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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00441


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PURL: https://purl.expasy.org/prosite/signature/PS00441

Direct ScanProsite submission
General information about the entry

Entry name [info] CHALCONE_SYNTH
Accession [info] PS00441
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00403
Associated ProRule [info] PRU10023

Name and characterization of the entry

Description [info] Chalcone and stilbene synthases active site.
Pattern [info] 
R-[LIVMFYS]-x-[LIVM]-x-[QHG]-x-G-C-[FYNA]-[GAPV]-G-[GAC]-[STAVK]-x-
[LIVMF]-[RAL].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 162 in 162 different sequences
Number of true positive hits 162 in 162 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 25
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 86.63 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 162 sequences 

2PS_GERHY   (P48391), ACS2_RUTGR  (Q9FSC0), ACS3_RUTGR  (Q9FSC2), 

ACS4_RUTGR  (Q9FSC1), BBS_PHASS   (P53416), BCSA_BACSU  (P54157), 
CHS1_CAMSI  (P48386), CHS1_CASGL  (Q9ZRR8), CHS1_CICAR  (Q9SML4), 
CHS1_CITSI  (Q9XJ58), CHS1_DAUCA  (Q9ZS41), CHS1_GERHY  (P48390), 
CHS1_HORVU  (P26018), CHS1_IPOBA  (Q9MB33), CHS1_MAIZE  (P24824), 
CHS1_MEDSA  (P30073), CHS1_ORYSI  (A2ZEX7), CHS1_ORYSJ  (Q2R3A1), 
CHS1_PEA(Q01286), CHS1_RUTGR  (Q9FSB9), CHS1_SECCE  (P53414), 
CHS1_SINAL  (P13416), CHS1_SOLLC  (P23418), CHS1_SORBI  (Q9XGX2), 
CHS1_SOYBN  (P24826), CHS1_TRISU  (P51083), CHS2_CAMSI  (P48387), 
CHS2_CITSI  (Q9XJ57), CHS2_DAUCA  (Q9ZS40), CHS2_HORVU  (Q96562), 
CHS2_IPOBA  (Q9MB41), CHS2_MAIZE  (P24825), CHS2_MEDSA  (P30074), 
CHS2_ORYSJ  (Q8H4L3), CHS2_PEA(Q01287), CHS2_RUTGR  (Q9FSB8), 
CHS2_SECCE  (P53415), CHS2_SOLLC  (P23419), CHS2_SOLTU  (Q43188), 
CHS2_SORBI  (Q9SBL7), CHS2_SOYBN  (P17957), CHS2_TRISU  (P51084), 
CHS3_BROFI  (O23729), CHS3_CAMSI  (P48388), CHS3_GERHY  (P48392), 
CHS3_IPOBA  (Q9MB40), CHS3_MEDSA  (P51077), CHS3_PEA(O23883), 
CHS3_RUTGR  (Q9FSB7), CHS3_SINAL  (P13417), CHS3_SORBI  (Q9SBL6), 
CHS3_SOYBN  (P19168), CHS3_TRISU  (P51085), CHS4_BROFI  (O23730), 
CHS4_IPOBA  (Q9MB39), CHS4_MEDSA  (P30075), CHS4_PEA(O23882), 
CHS4_SORBI  (Q9SBL5), CHS4_TRISU  (P51086), CHS5_MEDSA  (P51078), 
CHS5_PEA(O23884), CHS5_SORBI  (Q9SBL4), CHS5_SOYBN  (P48406), 
CHS5_TRISU  (P51087), CHS6_IPOBA  (Q9MB38), CHS6_MEDSA  (P51079), 
CHS6_PEA(Q01288), CHS6_SORBI  (Q9SBL3), CHS6_SOYBN  (P30080), 
CHS6_TRISU  (P51088), CHS7_IPOBA  (Q9MB37), CHS7_MEDSA  (P51080), 
CHS7_PICMA  (Q9M5M0), CHS7_SORBI  (Q9XGX1), CHS7_SOYBN  (P30081), 
CHS8_BROFI  (O23731), CHS8_IPOBA  (Q9MB36), CHS8_MEDSA  (P30076), 
CHS9_DAUCA  (Q9SB26), CHS9_MEDSA  (P30077), CHSA_IPOCO  (P48393), 
CHSA_IPONI  (P48395), CHSA_IPOPL  (P48400), CHSA_IPOPU  (P48397), 
CHSA_IPOTF  (P48401), CHSA_IPOTR  (P48403), CHSA_PEA(P51081), 
CHSA_PETHY  (P08894), CHSA_SOLTU  (Q41436), CHSB_IPOCO  (P48394), 
CHSB_IPONI  (P48396), CHSB_IPOPU  (P48398), CHSB_IPOTF  (P48402), 
CHSB_IPOTR  (P48404), CHSB_PEA(P51082), CHSB_PETHY  (P22924), 
CHSB_SOLTU  (Q43163), CHSC_IPOPU  (P48399), CHSD_IPONI  (O22045), 
CHSD_PETHY  (P22925), CHSE_IPONI  (O22046), CHSE_IPOPU  (O22047), 
CHSF_PETHY  (P22926), CHSG_PETHY  (P22927), CHSH1_HUMLU (Q9FEY5), 
CHSH2_HUMLU (A0AMG7), CHSH3_HUMLU (A0AMG8), CHSH4_HUMLU (A0AMG9), 
CHSJ_PETHY  (P22928), CHSY_ANTMA  (P06515), CHSY_ARAAL  (Q9SEP4), 
CHSY_ARATH  (P13114), CHSY_BETPN  (P51075), CHSY_CALCH  (P48385), 
CHSY_CARAN  (Q9SEP2), CHSY_CATRO  (Q9ZRS4), CHSY_CHRAE  (O04220), 
CHSY_DIACA  (P48389), CHSY_DIAMO  (Q9LKP7), CHSY_EQUAR  (Q9MBB1), 
CHSY_HYDMC  (O82144), CHSY_HYPAN  (Q9FUB7), CHSY_MATIN  (P17818), 
CHSY_ONOVI  (O22586), CHSY_PERAE  (Q9ZU06), CHSY_PERFR  (O04111), 
CHSY_PETCR  (P16107), CHSY_PHAVU  (P49440), CHSY_PINST  (O65872), 
CHSY_PINSY  (P30079), CHSY_PUEML  (P23569), CHSY_RAPSA  (O22652), 
CHSY_VIGUN  (P51089), CHSY_VITVI  (P51090), CHS_CANSA   (Q8RVK9), 
CHS_RHODA   (A0A2Z5QL08), DPS1_PINST  (P48407), DPS2_PINST  (P48408), 
DPSS_PINSY  (Q02323), OLIS_CANSA  (B1Q2B6), ORS_RHODA   (A0A2Z5QKZ7), 
PKS1_RUBID  (Q9AU11), PKS2_RUBID  (Q9AU10), PKS3_RUBID  (Q9AU09), 
PKS4_RUBID  (B0LDU5), PKS5_RUBID  (B0LDU6), PKSF3_CANSA (F1LKH5), 
PKSG1_CANSA (F1LKH6), PKSG2_CANSA (F1LKH7), PKSG4_CANSA (F1LKH8), 
PKSG5_CANSA (F1LKH9), THS1_ARAHY  (P20178), THS1_VITVI  (P28343), 
THS2_ARAHY  (P20077), THS2_VITVI  (P51070), THS3_ARAHY  (P51069), 
THS3_VITVI  (P51071), THS4_VITVI  (A5AEM3), THS5_VITVI  (A5C9M2), 
THS7_VITVI  (A2ICC6), VPS_HUMLU   (O80400), VPS_PSINU   (Q9SLX9)
» more

