PROSITE entry PS00452

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General information about the entry

Entry name [info]	GUANYLATE_CYCLASE_1
Accession [info]	PS00452
Entry type [info]	PATTERN
Date [info]	01-MAY-1991 CREATED; 01-DEC-2004 DATA UPDATE; 03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC00425

Name and characterization of the entry

Description [info]	Guanylate cyclase signature.
Pattern [info]	[GD]-[VI]-[LIVM]-x(0,1)-[GS]-x(5)-[FY]-x-[LIVM]-[FYWL]-[GS]-[DNTHKWE]- [DNTAS]-[IV]-[DNTAY]-x(5)-[DEC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.

Total number of hits	145 in 115 different sequences
Number of true positive hits	145 in 115 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	41
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	77.96 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	2
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

115 sequences

AC78C_DROME (Q9VP76    ), ADCY1_BOVIN (P19754    ), ADCY1_HUMAN (Q08828    ),

ADCY1_MOUSE (O88444    ), ADCY2_DROME (Q9VW60    ), ADCY2_HUMAN (Q08462    ), 
ADCY2_MOUSE (Q80TL1    ), ADCY2_RAT   (P26769    ), ADCY3_HUMAN (O60266    ), 
ADCY3_MOUSE (Q8VHH7    ), ADCY3_RAT   (P21932    ), ADCY4_HUMAN (Q8NFM4    ), 
ADCY4_MOUSE (Q91WF3    ), ADCY4_RAT   (P26770    ), ADCY5_CANLF (P30803    ), 
ADCY5_HUMAN (O95622    ), ADCY5_MOUSE (P84309    ), ADCY5_RABIT (P40144    ), 
ADCY5_RAT   (Q04400    ), ADCY6_CANLF (P30804    ), ADCY6_HUMAN (O43306    ), 
ADCY6_MOUSE (Q01341    ), ADCY6_RAT   (Q03343    ), ADCY7_BOVIN (Q29450    ), 
ADCY7_HUMAN (P51828    ), ADCY7_MOUSE (P51829    ), ADCY8_HUMAN (P40145    ), 
ADCY8_MOUSE (P97490    ), ADCY8_RAT   (P40146    ), ADCY9_CHICK (Q9DGG6    ), 
ADCY9_HUMAN (O60503    ), ADCY9_MOUSE (P51830    ), ADCY9_XENLA (P98999    ), 
ANPRA_HUMAN (P16066    ), ANPRA_MOUSE (P18293    ), ANPRA_RAT   (P18910    ), 
ANPRB_ANGJA (P55202    ), ANPRB_BOVIN (P46197    ), ANPRB_HUMAN (P20594    ), 
ANPRB_MOUSE (Q6VVW5    ), ANPRB_RAT   (P16067    ), CYA1_DROME  (P32870    ), 
CYA1_MYCBO  (P0A4Y1    ), CYA1_MYCTO  (P9WQ34    ), CYA1_MYCTU  (P9WQ35    ), 
CYAA_DICDI  (Q03100    ), CYAG_DICDI  (Q03101    ), GC76C_DROME (Q7JQ32    ), 
GCY12_CAEEL (Q19187    ), GCY13_CAEEL (Q19768    ), GCY14_CAEEL (Q23310    ), 
GCY15_CAEEL (P91550    ), GCY17_CAEEL (X5M8U1    ), GCY18_CAEEL (G5EFQ0    ), 
GCY19_CAEBR (A8XQC7    ), GCY19_CAEEL (O16544    ), GCY1_CAEEL  (Q09435    ), 
GCY20_CAEEL (O62179    ), GCY21_CAEEL (O16715    ), GCY22_CAEEL (Q9XTY1    ), 
GCY23_CAEEL (G5EEE9    ), GCY28_CAEEL (Q86GV3    ), GCY2_CAEEL  (Q10029    ), 
GCY31_CAEEL (Q86C56    ), GCY32_CAEEL (Q6DNF7    ), GCY33_CAEEL (P90895    ), 
GCY34_CAEEL (P92006    ), GCY35_CAEEL (O02298    ), GCY36_CAEEL (Q6DNF4    ), 
GCY37_CAEEL (Q6DNF3    ), GCY3E_DROME (Q07553    ), GCY3_CAEEL  (Q10028    ), 
GCY4_CAEBR  (A8WPG9    ), GCY4_CAEEL  (Q23681    ), GCY5_CAEEL  (Q23682    ), 
GCY6_CAEEL  (N1NVB7    ), GCY7_CAEEL  (H2L002    ), GCY8E_DROME (Q8INF0    ), 
GCY9_CAEEL  (E7EAU8    ), GCYA1_BOVIN (P19687    ), GCYA1_CANLF (Q4ZHS0    ), 
GCYA1_HUMAN (Q02108    ), GCYA1_MOUSE (Q9ERL9    ), GCYA1_RAT   (P19686    ), 
GCYA2_HUMAN (P33402    ), GCYA2_RAT   (Q9WVI4    ), GCYB1_BOVIN (P16068    ), 
GCYB1_CANLF (Q4ZHR9    ), GCYB1_HUMAN (Q02153    ), GCYB1_MOUSE (O54865    ), 
GCYB1_RAT   (P20595    ), GCYB2_HUMAN (O75343    ), GCYB2_RAT   (P22717    ), 
GCYDA_DROME (Q9VEU6    ), GCYDB_DROME (Q9VEU5    ), GCYH_DROME  (Q07093    ), 
GCY_STRPU   (P16065    ), GUC2C_CAVPO (P70106    ), GUC2C_HUMAN (P25092    ), 
GUC2C_MOUSE (Q3UWA6    ), GUC2C_PIG   (P55204    ), GUC2C_RAT   (P23897    ), 
GUC2D_BOVIN (P55203    ), GUC2D_CANLF (O19179    ), GUC2D_HUMAN (Q02846    ), 
GUC2D_MOUSE (A0A0U1RPR8), GUC2D_RAT   (P51839    ), GUC2E_MOUSE (P52785    ), 
GUC2E_RAT   (P51840    ), GUC2F_BOVIN (O02740    ), GUC2F_HUMAN (P51841    ), 
GUC2F_MOUSE (Q5SDA5    ), GUC2F_RAT   (P51842    ), GUC2G_MOUSE (Q6TL19    ), 
GUC2G_RAT   (P55205    )

