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Entry: PS00427

General information about the entry

Entry name [info] DISINTEGRIN_1
Accession [info] PS00427
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-APR-2006 DATA UPDATE;
05-JUN-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC00351

Name and characterization of the entry

Description [info] Disintegrins signature.
Pattern [info]
C-x(2)-[GS]-x-C-C-x(1,2)-[NQRSEKD]-C-x-[FMYLVI]-x(6)-C-[RKNQ].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_05 which contains 560'292 sequence entries.


Total number of hits 242 in 242 different sequences
Number of true positive hits 242 in 242 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 99
Number of 'partial' sequences 12
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 70.97 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 6
Site [info] disulfide at position 9
Site [info] disulfide at position 13
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
242 sequences

AD26A_MOUSE (Q9R158    ), ADA11_HUMAN (O75078    ), ADA11_MOUSE (Q9R1V4    ), 
ADA12_HUMAN (O43184    ), ADA12_MOUSE (Q61824    ), ADA18_HUMAN (Q9Y3Q7    ), 
ADA18_MACFA (Q95194    ), ADA18_RAT   (P97776    ), ADA19_HUMAN (Q9H013    ), 
ADA19_MOUSE (O35674    ), ADA20_HUMAN (O43506    ), ADA21_HUMAN (Q9UKJ8    ), 
ADA21_MOUSE (Q9JI76    ), ADA22_HUMAN (Q9P0K1    ), ADA22_MOUSE (Q9R1V6    ), 
ADA22_XENLA (O42596    ), ADA24_MOUSE (Q9R160    ), ADA28_HUMAN (Q9UKQ2    ), 
ADA28_MACFA (Q9XSL6    ), ADA28_MOUSE (Q9JLN6    ), ADA29_HUMAN (Q9UKF5    ), 
ADA29_MOUSE (Q811Q4    ), ADA30_HUMAN (Q9UKF2    ), ADA32_HUMAN (Q8TC27    ), 
ADA33_HUMAN (Q9BZ11    ), ADA33_MOUSE (Q923W9    ), ADAM1_RAT   (P70505    ), 
ADAM2_BOVIN (O77780    ), ADAM2_CAVPO (Q60411    ), ADAM2_HUMAN (Q99965    ), 
ADAM2_MACFA (Q28478    ), ADAM2_MOUSE (Q60718    ), ADAM2_RABIT (Q28660    ), 
ADAM2_RAT   (Q63202    ), ADAM5_CAVPO (Q60472    ), ADAM5_MACFA (Q28483    ), 
ADAM5_MOUSE (Q3TTE0    ), ADAM5_RAT   (Q5BK84    ), ADAM7_HUMAN (Q9H2U9    ), 
ADAM7_MACFA (Q28475    ), ADAM7_MOUSE (O35227    ), ADAM7_RAT   (Q63180    ), 
ADAM8_HUMAN (P78325    ), ADAM8_MOUSE (Q05910    ), ADAM9_HUMAN (Q13443    ), 
ADAM9_MOUSE (Q61072    ), ADM1A_MOUSE (Q60813    ), DID1A_MACLB (P83253    ), 
DID1_BITGA  (Q6T6T3    ), DID1_ECHOC  (Q3BER2    ), DID2A_MACLB (Q3BK13    ), 
DID2_BITGA  (Q6T6T2    ), DID4A_ECHOC (Q3BER3    ), DID4_MACLO  (P0C6A8    ), 