UniProtKB/Swiss-Prot
False negative sequences		 25 sequences 

BAS_RHEPA   (Q94FV7), CURS1_CURLO (C0SVZ6), CURS2_CURLO (C6L7V8), 

CURS3_CURLO (C6L7V9), CUS_ORYSJ   (Q8LIL0), DCS_CURLO   (C0SVZ5), 
DPGA_AMYBA  (Q939X3), DPGA_AMYOR  (G4V4T4), DPGA_STRTO  (Q8KLK5), 
OKS_ALOAR   (Q3L7F5), PCS_ALOAR   (Q58VP7), PHLD_PSEF5  (Q4K418), 
PHLD_PSEFL  (Q51725), PKS10_MYCTO (P9WPF4), PKS10_MYCTU (P9WPF5), 
PKS1_DICDI  (Q55E72), PKS3_ALOAR  (C4MBZ5), PKS4_ALOAR  (C4NF90), 
PKS5_ALOAR  (C4NF91), PKSA_ARATH  (O23674), PKSB_ARATH  (Q8LDM2), 
RPPA_STRC0  (B0FYK7), RPPA_STRCO  (Q9FCA7), RPPA_STRGR  (Q54240), 
STLB_DICDI  (Q54FI3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

CHSY_FRAAN  (P51076), CHSY_MALDO  (P30078)


				
	

	

		PDB
[Detailed view]		
		
			31 PDB
			


			pdb_00001bi5; pdb_00001bq6; pdb_00001cgk; pdb_00001cgz; pdb_00001d6h; pdb_00001d6i; pdb_00001ee0; pdb_00001i86; pdb_00001i88; pdb_00001i89; pdb_00001i8b; pdb_00001jwx; 
			
				pdb_00001qlv; pdb_00001u0u; pdb_00001u0v; pdb_00001u0w; pdb_00001xes; pdb_00001xet; pdb_00004yjy; pdb_00006dx9; pdb_00006dxa; pdb_00006dxb; pdb_00006dxd; pdb_00006gw3; 
				pdb_00007bur; pdb_00007bus; pdb_00007w6g; pdb_00008b32; pdb_00008b35; pdb_00008b3c; pdb_00008jrd
			
			

			» more