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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00556


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PURL: https://purl.expasy.org/prosite/signature/PS00556

Direct ScanProsite submission
General information about the entry

Entry name [info] HOK_GEF
Accession [info] PS00556
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-MAY-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00481

Name and characterization of the entry

Description [info] Hok/gef family cell toxic proteins signature.
Pattern [info] 
[LIVMA](4)-C-[LIVMFA]-T-[LIVMA](2)-x(4)-[LIVM]-x-[RG]-x(2)-L-[CY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 18 in 18 different sequences
Number of true positive hits 18 in 18 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] disulfide at position 12
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 18 sequences 

FLMA_ECO57  (P62671), FLMA_ECOLI  (P62670), HOKA_ECOLI  (P37305), 

HOKB_ECOLI  (P77494), HOKC_ECOLI  (P0ACG4), HOKC_SHIFL  (P0ACG5), 
HOKD_ECO57  (P0ACG7), HOKD_ECOLI  (P0ACG6), HOKD_SHIFL  (Q7UCD5), 
HOKE_ECO57  (Q8XBW9), HOKE_ECOLI  (P77091), HOKE_SHIFL  (Q7UDF9), 
HOKF_SHIFL  (Q7UDG0), HOK_ECOLX   (P11895), MOKC_ECOLI  (P33236), 
PNDA1_ECOLX (P11902), PNDA2_ECOLX (P16477), SRNB_ECOLI  (P13970)
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