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PROSITE entry PS00460


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00460
Entry name [info] GLUTATHIONE_PEROXID_1
Accession [info] PS00460
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-JAN-2008 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00396

Name and characterization of the entry

Description [info] Glutathione peroxidases active site.
Pattern [info] 
[GNDRC]-[RKHNQFYCS]-x-[LIVMFCS]-[LIVMF](2)-x-N-[VT]-x-[STCA]-x-[CU]-
[GA]-x-[TA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 97 in 97 different sequences
Number of true positive hits 97 in 97 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 15
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 86.61 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 12
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 97 sequences 

BSAA_BACSU  (P52035), BSAA_HALH5  (Q9Z9N7), BTUE_ECOLI  (P06610), 

GPO_LACLA   (Q9CFV1), GPO_LACLM   (O32770), GPWA_PSEWI  (O08368), 
GPX1_ARATH  (P52032), GPX1_BOVIN  (P00435), GPX1_CAEEL  (O02621), 
GPX1_CALJA  (Q0EF99), GPX1_CHLRE  (P83564), GPX1_HELAN  (O23970), 
GPX1_HUMAN  (P07203), GPX1_HYLLA  (Q4AEI2), GPX1_MACFU  (Q865R2), 
GPX1_MOUSE  (P11352), GPX1_PANTR  (Q0EFA0), GPX1_PEA(O24296), 
GPX1_PIG(Q8MJ14), GPX1_PONPY  (Q4AEI3), GPX1_RABIT  (P11909), 
GPX1_RAT(P04041), GPX1_SAPAP  (Q4AEI1), GPX1_SCHMA  (Q00277), 
GPX1_SCHPO  (O59858), GPX1_SYNY3  (P74250), GPX1_YEAST  (P36014), 
GPX2_ARATH  (O04922), GPX2_CAEEL  (O62327), GPX2_CALJA  (Q0EF98), 
GPX2_HUMAN  (P18283), GPX2_HYLLA  (Q4AEH9), GPX2_MACFU  (Q4AEH8), 
GPX2_MOUSE  (Q9JHC0), GPX2_PONPY  (Q4AEI0), GPX2_RAT(P83645), 
GPX2_SAPAP  (Q4AEH7), GPX2_SYNY3  (P73824), GPX2_YEAST  (P38143), 
GPX3_ARATH  (O22850), GPX3_BOVIN  (P37141), GPX3_CAEEL  (Q95003), 
GPX3_CANAL  (Q59WD3), GPX3_HUMAN  (P22352), GPX3_HYLLA  (Q4AEH5), 
GPX3_MACFU  (Q4AEH4), GPX3_MOUSE  (P46412), GPX3_PONPY  (Q5RFG3), 
GPX3_RAT(P23764), GPX3_SAPAP  (Q4AEH3), GPX3_YEAST  (P40581), 
GPX4_ARATH  (Q8L910), GPX4_BOVIN  (Q9N2J2), GPX4_CALJA  (Q32QL6), 
GPX4_CITSI  (Q06652), GPX4_GOSHI  (O49069), GPX4_HELAN  (O23968), 
GPX4_HUMAN  (P36969), GPX4_HYLLA  (Q4AEH1), GPX4_MACFU  (Q4AEH0), 
GPX4_MESCR  (Q9LEF0), GPX4_MOUSE  (O70325), GPX4_NICSY  (P30708), 
GPX4_PIG(P36968), GPX4_PONPY  (Q4AEH2), GPX4_RAT(P36970), 
GPX4_SAPAP  (Q4AEG9), GPX4_SOLLC  (O24031), GPX4_SPIOL  (O23814), 
GPX4_TOBAC  (Q9FXS3), GPX5_ARATH  (Q9LYB4), GPX5_CANLF  (O46607), 
GPX5_CHLRE  (O22448), GPX5_HUMAN  (O75715), GPX5_MACFA  (P28714), 
GPX5_MOUSE  (P21765), GPX5_PIG(O18994), GPX5_RAT(P30710), 
GPX6_ARATH  (O48646), GPX6_HUMAN  (P59796), GPX6_MOUSE  (Q91WR8), 
GPX6_RAT(Q64625), GPX7_ARATH  (Q9SZ54), GPX7_BOVIN  (A6QLY2), 
GPX7_HUMAN  (Q96SL4), GPX7_MOUSE  (Q99LJ6), GPX8_ARATH  (Q8LBU2), 
GPXA_NEIMA  (P0A0T4), GPXA_NEIMB  (P0A0T5), GPXA_NEIMC  (P0C2T0), 
GPXA_NEIMF  (A1KV41), GPXC_BRUMA  (P67877), GPXC_BRUPA  (P67878), 
GPXC_DIRIM  (P52033), GPXC_WUCBA  (P35666), GPX_MCV1(Q98234), 
GPX_PROCL   (G9JJU2)
» more

UniProtKB/Swiss-Prot
False negative sequences		 15 sequences 

BSAA_STAAC  (Q5HGC7), BSAA_STAAM  (P64290), BSAA_STAAN  (P99097), 

BSAA_STAAR  (Q6GHD0), BSAA_STAAS  (Q6G9Q8), BSAA_STAAW  (P64291), 
BSAA_STAEQ  (Q5HKZ3), BSAA_STAES  (Q8CSR9), GPX8A_XENLA (Q6IRC8), 
GPX8B_XENLA (Q5U583), GPX8_BOVIN  (Q2NL01), GPX8_DANRE  (Q7ZV14), 
GPX8_HUMAN  (Q8TED1), GPX8_MOUSE  (Q9D7B7), GPX8_TETNG  (Q4RSM6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

GPX4_PINPS  (P81087)


				
	

	

		PDB
[Detailed view]		
		
			28 PDB
			


			1GP1; 2HE3; 2I3Y; 2OBI; 2P31; 2V1M; 3CMI; 5H5Q; 5H5R; 5H5S; 5L71; 6ELW; 
			
				6HKQ; 6HN3; 7FC2; 7L8K; 7L8L; 7L8M; 7L8Q; 7L8R; 7U4I; 7U4J; 7U4K; 7U4L; 
				7U4M; 7U4N; 8Q8J; 8Q8N
			
			

			» more