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PROSITE entry PS00427


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00427
Entry name [info] DISINTEGRIN_1
Accession [info] PS00427
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00351

Name and characterization of the entry

Description [info] Disintegrins signature.
Pattern [info] 
C-x(2)-[GS]-x-C-C-x(1,2)-[NQRSEKD]-C-x-[FMYLVI]-x(6)-C-[RKNQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 246 in 246 different sequences
Number of true positive hits 246 in 246 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 103
Number of 'partial' sequences 13
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 70.49 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 6
Site [info] disulfide at position 9
Site [info] disulfide at position 13
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 246 sequences 

AD26A_MOUSE (Q9R158), ADA11_HUMAN (O75078), ADA11_MOUSE (Q9R1V4), 

ADA12_HUMAN (O43184), ADA12_MOUSE (Q61824), ADA18_HUMAN (Q9Y3Q7), 
ADA18_MACFA (Q95194), ADA18_RAT   (P97776), ADA19_HUMAN (Q9H013), 
ADA19_MOUSE (O35674), ADA20_HUMAN (O43506), ADA21_HUMAN (Q9UKJ8), 
ADA21_MOUSE (Q9JI76), ADA22_HUMAN (Q9P0K1), ADA22_MOUSE (Q9R1V6), 
ADA22_XENLA (O42596), ADA24_MOUSE (Q9R160), ADA28_HUMAN (Q9UKQ2), 
ADA28_MACFA (Q9XSL6), ADA28_MOUSE (Q9JLN6), ADA29_HUMAN (Q9UKF5), 
ADA29_MOUSE (Q811Q4), ADA30_HUMAN (Q9UKF2), ADA32_HUMAN (Q8TC27), 
ADA33_HUMAN (Q9BZ11), ADA33_MOUSE (Q923W9), ADAM1_RAT   (P70505), 
ADAM2_BOVIN (O77780), ADAM2_CAVPO (Q60411), ADAM2_HUMAN (Q99965), 
ADAM2_MACFA (Q28478), ADAM2_MOUSE (Q60718), ADAM2_RABIT (Q28660), 
ADAM2_RAT   (Q63202), ADAM5_CAVPO (Q60472), ADAM5_MACFA (Q28483), 
ADAM5_MOUSE (Q3TTE0), ADAM5_RAT   (Q5BK84), ADAM7_HUMAN (Q9H2U9), 
ADAM7_MACFA (Q28475), ADAM7_MOUSE (O35227), ADAM7_RAT   (Q63180), 
ADAM8_HUMAN (P78325), ADAM8_MOUSE (Q05910), ADAM9_HUMAN (Q13443), 
ADAM9_MOUSE (Q61072), ADM1A_MOUSE (Q60813), DID1A_MACLB (P83253), 
DID1_BITGA  (Q6T6T3), DID1_ECHOC  (Q3BER2), DID2A_MACLB (Q3BK13), 
DID2_BITGA  (Q6T6T2), DID4A_ECHOC (Q3BER3), DID4_MACLO  (P0C6A8), 
DID5A_ECHOC (Q3BER4), DID5B_ECHOC (P0C6A4), DID5B_MACLO (P0C6B0), 
