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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00472


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PURL: https://purl.expasy.org/prosite/signature/PS00472

Direct ScanProsite submission
General information about the entry

Entry name [info] SMALL_CYTOKINES_CC
Accession [info] PS00472
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00434

Name and characterization of the entry

Description [info] Small cytokines (intercrine/chemokine) C-C subfamily signature.
Pattern [info] 
C-C-[LIFYTRQ]-x(5,8)-[LIR]-x(4)-[LIVMFA]-x(2)-[FYWECI]-x(5,8)-C-x(3,4)-
[SAG]-[LIVM](2)-[FL]-x(7,9)-C-[STAV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 92 in 92 different sequences
Number of true positive hits 92 in 92 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 14
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 86.79 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 2
Site [info] disulfide at position 11
Site [info] disulfide at position 17
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 92 sequences 

CC4L_HUMAN  (Q8NHW4), CCL11_BOVIN (Q9TTS6), CCL11_CAVPO (P80325), 

CCL11_HORSE (Q9TTQ4), CCL11_HUMAN (P51671), CCL11_MACMU (Q8MIT7), 
CCL11_MOUSE (P48298), CCL11_RAT   (P97545), CCL12_MOUSE (Q62401), 
CCL13_CANLF (Q68Y88), CCL13_HUMAN (Q99616), CCL14_HUMAN (Q16627), 
CCL15_HUMAN (Q16663), CCL16_HUMAN (O15467), CCL17_CANLF (Q95N01), 
CCL17_FELCA (Q8I021), CCL17_HUMAN (Q92583), CCL17_MACMU (Q8HYP9), 
CCL17_MOUSE (Q9WUZ6), CCL17_RAT   (Q9ERE0), CCL18_HUMAN (P55774), 
CCL18_MACMU (Q8HYP8), CCL19_HUMAN (Q99731), CCL19_MOUSE (O70460), 
CCL1_HUMAN  (P22362), CCL1_MOUSE  (P10146), CCL20_BOVIN (Q8SQB1), 
CCL20_HUMAN (P78556), CCL20_MOUSE (O89093), CCL22_HUMAN (O00626), 
CCL22_MOUSE (O88430), CCL23_HUMAN (P55773), CCL23_MACMU (Q8HYP4), 
CCL24_MOUSE (Q9JKC0), CCL25_CANLF (Q68A93), CCL26_CANLF (Q64H35), 
CCL26_HUMAN (Q9Y258), CCL28_CANLF (Q68A91), CCL28_HUMAN (Q9NRJ3), 
CCL2_BOVIN  (P28291), CCL2_CANLF  (P52203), CCL2_CAVPO  (Q08782), 
CCL2_HORSE  (Q9TTQ3), CCL2_HUMAN  (P13500), CCL2_MACFA  (P61274), 
CCL2_MACMU  (P61275), CCL2_MOUSE  (P10148), CCL2_PIG(P42831), 
CCL2_PONAB  (Q5RA36), CCL2_RABIT  (P28292), CCL2_RAT(P14844), 
CCL3_BOVIN  (Q8SQA6), CCL3_CANLF  (Q68A92), CCL3_HUMAN  (P10147), 
CCL3_MACMU  (Q8HYQ3), CCL3_MOUSE  (P10855), CCL3_PANTR  (Q5I1Z0), 
CCL3_RAT(P50229), CCL4_BOVIN  (Q17QA1), CCL4_CANLF  (Q68AZ0), 
CCL4_CHICK  (Q90826), CCL4_HUMAN  (P13236), CCL4_MACMU  (Q8HYQ2), 
CCL4_MOUSE  (P14097), CCL4_PIG(Q711P4), CCL4_RABIT  (P46632), 
CCL4_RAT(P50230), CCL5_BOVIN  (O97919), CCL5_CANLF  (Q8HYS0), 
CCL5_CAVPO  (P97272), CCL5_FELCA  (Q8SQ40), CCL5_HORSE  (Q8MKD0), 
CCL5_HUMAN  (P13501), CCL5_MACMU  (Q8HYQ1), CCL5_MOUSE  (P30882), 
CCL5_RAT(P50231), CCL5_SIGHI  (Q91ZL1), CCL6_MOUSE  (P27784), 
CCL6_RAT(Q68FP3), CCL7_HUMAN  (P80098), CCL7_MOUSE  (Q03366), 
CCL7_RAT(Q9QXY8), CCL8_BOVIN  (Q09141), CCL8_CANLF  (Q68AY9), 
CCL8_HUMAN  (P80075), CCL8_MOUSE  (Q9Z121), CCL8_PIG(P49873), 
CCL9_MOUSE  (P51670), CL3L1_HUMAN (P16619), MCPB_BOVIN  (P80343), 
REG1_BOVIN  (P82943), VMI2_HHV8P  (Q98157)
» more

