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PROSITE entry PS00478


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General information about the entry

Entry name [info] LIM_DOMAIN_1
Accession [info] PS00478
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00382

Name and characterization of the entry

Description [info] LIM zinc-binding domain signature.
Pattern [info] 
C-x(2)-C-x(15,21)-[FYWHPCR]-H-x(2)-[CH]-x(2)-C-x(2)-C-x(3)-[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 792 in 400 different sequences
Number of true positive hits 790 in 398 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 7
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.75 %
Recall (true positives / (true positives + false negatives)) 99.12 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 5
Site [info] zinc at position 1
Site [info] zinc at position 3
Site [info] zinc at position 6
Site [info] zinc at position 8
Site [info] zinc at position 10
Site [info] zinc at position 12
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 398 sequences 

ABLM1_HUMAN (O14639), ABLM1_MOUSE (Q8K4G5), ABLM2_HUMAN (Q6H8Q1), 

ABLM2_MOUSE (Q8BL65), ABLM2_RAT   (Q6KC51), ABLM3_HUMAN (O94929), 
ABLM3_MOUSE (Q69ZX8), AJUBA_BOVIN (E1BKA3), AJUBA_DROME (Q9VY77), 
AJUBA_HUMAN (Q96IF1), AJUBA_MOUSE (Q91XC0), AJUBA_RAT   (Q5U2Z2), 
APTE_DROME  (P29673), AWH_DROME   (Q8IRC7), CRIP1_BOVIN (Q56K04), 
CRIP1_HUMAN (P50238), CRIP1_MOUSE (P63254), CRIP1_RAT   (P63255), 
CRIP2_BOVIN (Q0VFX8), CRIP2_HUMAN (P52943), CRIP2_MOUSE (Q9DCT8), 
CRIP2_PONAB (Q5R7Y1), CRIP2_RAT   (P36201), CRIP3_HUMAN (Q6Q6R5), 
CRIP3_MOUSE (Q6Q6R3), CSRP1_BOVIN (Q3MHY1), CSRP1_CHICK (P67966), 
CSRP1_COTJA (P67967), CSRP1_HUMAN (P21291), CSRP1_MOUSE (P97315), 
CSRP1_PONAB (Q5RCT4), CSRP1_RAT   (P47875), CSRP2_BOVIN (Q32LE9), 
CSRP2_CHICK (P50460), CSRP2_COTJA (Q05158), CSRP2_HUMAN (Q16527), 
CSRP2_MOUSE (P97314), CSRP2_RAT   (Q62908), CSRP3_BOVIN (Q4U0T9), 
CSRP3_HUMAN (P50461), CSRP3_MOUSE (P50462), CSRP3_RAT   (P50463), 
DA1_ARATH   (P0C7Q8), DAR1_ARATH  (Q8W4F0), DAR2_ARATH  (Q0WSN2), 
DAR4_ARATH  (Q9FKN7), DAR5_ARATH  (Q84WJ0), DAR6_ARATH  (Q9FJX8), 
DAR7_ARATH  (Q9FJX9), ESN_DROME   (Q9U1I1), ESN_DROPS   (Q292U5), 
FBLI1_BOVIN (Q1JQB5), FBLI1_HUMAN (Q8WUP2), FBLI1_MOUSE (Q71FD7), 
FBLI1_PONAB (Q5REN1), FHL1_HUMAN  (Q13642), FHL1_MOUSE  (P97447), 
FHL1_RAT(Q9WUH4), FHL2_BOVIN  (Q2KI95), FHL2_HUMAN  (Q14192), 
FHL2_MOUSE  (O70433), FHL2_RAT(O35115), FHL3_BOVIN  (Q3ZBI6), 
