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PROSITE entry PS00472


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PURL: https://purl.expasy.org/prosite/signature/PS00472

Direct ScanProsite submission
General information about the entry

Entry name [info] SMALL_CYTOKINES_CC
Accession [info] PS00472
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00434

Name and characterization of the entry

Description [info] Small cytokines (intercrine/chemokine) C-C subfamily signature.
Pattern [info] 
C-C-[LIFYTRQ]-x(5,8)-[LIR]-x(4)-[LIVMFA]-x(2)-[FYWECI]-x(5,8)-C-x(3,4)-
[SAG]-[LIVM](2)-[FL]-x(7,9)-C-[STAV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 92 in 92 different sequences
Number of true positive hits 92 in 92 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 14
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 86.79 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 2
Site [info] disulfide at position 11
Site [info] disulfide at position 17
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 92 sequences 

CC4L_HUMAN  (Q8NHW4), CCL11_BOVIN (Q9TTS6), CCL11_CAVPO (P80325), 

CCL11_HORSE (Q9TTQ4), CCL11_HUMAN (P51671), CCL11_MACMU (Q8MIT7), 
CCL11_MOUSE (P48298), CCL11_RAT   (P97545), CCL12_MOUSE (Q62401), 
CCL13_CANLF (Q68Y88), CCL13_HUMAN (Q99616), CCL14_HUMAN (Q16627), 
CCL15_HUMAN (Q16663), CCL16_HUMAN (O15467), CCL17_CANLF (Q95N01), 
CCL17_FELCA (Q8I021), CCL17_HUMAN (Q92583), CCL17_MACMU (Q8HYP9), 
CCL17_MOUSE (Q9WUZ6), CCL17_RAT   (Q9ERE0), CCL18_HUMAN (P55774), 
CCL18_MACMU (Q8HYP8), CCL19_HUMAN (Q99731), CCL19_MOUSE (O70460), 
CCL1_HUMAN  (P22362), CCL1_MOUSE  (P10146), CCL20_BOVIN (Q8SQB1), 
CCL20_HUMAN (P78556), CCL20_MOUSE (O89093), CCL22_HUMAN (O00626), 
CCL22_MOUSE (O88430), CCL23_HUMAN (P55773), CCL23_MACMU (Q8HYP4), 
CCL24_MOUSE (Q9JKC0), CCL25_CANLF (Q68A93), CCL26_CANLF (Q64H35), 
CCL26_HUMAN (Q9Y258), CCL28_CANLF (Q68A91), CCL28_HUMAN (Q9NRJ3), 
CCL2_BOVIN  (P28291), CCL2_CANLF  (P52203), CCL2_CAVPO  (Q08782), 
CCL2_HORSE  (Q9TTQ3), CCL2_HUMAN  (P13500), CCL2_MACFA  (P61274), 
CCL2_MACMU  (P61275), CCL2_MOUSE  (P10148), CCL2_PIG(P42831), 
CCL2_PONAB  (Q5RA36), CCL2_RABIT  (P28292), CCL2_RAT(P14844), 
CCL3_BOVIN  (Q8SQA6), CCL3_CANLF  (Q68A92), CCL3_HUMAN  (P10147), 
CCL3_MACMU  (Q8HYQ3), CCL3_MOUSE  (P10855), CCL3_PANTR  (Q5I1Z0), 
CCL3_RAT(P50229), CCL4_BOVIN  (Q17QA1), CCL4_CANLF  (Q68AZ0), 
CCL4_CHICK  (Q90826), CCL4_HUMAN  (P13236), CCL4_MACMU  (Q8HYQ2), 
CCL4_MOUSE  (P14097), CCL4_PIG(Q711P4), CCL4_RABIT  (P46632), 
CCL4_RAT(P50230), CCL5_BOVIN  (O97919), CCL5_CANLF  (Q8HYS0), 
CCL5_CAVPO  (P97272), CCL5_FELCA  (Q8SQ40), CCL5_HORSE  (Q8MKD0), 
CCL5_HUMAN  (P13501), CCL5_MACMU  (Q8HYQ1), CCL5_MOUSE  (P30882), 
CCL5_RAT(P50231), CCL5_SIGHI  (Q91ZL1), CCL6_MOUSE  (P27784), 
CCL6_RAT(Q68FP3), CCL7_HUMAN  (P80098), CCL7_MOUSE  (Q03366), 
CCL7_RAT(Q9QXY8), CCL8_BOVIN  (Q09141), CCL8_CANLF  (Q68AY9), 
CCL8_HUMAN  (P80075), CCL8_MOUSE  (Q9Z121), CCL8_PIG(P49873), 
CCL9_MOUSE  (P51670), CL3L1_HUMAN (P16619), MCPB_BOVIN  (P80343), 
REG1_BOVIN  (P82943), VMI2_HHV8P  (Q98157)
» more

