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PROSITE entry PS00497


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General information about the entry

Entry name [info] TYROSINASE_1
Accession [info] PS00497
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00398

Name and characterization of the entry

Description [info] Tyrosinase CuA-binding region signature.
Pattern [info]
H-x(4,5)-F-[LIVMFTP]-x-[FW]-H-R-x(2)-[LVMT]-x(3)-E.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 96 in 76 different sequences
Number of true positive hits 96 in 76 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 13
Number of 'partial' sequences 31
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 88.07 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 7
Site [info] copper at position 1
Site [info] copper at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
76 sequences

GRIF_STRGG  (B1VTI5), HC2C_MEGCR  (P81732), HCY1_MEGCR  (Q10583), 
HCY2A_RAPVE (P80960), HCY2E_RAPVE (P83040), HCY2_MEGCR  (Q10584), 
HCYA_ENTDO  (P12659), HCYB_HELPO  (P12031), HCYC_SEPOF  (P56824), 
HCYE_SEPOF  (P56825), HCYG_ENTDO  (O61363), HCYG_HELPO  (P56823), 
HCYG_SEPOF  (P56826), HKM6_ASPHA  (P0DUQ0), LAHY_LARTR  (Q6UIL3), 
ORSC_EMENI  (Q5AUW8), PHOQ2_DIALO (A0A8J9RRY2), PHQ11_DIALO (A0A8J9R8H5), 
PHQ12_DIALO (A0A142I737), PPO1_AGABI  (Q00024), PPO1_IPOBA  (Q9ZP19), 
PPO2_AGABI  (O42713), PPO2_IPOBA  (Q9MB14), PPO4_AGABI  (C7FF05), 
PPOA_SOLLC  (Q08303), PPOB_SOLLC  (Q08304), PPOB_SOLTU  (Q06355), 
PPOC_SOLLC  (Q08305), PPOD_SOLLC  (Q08306), PPOE_SOLLC  (Q08307), 
PPOF_SOLLC  (Q08296), PPO_MALDO   (P43309), PPO_PRUAR   (O81103), 
PPO_SPIOL   (P43310), PPO_VICFA   (Q06215), PPO_VITVI   (P43311), 
TYR1_CAEEL  (P34269), TYR3_CAEEL  (Q19673), TYRO1_PINMG (H2A0L0), 
TYRO2_PINMG (H2A0L1), TYRO_ASPFU  (Q8J130), TYRO_ASPOR  (Q00234), 
TYRO_BOVIN  (Q8MIU0), TYRO_CANLF  (P54834), TYRO_CHICK  (P55024), 
TYRO_COTJA  (Q08410), TYRO_FELCA  (P55033), TYRO_GORGO  (Q9BDE0), 
TYRO_HUMAN  (P14679), TYRO_MOUSE  (P11344), TYRO_NEUCR  (P00440), 
TYRO_ORYLA  (P55025), TYRO_PELLE  (Q0MVP0), TYRO_PELNI  (Q04604), 
TYRO_PELSI  (P55026), TYRO_PHONA  (A7BHQ9), TYRO_PINMA  (P86952), 
TYRO_PODAS  (Q92396), TYRO_RHIML  (P33180), TYRO_STRAT  (P07524), 
TYRO_STRGA  (P06845), TYRO_STRGB  (P55022), TYRO_STRLN  (P55023), 
TYRP1_AMBME (P55027), TYRP1_BOVIN (Q8WN57), TYRP1_CARAU (P55028), 
TYRP1_CHICK (O57405), TYRP1_FELCA (Q2VPW6), TYRP1_HUMAN (P17643), 
TYRP1_MOUSE (P07147), TYRP2_BOVIN (Q95119), TYRP2_CHICK (O93505), 
TYRP2_HUMAN (P40126), TYRP2_MOUSE (P29812), TYRP2_PIG   (Q4R1H1), 
USTQ_ASPFN  (B8NM74)
» more

UniProtKB/Swiss-Prot
False negative sequences
13 sequences

AS1_ANTMA   (Q9FRX6), HCY_SCYOL   (C0HLU7), HCY_SCYSE   (C0HLU8), 
PHCY1_HOMAM (Q6KF82), PHCY2_HOMAM (Q6KF81), PPO1_SPOLT  (Q3ZPT5), 
PPO2_DROME  (Q9V521), PPO3_DROER  (Q8I1F6), PPO3_DROME  (Q9W1V6), 
PRP1_BOMMO  (Q27451), PRP1_MANSE  (O44249), PRP2_BOMMO  (Q27452), 
PRP2_MANSE  (Q25519)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
31 sequences

HCY1_HOMAM  (P82296), HCY1_LIODE  (P84461), HCY1_MAJSQ  (P82302), 
HCY1_NECPU  (P84846), HCY2_HOMAM  (P82297), HCY2_LIODE  (P84462), 
HCY2_MAJSQ  (P82303), HCY2_PANJA  (P82312), HCY3_HOMAM  (P82298), 
HCY3_MAJSQ  (P82304), HCY3_PANJA  (P82313), HCY4E_MAJSQ (P82306), 
HCY4_CARMA  (P82309), HCY4_HOMAM  (P82299), HCY4_MAJSQ  (P82305), 
HCY5_HOMAM  (P82300), HCY5_MAJSQ  (P82307), HCY6_HOMAM  (P82301), 
HCY6_MAJSQ  (P82308), HCYA_CONCC  (P84619), HCYB_CONCC  (P84620), 
HCYIA_PANJA (P82310), HCYIB_PANJA (P82311), LEC_PENST   (P84821), 
PHCY_LIODE  (P84460), PHCY_LIOHO  (P84768), PHCY_LIOMA  (P84769), 
PHCY_NECPU  (P84847), PPO3_SARAR  (C0HJM0), PPO_ZINOF   (P85026), 
PRP1_SIMDA  (P85046)
» more

PDB
[Detailed view]
27 PDB

1BT1; 1BT2; 1BT3; 1BUG; 1JS8; 1LNL; 2P3X; 3L6W; 3QJO; 4BED; 5M6B; 5M8L; 5M8M; 5M8N; 5M8O; 5M8P; 5M8Q; 5M8R; 5M8S; 5M8T; 6ELS; 6HQI; 6HQJ; 9EY5; 9EY6; 9EY7; 9EY8
» more