DID5A_ECHOC (Q3BER4    ), DID5B_ECHOC (P0C6A4    ), DID5B_MACLO (P0C6B0    ), 
DID5_CERCE  (P83041    ), DID6A_ECHCS (P82465    ), DID7A_VIPBB (P0C6A6    ), 
DID8A_CERCE (P83043    ), DIDAA_ERIMA (P81742    ), DIDA_AGKCO  (Q805F7    ), 
DIDA_AGKPI  (Q805F5    ), DIDA_AGKPL  (C9E1S2    ), DIDA_CERVI  (Q3BK16    ), 
DIDBA_ECHML (P0C6A3    ), DIDB_CERVI  (Q3BK15    ), DIDLA_ECHCA (P0C6B4    ), 
DIDLB_ECHCA (P0C6B5    ), DIDS_ECHCA  (P83658    ), DID_ATHCH   (M5BGY5    ), 
DID_ATHNI   (M5BHN0    ), DID_ATHSQ   (M5BGS2    ), DID_ECHCA   (Q5EE07    ), 
DIS_ECHOC   (Q3BER1    ), VM212_CROHD (P0C7X6    ), VM212_CROSS (P0C7X7    ), 
VM23A_ECHCA (P81630    ), VM23B_ECHCA (P81631    ), VM25A_BITAR (P0DM97    ), 
VM25A_MACLO (P0C6A9    ), VM26B_ECHCS (P82466    ), VM28_CROAD  (J3SBP9    ), 
VM2A6_VIPAA (P0C6A5    ), VM2AB_AGKCO (Q805F6    ), VM2AE_CROAT (P34182    ), 
VM2AG_GLOHA (Q8AWX7    ), VM2AL_TRIAB (P0C6B6    ), VM2B1_AGKBI (P0C6E3    ), 
VM2BI_BITGA (Q6T271    ), VM2B_TRIGA  (P17495    ), VM2CO_AGKCO (Q9IAB0    ), 
VM2C_PROFL  (P23323    ), VM2D2_BITAR (Q4JCS1    ), VM2D3_BITAR (Q4JCS0    ), 
VM2DI_GLOHA (Q1PBD1    ), VM2E1_PROEL (P17349    ), VM2E2_PROEL (Q90YA6    ), 
VM2EA_ECHCS (P17347    ), VM2EB_ECHPL (Q7LZK1    ), VM2EG_ECHPL (Q7LZK0    ), 
VM2FL_PROFL (P18619    ), VM2G_TRIAB  (P62384    ), VM2G_TRIGA  (P62383    ), 
VM2H1_BOTLA (U5PZ28    ), VM2H1_GLOHA (Q90220    ), VM2H2_GLOHA (Q90221    ), 
VM2HA_PROFL (P14530    ), VM2HS_GLOBR (Q90WC0    ), VM2I1_GLOUS (Q7LZI5    ), 
VM2I2_GLOUS (Q7LZT4    ), VM2IA_BOTIN (Q5XUW8    ), VM2IA_CROAT (A2CJE5    ), 
VM2IC_CROAT (P68520    ), VM2IV_CROVV (A2CJE6    ), VM2I_CROBA  (P31981    ), 
VM2I_CROCC  (P31982    ), VM2I_CROCE  (P31985    ), VM2I_CRODD  (P68521    ), 
VM2I_CROMM  (P31984    ), VM2I_CROOL  (P31986    ), VM2I_CROVV  (P31987    ), 
VM2I_LACMU  (P31990    ), VM2I_SISMB  (P22827    ), VM2I_SISTE  (P22828    ), 
VM2J2_BOTJA (Q98SP2    ), VM2JA_BOTJA (Q0NZX5    ), VM2JC_BOTJA (P31989    ), 
VM2JN_PROJR (P0C6E4    ), VM2JR_BOTJA (Q0NZX6    ), VM2JT_PROJR (P83912    ), 
VM2J_PROJR  (Q7ZZS9    ), VM2L2_MACLB (Q98995    ), VM2L4_GLOBR (Q698K8    ), 
VM2LA_ECHLE (P0C7A7    ), VM2LB_ECHLE (P0C7A8    ), VM2MB_GLOBR (O73795    ), 
VM2MC_GLOBR (Q9YI19    ), VM2MD_GLOBR (Q9PVK9    ), VM2MU_ECHML (P0C6R5    ), 
VM2OC_ECHOC (Q14FJ4    ), VM2OI_ECHOC (P0C6R6    ), VM2P1_PROMU (E9NW26    ), 
VM2P2_PROMU (E9NW27    ), VM2PA_ECHPL (P0C6R7    ), VM2PB_ECHPL (P0C6R8    ), 
VM2RH_CALRH (P30403    ), VM2S2_GLOBR (O93516    ), VM2S3_GLOBR (O93515    ), 
VM2SA_GLOSA (Q7SZE0    ), VM2T3_PROMU (O57413    ), VM2TA_TRIGA (P15503    ), 
VM2TI_ERIMA (P22826    ), VM2TO_ERIMA (P0C6S4    ), VM2T_PROFL  (P21859    ), 
VM2US_GLOUS (Q7SZD9    ), VM2V2_CROAT (C9E1R7    ), VM2V2_CROVV (C9E1R9    ), 
VM2_AGKPI   (P16338    ), VM2_BITAR   (P17497    ), VM2_BOTAL   (Q801Z4    ), 
VM2_BOTAS   (Q072L5    ), VM2_BOTAT   (P18618    ), VM2_BOTCO   (P31988    ), 
VM2_CROAD   (J9Z332    ), VM2_CRORU   (H9M5U4    ), VM2_CROSM   (C0HJM4    ), 
VM2_CROTA   (C0HK50    ), VM2_GLOBL   (P21858    ), VM2_GLOHA   (Q9DGH6    ), 
VM2_TRIST   (P0DM87    ), VM31_BOTAT  (C5H5D2    ), VM31_CRODC  (C5H5D1    ), 
VM31_CRODU  (Q076D1    ), VM31_LACMR  (C5H5D5    ), VM32A_CROAD (J3S829    ), 
VM32A_GLOBR (P0DM89    ), VM32B_GLOBR (P0DM90    ), VM32D_CROAD (J3SDW6    ), 
VM32_BOTAT  (C5H5D3    ), VM32_LACMR  (C5H5D6    ), VM33_BOTAT  (C5H5D4    ), 
VM33_CROAD  (J3S830    ), VM34_CROAD  (F8S108    ), VM34_DRYCN  (F8RKW1    ), 
VM36A_BOTIN (Q8QG88    ), VM38_CROAD  (J3SDW8    ), VM38_DRYCN  (F8RKW0    ), 
VM39_DRYCN  (F8RKV9    ), VM3AA_CROAT (Q92043    ), VM3AD_AGKCL (O42138    ), 
VM3AH_DEIAC (Q9W6M5    ), VM3AK_DEIAC (Q1PS45    ), VM3B1_BOTJA (Q0NZY0    ), 
VM3B1_BOTJR (Q1PHZ4    ), VM3B2_BOTJA (Q0NZX9    ), VM3B3_BOTJA (Q0NZX8    ), 
VM3B4_BOTJA (Q0NZX7    ), VM3BE_BOTER (Q8UVG0    ), VM3BP_BOTJA (O93523    ), 
VM3CX_DABSI (Q7LZ61    ), VM3CX_MACLB (Q7T046    ), VM3C_CROAT  (A2CJE4    ), 
VM3DK_DABRR (B8K1W0    ), VM3E1_ECHOC (Q2UXR0    ), VM3E2_ECHOC (Q2UXQ5    ), 
VM3E6_ECHOC (Q6X1T6    ), VM3E_ECHCA  (Q90495    ), VM3G1_TRIGA (P0C6E8    ), 
VM3H1_CRORU (Q9PSN7    ), VM3H1_PROFL (Q90ZI3    ), VM3H3_BOTJA (Q98UF9    ), 
VM3H6_GLOBR (P0C7B0    ), VM3HA_GLOHA (Q8AWI5    ), VM3HA_PROFL (Q8JIR2    ), 
VM3HB_PROFL (P20164    ), VM3H_GLOHA  (Q90Y44    ), VM3JA_BOTJA (P30431    ), 
VM3LB_BOTLC (P86092    ), VM3LC_MACLN (C0LZJ5    ), VM3L_BOTLC  (P0DJ87    ), 
VM3M1_NAJMO (Q10749    ), VM3S4_GLOBR (O93517    ), VM3S5_GLOBR (O93518    ), 
VM3SA_TRIST (Q3HTN1    ), VM3SB_TRIST (Q3HTN2    ), VM3S_CROSS  (A2CJE2    ), 
VM3TM_TRIST (Q2LD49    ), VM3V1_CROAT (Q9DGB9    ), VM3V3_AGKPL (C9E1S0    ), 
VM3V3_CROVV (C9E1R8    ), VM3VA_CROAT (A4PBQ9    ), VM3VA_MACLB (Q4VM08    ), 
VM3VB_CROAT (Q90282    ), VM3VB_MACLB (Q4VM07    ), VM3V_CROVV  (A2CJE3    ), 
VM3_BUNFA   (A8QL48    ), VM3_BUNMU   (A8QL49    ), VM3_CRODD   (Q2QA02    ), 
VM3_NAJAT   (A8QL59    ), VM3_OPHHA   (A3R0T9    )
» more