UniProtKB/Swiss-Prot
False negative sequences		 14 sequences 

CC21A_MOUSE (P84444), CC21B_MOUSE (P86792), CC21C_MOUSE (P86793), 

CCL20_RAT   (P97884), CCL21_HUMAN (O00585), CCL21_MACMU (Q8HYP5), 
CCL24_CANLF (Q68Y86), CCL24_HUMAN (O00175), CCL25_HUMAN (O15444), 
CCL25_MOUSE (O35903), CCL25_PIG   (Q4PR21), CCL27_HUMAN (Q9Y4X3), 
CCL27_MOUSE (Q9Z1X0), CCL28_MOUSE (Q9JIL2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

CCL5_PIG(Q29288)


				
	

	

		PDB
[Detailed view]		
		
			114 PDB
			


			pdb_00001b3a; pdb_00001b50; pdb_00001b53; pdb_00001bo0; pdb_00001cm9; pdb_00001dok; pdb_00001dol; pdb_00001dom; pdb_00001don; pdb_00001el0; pdb_00001eot; pdb_00001esr; 
			
				pdb_00001g2s; pdb_00001g2t; pdb_00001g91; pdb_00001ha6; pdb_00001hfg; pdb_00001hfn; pdb_00001hhv; pdb_00001hrj; pdb_00001hum; pdb_00001hun; pdb_00001m8a; pdb_00001ml0; 
				pdb_00001ncv; pdb_00001nr2; pdb_00001nr4; pdb_00001rtn; pdb_00001rto; pdb_00001u4l; pdb_00001u4m; pdb_00001u4p; pdb_00001u4r; pdb_00001vmp; pdb_00002bdn; pdb_00002eot; 
				pdb_00002ffk; pdb_00002fht; pdb_00002fin; pdb_00002fj2; pdb_00002hcc; pdb_00002hci; pdb_00002jyo; pdb_00002l9h; pdb_00002mp1; pdb_00002mpm; pdb_00002nz1; pdb_00002q8r; 
				pdb_00002q8t; pdb_00002ra4; pdb_00002vxw; pdb_00002x69; pdb_00002x6g; pdb_00002x6l; pdb_00003fpu; pdb_00003h44; pdb_00003ifd; pdb_00003kbx; pdb_00003tn2; pdb_00004dn4; 
				pdb_00004mhe; pdb_00004oij; pdb_00004oik; pdb_00004r8i; pdb_00004ra8; pdb_00004ral; pdb_00004rws; pdb_00004zk9; pdb_00004zkb; pdb_00004zkc; pdb_00004zlt; pdb_00005cmd; 
				pdb_00005cor; pdb_00005coy; pdb_00005d65; pdb_00005dnf; pdb_00005l2u; pdb_00005ltl; pdb_00005uiw; pdb_00005ur7; pdb_00005wk3; pdb_00005yam; pdb_00006aez; pdb_00006c6d; 
				pdb_00006cws; pdb_00006fgp; pdb_00006stk; pdb_00006wwz; pdb_00007f1q; pdb_00007f1r; pdb_00007f1t; pdb_00007o7f; pdb_00007s4n; pdb_00007s58; pdb_00007s59; pdb_00007s5a; 
				pdb_00007scs; pdb_00007sct; pdb_00007scu; pdb_00007scv; pdb_00007so0; pdb_00007sta; pdb_00007t1e; pdb_00007vl9; pdb_00007vla; pdb_00007xa3; pdb_00008fj0; pdb_00008fj2; 
				pdb_00008fk6; pdb_00008fk8; pdb_00008fk9; pdb_00008jps; pdb_00008skk; pdb_00008u1u
			
			

			» more