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PROSITE entry PS00477


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General information about the entry

Entry name [info] ALPHA_2_MACROGLOBULIN
Accession [info] PS00477
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-MAY-1991 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00440

Name and characterization of the entry

Description [info] Alpha-2-macroglobulin family thiolester region signature.
Pattern [info]
[PG]-x-[GS]-C-[GA]-E-[EQ]-x-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 51 in 51 different sequences
Number of true positive hits 45 in 45 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 5
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 88.24 %
Recall (true positives / (true positives + false negatives)) 90.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] thiolester at position 4
Site [info] thiolester at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
45 sequences

A1I3_RAT(P14046), A1M_RAT (Q63041), A2MG_BOVIN  (Q7SIH1), 
A2MG_HUMAN  (P01023), A2MG_MOUSE  (Q6GQT1), A2MG_PONAB  (Q5R4N8), 
A2MG_RAT(P06238), A2ML1_HUMAN (A8K2U0), A2M_HOMAM   (P20737), 
A2M_OCTVU   (P30800), A2M_PACLE   (P20738), CD109_HUMAN (Q6YHK3), 
CD109_MOUSE (Q8R422), CO3_BOVIN   (Q2UVX4), CO3_CAVPO   (P12387), 
CO3_EPTBU   (P98094), CO3_HUMAN   (P01024), CO3_LETCA   (Q00685), 
CO3_MOUSE   (P01027), CO3_NAJNA   (Q01833), CO3_ONCMY   (P98093), 
CO3_PIG (P01025), CO3_RABIT   (P12247), CO3_RAT (P01026), 
CO4A_HUMAN  (P0C0L4), CO4B_HUMAN  (P0C0L5), CO4B_MOUSE  (P01029), 
CO4_BOVIN   (P01030), CO4_RAT (P08649), CPMD8_HUMAN (Q8IZJ3), 
MUG1_MOUSE  (P28665), MUG1_RAT(Q03626), MUG2_MOUSE  (P28666), 
MUG2_RAT(Q6IE52), OVOS_ANAPL  (P20739), OVOS_MOUSE  (Q3UU35), 
PZP_HUMAN   (P20742), PZP_MOUSE   (Q61838), TEPR1_ANOGA (C9XI66), 
TEPS1_ANOGA (Q9GYW4), TEPS3_ANOGA (C9XI63), VCO31_AUSSU (Q0ZZJ6), 
VCO3_CROAD  (J3S836), VCO3_NAJKA  (Q91132), VCO3_OPHHA  (I2C090)
» more

UniProtKB/Swiss-Prot
False negative sequences
5 sequences

CO5_HUMAN   (P01031), CO5_MOUSE   (P06684), OVOS1_HUMAN (Q6IE37), 
OVOS_CHICK  (P20740), VCO32_AUSSU (A0RZC6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
5 sequences

CO3_XENLA   (P23667), CO4_CAVPO   (P19069), CO5_BOVIN   (P12082), 
CO5_PIG (P01032), CO5_RAT (P08650)
» more

UniProtKB/Swiss-Prot
False positive sequences
6 sequences

GALT5_HUMAN (Q7Z7M9), GALT5_MOUSE (Q8C102), GALT5_RAT   (O88422), 
ISPE_CHLAB  (Q5L568), ISPE_CHLCV  (Q821X0), OACYL_MOUSE (Q8BML2)
» more

PDB
[Detailed view]
60 PDB

1HZF; 2A73; 2I07; 2ICF; 2PN5; 2WII; 2WIN; 2XWB; 2XWJ; 3G6J; 3L5N; 3PRX; 3PVM; 4D94; 4LNV; 5FO7; 5FO8; 5FO9; 5FOA; 5FOB; 5JPM; 5JPN; 5JTW; 5O32; 5O35; 6EHG; 6RMT; 6RMU; 6RUR; 6RUV; 6TAV; 6YO6; 6YSQ; 7AKK; 7BAG; 7NOZ; 7O7L; 7O7M; 7O7N; 7O7O; 7O7P; 7O7Q; 7O7R; 7O7S; 7Q1Y; 7Q5Z; 7Q60; 7Q61; 7Q62; 7QIV; 7TV9; 7VON; 7VOO; 7ZGK; 8AYH; 8CEM; 8ENU; 8EOK; 8OQ3; 8OVB
» more