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PROSITE entry PS00560


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PURL: https://purl.expasy.org/prosite/signature/PS00560

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General information about the entry

Entry name [info] CARBOXYPEPT_SER_HIS
Accession [info] PS00560
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00122
Associated ProRule [info] PRU10075

Name and characterization of the entry

Description [info] Serine carboxypeptidases, histidine active site.
Pattern [info] 
[LIVF]-x(2)-[LIVSTA]-x-[IVPST]-x-[GSDNQL]-[SAGV]-[SG]-H-x-[IVAQ]-P-x(3)-
[PSA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 83 in 83 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 129
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 98.81 %
Recall (true positives / (true positives + false negatives)) 39.15 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 83 sequences 

ATG42_YEAST (P38109), CBP1_HORVU  (P07519), CBP1_ORYSJ  (P37890), 

CBP21_HORVU (P55747), CBP22_HORVU (P55748), CBP23_HORVU (P52711), 
CBP2_HORVU  (P08818), CBP2_WHEAT  (P08819), CBP3_HORVU  (P21529), 
CBP3_ORYSJ  (P37891), CBP3_WHEAT  (P11515), CBPX_ORYSJ  (P52712), 
CBPX_PEA(Q41005), CBPYA_BOTFB (A6RUD7), CBPYA_SCLS1 (A7F4H5), 
CBPY_CANAX  (P30574), CBPY_KOMPG  (P52710), CBPY_YEAST  (P00729), 
CPS1_PENJA  (P34946), CPVL_DICDI  (Q869Q8), CTS11_CAEEL (P52717), 
CTS12_CAEEL (P52715), CTS31_CAEEL (P52716), CTS32_CAEEL (P52714), 
CTS41_CAEEL (Q09991), HNLS_SORBI  (P52708), KEX1_ASPNC  (A2QPW5), 
KEX1_CANAL  (Q5AFP8), KEX1_CANAW  (C4YTG0), KEX1_CANDC  (B9WJJ7), 
KEX1_CANTT  (C5MFP8), KEX1_CLAL4  (C4Y8B4), KEX1_COPC7  (A8NYP0), 
KEX1_DEBHA  (B5RUL7), KEX1_EREGS  (Q752M5), KEX1_FUSV7  (C7YRS6), 
KEX1_KLULA  (Q6CKK4), KEX1_LODEL  (A5E751), KEX1_OGAPD  (E7R7R2), 
KEX1_PHYIT  (D0MVS1), KEX1_PICGU  (A5DAT0), KEX1_PUCGT  (E3L8A5), 
KEX1_SCHJY  (B6K7U7), KEX1_TUBMM  (D5G4B1), KEX1_YARLI  (Q6CFP3), 
KEX1_YEAS2  (C7GWZ2), KEX1_YEAS8  (C8Z852), KEX1_YEASO  (E7NHF8), 
KEX1_YEAST  (P09620), KEX1_ZYGRC  (C5DT72), NF314_NAEFO (P42661), 
PEPF_ASPNG  (P52718), PEPS_ASPPH  (P52719), PPGB_BOVIN  (Q3MI05), 
PPGB_HUMAN  (P10619), PPGB_MOUSE  (P16675), SCP1_MEDTR  (A0A0C3VJP4), 
SCP20_ARATH (Q8L7B2), SCP21_ARATH (Q9LSV8), SCP22_ARATH (Q1PF08), 
SCP23_ARATH (O82229), SCP24_ARATH (Q9M099), SCP25_ARATH (Q8L9Y0), 
SCP26_ARATH (Q9ZQQ0), SCP27_ARATH (Q9SFB5), SCP29_ARATH (Q949Q7), 
SCP33_ARATH (Q9LSM9), SCP34_ARATH (Q0WPR4), SCP35_ARATH (Q9LEY1), 
SCP36_ARATH (Q9SV04), SCP37_ARATH (Q84WF0), SCP38_ARATH (Q9ZUG3), 
SCP39_ARATH (Q9SV02), SCP40_ARATH (Q0WRX3), SCP45_ARATH (Q93Y09), 
SCP47_ARATH (Q9FFB0), SCP48_ARATH (Q56WF8), SCP49_ARATH (P32826), 
SCP50_ARATH (Q9M9Q6), SCPD_ARTBC  (D4B0Q6), SXA2_SCHPO  (P32825), 
VCP_AEDAE   (P42660), VCP_APIME   (C9WMM5)
» more

