Home  |  Contact
Due to work on this service, it may not be fully operational on Wednesday March 20 between 1.30 pm and 2.30 pm CEST. Apologies for the inconvenience.
Entry: PS00497

General information about the entry

Entry name [info] TYROSINASE_1
Accession [info] PS00497
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE;
13-FEB-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC00398

Name and characterization of the entry

Description [info] Tyrosinase CuA-binding region signature.
Pattern [info]
H-x(4,5)-F-[LIVMFTP]-x-[FW]-H-R-x(2)-[LVMT]-x(3)-E.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_02 which contains 559'228 sequence entries.


Total number of hits 76 in 68 different sequences
Number of true positive hits 76 in 68 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 10
Number of 'partial' sequences 32
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 88.37 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 7
Site [info] copper at position 1
Site [info] copper at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
68 sequences

GRIF_STRGG  (B1VTI5    ), HC2C_MEGCR  (P81732    ), HCY2A_RAPVE (P80960    ), 
HCY2E_RAPVE (P83040    ), HCYA_ENTDO  (P12659    ), HCYB_HELPO  (P12031    ), 
HCYC_SEPOF  (P56824    ), HCYE_SEPOF  (P56825    ), HCYG_ENTDO  (O61363    ), 
HCYG_HELPO  (P56823    ), HCYG_SEPOF  (P56826    ), LAHY_LARTR  (Q6UIL3    ), 
ORSC_EMENI  (Q5AUW8    ), PPO1_AGABI  (Q00024    ), PPO1_IPOBA  (Q9ZP19    ), 
PPO2_AGABI  (O42713    ), PPO2_IPOBA  (Q9MB14    ), PPO4_AGABI  (C7FF05    ), 
PPOA_SOLLC  (Q08303    ), PPOB_SOLLC  (Q08304    ), PPOB_SOLTU  (Q06355    ), 
PPOC_SOLLC  (Q08305    ), PPOD_SOLLC  (Q08306    ), PPOE_SOLLC  (Q08307    ), 
PPOF_SOLLC  (Q08296    ), PPO_MALDO   (P43309    ), PPO_PRUAR   (O81103    ), 
PPO_SPIOL   (P43310    ), PPO_VICFA   (Q06215    ), PPO_VITVI   (P43311    ), 
TYR1_CAEEL  (P34269    ), TYR3_CAEEL  (Q19673    ), TYRO1_PINMG (H2A0L0    ), 
TYRO2_PINMG (H2A0L1    ), TYRO_ASPFU  (Q8J130    ), TYRO_ASPOR  (Q00234    ), 
TYRO_BOVIN  (Q8MIU0    ), TYRO_CANLF  (P54834    ), TYRO_CHICK  (P55024    ), 
TYRO_COTJA  (Q08410    ), TYRO_GORGO  (Q9BDE0    ), TYRO_HUMAN  (P14679    ), 
TYRO_MOUSE  (P11344    ), TYRO_NEUCR  (P00440    ), TYRO_ORYLA  (P55025    ), 
TYRO_PELES  (Q0MVP0    ), TYRO_PELNI  (Q04604    ), TYRO_PELSI  (P55026    ), 
TYRO_PHONA  (A7BHQ9    ), TYRO_PINMA  (P86952    ), TYRO_PODAS  (Q92396    ), 
TYRO_RHIML  (P33180    ), TYRO_STRAT  (P07524    ), TYRO_STRGA  (P06845    ), 
TYRO_STRGB  (P55022    ), TYRO_STRLN  (P55023    ), TYRP1_AMBME (P55027    ), 
TYRP1_BOVIN (Q8WN57    ), TYRP1_CARAU (P55028    ), TYRP1_CHICK (O57405    ), 
TYRP1_HUMAN (P17643    ), TYRP1_MOUSE (P07147    ), TYRP2_BOVIN (Q95119    ), 
TYRP2_CHICK (O93505    ), TYRP2_HUMAN (P40126    ), TYRP2_MOUSE (P29812    ), 
TYRP2_PIG   (Q4R1H1    ), USTQ_ASPFN  (B8NM74    )
» more

UniProtKB/Swiss-Prot
False negative sequences
10 sequences

AS1_ANTMA   (Q9FRX6    ), PHCY1_HOMAM (Q6KF82    ), PHCY2_HOMAM (Q6KF81    ), 
PPO2_DROME  (Q9V521    ), PPO3_DROER  (Q8I1F6    ), PPO3_DROME  (Q9W1V6    ), 
PRP1_BOMMO  (Q27451    ), PRP1_MANSE  (O44249    ), PRP2_BOMMO  (Q27452    ), 
PRP2_MANSE  (Q25519    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
32 sequences

HCY1_HOMAM  (P82296    ), HCY1_LIODE  (P84461    ), HCY1_MAJSQ  (P82302    ), 
HCY1_NECPU  (P84846    ), HCY2_HOMAM  (P82297    ), HCY2_LIODE  (P84462    ), 
HCY2_MAJSQ  (P82303    ), HCY2_PANJA  (P82312    ), HCY3_HOMAM  (P82298    ), 
HCY3_MAJSQ  (P82304    ), HCY3_PANJA  (P82313    ), HCY4E_MAJSQ (P82306    ), 
HCY4_CARMA  (P82309    ), HCY4_HOMAM  (P82299    ), HCY4_MAJSQ  (P82305    ), 
HCY5_HOMAM  (P82300    ), HCY5_MAJSQ  (P82307    ), HCY6_HOMAM  (P82301    ), 
HCY6_MAJSQ  (P82308    ), HCYA_CONCC  (P84619    ), HCYB_CONCC  (P84620    ), 
HCYIA_PANJA (P82310    ), HCYIB_PANJA (P82311    ), LEC_PENST   (P84821    ), 
PHCY_LIODE  (P84460    ), PHCY_LIOHO  (P84768    ), PHCY_LIOMA  (P84769    ), 
PHCY_NECPU  (P84847    ), PPO3_SARAR  (C0HJM0    ), PPO_ZINOF   (P85026    ), 
PRP1_SIMDA  (P85046    ), TYRO_FELCA  (P55033    )
» more

PDB
[Detailed view]
17 PDB

1BT1; 1BT2; 1BT3; 1BUG; 1JS8; 1LNL; 2P3X; 5M6B; 5M8L; 5M8M; 5M8N; 5M8O; 5M8P; 5M8Q; 5M8R; 5M8S; 5M8T
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission