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PROSITE entry PS00498


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00498
Entry name [info] TYROSINASE_2
Accession [info] PS00498
Entry type [info] PATTERN
Date [info] 01-MAY-1991 CREATED;
01-MAY-1991 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00398

Name and characterization of the entry

Description [info] Tyrosinase and hemocyanins CuB-binding region signature.
Pattern [info] 
D-P-x-F-[LIVMFYW]-x(2)-H-x(3)-D.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 139 in 119 different sequences
Number of true positive hits 133 in 113 different sequences
Number of 'unknown' hits 0
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 1
Number of 'partial' sequences 34
Precision (true positives / (true positives + false positives)) 95.68 %
Recall (true positives / (true positives + false negatives)) 99.25 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 8
Site [info] copper at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 113 sequences 

AS1_ANTMA   (Q9FRX6), GRIF_STRGG  (B1VTI5), HC2C_MEGCR  (P81732), 

HCY1_MEGCR  (Q10583), HCY2A_RAPVE (P80960), HCY2E_RAPVE (P83040), 
HCY2_CARAE  (P84293), HCY2_LIMPO  (P04253), HCY2_MEGCR  (Q10584), 
HCY6_ANDAU  (P80476), HCYA_APHSP  (P14750), HCYA_ENTDO  (P12659), 
HCYA_PANIN  (P04254), HCYA_SCUCO  (Q95P08), HCYB_APHSP  (Q9NFH9), 
HCYB_ASTLP  (P83180), HCYB_HELPO  (P12031), HCYB_PANIN  (P10787), 
HCYB_SCUCO  (Q8IFJ8), HCYC_APHSP  (Q9NFL6), HCYC_PANIN  (P80096), 
HCYC_SCUCO  (Q8T115), HCYD_APHSP  (P02241), HCYD_SCUCO  (Q95P07), 
HCYE_APHSP  (P02242), HCYF_APHSP  (Q9NFL5), HCYG_APHSP  (Q9NFL4), 
HCYG_ENTDO  (O61363), HCYG_HELPO  (P56823), HCYG_SEPOF  (P56826), 
HCYX_SCUCO  (Q8T116), HCY_PALVU   (P80888), HCY_SCYOL   (C0HLU7), 
HCY_SCYSE   (C0HLU8), HKM6_ASPHA  (P0DUQ0), IVOB_EMENI  (Q5BGU9), 
LAHY_LARTR  (Q6UIL3), ORSC_EMENI  (Q5AUW8), PHCY1_HOMAM (Q6KF82), 
PHCY2_HOMAM (Q6KF81), PHOQ2_DIALO (A0A8J9RRY2), PHQ11_DIALO (A0A8J9R8H5), 
PHQ12_DIALO (A0A142I737), PPO1_AGABI  (Q00024), PPO1_HOLDI  (Q8I6K1), 
PPO1_SPOLT  (Q3ZPT5), PPO2_AGABI  (O42713), PPO2_DROME  (Q9V521), 
PPO2_HOLDI  (Q8I6K2), PPO3_AGABI  (C7FF04), PPO3_DROER  (Q8I1F6), 
PPO3_DROME  (Q9W1V6), PPO4_AGABI  (C7FF05), PPO8_ANOGA  (Q8MZM3), 
PPOA_SOLLC  (Q08303), PPOB_SOLLC  (Q08304), PPOB_SOLTU  (Q06355), 
PPOC_SOLLC  (Q08305), PPOD_SOLLC  (Q08306), PPOE_SOLLC  (Q08307), 
PPOF_SOLLC  (Q08296), PPO_MALDO   (P43309), PPO_PRUAR   (O81103), 
PPO_SPIOL   (P43310), PPO_VICFA   (Q06215), PPO_VITVI   (P43311), 
PRP1_BOMMO  (Q27451), PRP1_MANSE  (O44249), PRP1_SIMDA  (P85046), 
PRP2_BOMMO  (Q27452), PRP2_GALME  (Q6UEH6), PRP2_MANSE  (Q25519), 
TYR1_CAEEL  (P34269), TYR1_HAHS4  (A0A261GRE4), TYR2_HAHS4  (A0A261GVB1), 
TYR3_CAEEL  (Q19673), TYRO1_PINMG (H2A0L0), TYRO2_PINMG (H2A0L1), 
TYRO_ASPFU  (Q8J130), TYRO_ASPOR  (Q00234), TYRO_BOVIN  (Q8MIU0), 
TYRO_CANLF  (P54834), TYRO_CHICK  (P55024), TYRO_FELCA  (P55033), 
TYRO_GORGO  (Q9BDE0), TYRO_HUMAN  (P14679), TYRO_MOUSE  (P11344), 
TYRO_NEUCR  (P00440), TYRO_ORYLA  (P55025), TYRO_PELLE  (Q0MVP0), 
TYRO_PELNI  (Q04604), TYRO_PHONA  (A7BHQ9), TYRO_PINMA  (P86952), 
TYRO_PODAS  (Q92396), TYRO_RHIML  (P33180), TYRO_STRAT  (P07524), 
TYRO_STRGA  (P06845), TYRO_STRLN  (P55023), TYRP1_AMBME (P55027), 
TYRP1_BOVIN (Q8WN57), TYRP1_CARAU (P55028), TYRP1_CHICK (O57405), 
TYRP1_FELCA (Q2VPW6), TYRP1_HUMAN (P17643), TYRP1_MOUSE (P07147), 
TYRP2_BOVIN (Q95119), TYRP2_CHICK (O93505), TYRP2_HUMAN (P40126), 
TYRP2_MOUSE (P29812), TYRP2_PIG   (Q4R1H1), TYRP_ASPTE  (A0A336U966), 
TYRP_ASPTN  (Q0CRX0), USTQ_ASPFN  (B8NM74)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