UniProtKB/Swiss-Prot
False negative sequences		 129 sequences 

CBPYA_AJECG (C0NX46), CBPYA_AJECN (A6RGA0), CBPYA_AJEDR (C5GEU5), 

CBPYA_ARTBC (D4AZ71), CBPYA_ARTGP (E4USS9), CBPYA_ARTOC (C5FWJ1), 
CBPYA_ASPCL (A1CUJ5), CBPYA_ASPFN (B8NXS9), CBPYA_ASPFU (Q5VJG9), 
CBPYA_ASPNC (A5AB21), CBPYA_ASPOR (Q2TYA1), CBPYA_ASPTN (Q0CSD3), 
CBPYA_BLAGS (C5K1Y9), CBPYA_CHAGB (Q2H9G6), CBPYA_COCP7 (C5P212), 
CBPYA_COLGM (E3QR43), CBPYA_EMENI (Q96VC4), CBPYA_FUSV7 (C7YQJ2), 
CBPYA_LEPMJ (E5A7I6), CBPYA_NEOFI (A1DP75), CBPYA_NEUCR (Q7RXW8), 
CBPYA_PARBA (C1GXD8), CBPYA_PARBD (C1GG77), CBPYA_PARBP (C0SGX7), 
CBPYA_PENRW (B6HPP6), CBPYA_PHANO (Q0V1R1), CBPYA_PODAN (B2AWD5), 
CBPYA_PYRO7 (A4RPY8), CBPYA_PYRTR (B2WKF1), CBPYA_SORMK (D1ZG13), 
CBPYA_TALMQ (B6QAN5), CBPYA_TALSN (B8M044), CBPYA_TRIEQ (B8XGR4), 
CBPYA_TRIRU (Q5J6J0), CBPYA_TRITO (A5YCB8), CBPYA_TRIVH (D4DLI1), 
CBPYA_UNCRE (C4JNM2), CBPY_SCHPO  (O13849), CPVL_HUMAN  (Q9H3G5), 
CPVL_MOUSE  (Q9D3S9), CPVL_PONAB  (Q5RFE4), CPVL_RAT(Q4QR71), 
KEX1_AJECN  (A6QX86), KEX1_AJEDR  (C5GC75), KEX1_ARTBC  (D4B5L8), 
KEX1_ARTOC  (C5FTV7), KEX1_ASPCL  (A1CQL5), KEX1_ASPFC  (B0XQ16), 
KEX1_ASPFU  (Q4WTK9), KEX1_ASPOR  (Q2UPI1), KEX1_ASPTN  (Q0CCR9), 
KEX1_BLAGS  (C5JN54), KEX1_CANGA  (Q6FTM9), KEX1_CHAGB  (Q2GYB7), 
KEX1_COCP7  (C5P635), KEX1_COCPS  (E9CS37), KEX1_COLGM  (E3QDT3), 
KEX1_CRYGW  (E6R6G5), KEX1_EMENI  (Q5BDJ6), KEX1_KOMPG  (C4QZV7), 
KEX1_LACTC  (C5DLM9), KEX1_LEPMJ  (E5R540), KEX1_METAQ  (E9E1Z2), 
KEX1_METRA  (E9ESM3), KEX1_MYCMD  (Q4P8U8), KEX1_NEOFI  (A1D3I1), 
KEX1_NEUCR  (Q1K722), KEX1_PARBA  (C1GP85), KEX1_PARBD  (C1G2I2), 
KEX1_PARBP  (C0SGJ2), KEX1_PENRW  (B6H7A4), KEX1_PHANO  (Q0USX0), 
KEX1_PICPA  (O74702), KEX1_PODAN  (B2B762), KEX1_PYRO7  (A4RE47), 
KEX1_PYRTR  (B2W340), KEX1_SCLS1  (A7EYY7), KEX1_SORMK  (D1ZEM2), 
KEX1_TALMQ  (B6QQZ9), KEX1_TALSN  (B8M719), KEX1_UNCRE  (C4JTD3), 
KEX1_VANPO  (A7TLB3), KEX1_VERA1  (C9S688), RISC_HUMAN  (Q9HB40), 
RISC_MOUSE  (Q920A5), RISC_RAT(Q920A6), SCP10_ARATH (O64810), 
SCP11_ARATH (Q2V465), SCP12_ARATH (O81009), SCP13_ARATH (Q8H780), 
SCP14_ARATH (Q9C7D3), SCP15_ARATH (Q9C7D2), SCP16_ARATH (Q9C7D4), 
SCP17_ARATH (Q9C7D6), SCP18_ARATH (Q9C7Z9), SCP19_ARATH (Q8VZU3), 
SCP1_ARATH  (Q8RWJ6), SCP28_ARATH (Q8S8K6), SCP30_ARATH (O23364), 
SCP31_ARATH (O04084), SCP32_ARATH (Q4PSY2), SCP3_ARATH  (Q9CAU1), 
SCP41_ARATH (Q9FH06), SCP42_ARATH (Q9FH05), SCP43_ARATH (Q84W27), 
SCP44_ARATH (Q9MAR8), SCP46_ARATH (Q8VY01), SCP4_ARATH  (Q9CAU4), 
SCP51_ARATH (Q67Y83), SCP52_ARATH (Q8S8P0), SCP53_ARATH (Q9LXY6), 
SCP54_ARATH (Q9FFB2), SCP5_ARATH  (Q9CAU2), SCP6_ARATH  (Q9CAU0), 
SCP7_ARATH  (Q9SQX6), SCP8_ARATH  (Q8RUW5), SCP9_ARATH  (O64811), 
SCPA_ARTBC  (D4AIF1), SCPA_TRITO  (B6V867), SCPA_TRIVH  (D4DD24), 
SCPB_ARTBC  (D4AP52), SCPB_ARTOC  (C5FGX1), SCPB_TRIRU  (Q5J6J2), 
SCPL1_DICDI (Q54DY7), SCPL2_ARATH (Q9CAU3), SCPL2_DICDI (Q54VW1), 
SPCA_ARTOC  (C5FW30), SPCA_TRIEQ  (A7UKV5), SPCA_TRIRU  (Q5J6J1)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PEP1_ASPNG  (P55749)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
AZPB2_ASPTN (Q0CF73)


				
	

	

		PDB
[Detailed view]		
		
			20 PDB
			


			1AC5; 1BCR; 1BCS; 1CPY; 1GXS; 1IVY; 1WHS; 1WHT; 1WPX; 1YSC; 3SC2; 4AZ0; 
			
				4AZ3; 4CI9; 4CIA; 4CIB; 4MWS; 4MWT; 6WIA; 7KDV
			
			

			» more