCN  (F8RKW1), VM36A_BOTIN (Q8QG88), VM38_CROAD  (J3SDW8), 
VM38_DRYCN  (F8RKW0), VM39_DRYCN  (F8RKV9), VM3AA_CROAT (Q92043), 
VM3AD_AGKCL (O42138), VM3AH_DEIAC (Q9W6M5), VM3AK_DEIAC (Q1PS45), 
VM3B1_BOTJA (Q0NZY0), VM3B1_BOTJR (Q1PHZ4), VM3B2_BOTJA (Q0NZX9), 
VM3B3_BOTJA (Q0NZX8), VM3B4_BOTJA (Q0NZX7), VM3BE_BOTER (Q8UVG0), 
VM3BP_BOTJA (O93523), VM3CX_DABSI (Q7LZ61), VM3CX_MACLB (Q7T046), 
VM3C_CROAT  (A2CJE4), VM3DK_DABRR (B8K1W0), VM3E1_ECHOC (Q2UXR0), 
VM3E2_ECHOC (Q2UXQ5), VM3E6_ECHOC (Q6X1T6), VM3E_ECHCA  (Q90495), 
VM3G1_CRAGM (P0C6E8), VM3H1_CRORU (Q9PSN7), VM3H1_PROFL (Q90ZI3), 
VM3H3_BOTJA (Q98UF9), VM3H6_GLOBR (P0C7B0), VM3HA_GLOHA (Q8AWI5), 
VM3HA_PROFL (Q8JIR2), VM3HB_PROFL (P20164), VM3H_GLOHA  (Q90Y44), 
VM3JA_BOTJA (P30431), VM3LB_BOTLC (P86092), VM3LC_MACLN (C0LZJ5), 
VM3L_BOTLC  (P0DJ87), VM3M1_NAJMO (Q10749), VM3S4_GLOBR (O93517), 
VM3S5_GLOBR (O93518), VM3SA_TRIST (Q3HTN1), VM3SB_TRIST (Q3HTN2), 
VM3S_CROSS  (A2CJE2), VM3TM_TRIST (Q2LD49), VM3V1_CROAT (Q9DGB9), 
VM3V3_AGKPL (C9E1S0), VM3V3_CROVV (C9E1R8), VM3VA_CROAT (A4PBQ9), 
VM3VA_MACLB (Q4VM08), VM3VB_CROAT (Q90282), VM3VB_MACLB (Q4VM07), 
VM3V_CROVV  (A2CJE3), VM3_BUNFA   (A8QL48), VM3_BUNMU   (A8QL49), 
VM3_CRODD   (Q2QA02), VM3_NAJAT   (A8QL59), VM3_OPHHA   (A3R0T9), 
VMF1_VIPAA  (A0A0B4U9L8), VMH3_VIPAA  (R4NNL0), VMH4A_VIPAA (V5TBK6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 103 sequences 