DID5_CERCE  (P83041), DID6A_ECHCS (P82465), DID7A_VIPBB (P0C6A6), 
DID8A_CERCE (P83043), DIDAA_ERIMA (P81742), DIDA_AGKCO  (Q805F7), 
DIDA_AGKPI  (Q805F5), DIDA_AGKPL  (C9E1S2), DIDA_CERVI  (Q3BK16), 
DIDBA_ECHML (P0C6A3), DIDB_CERVI  (Q3BK15), DIDLA_ECHCA (P0C6B4), 
DIDLB_ECHCA (P0C6B5), DIDS_ECHCA  (P83658), DID_ATHCH   (M5BGY5), 
DID_ATHNI   (M5BHN0), DID_ATHSQ   (M5BGS2), DID_ECHCA   (Q5EE07), 
DIS_ECHOC   (Q3BER1), VM212_CROHD (P0C7X6), VM212_CROSS (P0C7X7), 
VM23A_ECHCA (P81630), VM23B_ECHCA (P81631), VM25A_BITAR (P0DM97), 
VM25A_MACLO (P0C6A9), VM26B_ECHCS (P82466), VM28_CROAD  (J3SBP9), 
VM2A6_VIPAA (P0C6A5), VM2AB_AGKCO (Q805F6), VM2AE_CROAT (P34182), 
VM2AG_GLOHA (Q8AWX7), VM2AL_TRIAB (P0C6B6), VM2B1_AGKBI (P0C6E3), 
VM2BI_BITGA (Q6T271), VM2B_CRAGM  (P17495), VM2C1_CRODO (C0L2T8), 
VM2CO_AGKCO (Q9IAB0), VM2C_PROFL  (P23323), VM2D2_BITAR (Q4JCS1), 
VM2D3_BITAR (Q4JCS0), VM2DI_GLOHA (Q1PBD1), VM2E1_PROEL (P17349), 
VM2E2_PROEL (Q90YA6), VM2EA_ECHCS (P17347), VM2EB_ECHPL (Q7LZK1), 
VM2EG_ECHPL (Q7LZK0), VM2FL_PROFL (P18619), VM2G_CRAGM  (P62383), 
VM2G_TRIAB  (P62384), VM2H1_BOTLA (U5PZ28), VM2H1_GLOHA (Q90220), 
VM2H2_GLOHA (Q90221), VM2HA_PROFL (P14530), VM2HS_GLOBR (Q90WC0), 
VM2I1_GLOUS (Q7LZI5), VM2I2_GLOUS (Q7LZT4), VM2IA_BOTIN (Q5XUW8), 
VM2IA_CROAT (A2CJE5), VM2IC_CROAT (P68520), VM2IV_CROVV (A2CJE6), 
VM2I_CROBA  (P31981), VM2I_CROCC  (P31982), VM2I_CROCE  (P31985), 
VM2I_CRODD  (P68521), VM2I_CROLT  (P31986), VM2I_CROMM  (P31984), 
VM2I_CROVV  (P31987), VM2I_LACMU  (P31990), VM2I_SISMB  (P22827), 
VM2I_SISTE  (P22828), VM2J2_BOTJA (Q98SP2), VM2JA_BOTJA (Q0NZX5), 
VM2JC_BOTJA (P31989), VM2JN_PROJR (P0C6E4), VM2JR_BOTJA (Q0NZX6), 
VM2JT_PROJR (P83912), VM2J_PROJR  (Q7ZZS9), VM2L2_MACLB (Q98995), 
VM2L4_GLOBR (Q698K8), VM2LA_ECHLE (P0C7A7), VM2LB_ECHLE (P0C7A8), 
VM2MB_GLOBR (O73795), VM2MC_GLOBR (Q9YI19), VM2MD_GLOBR (Q9PVK9), 
VM2MU_ECHML (P0C6R5), VM2OC_ECHOC (Q14FJ4), VM2OI_ECHOC (P0C6R6), 
VM2P1_PROMU (E9NW26), VM2P2_PROMU (E9NW27), VM2PA_ECHPL (P0C6R7), 
VM2PB_ECHPL (P0C6R8), VM2RH_CALRH (P30403), VM2S2_GLOBR (O93516), 
VM2S3_GLOBR (O93515), VM2SA_GLOIT (Q7SZE0), VM2T3_PROMU (O57413), 
