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PROSITE entry PS00606


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PURL: https://purl.expasy.org/prosite/signature/PS00606

Direct ScanProsite submission
General information about the entry

Entry name [info] KS3_1
Accession [info] PS00606
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00529
Associated ProRule [info] PRU10022

Name and characterization of the entry

Description [info] Ketosynthase family 3 (KS3) active site signature.
Pattern [info] 
G-{A}-{KGR}-x(2)-[LIVMFTAP]-{R}-x-[AGC]-C-[STA](2)-[STAG]-x(2)-{LI}-
[LIVMF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 446 in 426 different sequences
Number of true positive hits 435 in 415 different sequences
Number of 'unknown' hits 0
Number of false positive hits 11 in 11 different sequences
Number of false negative sequences 19
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 97.53 %
Recall (true positives / (true positives + false negatives)) 95.81 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 4
Site [info] active_site at position 9
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 415 sequences 

5MOAS_ASPTN (Q0CRQ5), ACE1_PYRO7  (G4MVZ2), ACRA_ASPA1  (A0A1L9WQM9), 

ACRS2_ALTAL (R4WH05), ACTI1_STRCO (Q02059), ACTS3_ALTAL (D9N1A1), 
ACUA_ASPA1  (A0A1L9WN37), ADAA_ASPNC  (A2QX22), ADAA_ASPNG  (G3KLH6), 
ADRD_PENRO  (A0A1Y0BRF1), ADRD_PENRW  (B6HV32), AF161_ALTAL (V5Y0F7), 
AFLA_ASPPU  (Q8TGA2), AFOE_EMENI  (Q5BEJ6), AFVB_ASPFN  (B8N8R0), 
AGPKS_PAEDI (A0A411PQP9), ALB1_ASPFU  (Q4WZA8), ALBA_ASPBC  (A0A1L9UCG2), 
ALBA_ASPNA  (G3XLL5), ALBA_ASPNC  (A2QUI2), ALNA_EMENI  (C8VJR7), 
ALT1_ALTAL  (A0A3G9H990), ALT5_ALTSO  (Q5KTM9), ANDM_EMEVA  (A0A097ZPE0), 
AOIG_ASPOR  (Q2TXQ8), APDA_EMENI  (Q5ATG8), APF5_GIBF5  (S0DL59), 
APTA_EMENI  (Q5B0D0), AR283_ARTOA (G1XU04), ARMB_ARMGA  (A0A2H3CTK0), 
ARMB_ARMME  (I3ZNU9), ARMB_ARMOS  (A0A284RE13), ASC5_DIDFA  (A0A5C1RD96), 
ASC7_DIDFA  (A0A5C1RDA3), ASCC_ACREG  (A0A455R5P9), AT325_ASPTN (Q0D159), 
ATNF_EMENI  (Q5AV00), ATNH_ARTSZ  (A0A455LLX1), ATR1_STEAL  (A0A8F4SKJ7), 
ATX_ASPTN   (Q0CJ59), AURA_CALAK  (A0A0M4L8I7), AUSA_ASPCI  (A0A0U5GFS8), 
AUSA_EMENI  (Q5ATJ7), AUSA_PENBI  (A0A0F7U103), AZAB_ASPNA  (G3XMD1), 
AZPB2_ASPTN (Q0CF73), BET1_NEOBT  (A0A0C6E0I7), BIK1_GIBF5  (S0DZM7), 
BOA6_BOTFB  (B1GVX7), BUAA_PETAA  (A0A411L027), CAAA_ASPNC  (A2QQV0), 
CALA_PENDC  (A0A1V6PAF7), CAZM_CHAGB  (A0A0K0MCJ4), CCSA_ASPCL  (A1CLY8), 
CEM1_YEAST  (P39525), CFOA_ASPCN  (A0A2I2F2N6), CGHG_CHAGB  (Q2HBN0), 
CHEA_CHAGB  (Q2HEW5), CITS_MONPU  (Q65Z23), CITS_MONRU  (A0A161CEU9), 
CLA3_CLACD  (A0A125R003), CLAF_PENCR  (A0A481WQB6), CLAG_PASFU  (P0CU67), 