ADA10_BOVIN (Q10741), ADA10_CAEEL (G5EFD9), ADA10_HUMAN (O14672), 

ADA10_MOUSE (O35598), ADA10_PIG   (O77633), ADA10_RAT   (Q10743), 
ADA10_XENLA (Q8JIY1), ADA11_XENLA (Q9PSZ3), ADA15_HUMAN (Q13444), 
ADA15_MOUSE (O88839), ADA15_RAT   (Q9QYV0), ADA17_CAEEL (Q94316), 
ADA17_DROME (Q9VAC5), ADA17_HUMAN (P78536), ADA17_MOUSE (Q9Z0F8), 
ADA17_RAT   (Q9Z1K9), ADA18_MOUSE (Q9R157), ADA23_HUMAN (O75077), 
ADA23_MOUSE (Q9R1V7), ADA25_MOUSE (Q9R159), ADA32_MOUSE (Q8K410), 
ADAM5_HUMAN (Q6NVV9), ADEC1_HUMAN (O15204), ADEC1_MOUSE (Q9R0X2), 
ADM1B_MOUSE (Q8R534), ADMB_ARTBC  (D4B1G0), ADMB_ARTOC  (C5FUK3), 
ADMB_ASPFU  (Q4WQ08), ADMB_TRIVH  (D4DCV9), ADT1_CAEEL  (G5ECS8), 
ADT2_CAEEL  (Q19204), ATS10_HUMAN (Q9H324), ATS10_MOUSE (P58459), 
ATS12_HUMAN (P58397), ATS12_MOUSE (Q811B3), ATS13_HUMAN (Q76LX8), 
ATS13_MOUSE (Q769J6), ATS14_HUMAN (Q8WXS8), ATS15_HUMAN (Q8TE58), 
ATS15_MOUSE (P59384), ATS16_HUMAN (Q8TE57), ATS16_MOUSE (Q69Z28), 
ATS17_HUMAN (Q8TE56), ATS18_HUMAN (Q8TE60), ATS18_MOUSE (Q4VC17), 
ATS19_HUMAN (Q8TE59), ATS19_MOUSE (P59509), ATS1_BOMMO  (Q5W7F4), 
ATS1_HUMAN  (Q9UHI8), ATS1_MOUSE  (P97857), ATS1_RAT(Q9WUQ1), 
ATS20_HUMAN (P59510), ATS20_MOUSE (P59511), ATS2_BOVIN  (P79331), 
ATS2_HUMAN  (O95450), ATS2_MOUSE  (Q8C9W3), ATS3_HUMAN  (O15072), 
ATS4_BOVIN  (Q9TT93), ATS4_HUMAN  (O75173), ATS4_MOUSE  (Q8BNJ2), 
ATS4_PONAB  (Q5RFQ8), ATS4_RAT(Q9ESP7), ATS5_BOVIN  (Q9TT92), 
ATS5_HUMAN  (Q9UNA0), ATS5_MOUSE  (Q9R001), ATS6_HUMAN  (Q9UKP5), 
ATS7_HUMAN  (Q9UKP4), ATS7_MOUSE  (Q68SA9), ATS7_RAT(Q1EHB3), 
ATS8_HUMAN  (Q9UP79), ATS8_MOUSE  (P57110), ATS9_HUMAN  (Q9P2N4), 
ATSL_BOMMO  (Q5W7F3), DID1B_MACLB (P83254), DID8B_CERCE (P83044), 
DIS_CERVI   (Q3BK17), DIS_DABPA   (P0C6E2), DIS_MACLB   (Q3BK14), 
DIS_MACLO   (P83469), DIS_PROJR   (Q7ZZM2), GON1_CAEEL  (Q19791), 
MDE10_SCHPO (O13766), MIG17_CAEEL (Q20930), UNC71_CAEEL (G5EFD5), 
VM27B_VIPBB (P0C6A7), VM2A2_DEIAC (Q9PWJ0), VM2AB_ERIMA (P81743), 
VM2M2_DEIAC (Q9IAX6), VM2PB_AGKPI (Q805F4), VM2V2_AGKPL (C9E1S1), 
VM2_CERSA   (C0HJM5), VM2_DEIAC   (P0DM77), VM2_METMX   (P0DW30), 
VM3A_BOTAL  (P0C6R9), VM3A_NAJAT  (D5LMJ3), VM3B_NAJAT  (D6PXE8), 
VM3H_NAJAT  (D3TTC2), VM3KL_NAJAT (D3TTC1), VM3K_NAJKA  (P82942), 
VM3_CERRY   (D8VNS0), VM3_MICIK   (P0DJ43), VM3_NAJKA   (Q9PVK7), 
VMMP3_VIPAA (A0A6B7FMR5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 13 sequences 

VM2_BOTFO   (P0DMH4), VM2_CROMR   (P0DW29), VM3AL_TRIAB (P0DJH2), 

VM3A_VIPAA  (P0DJE2), VM3B_BOTJA  (P22028), VM3CR_CROVV (P0C7N3), 
VM3PN_PROSR (P85005), VM3_BOTMO   (P0DKR0), VM3_NAJOX   (P0DJJ4), 
VM3_PROJR   (P0DM88), VM3_VIPAA   (P0DJ44), VMP3A_DEIAC (P0DJH3), 
VMXP_PROSR  (P85006)
» more

PDB
[Detailed view]		 46 PDB

pdb_00001fvl; pdb_00001j2l; pdb_00001l3x; pdb_00001n4y; pdb_00001q7i; pdb_00001q7j; pdb_00001rmr; pdb_00001ro3; pdb_00001tej; pdb_00001z1x; pdb_00002dw0; pdb_00002dw1; pdb_00002dw2; pdb_00002e3x; pdb_00002ech; pdb_00002ero; pdb_00002erp; pdb_00002erq; pdb_00002ljv; pdb_00002m75; pdb_00002m7f; pdb_00002m7h; pdb_00002mop; pdb_00002mp5; pdb_00002pjf; pdb_00002pjg; pdb_00002pji; pdb_00003c05; pdb_00003dsl; pdb_00003g5c; pdb_00003uci; pdb_00004m4c; pdb_00004r5r; pdb_00004rqg; pdb_00005y2z; pdb_00005y31; pdb_00006lsq; pdb_00007x4s; pdb_00007x4v; pdb_00007x4z; pdb_00008hpy; pdb_00008hq1; pdb_00008hq2; pdb_00008s9e; pdb_00008y6b; pdb_00009clp
» more