UniProtKB/Swiss-Prot
False negative sequences		 14 sequences 

CC21A_MOUSE (P84444), CC21B_MOUSE (P86792), CC21C_MOUSE (P86793), 

CCL20_RAT   (P97884), CCL21_HUMAN (O00585), CCL21_MACMU (Q8HYP5), 
CCL24_CANLF (Q68Y86), CCL24_HUMAN (O00175), CCL25_HUMAN (O15444), 
CCL25_MOUSE (O35903), CCL25_PIG   (Q4PR21), CCL27_HUMAN (Q9Y4X3), 
CCL27_MOUSE (Q9Z1X0), CCL28_MOUSE (Q9JIL2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

CCL5_PIG(Q29288)


				
	

	

		PDB
[Detailed view]		
		
			114 PDB
			


			pdb_00001b3a; pdb_00001b50; pdb_00001b53; pdb_00001bo0; pdb_00001cm9; pdb_00001dok; pdb_00001dol; pdb_00001dom; pdb_00001don; pdb_00001el0; pdb_00001eot; pdb_00001esr; 
			
				pdb_00001g2s; pdb_00001g2t; pdb_00001g91; pdb_00001ha6; pdb_00001hfg; pdb_00001hfn; pdb_00001hhv; pdb_00001hrj; pdb_00001hum; pdb_00001hun; pdb_00001m8a; pdb_00001ml0; 
				pdb_00001ncv; pdb_00001nr2; pdb_00001nr4; pdb_00001rtn; pdb_00001rto; pdb_00001u4l; pdb_00001u4m; pdb_00001u4p; pdb_00001u4r; pdb_00001vmp; pdb_00002bdn; pdb_00002eot; 
				pdb_00002ffk; pdb_00002fht; pdb_00002fin; pdb_00002fj2; pdb_00002hcc; pdb_00002hci; pdb_00002jyo; pdb_00002l9h; pdb_00002mp1; pdb_00002mpm; pdb_00002nz1; pdb_00002q8r; 
				pdb_00002q8t; pdb_00002ra4; pdb_00002vxw; pdb_00002x69; pdb_00002x6g; pdb_00002x6l; pdb_00003fpu; pdb_00003h44; pdb_00003ifd; pdb_00003kbx; pdb_00003tn2; pdb_00004dn4; 
				pdb_00004mhe; pdb_00004oij; pdb_00004oik; pdb_00004r8i; pdb_00004ra8; pdb_00004ral; pdb_00004rws; pdb_00004zk9; pdb_00004zkb; pdb_00004zkc; pdb_00004zlt; pdb_00005cmd; 
				pdb_00005cor; pdb_00005coy; pdb_00005d65; pdb_00005dnf; pdb_00005l2u; pdb_00005ltl; pdb_00005uiw; pdb_00005ur7; pdb_00005wk3; pdb_00005yam; pdb_00006aez; pdb_00006c6d; 
				pdb_00006cws; pdb_00006fgp; pdb_00006stk; pdb_00006wwz; pdb_00007f1q; pdb_00007f1r; pdb_00007f1t; pdb_00007o7f; pdb_00007s4n; pdb_00007s58; pdb_00007s59; pdb_00007s5a; 
				pdb_00007scs; pdb_00007sct; pdb_00007scu; pdb_00007scv; pdb_00007so0; pdb_00007sta; pdb_00007t1e; pdb_00007vl9; pdb_00007vla; pdb_00007xa3; pdb_00008fj0; pdb_00008fj2; 
				pdb_00008fk6; pdb_00008fk8; pdb_00008fk9; pdb_00008jps; pdb_00008skk; pdb_00008u1u
			
			

			» more