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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00589


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PURL: https://purl.expasy.org/prosite/signature/PS00589

Direct ScanProsite submission
General information about the entry

Entry name [info] PTS_HPR_SER
Accession [info] PS00589
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00318

Name and characterization of the entry

Description [info] PTS HPR domain serine phosphorylation site signature.
Pattern [info] 
[GSTADE]-[KREQSTIV]-x-{EPRK}-{VPGL}-x-[KRDN]-S-[LIVMF](2)-{EVPL}-[LIVM]-
{EATN}-x-[LIVM]-[GADE].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 145 in 144 different sequences
Number of true positive hits 79 in 78 different sequences
Number of 'unknown' hits 0
Number of false positive hits 66 in 66 different sequences
Number of false negative sequences 10
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 54.48 %
Recall (true positives / (true positives + false negatives)) 88.76 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Site [info] phosphorylation at position 8
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 78 sequences 

ACRB_ASPCL  (A1CIK0), ACRB_ASPFC  (B0Y4N5), ACRB_ASPFU  (Q4WQG9), 

ACRB_ASPNC  (A2Q9L8), ACRB_ASPOR  (Q2UUI0), ACRB_ASPTN  (Q0CT23), 
ACRB_EMENI  (Q876Q0), ACRB_NEOFI  (A1CW63), CRH_BACSU   (O06976), 
CRH_HALH5   (Q9K708), PGLX_ECOHS  (P0DUF9), PTFAH_ECO57 (P69812), 
PTFAH_ECOLI (P69811), PTFAH_HAEIN (P44715), PTFAH_SALTI (Q8Z591), 
PTFAH_SALTY (P17127), PTFAH_VIBCH (Q9KM70), PTFAX_RHOCA (P23388), 
PTFAX_XANCP (P45597), PTHP_BACSU  (P08877), PTHP_BACTI  (Q9F166), 
PTHP_BORBU  (O51507), PTHP_BUCAI  (Q9WXI5), PTHP_BUCAP  (Q8KA49), 
PTHP_BUCBP  (Q89B03), PTHP_CHLMU  (Q9PK56), PTHP_CHLPN  (Q9Z9E4), 
PTHP_CHLTR  (O84341), PTHP_CUPNH  (P23537), PTHP_ECO57  (P0AA06), 
PTHP_ECOL6  (P0AA05), PTHP_ECOLI  (P0AA04), PTHP_ENTFA  (P07515), 
PTHP_GEOSE  (P42013), PTHP_HAEIN  (P43921), PTHP_HALH5  (Q9K8D2), 
PTHP_KLEPN  (P16481), PTHP_LACCA  (Q9KJV3), PTHP_LACLA  (Q9CJ83), 
PTHP_LACLC  (Q9ZAD9), PTHP_LATSK  (O07125), PTHP_LISIN  (P0A439), 
PTHP_LISMO  (P0A438), PTHP_LYSSH  (Q84F84), PTHP_MYCCT  (P45611), 
PTHP_MYCGE  (P47287), PTHP_MYCPN  (P75061), PTHP_NEIMA  (P65876), 
PTHP_NEIMB  (P65877), PTHP_PRIMG  (O69250), PTHP_PSEAE  (Q9HVV2), 
PTHP_PSEPU  (Q9Z426), PTHP_SALTI  (P0AA08), PTHP_SALTY  (P0AA07), 
PTHP_SHIFL  (P0AA09), PTHP_STAAC  (Q5HH02), PTHP_STAAM  (P0A0E1), 
PTHP_STAAN  (P99143), PTHP_STAAR  (Q6GI02), PTHP_STAAS  (Q6GAD1), 
PTHP_STAAU  (P0A0E3), PTHP_STAAW  (P0A0E2), PTHP_STACA  (P23534), 
PTHP_STAXY  (Q9EYQ9), PTHP_STREI  (Q9WXK8), PTHP_STRMU  (P45596), 
PTHP_STRSL  (P24366), PTHP_TREPA  (O83598), PTHP_VIBCH  (Q9KTD6), 
PTHP_XYLFA  (Q9PDH6), PTHP_XYLFT  (Q87DQ0), PTSO_ECO57  (P0A9N2), 
PTSO_ECOL6  (P0A9N1), PTSO_ECOLI  (P0A9N0), PTSO_KLEOX  (P51185), 
PTSO_PROMH  (Q9ZA86), PTSO_SHIFL  (P0A9N3), PTSO_VIBCH  (Q9KP46)
» more

UniProtKB/Swiss-Prot
False negative sequences		 10 sequences 

DHAM_ECOLI  (P37349), DHAM_KLEM8  (A0A0H3H456), DHAM_PANAM  (D4GL26), 

DHAM_PROSM  (P0DN88), PTFX1_ECOLI (P77439), PTFX2_ECOLI (P32670), 
PTFX_ECO57  (Q8XBQ8), PTFX_ECOL6  (Q8FFD8), PTFX_SHIFL  (Q83QP3), 
PTSO_SHEVD  (Q9S0K8)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PTHP_STRSA  (P24365)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			66 sequences
			


