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PROSITE entry PS00589


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00589
Entry name [info] PTS_HPR_SER
Accession [info] PS00589
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00318

Name and characterization of the entry

Description [info] PTS HPR domain serine phosphorylation site signature.
Pattern [info] 
[GSTADE]-[KREQSTIV]-x-{EPRK}-{VPGL}-x-[KRDN]-S-[LIVMF](2)-{EVPL}-[LIVM]-
{EATN}-x-[LIVM]-[GADE].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 145 in 144 different sequences
Number of true positive hits 79 in 78 different sequences
Number of 'unknown' hits 0
Number of false positive hits 66 in 66 different sequences
Number of false negative sequences 10
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 54.48 %
Recall (true positives / (true positives + false negatives)) 88.76 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Site [info] phosphorylation at position 8
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 78 sequences 

ACRB_ASPCL  (A1CIK0), ACRB_ASPFC  (B0Y4N5), ACRB_ASPFU  (Q4WQG9), 

ACRB_ASPNC  (A2Q9L8), ACRB_ASPOR  (Q2UUI0), ACRB_ASPTN  (Q0CT23), 
ACRB_EMENI  (Q876Q0), ACRB_NEOFI  (A1CW63), CRH_BACSU   (O06976), 
CRH_HALH5   (Q9K708), PGLX_ECOHS  (P0DUF9), PTFAH_ECO57 (P69812), 
PTFAH_ECOLI (P69811), PTFAH_HAEIN (P44715), PTFAH_SALTI (Q8Z591), 
PTFAH_SALTY (P17127), PTFAH_VIBCH (Q9KM70), PTFAX_RHOCA (P23388), 
PTFAX_XANCP (P45597), PTHP_BACSU  (P08877), PTHP_BACTI  (Q9F166), 
PTHP_BORBU  (O51507), PTHP_BUCAI  (Q9WXI5), PTHP_BUCAP  (Q8KA49), 
PTHP_BUCBP  (Q89B03), PTHP_CHLMU  (Q9PK56), PTHP_CHLPN  (Q9Z9E4), 
PTHP_CHLTR  (O84341), PTHP_CUPNH  (P23537), PTHP_ECO57  (P0AA06), 
PTHP_ECOL6  (P0AA05), PTHP_ECOLI  (P0AA04), PTHP_ENTFA  (P07515), 
PTHP_GEOSE  (P42013), PTHP_HAEIN  (P43921), PTHP_HALH5  (Q9K8D2), 
PTHP_KLEPN  (P16481), PTHP_LACCA  (Q9KJV3), PTHP_LACLA  (Q9CJ83), 
PTHP_LACLC  (Q9ZAD9), PTHP_LATSK  (O07125), PTHP_LISIN  (P0A439), 
PTHP_LISMO  (P0A438), PTHP_LYSSH  (Q84F84), PTHP_MYCCT  (P45611), 
PTHP_MYCGE  (P47287), PTHP_MYCPN  (P75061), PTHP_NEIMA  (P65876), 
PTHP_NEIMB  (P65877), PTHP_PRIMG  (O69250), PTHP_PSEAE  (Q9HVV2), 
PTHP_PSEPU  (Q9Z426), PTHP_SALTI  (P0AA08), PTHP_SALTY  (P0AA07), 
PTHP_SHIFL  (P0AA09), PTHP_STAAC  (Q5HH02), PTHP_STAAM  (P0A0E1), 
PTHP_STAAN  (P99143), PTHP_STAAR  (Q6GI02), PTHP_STAAS  (Q6GAD1), 
PTHP_STAAU  (P0A0E3), PTHP_STAAW  (P0A0E2), PTHP_STACA  (P23534), 
PTHP_STAXY  (Q9EYQ9), PTHP_STREI  (Q9WXK8), PTHP_STRMU  (P45596), 
PTHP_STRSL  (P24366), PTHP_TREPA  (O83598), PTHP_VIBCH  (Q9KTD6), 
PTHP_XYLFA  (Q9PDH6), PTHP_XYLFT  (Q87DQ0), PTSO_ECO57  (P0A9N2), 
PTSO_ECOL6  (P0A9N1), PTSO_ECOLI  (P0A9N0), PTSO_KLEOX  (P51185), 
PTSO_PROMH  (Q9ZA86), PTSO_SHIFL  (P0A9N3), PTSO_VIBCH  (Q9KP46)
» more