FHL3_HUMAN  (Q13643), FHL3_MOUSE  (Q9R059), FHL5_BOVIN  (Q2YDK0), 
FHL5_HUMAN  (Q5TD97), FHL5_MACFA  (Q4R7A4), FHL5_MOUSE  (Q9WTX7), 
FHL5_RAT(Q6AXT1), HDR3_ORYSJ  (Q10NJ6), HIL_DROME   (Q0E908), 
HM14_CAEEL  (P20271), ISL1_CHICK  (P50211), ISL1_DANRE  (P53405), 
ISL1_HUMAN  (P61371), ISL1_MESAU  (P61373), ISL1_MOUSE  (P61372), 
ISL1_RAT(P61374), ISL2A_DANRE (P53406), ISL2A_ONCTS (P53408), 
ISL2B_DANRE (P53407), ISL2B_ONCTS (P50212), ISL2_CHICK  (P53410), 
ISL2_HUMAN  (Q96A47), ISL2_MOUSE  (Q9CXV0), ISL2_RAT(P50480), 
ISL3_ONCTS  (P53409), KY_CAEEL(G5EF51), LASP1_BOVIN (Q3B7M5), 
LASP1_DROME (Q8I7C3), LASP1_HUMAN (Q14847), LASP1_MOUSE (Q61792), 
LASP1_PONAB (Q5R5W0), LASP1_RABIT (O77506), LASP1_RAT   (Q99MZ8), 
LDB3_HUMAN  (O75112), LDB3_MOUSE  (Q9JKS4), LHX1_CHICK  (P53411), 
LHX1_DANRE  (Q90476), LHX1_HUMAN  (P48742), LHX1_MESAU  (P63008), 
LHX1_MOUSE  (P63006), LHX1_PANTR  (Q5IS44), LHX1_RAT(P63007), 
LHX1_SAIBB  (Q5IS89), LHX1_XENLA  (P29674), LHX2_HUMAN  (P50458), 
LHX2_MOUSE  (Q9Z0S2), LHX2_RAT(P36198), LHX3_CHICK  (P53412), 
LHX3_DANRE  (Q90421), LHX3_HUMAN  (Q9UBR4), LHX3_MOUSE  (P50481), 
LHX3_PIG(O97581), LHX3_XENLA  (P36200), LHX4_HUMAN  (Q969G2), 
LHX4_MOUSE  (P53776), LHX5_DANRE  (P52889), LHX5_HUMAN  (Q9H2C1), 
LHX5_MOUSE  (P61375), LHX5_RAT(P61376), LHX5_XENLA  (P37137), 
LHX6_HUMAN  (Q9UPM6), LHX6_MOUSE  (Q9R1R0), LHX8_HUMAN  (Q68G74), 
LHX8_MOUSE  (O35652), LHX9_BOVIN  (A0JNI8), LHX9_CHICK  (Q90881), 
LHX9_DANRE  (Q1LWV4), LHX9_GLARU  (A2PZF9), LHX9_HUMAN  (Q9NQ69), 
LHX9_MOUSE  (Q9WUH2), LHX9_PSAFA  (A2I8Z7), LHX9_RAT(Q80W90), 
LHX9_XENLA  (Q68EY3), LIM4_CAEEL  (G5EEA1), LIM6_CAEEL  (Q21192), 
LIM7_CAEEL  (G5EC36), LIMA1_HUMAN (Q9UHB6), LIMA1_MOUSE (Q9ERG0), 
LIMA1_PIG   (B0KYV5), LIMA1_RAT   (F1LR10), LIMA_DICDI  (Q54QR1), 
LIMB_DICDI  (Q54NW4), LIMC1_HUMAN (Q9UPQ0), LIMC1_MOUSE (Q3UH68), 
LIMC1_XENLA (Q3KQW7), LIMCH_DICDI (Q55GV9), LIMC_DICDI  (Q9BIW5), 
LIMD1_BOVIN (G5E5X0), LIMD1_HUMAN (Q9UGP4), LIMD1_MOUSE (Q9QXD8), 
LIMD1_RAT   (B5DEH0), LIMD1_XENLA (Q06BR1), LIMD1_XENTR (B7ZUL2), 
LIMD2_BOVIN (Q1LZA7), LIMD2_HUMAN (Q9BT23), LIMD2_MOUSE (Q8BGB5), 
LIMD2_RAT   (Q4KM31), LIMD_DICDI  (Q9BIW4), LIME_DICDI  (O60952), 
LIMF_DICDI  (Q86I44), LIMG_DICDI  (Q55DS4), LIMK1_CHICK (Q8QFP8), 
LIMK1_DROME (Q8IR79), LIMK1_HUMAN (P53667), LIMK1_MOUSE (P53668), 
LIMK1_RAT   (P53669), LIMK1_XENLA (O42565), LIMK2_BOVIN (Q32L23), 
LIMK2_CHICK (P53666), LIMK2_HUMAN (P53671), LIMK2_MOUSE (O54785), 
LIMK2_RAT   (P53670), LIMKA_DICDI (Q54L00), LIMKB_DICDI (P0CD62), 