UniProtKB/Swiss-Prot
False negative sequences
99 sequences

ADA10_BOVIN (Q10741    ), ADA10_CAEEL (G5EFD9    ), ADA10_HUMAN (O14672    ), 
ADA10_MOUSE (O35598    ), ADA10_PIG   (O77633    ), ADA10_RAT   (Q10743    ), 
ADA10_XENLA (Q8JIY1    ), ADA11_XENLA (Q9PSZ3    ), ADA15_HUMAN (Q13444    ), 
ADA15_MOUSE (O88839    ), ADA15_RAT   (Q9QYV0    ), ADA17_CAEEL (Q94316    ), 
ADA17_DROME (Q9VAC5    ), ADA17_HUMAN (P78536    ), ADA17_MOUSE (Q9Z0F8    ), 
ADA17_RAT   (Q9Z1K9    ), ADA18_MOUSE (Q9R157    ), ADA23_HUMAN (O75077    ), 
ADA23_MOUSE (Q9R1V7    ), ADA25_MOUSE (Q9R159    ), ADA32_MOUSE (Q8K410    ), 
ADAM5_HUMAN (Q6NVV9    ), ADEC1_HUMAN (O15204    ), ADEC1_MOUSE (Q9R0X2    ), 
ADM1B_MOUSE (Q8R534    ), ADMB_ARTBC  (D4B1G0    ), ADMB_ARTOC  (C5FUK3    ), 
ADMB_ASPFU  (Q4WQ08    ), ADMB_TRIVH  (D4DCV9    ), ADT1_CAEEL  (G5ECS8    ), 
ADT2_CAEEL  (Q19204    ), ATS10_HUMAN (Q9H324    ), ATS10_MOUSE (P58459    ), 
ATS12_HUMAN (P58397    ), ATS12_MOUSE (Q811B3    ), ATS13_HUMAN (Q76LX8    ), 
ATS13_MOUSE (Q769J6    ), ATS14_HUMAN (Q8WXS8    ), ATS15_HUMAN (Q8TE58    ), 
ATS15_MOUSE (P59384    ), ATS16_HUMAN (Q8TE57    ), ATS16_MOUSE (Q69Z28    ), 
ATS17_HUMAN (Q8TE56    ), ATS18_HUMAN (Q8TE60    ), ATS18_MOUSE (Q4VC17    ), 
ATS19_HUMAN (Q8TE59    ), ATS19_MOUSE (P59509    ), ATS1_HUMAN  (Q9UHI8    ), 
ATS1_MOUSE  (P97857    ), ATS1_RAT    (Q9WUQ1    ), ATS20_HUMAN (P59510    ), 
ATS20_MOUSE (P59511    ), ATS2_BOVIN  (P79331    ), ATS2_HUMAN  (O95450    ), 
ATS2_MOUSE  (Q8C9W3    ), ATS3_HUMAN  (O15072    ), ATS4_BOVIN  (Q9TT93    ), 
ATS4_HUMAN  (O75173    ), ATS4_MOUSE  (Q8BNJ2    ), ATS4_PONAB  (Q5RFQ8    ), 
ATS4_RAT    (Q9ESP7    ), ATS5_BOVIN  (Q9TT92    ), ATS5_HUMAN  (Q9UNA0    ), 
ATS5_MOUSE  (Q9R001    ), ATS6_HUMAN  (Q9UKP5    ), ATS7_HUMAN  (Q9UKP4    ), 
ATS7_MOUSE  (Q68SA9    ), ATS7_RAT    (Q1EHB3    ), ATS8_HUMAN  (Q9UP79    ), 
ATS8_MOUSE  (P57110    ), ATS9_HUMAN  (Q9P2N4    ), DID1B_MACLB (P83254    ), 
DID8B_CERCE (P83044    ), DIS_CERVI   (Q3BK17    ), DIS_DABPA   (P0C6E2    ), 
DIS_MACLB   (Q3BK14    ), DIS_MACLO   (P83469    ), DIS_PROJR   (Q7ZZM2    ), 
GON1_CAEEL  (Q19791    ), MDE10_SCHPO (O13766    ), MIG17_CAEEL (Q20930    ), 
UNC71_CAEEL (G5EFD5    ), VM27B_VIPBB (P0C6A7    ), VM2A2_DEIAC (Q9PWJ0    ), 
VM2AB_ERIMA (P81743    ), VM2M2_DEIAC (Q9IAX6    ), VM2PB_AGKPI (Q805F4    ), 
VM2V2_AGKPL (C9E1S1    ), VM2_CERSA   (C0HJM5    ), VM2_DEIAC   (P0DM77    ), 
VM3A_BOTAL  (P0C6R9    ), VM3A_NAJAT  (D5LMJ3    ), VM3B_NAJAT  (D6PXE8    ), 
VM3H_NAJAT  (D3TTC2    ), VM3KL_NAJAT (D3TTC1    ), VM3K_NAJKA  (P82942    ), 
VM3_CERRY   (D8VNS0    ), VM3_MICIK   (P0DJ43    ), VM3_NAJKA   (Q9PVK7    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
12 sequences

VM2_BOTFO   (P0DMH4    ), VM3AL_TRIAB (P0DJH2    ), VM3A_VIPAA  (P0DJE2    ), 
VM3B_BOTJA  (P22028    ), VM3CR_CROVV (P0C7N3    ), VM3PN_PROSR (P85005    ), 
VM3_BOTMO   (P0DKR0    ), VM3_NAJOX   (P0DJJ4    ), VM3_PROJR   (P0DM88    ), 
VM3_VIPAA   (P0DJ44    ), VMP3A_DEIAC (P0DJH3    ), VMXP_PROSR  (P85006    )
» more

PDB
[Detailed view]
36 PDB

1FVL; 1J2L; 1L3X; 1N4Y; 1Q7I; 1Q7J; 1RMR; 1RO3; 1TEJ; 1Z1X; 2DW0; 2DW1; 2DW2; 2E3X; 2ECH; 2ERO; 2ERP; 2ERQ; 2LJV; 2M75; 2M7F; 2M7H; 2MOP; 2MP5; 2PJF; 2PJG; 2PJI; 3C05; 3DSL; 3G5C; 3UCI; 4M4C; 4R5R; 4RQG; 5Y2Z; 5Y31
» more

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