VM2TA_CRAGM (P15503), VM2TI_ERIMA (P22826), VM2TO_ERIMA (P0C6S4), 
VM2T_PROFL  (P21859), VM2US_GLOUS (Q7SZD9), VM2V2_CROAT (C9E1R7), 
VM2V2_CROVV (C9E1R9), VM2_AGKPI   (P16338), VM2_BITAR   (P17497), 
VM2_BOTAL   (Q801Z4), VM2_BOTAS   (Q072L5), VM2_BOTAT   (P18618), 
VM2_BOTCO   (P31988), VM2_CROAD   (J9Z332), VM2_CRORU   (H9M5U4), 
VM2_CROSM   (C0HJM4), VM2_CROTA   (C0HK50), VM2_GLOBL   (P21858), 
VM2_GLOHA   (Q9DGH6), VM2_TRIST   (P0DM87), VM31_BOTAT  (C5H5D2), 
VM31_CRODC  (C5H5D1), VM31_CRODU  (Q076D1), VM31_LACMR  (C5H5D5), 
VM32A_CROAD (J3S829), VM32A_GLOBR (P0DM89), VM32B_GLOBR (P0DM90), 
VM32D_CROAD (J3SDW6), VM32_BOTAT  (C5H5D3), VM32_LACMR  (C5H5D6), 
VM33_BOTAT  (C5H5D4), VM33_CROAD  (J3S830), VM34_CROAD  (F8S108), 
VM34_DRYCN  (F8RKW1), VM36A_BOTIN (Q8QG88), VM38_CROAD  (J3SDW8), 
VM38_DRYCN  (F8RKW0), VM39_DRYCN  (F8RKV9), VM3AA_CROAT (Q92043), 
VM3AD_AGKCL (O42138), VM3AH_DEIAC (Q9W6M5), VM3AK_DEIAC (Q1PS45), 
VM3B1_BOTJA (Q0NZY0), VM3B1_BOTJR (Q1PHZ4), VM3B2_BOTJA (Q0NZX9), 
VM3B3_BOTJA (Q0NZX8), VM3B4_BOTJA (Q0NZX7), VM3BE_BOTER (Q8UVG0), 
VM3BP_BOTJA (O93523), VM3CX_DABSI (Q7LZ61), VM3CX_MACLB (Q7T046), 
VM3C_CROAT  (A2CJE4), VM3DK_DABRR (B8K1W0), VM3E1_ECHOC (Q2UXR0), 
VM3E2_ECHOC (Q2UXQ5), VM3E6_ECHOC (Q6X1T6), VM3E_ECHCA  (Q90495), 
VM3G1_CRAGM (P0C6E8), VM3H1_CRORU (Q9PSN7), VM3H1_PROFL (Q90ZI3), 
VM3H3_BOTJA (Q98UF9), VM3H6_GLOBR (P0C7B0), VM3HA_GLOHA (Q8AWI5), 
VM3HA_PROFL (Q8JIR2), VM3HB_PROFL (P20164), VM3H_GLOHA  (Q90Y44), 
VM3JA_BOTJA (P30431), VM3LB_BOTLC (P86092), VM3LC_MACLN (C0LZJ5), 
VM3L_BOTLC  (P0DJ87), VM3M1_NAJMO (Q10749), VM3S4_GLOBR (O93517), 
VM3S5_GLOBR (O93518), VM3SA_TRIST (Q3HTN1), VM3SB_TRIST (Q3HTN2), 
VM3S_CROSS  (A2CJE2), VM3TM_TRIST (Q2LD49), VM3V1_CROAT (Q9DGB9), 
VM3V3_AGKPL (C9E1S0), VM3V3_CROVV (C9E1R8), VM3VA_CROAT (A4PBQ9), 
VM3VA_MACLB (Q4VM08), VM3VB_CROAT (Q90282), VM3VB_MACLB (Q4VM07), 
VM3V_CROVV  (A2CJE3), VM3_BUNFA   (A8QL48), VM3_BUNMU   (A8QL49), 
VM3_CRODD   (Q2QA02), VM3_NAJAT   (A8QL59), VM3_OPHHA   (A3R0T9), 
VMF1_VIPAA  (A0A0B4U9L8), VMH3_VIPAA  (R4NNL0), VMH4A_VIPAA (V5TBK6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 103 sequences 