LIMS1_HUMAN (P48059), LIMS1_MOUSE (Q99JW4), LIMS2_BOVIN (Q2KJ33), 
LIMS2_HUMAN (Q7Z4I7), LIMS2_MOUSE (Q91XD2), LIMS3_HUMAN (P0CW19), 
LIMS4_HUMAN (P0CW20), LIN11_CAEEL (P20154), LMCD1_BOVIN (Q17QE2), 
LMCD1_HUMAN (Q9NZU5), LMCD1_MOUSE (Q8VEE1), LMCD1_PIG   (Q5PXT2), 
LMO3_BOVIN  (Q2KIA3), LMO3_DANRE  (Q503U0), LMO3_HUMAN  (Q8TAP4), 
LMO3_MOUSE  (Q8BZL8), LMO3_PONAB  (Q5RBW7), LMO3_RAT(Q99MB5), 
LMO3_XENLA  (Q9YH16), LMO41_XENTR (Q5FVB2), LMO42_XENTR (Q6DJ06), 
LMO4A_XENLA (Q8AW92), LMO4B_XENLA (Q801P0), LMO4_BOVIN  (Q3SWZ8), 
LMO4_HUMAN  (P61968), LMO4_MOUSE  (P61969), LMO7_HUMAN  (Q8WWI1), 
LMX1A_HUMAN (Q8TE12), LMX1A_MESAU (Q04650), LMX1A_MOUSE (Q9JKU8), 
LMX1B_CHICK (P53413), LMX1B_HUMAN (O60663), LMX1B_MESAU (Q60564), 
LMX1B_MOUSE (O88609), LMX1B_XENLA (Q8UVR3), LNEBL_MOUSE (Q9DC07), 
LPP_CHICK   (Q5F464), LPP_HUMAN   (Q93052), LPP_MOUSE   (Q8BFW7), 
LPP_RAT (Q5XI07), LPXN_HUMAN  (O60711), LPXN_MOUSE  (Q99N69), 
LPXN_RABIT  (Q9N261), LRG1_YEAST  (P35688), MCA2B_DANRE (F1RA39), 
MCA3A_DANRE (F1QH17), MCA3B_DANRE (F1QWK4), MEC3_CAEBR  (P34764), 
MEC3_CAEEL  (P09088), MEC3_CAERE  (P34765), MICA1_BOVIN (F1MH07), 
MICA1_DANRE (E7F9T0), MICA1_HUMAN (Q8TDZ2), MICA1_MOUSE (Q8VDP3), 
MICA1_RAT   (D3ZBP4), MICA2_BOVIN (F1MF74), MICA2_HUMAN (O94851), 
MICA2_MOUSE (Q8BML1), MICA2_RAT   (D4A1F2), MICA2_XENTR (F6QZ15), 
MICA3_BOVIN (G3MWR8), MICA3_HUMAN (Q7RTP6), MICA3_MOUSE (Q8CJ19), 
MILK1_BOVIN (E1BBG2), MILK1_HUMAN (Q8N3F8), MILK1_MOUSE (Q8BGT6), 
MILK1_RAT   (D3ZQL6), MILK2_HUMAN (Q8IY33), MILK2_MOUSE (Q3TN34), 
MILK2_RAT   (D3ZEN0), MLP1_DROME  (P53777), MLP2_DROME  (Q24400), 
NRAP_HUMAN  (Q86VF7), NRAP_MOUSE  (Q80XB4), PAXB_DICDI  (Q8MML5), 
PAXI_CHICK  (P49024), PAXI_HUMAN  (P49023), PAXI_MOUSE  (Q8VI36), 
PAXI_PONAB  (Q5R7I1), PAXI_RAT(Q66H76), PDLI1_BOVIN (Q5E9E1), 
PDLI1_HUMAN (O00151), PDLI1_MOUSE (O70400), PDLI1_RAT   (P52944), 
PDLI2_BOVIN (Q3T0C8), PDLI2_HUMAN (Q96JY6), PDLI2_MACFA (Q9GKU1), 
PDLI2_MOUSE (Q8R1G6), PDLI2_RAT   (Q6AYD6), PDLI3_BOVIN (Q3SYZ8), 
PDLI3_CHICK (Q9PU47), PDLI3_HUMAN (Q53GG5), PDLI3_MOUSE (O70209), 
PDLI3_PIG   (Q6QGC0), PDLI3_RAT   (Q66HS7), PDLI3_XENLA (Q6GLJ6), 
PDLI4_BOVIN (Q3T005), PDLI4_CHICK (Q9PW72), PDLI4_HUMAN (P50479), 
PDLI4_MOUSE (P70271), PDLI4_RAT   (P36202), PDLI5_HUMAN (Q96HC4), 
PDLI5_MOUSE (Q8CI51), PDLI5_RAT   (Q62920), PDLI7_BOVIN (Q3SX40), 
PDLI7_CHICK (Q679P3), PDLI7_DANRE (Q6P7E4), PDLI7_HUMAN (Q9NR12), 
PDLI7_MOUSE (Q3TJD7), PDLI7_RAT   (Q9Z1Z9), PDLI7_XENLA (Q6INU3), 