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

41 sequences

ACXE_DROME  (Q9VK50    ), ADCYA_HUMAN (Q96PN6    ), ADCYA_MOUSE (Q8C0T9    ),

ADCYA_RABIT (Q866F4    ), ADCYA_RAT   (Q9Z286    ), CYAA_NEUCR  (Q01631    ), 
CYAD_DICDI  (Q55F68    ), DAF11_CAEEL (Q8I4N4    ), GCA_DICDI   (Q553Y7    ), 
GCY10_CAEEL (B1Q257    ), GCY11_CAEEL (Q18331    ), GCY25_CAEEL (A0A078BQP2), 
GCY27_CAEEL (Q9XU42    ), GCY29_CAEEL (O62026    ), GCY8_CAEEL  (Q9GYQ4    ), 
GCYA_PLAF7  (Q8IHY1    ), GCYB_PLABA  (A0A509APX1), GCYB_PLAF7  (Q8IDA0    ), 
GCY_TOXGG   (S7VVK4    ), PAL1F_EUGGR (P84738    ), PALFB_EUGGR (P84737    ), 
PALST_EUGGR (P84739    ), PBL1F_EUGGR (P84742    ), PBLFB_EUGGR (P84741    ), 
PBLST_EUGGR (P84743    ), PCYAA_EUGGR (Q8S9F2    ), PCYAA_EUGLO (Q76L34    ), 
PCYAB_EUGGR (Q8S9F1    ), PCYAB_EUGLO (Q76L33    ), PYCC1_ECOLX (P0DV24    ), 
PYCC2_ECOLX (P0DV26    ), PYCC_BURCE  (A0A0J5ZXG5), PYCC_GULMO  (P0DV42    ), 
PYCC_PSEAI  (P0DV40    ), PYCC_RHOS2  (A0A1V0HUX5), PYCC_STAAU  (P0DV38    ), 
PYCC_TREPO  (A0A1T4LJ54), PYCC_XANPE  (P0DV28    ), YR818_MIMIV (Q5UQG7    ), 
YR826_MIMIV (Q7T6X2    ), YR831_MIMIV (Q7T6Y2    )

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PDB
[Detailed view]

33 PDB

1AB8; 1AZS; 1CJK; 1CJT; 1CJU; 1CJV; 1CS4; 1CUL; 1TL7; 1U0H; 1YK9; 2GVD; 2GVZ; 2WZ1; 3C14; 3C15; 3C16; 3G82; 3MAA; 3UVJ; 4NI2; 4P2F; 4P2M; 4P2X; 6JT0; 6JT1; 6JT2; 7D9R; 7D9S; 7D9T; 7D9U; 7YZ9; 7YZI
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