UniProtKB/Swiss-Prot
False negative sequences		 10 sequences 

DHAM_ECOLI  (P37349), DHAM_KLEM8  (A0A0H3H456), DHAM_PANAM  (D4GL26), 

DHAM_PROSM  (P0DN88), PTFX1_ECOLI (P77439), PTFX2_ECOLI (P32670), 
PTFX_ECO57  (Q8XBQ8), PTFX_ECOL6  (Q8FFD8), PTFX_SHIFL  (Q83QP3), 
PTSO_SHEVD  (Q9S0K8)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

PTHP_STRSA  (P24365)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			66 sequences
			


			
206L_IIV6   (Q91FW4), AB39G_ARATH (Q7PC84), AB5F_ARATH  (Q9LV93), 

			
ABTB1_MOUSE (Q99LJ2), ABTB1_RAT   (Q5XIU1), AMPM_HELVI  (Q11000), 
ATX2_YEAST  (Q12067), AURI_STRTU  (Q70KH3), DGGGP_SULAC (Q4J8K2), 
DNLJ_MYCGA  (Q7NAF8), FAP1_ARATH  (Q9M1X2), FLD1_CAEEL  (G5EF48), 
FOXF_DROME  (Q9VS05), GPPA_PSEA6  (Q15N19), HNMT_XENTR  (Q0V9P1), 
ILVD_PROMT  (Q46LF6), IQG1_CANAL  (Q5AH02), LRCH1_HUMAN (Q9Y2L9), 
MABP1_HUMAN (O60336), MABP1_MOUSE (Q6NS57), MASZ1_PSESM (Q88AB2), 
MASZ_ECOL6  (Q8FDN6), MASZ_ECOLI  (P37330), MASZ_PSEFL  (O05137), 
MASZ_PSEPK  (Q88QX8), MASZ_SHIFL  (P59663), MFTC_MYCS2  (A0QSB8), 
MHPA1_BURVG (A4JPY1), MHPA_COMTE  (Q9S158), MHPA_CUPPJ  (Q476N1), 
MHPA_PARXL  (Q13QI0), NODD1_HYPPI (A0A2I6PIZ7), NRG1_RAT(P43322), 
OR83A_DROME (Q9VNB3), PBS5_CAEEL  (Q9XUV0), PHYB1_SOLLC (Q9ZS62), 
PKS5_DICDI  (Q86JI5), PPA14_ARATH (Q84LR6), PPA29_ARATH (Q9FMK9), 
PRIS_HALMA  (Q5V554), RBGA_BACCR  (Q819W8), RBGA_BACLD  (Q65JP4), 
RK14_BIGNA  (Q06J57), RL14_BDEBA  (Q6MJ24), RPOC2_PROM1 (A2C4N0), 
RPOC2_PROMT (Q46J24), RS1_BUCBP   (Q89AJ3), RS5_RHOBA   (Q7UN03), 
SATC_AQUAE  (O67174), SSTT_DESHY  (Q24XD0), SYC_TREDE   (Q73RJ6), 
TEX2_HUMAN  (Q8IWB9), TEX2_MOUSE  (Q6ZPJ0), TM41B_HUMAN (Q5BJD5), 
TM41B_PONAB (Q5RBZ8), TM41B_RAT   (Q5FVN2), TM41B_XENLA (Q5U4K5), 
TM41B_XENTR (A4II98), TP53B_MOUSE (P70399), TRM5_ENCCU  (Q8SVV3), 
TRPG_CRYNB  (P0CN87), TRPG_CRYNH  (P27710), TRPG_CRYNJ  (P0CN86), 
VPS25_DANRE (Q6NWF4), Y389_CHLPN  (Q9Z8F4), YCF2_PSINU  (Q8WHW9)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			54 PDB
			


			1CM2; 1CM3; 1FU0; 1GGR; 1HDN; 1J6T; 1JEM; 1K1C; 1KA5; 1KKL; 1KKM; 1MO1; 
			
				1MU4; 1PCH; 1PFH; 1POH; 1PTF; 1QFR; 1QR5; 1RZR; 1TXE; 1VRC; 1Y4Y; 1Y50; 
				1Y51; 1ZVV; 2AK7; 2FEP; 2HID; 2HPR; 2JEL; 2LRK; 2LRL; 2NZU; 2NZV; 2OEN; 
				2RLZ; 2XDF; 3CCD; 3EZA; 3EZB; 3EZE; 3OQM; 3OQN; 3OQO; 4XWJ; 5T17; 5T1N; 
				5T1O; 5YA0; 5YA1; 5YA2; 6KCR; 7X7H
			
			

			» more