PIN2_CAEEL  (Q19157), PLI2A_ARATH (O80839), PLI2B_ARATH (Q1ECF5), 
PLI2B_ORYSJ (Q7F9R9), PLI2C_ARATH (Q500W4), PRC3A_XENLA (A8WH69), 
PRC3B_XENLA (A0A1L8F1M4), PRI1A_XENLA (Q90Z06), PRI1B_XENLA (Q90WV2), 
PRIC1_AEDAE (Q174I2), PRIC1_ANOGA (Q7QJT4), PRIC1_DROME (A1Z6W3), 
PRIC1_DROPS (Q292U2), PRIC1_HUMAN (Q96MT3), PRIC1_MOUSE (Q3U5C7), 
PRIC1_RAT   (Q71QF9), PRIC1_XENTR (Q28FG2), PRIC2_HUMAN (Q7Z3G6), 
PRIC2_MOUSE (Q80Y24), PRIC3_HUMAN (O43900), PRIC3_MOUSE (Q80VL3), 
PRIC4_HUMAN (Q2TBC4), PXL1_CAEEL  (Q09476), PXL1_YEAST  (P36166), 
PZF1_CAEEL  (G5EGQ2), RBTN1_BOVIN (Q0P5B3), RBTN1_DANRE (Q8JFQ2), 
RBTN1_HUMAN (P25800), RBTN1_MOUSE (Q924W9), RBTN1_XENLA (Q3B8H4), 
RBTN2_BOVIN (Q1LZ94), RBTN2_DANRE (Q9PTJ3), RBTN2_HUMAN (P25791), 
RBTN2_MOUSE (P25801), RBTN2_XENLA (Q90XH3), RBTN2_XENTR (Q5M8V8), 
RGA1_SCHPO  (O43052), RGA1_YEAST  (P39083), RGA2_YEAST  (Q06407), 
RGA3_SCHPO  (O14014), RGA4_SCHPO  (O74360), SCEL_HUMAN  (O95171), 
SCEL_MOUSE  (Q9EQG3), SF3_HELAN   (P29675), TES_AOTNA   (Q07DW1), 
TES_ATEAB   (Q00PK1), TES_ATEGE   (Q09YL5), TES_BOVIN   (Q2YDE9), 
TES_CALJA   (Q2QLG8), TES_CANLF   (A0M8U6), TES_CHICK   (Q90YH9), 
TES_CHLAE   (Q2IBA3), TES_COLGU   (Q07DZ4), TES_DASNO   (Q07E51), 
TES_EULMM   (Q2IBH0), TES_FELCA   (A0M8S5), TES_HORSE   (Q2QLB2), 
TES_HUMAN   (Q9UGI8), TES_LOXAF   (Q108U9), TES_MICMU   (Q2QL92), 
TES_MONDO   (Q2QLA1), TES_MOUSE   (P47226), TES_MUNMU   (Q09YK3), 
TES_MUNRE   (Q07DX3), TES_MUSPF   (Q07E27), TES_NEONE   (Q07E40), 
TES_NOMLE   (Q07DY3), TES_OTOGA   (Q2QLH9), TES_PANTR   (Q2QLF4), 
TES_PAPAN   (A0M8R4), TES_PIG (Q2QLE3), TES_PLEMO   (Q2QLC3), 
TES_PONAB   (Q5RC52), TES_RABIT   (Q09YN8), TES_RAT (Q2LAP6), 
TES_RHIFE   (Q2IBC3), TES_SAIBB   (Q09YI0), TES_SHEEP   (Q09YJ2), 
TES_XENLA   (Q7ZXE9), TES_XENTR   (Q6DIR5), TGFI1_BOVIN (Q3MHZ4), 
TGFI1_HUMAN (O43294), TGFI1_MOUSE (Q62219), TGFI1_RAT   (Q99PD6), 
TGFI1_XENLA (Q2TCH4), TRIP6_BOVIN (Q3SX26), TRIP6_HUMAN (Q15654), 
TRIP6_MOUSE (Q9Z1Y4), TTX3_CAEEL  (G5EE86), UNC95_CAEEL (Q9NEZ5), 
UNC97_CAEEL (P50464), WLI2A_ARATH (O04193), WLI2B_ARATH (Q9M047), 
WLIM1_ARATH (Q94JX5), WTIP_DANRE  (A8DZE6), WTIP_HUMAN  (A6NIX2), 
WTIP_MOUSE  (Q7TQJ8), WTIP_XENLA  (A9LS46), XIRP2_MOUSE (Q4U4S6), 
Y6787_DICDI (Q55BI0), YOCC_SCHPO  (O74398), ZASP_DROME  (A1ZA47), 
ZN185_HUMAN (O15231), ZN185_MOUSE (Q62394), ZYX_CAEEL   (Q9U3F4), 
ZYX_CHICK   (Q04584), ZYX_HUMAN   (Q15942), ZYX_MOUSE   (Q62523), 
ZYX_XENLA   (A5H447), ZYX_XENTR   (Q0VA45)
» more