ADA10_BOVIN (Q10741), ADA10_CAEEL (G5EFD9), ADA10_HUMAN (O14672), 

ADA10_MOUSE (O35598), ADA10_PIG   (O77633), ADA10_RAT   (Q10743), 
ADA10_XENLA (Q8JIY1), ADA11_XENLA (Q9PSZ3), ADA15_HUMAN (Q13444), 
ADA15_MOUSE (O88839), ADA15_RAT   (Q9QYV0), ADA17_CAEEL (Q94316), 
ADA17_DROME (Q9VAC5), ADA17_HUMAN (P78536), ADA17_MOUSE (Q9Z0F8), 
ADA17_RAT   (Q9Z1K9), ADA18_MOUSE (Q9R157), ADA23_HUMAN (O75077), 
ADA23_MOUSE (Q9R1V7), ADA25_MOUSE (Q9R159), ADA32_MOUSE (Q8K410), 
ADAM5_HUMAN (Q6NVV9), ADEC1_HUMAN (O15204), ADEC1_MOUSE (Q9R0X2), 
ADM1B_MOUSE (Q8R534), ADMB_ARTBC  (D4B1G0), ADMB_ARTOC  (C5FUK3), 
ADMB_ASPFU  (Q4WQ08), ADMB_TRIVH  (D4DCV9), ADT1_CAEEL  (G5ECS8), 
ADT2_CAEEL  (Q19204), ATS10_HUMAN (Q9H324), ATS10_MOUSE (P58459), 
ATS12_HUMAN (P58397), ATS12_MOUSE (Q811B3), ATS13_HUMAN (Q76LX8), 
ATS13_MOUSE (Q769J6), ATS14_HUMAN (Q8WXS8), ATS15_HUMAN (Q8TE58), 
ATS15_MOUSE (P59384), ATS16_HUMAN (Q8TE57), ATS16_MOUSE (Q69Z28), 
ATS17_HUMAN (Q8TE56), ATS18_HUMAN (Q8TE60), ATS18_MOUSE (Q4VC17), 
ATS19_HUMAN (Q8TE59), ATS19_MOUSE (P59509), ATS1_BOMMO  (Q5W7F4), 
ATS1_HUMAN  (Q9UHI8), ATS1_MOUSE  (P97857), ATS1_RAT(Q9WUQ1), 
ATS20_HUMAN (P59510), ATS20_MOUSE (P59511), ATS2_BOVIN  (P79331), 
ATS2_HUMAN  (O95450), ATS2_MOUSE  (Q8C9W3), ATS3_HUMAN  (O15072), 
ATS4_BOVIN  (Q9TT93), ATS4_HUMAN  (O75173), ATS4_MOUSE  (Q8BNJ2), 
ATS4_PONAB  (Q5RFQ8), ATS4_RAT(Q9ESP7), ATS5_BOVIN  (Q9TT92), 
ATS5_HUMAN  (Q9UNA0), ATS5_MOUSE  (Q9R001), ATS6_HUMAN  (Q9UKP5), 
ATS7_HUMAN  (Q9UKP4), ATS7_MOUSE  (Q68SA9), ATS7_RAT(Q1EHB3), 
ATS8_HUMAN  (Q9UP79), ATS8_MOUSE  (P57110), ATS9_HUMAN  (Q9P2N4), 
ATSL_BOMMO  (Q5W7F3), DID1B_MACLB (P83254), DID8B_CERCE (P83044), 
DIS_CERVI   (Q3BK17), DIS_DABPA   (P0C6E2), DIS_MACLB   (Q3BK14), 
DIS_MACLO   (P83469), DIS_PROJR   (Q7ZZM2), GON1_CAEEL  (Q19791), 
MDE10_SCHPO (O13766), MIG17_CAEEL (Q20930), UNC71_CAEEL (G5EFD5), 
VM27B_VIPBB (P0C6A7), VM2A2_DEIAC (Q9PWJ0), VM2AB_ERIMA (P81743), 
VM2M2_DEIAC (Q9IAX6), VM2PB_AGKPI (Q805F4), VM2V2_AGKPL (C9E1S1), 
VM2_CERSA   (C0HJM5), VM2_DEIAC   (P0DM77), VM2_METMX   (P0DW30), 
VM3A_BOTAL  (P0C6R9), VM3A_NAJAT  (D5LMJ3), VM3B_NAJAT  (D6PXE8), 
VM3H_NAJAT  (D3TTC2), VM3KL_NAJAT (D3TTC1), VM3K_NAJKA  (P82942), 
VM3_CERRY   (D8VNS0), VM3_MICIK   (P0DJ43), VM3_NAJKA   (Q9PVK7), 
VMMP3_VIPAA (A0A6B7FMR5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 13 sequences 

VM2_BOTFO   (P0DMH4), VM2_CROMR   (P0DW29), VM3AL_TRIAB (P0DJH2), 

VM3A_VIPAA  (P0DJE2), VM3B_BOTJA  (P22028), VM3CR_CROVV (P0C7N3), 
VM3PN_PROSR (P85005), VM3_BOTMO   (P0DKR0), VM3_NAJOX   (P0DJJ4), 
VM3_PROJR   (P0DM88), VM3_VIPAA   (P0DJ44), VMP3A_DEIAC (P0DJH3), 
VMXP_PROSR  (P85006)
» more

PDB
[Detailed view]		 46 PDB

1FVL; 1J2L; 1L3X; 1N4Y; 1Q7I; 1Q7J; 1RMR; 1RO3; 1TEJ; 1Z1X; 2DW0; 2DW1; 2DW2; 2E3X; 2ECH; 2ERO; 2ERP; 2ERQ; 2LJV; 2M75; 2M7F; 2M7H; 2MOP; 2MP5; 2PJF; 2PJG; 2PJI; 3C05; 3DSL; 3G5C; 3UCI; 4M4C; 4R5R; 4RQG; 5Y2Z; 5Y31; 6LSQ; 7X4S; 7X4V; 7X4Z; 8HPY; 8HQ1; 8HQ2; 8S9E; 8Y6B; 9CLP
» more