PROSITE entry PS00452

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PURL: https://purl.expasy.org/prosite/signature/PS00452

Direct ScanProsite submission

General information about the entry

Entry name [info]	GUANYLATE_CYCLASE_1
Accession [info]	PS00452
Entry type [info]	PATTERN
Date [info]	01-MAY-1991 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00425

Name and characterization of the entry

Description [info]	Guanylate cyclase signature.
Pattern [info]	[GD]-[VI]-[LIVM]-x(0,1)-[GS]-x(5)-[FY]-x-[LIVM]-[FYWL]-[GS]-[DNTHKWE]- [DNTAS]-[IV]-[DNTAY]-x(5)-[DEC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	145 in 115 different sequences
Number of true positive hits	145 in 115 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	42
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	77.54 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	2
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

115 sequences

AC78C_DROME (Q9VP76), ADCY1_BOVIN (P19754), ADCY1_HUMAN (Q08828),

ADCY1_MOUSE (O88444), ADCY2_DROME (Q9VW60), ADCY2_HUMAN (Q08462), 
ADCY2_MOUSE (Q80TL1), ADCY2_RAT   (P26769), ADCY3_HUMAN (O60266), 
ADCY3_MOUSE (Q8VHH7), ADCY3_RAT   (P21932), ADCY4_HUMAN (Q8NFM4), 
ADCY4_MOUSE (Q91WF3), ADCY4_RAT   (P26770), ADCY5_CANLF (P30803), 
ADCY5_HUMAN (O95622), ADCY5_MOUSE (P84309), ADCY5_RABIT (P40144), 
ADCY5_RAT   (Q04400), ADCY6_CANLF (P30804), ADCY6_HUMAN (O43306), 
ADCY6_MOUSE (Q01341), ADCY6_RAT   (Q03343), ADCY7_BOVIN (Q29450), 
ADCY7_HUMAN (P51828), ADCY7_MOUSE (P51829), ADCY8_HUMAN (P40145), 
ADCY8_MOUSE (P97490), ADCY8_RAT   (P40146), ADCY9_CHICK (Q9DGG6), 
ADCY9_HUMAN (O60503), ADCY9_MOUSE (P51830), ADCY9_XENLA (P98999), 
ANPRA_HUMAN (P16066), ANPRA_MOUSE (P18293), ANPRA_RAT   (P18910), 
ANPRB_ANGJA (P55202), ANPRB_BOVIN (P46197), ANPRB_HUMAN (P20594), 
ANPRB_MOUSE (Q6VVW5), ANPRB_RAT   (P16067), CYA1_DROME  (P32870), 
CYA1_MYCBO  (P0A4Y1), CYA1_MYCTO  (P9WQ34), CYA1_MYCTU  (P9WQ35), 
CYAA_DICDI  (Q03100), CYAG_DICDI  (Q03101), GC76C_DROME (Q7JQ32), 
GCY12_CAEEL (Q19187), GCY13_CAEEL (Q19768), GCY14_CAEEL (Q23310), 
GCY15_CAEEL (P91550), GCY17_CAEEL (X5M8U1), GCY18_CAEEL (G5EFQ0), 
GCY19_CAEBR (A8XQC7), GCY19_CAEEL (O16544), GCY1_CAEEL  (Q09435), 
GCY20_CAEEL (O62179), GCY21_CAEEL (O16715), GCY22_CAEEL (Q9XTY1), 
GCY23_CAEEL (G5EEE9), GCY28_CAEEL (Q86GV3), GCY2_CAEEL  (Q10029), 
GCY31_CAEEL (Q86C56), GCY32_CAEEL (Q6DNF7), GCY33_CAEEL (P90895), 
GCY34_CAEEL (P92006), GCY35_CAEEL (O02298), GCY36_CAEEL (Q6DNF4), 
GCY37_CAEEL (Q6DNF3), GCY3E_DROME (Q07553), GCY3_CAEEL  (Q10028), 
GCY4_CAEBR  (A8WPG9), GCY4_CAEEL  (Q23681), GCY5_CAEEL  (Q23682), 
GCY6_CAEEL  (N1NVB7), GCY7_CAEEL  (H2L002), GCY8E_DROME (Q8INF0), 
GCY9_CAEEL  (E7EAU8), GCYA1_BOVIN (P19687), GCYA1_CANLF (Q4ZHS0), 
GCYA1_HUMAN (Q02108), GCYA1_MOUSE (Q9ERL9), GCYA1_RAT   (P19686), 
GCYA2_HUMAN (P33402), GCYA2_RAT   (Q9WVI4), GCYB1_BOVIN (P16068), 
GCYB1_CANLF (Q4ZHR9), GCYB1_HUMAN (Q02153), GCYB1_MOUSE (O54865), 
GCYB1_RAT   (P20595), GCYB2_HUMAN (O75343), GCYB2_RAT   (P22717), 
GCYDA_DROME (Q9VEU6), GCYDB_DROME (Q9VEU5), GCYH_DROME  (Q07093), 
GCY_STRPU   (P16065), GUC2C_CAVPO (P70106), GUC2C_HUMAN (P25092), 
GUC2C_MOUSE (Q3UWA6), GUC2C_PIG   (P55204), GUC2C_RAT   (P23897), 
GUC2D_BOVIN (P55203), GUC2D_CANLF (O19179), GUC2D_HUMAN (Q02846), 
GUC2D_MOUSE (A0A0U1RPR8), GUC2D_RAT   (P51839), GUC2E_MOUSE (P52785), 
GUC2E_RAT   (P51840), GUC2F_BOVIN (O02740), GUC2F_HUMAN (P51841), 
GUC2F_MOUSE (Q5SDA5), GUC2F_RAT   (P51842), GUC2G_MOUSE (Q6TL19), 
GUC2G_RAT   (P55205)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