UniProtKB/Swiss-Prot
False negative sequences		 7 sequences 

ADCE_DICDI  (Q55GN8), HEL2_SCHPO  (Q76PD2), HEL2_YEAST  (Q05580), 

LASP1_CAEEL (P34416), LHX3_HALRO  (Q25132), MICAL_DROME (Q86BA1), 
Y2098_DICDI (Q55A66)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

LASP1_PIG   (P80171)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			2 sequences
			


			
SIR7_DROME  (Q9VAQ1), YEMC_SCHPO  (O14033)


				
	

	

		PDB
[Detailed view]		
		
			69 PDB
			


			1A7I; 1B8T; 1CTL; 1CXX; 1G47; 1IBI; 1IML; 1J2O; 1M3V; 1NYP; 1QLI; 1RUT; 
			
				1U5S; 1V6G; 1WIG; 1WYH; 1X3H; 1X4K; 1X4L; 1X61; 1X62; 1X63; 1X64; 1X68; 
				1X6A; 2CO8; 2COR; 2CU8; 2CUP; 2CUQ; 2CUR; 2D8X; 2D8Y; 2D8Z; 2DFY; 2DJ7; 
				2DLO; 2EGQ; 2EHE; 2JTN; 2KBX; 2L4Z; 2L6Y; 2L6Z; 2LXD; 2LZU; 2MBV; 2MIU; 
				2O10; 2O13; 2RGT; 2XJY; 2XJZ; 2XQN; 2YPA; 3F6Q; 3IXE; 3MMK; 4HI8; 4HI9; 
				4JCJ; 4KFZ; 6CME; 6U4M; 6U4N; 7D2T; 7D2U; 7LT9; 7QB0
			
			

			» more