			
206L_IIV6   (Q91FW4), AB39G_ARATH (Q7PC84), AB5F_ARATH  (Q9LV93), 

			
ABTB1_MOUSE (Q99LJ2), ABTB1_RAT   (Q5XIU1), AMPM_HELVI  (Q11000), 
ATX2_YEAST  (Q12067), AURI_STRTU  (Q70KH3), DGGGP_SULAC (Q4J8K2), 
DNLJ_MYCGA  (Q7NAF8), FAP1_ARATH  (Q9M1X2), FLD1_CAEEL  (G5EF48), 
FOXF_DROME  (Q9VS05), GPPA_PSEA6  (Q15N19), HNMT_XENTR  (Q0V9P1), 
ILVD_PROMT  (Q46LF6), IQG1_CANAL  (Q5AH02), LRCH1_HUMAN (Q9Y2L9), 
MABP1_HUMAN (O60336), MABP1_MOUSE (Q6NS57), MASZ1_PSESM (Q88AB2), 
MASZ_ECOL6  (Q8FDN6), MASZ_ECOLI  (P37330), MASZ_PSEFL  (O05137), 
MASZ_PSEPK  (Q88QX8), MASZ_SHIFL  (P59663), MFTC_MYCS2  (A0QSB8), 
MHPA1_BURVG (A4JPY1), MHPA_COMTE  (Q9S158), MHPA_CUPPJ  (Q476N1), 
MHPA_PARXL  (Q13QI0), NODD1_HYPPI (A0A2I6PIZ7), NRG1_RAT(P43322), 
OR83A_DROME (Q9VNB3), PBS5_CAEEL  (Q9XUV0), PHYB1_SOLLC (Q9ZS62), 
PKS5_DICDI  (Q86JI5), PPA14_ARATH (Q84LR6), PPA29_ARATH (Q9FMK9), 
PRIS_HALMA  (Q5V554), RBGA_BACCR  (Q819W8), RBGA_BACLD  (Q65JP4), 
RK14_BIGNA  (Q06J57), RL14_BDEBA  (Q6MJ24), RPOC2_PROM1 (A2C4N0), 
RPOC2_PROMT (Q46J24), RS1_BUCBP   (Q89AJ3), RS5_RHOBA   (Q7UN03), 
SATC_AQUAE  (O67174), SSTT_DESHY  (Q24XD0), SYC_TREDE   (Q73RJ6), 
TEX2_HUMAN  (Q8IWB9), TEX2_MOUSE  (Q6ZPJ0), TM41B_HUMAN (Q5BJD5), 
TM41B_PONAB (Q5RBZ8), TM41B_RAT   (Q5FVN2), TM41B_XENLA (Q5U4K5), 
TM41B_XENTR (A4II98), TP53B_MOUSE (P70399), TRM5_ENCCU  (Q8SVV3), 
TRPG_CRYNB  (P0CN87), TRPG_CRYNH  (P27710), TRPG_CRYNJ  (P0CN86), 
VPS25_DANRE (Q6NWF4), Y389_CHLPN  (Q9Z8F4), YCF2_PSINU  (Q8WHW9)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			57 PDB
			


			pdb_00001cm2; pdb_00001cm3; pdb_00001fu0; pdb_00001ggr; pdb_00001hdn; pdb_00001j6t; pdb_00001jem; pdb_00001k1c; pdb_00001ka5; pdb_00001kkl; pdb_00001kkm; pdb_00001mo1; 
			
				pdb_00001mu4; pdb_00001pch; pdb_00001pfh; pdb_00001poh; pdb_00001ptf; pdb_00001qfr; pdb_00001qr5; pdb_00001rzr; pdb_00001txe; pdb_00001vrc; pdb_00001y4y; pdb_00001y50; 
				pdb_00001y51; pdb_00001zvv; pdb_00002ak7; pdb_00002fep; pdb_00002hid; pdb_00002hpr; pdb_00002jel; pdb_00002lrk; pdb_00002lrl; pdb_00002nzu; pdb_00002nzv; pdb_00002oen; 
				pdb_00002rlz; pdb_00002xdf; pdb_00003ccd; pdb_00003eza; pdb_00003ezb; pdb_00003eze; pdb_00003oqm; pdb_00003oqn; pdb_00003oqo; pdb_00004xwj; pdb_00005t17; pdb_00005t1n; 
				pdb_00005t1o; pdb_00005ya0; pdb_00005ya1; pdb_00005ya2; pdb_00006kcr; pdb_00007x7h; pdb_00009ewz; pdb_00009ex7; pdb_00009exh
			
			

			» more