42 sequences

ACXE_DROME  (Q9VK50), ADCYA_HUMAN (Q96PN6), ADCYA_MOUSE (Q8C0T9),

ADCYA_RABIT (Q866F4), ADCYA_RAT   (Q9Z286), CYAA_NEUCR  (Q01631), 
CYAD_DICDI  (Q55F68), DAF11_CAEEL (Q8I4N4), GCA_DICDI   (Q553Y7), 
GCY10_CAEEL (B1Q257), GCY11_CAEEL (Q18331), GCY25_CAEEL (A0A078BQP2), 
GCY27_CAEEL (Q9XU42), GCY29_CAEEL (O62026), GCY8_CAEEL  (Q9GYQ4), 
GCYA_PLAF7  (Q8IHY1), GCYB_PLABA  (A0A509APX1), GCYB_PLAF7  (Q8IDA0), 
GCY_TOXGG   (S7VVK4), LIPJ_MYCTU  (O07732), PAL1F_EUGGR (P84738), 
PALFB_EUGGR (P84737), PALST_EUGGR (P84739), PBL1F_EUGGR (P84742), 
PBLFB_EUGGR (P84741), PBLST_EUGGR (P84743), PCYAA_EUGGR (Q8S9F2), 
PCYAA_EUGLO (Q76L34), PCYAB_EUGGR (Q8S9F1), PCYAB_EUGLO (Q76L33), 
PYCC1_ECOLX (P0DV24), PYCC2_ECOLX (P0DV26), PYCC_BURCE  (A0A0J5ZXG5), 
PYCC_GULMO  (P0DV42), PYCC_PSEAI  (P0DV40), PYCC_RHOS2  (A0A1V0HUX5), 
PYCC_STAAU  (P0DV38), PYCC_TREPO  (A0A1T4LJ54), PYCC_XANPE  (P0DV28), 
YR818_MIMIV (Q5UQG7), YR826_MIMIV (Q7T6X2), YR831_MIMIV (Q7T6Y2)

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PDB
[Detailed view]

47 PDB

pdb_00001ab8; pdb_00001azs; pdb_00001cjk; pdb_00001cjt; pdb_00001cju; pdb_00001cjv; pdb_00001cs4; pdb_00001cul; pdb_00001tl7; pdb_00001u0h; pdb_00001yk9; pdb_00002gvd; pdb_00002gvz; pdb_00002wz1; pdb_00003c14; pdb_00003c15; pdb_00003c16; pdb_00003g82; pdb_00003maa; pdb_00003uvj; pdb_00004ni2; pdb_00004p2f; pdb_00004p2m; pdb_00004p2x; pdb_00006jt0; pdb_00006jt1; pdb_00006jt2; pdb_00007d9r; pdb_00007d9s; pdb_00007d9t; pdb_00007d9u; pdb_00007yz9; pdb_00007yzi; pdb_00007yzk; pdb_00008fx4; pdb_00008hbe; pdb_00008hbf; pdb_00008hbh; pdb_00008sl3; pdb_00008sl4; pdb_00009bcl; pdb_00009bcn; pdb_00009bco; pdb_00009bcp; pdb_00009bcq; pdb_00009bcs; pdb_00009bcv
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