TYRO_STRGB  (P55022)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			34 sequences
			


			
HCY1_HOMAM  (P82296), HCY1_LIODE  (P84461), HCY1_MAJSQ  (P82302), 

			
HCY1_NECPU  (P84846), HCY2_HOMAM  (P82297), HCY2_LIODE  (P84462), 
HCY2_MAJSQ  (P82303), HCY2_PANJA  (P82312), HCY3_HOMAM  (P82298), 
HCY3_MAJSQ  (P82304), HCY3_PANJA  (P82313), HCY4E_MAJSQ (P82306), 
HCY4_CARMA  (P82309), HCY4_HOMAM  (P82299), HCY4_MAJSQ  (P82305), 
HCY5_HOMAM  (P82300), HCY5_MAJSQ  (P82307), HCY6_HOMAM  (P82301), 
HCY6_MAJSQ  (P82308), HCYA_CONCC  (P84619), HCYB_CONCC  (P84620), 
HCYC_SEPOF  (P56824), HCYE_SEPOF  (P56825), HCYIA_PANJA (P82310), 
HCYIB_PANJA (P82311), LEC_PENST   (P84821), PHCY_LIODE  (P84460), 
PHCY_LIOHO  (P84768), PHCY_LIOMA  (P84769), PHCY_NECPU  (P84847), 
PPO3_SARAR  (C0HJM0), PPO_ZINOF   (P85026), TYRO_COTJA  (Q08410), 
TYRO_PELSI  (P55026)


			
			» more
			


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			6 sequences
			


			
3HID1_ARATH (Q9SZE1), 5053R_ASFB7 (Q89642), 5053R_ASFM2 (Q65129), 

			
5053R_ASFP4 (P0C9T0), 5053R_ASFWA (P0C9T1), LE607_CAEEL (O44743)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			36 PDB
			


			1HC1; 1HCY; 1JS8; 1LL1; 1LLA; 1LNL; 1NOL; 1OXY; 2P3X; 2Y9W; 2Y9X; 3HHS; 
			
				3IXV; 3IXW; 3L6W; 3QJO; 4BED; 4YZW; 5M6B; 5M8L; 5M8M; 5M8N; 5M8O; 5M8P; 
				5M8Q; 5M8R; 5M8S; 5M8T; 6ELS; 6HQI; 6HQJ; 8B74; 9EY5; 9EY6; 9EY7; 9EY8
			
			

			» more