CLE1_ASPVE  (A0A3T0ZHJ0), CLZ14_COCLU (A0A345BJN0), CM3B_CORMM  (G3J453), 
CNSI_PENEN  (A0A0A2JW91), CPAS_ASPOZ  (B6F209), CRZ7_CLAME  (A0A6H0YV38), 
CTB1_CERBT  (A0A2G5IC96), CTB1_CERNC  (Q6DQW3), CTVA_ASPTN  (Q0C9L7), 
CURS2_ASPTE (L7XAV2), DEP5_ALTBR  (D2E9X0), DEP5_FUSLA  (A0A0N0DCA3), 
DHC5_ALTCI  (A0A0N7D745), DMPKS_CRYX8 (A0A4P8DJU2), DMXL2_CRYX8 (A0A4P8DJV2), 
DPASA_APISA (P9WEX0), DPCHA_COLHI (A0A1B7YCC9), DPFGA_GIBZE (I1RL11), 
DPMAA_METAN (P9WEX6), DPMPA_MACPH (K2QVI8), EASB_EMENI  (Q5BA83), 
ELCA_PHANO  (Q0UI00), EQXS_FUSHE  (S4W172), EQXS_GIBF5  (S0DS59), 
ERYA1_SACER (Q03131), ERYA2_SACER (Q03132), ERYA3_SACER (Q03133), 
ESDPA_PENSH (A0A8D5M692), EUPA_PHOSX  (A0A4P8GHJ1), FABB_BUCAI  (P57193), 
FABB_BUCAP  (Q8KA28), FABB_BUCBP  (Q89AY4), FABB_ECOL6  (P0A954), 
FABB_ECOLI  (P0A953), FABB_HAEIN  (P43710), FABB_PSEAB  (Q02K94), 
FABF_BACSU  (O34340), FABF_COXBU  (Q83E37), FABF_ECO57  (P0AAI7), 
FABF_ECOL6  (P0AAI6), FABF_ECOLI  (P0AAI5), FABF_RHIME  (P56902), 
FABF_SHIFL  (P0AAI8), FABF_STAAC  (Q5HHA1), FABF_STAAM  (Q99VA6), 
FABF_STAAN  (Q7A6F8), FABF_STAAR  (Q6GIA3), FABF_STAAS  (Q6GAU2), 
FABF_STAAU  (Q5TKS0), FABF_STAAW  (Q8NXE1), FABF_SYNY3  (P73283), 
FABF_VIBCH  (Q9KQH9), FABF_VIBHA  (P55338), FAS2_CANAX  (P43098), 
FAS2_CANPC  (G8BAW7), FAS2_EMEND  (P78615), FAS2_LACKL  (Q765N2), 
FAS2_MYCMD  (A0A0D1DNX1), FAS2_PENPA  (P15368), FAS2_SCHPO  (Q10289), 
FAS2_YEAST  (P19097), FAS_ANSAN   (P36189), FAS_BOVIN   (Q71SP7), 
FAS_CHICK   (P12276), FAS_HUMAN   (P49327), FAS_MOUSE   (P19096), 
FAS_RAT (P12785), FFSA_ASPFV  (A0A7L8UVC9), FGNA_ASPFU  (Q4WKW9), 
FGR1_GIBZE  (I1RLA7), FLUP_ASPFN  (B8NYX0), FMAB_ASPFU  (Q4WAY3), 
FMN1_FUSMA  (A0A1L7U4V5), FNSA_PESFW  (W3X8X8), FOGA_ASPRC  (A0A017SEX7), 
FRBB_DOTX1  (A0A0S6XH49), FSA1_FUSSF  (A0A0E4AZP0), FSDS_FUSHE  (Q5SBL6), 
FSL1_GIBZE  (I1S166), FSR1_GIBF5  (S0DTP6), FUB1_FUSO4  (A0A0D2YG10), 
FUB1_GIBF5  (S0DRI1), FUB1_GIBM7  (W7MT31), FUJ1_GIBF5  (S0EET5), 
FUM1_GIBM7  (W7LKX1), FUS1_GIBF5  (S0EEY3), FUS1_GIBM7  (W7MLD7), 
FUSA1_GIBZE (I1RVD8), G433_FUSSX  (A0A6S5ZY48), GEDC_ASPTN  (Q0CCY3), 
GFSA_STRHA  (E0D202), GFSB_STRHA  (E0D203), GFSC_STRHA  (E0D204), 
GFSD_STRHA  (E0D205), GFSE_STRHA  (E0D206), GKAA_PENCI  (A0A8F4S8Q3), 
GLOL_GLAL2  (S3D9F1), GRA1_CLAGR  (E9KMQ2), GRA9_GIBZE  (I1R9A6), 
GRGA_PENSQ  (A0A6F8RNP4), GSFA_PENAE  (D7PI15), HEXA_DOTSN  (M2YJJ3), 
HIMA_ASPJA  (A0A2Z5TM64), HPM3_HYPSB  (B3FWS8), HPS1_DOTSN  (M2YKT6), 
ICCA_TALVA  (A0A482N9V7), ILIA_HYPJQ  (G0REX6), ILIA_NEOS2  (P0DO30), 
KAS1_STRCN  (Q02578), KAS1_STRCO  (P23155), KAS1_STRHA  (Q05356), 
KAS1_STRRM  (P43678), KAS1_STRVG  (P41175), KAS1_STRVN  (P16540), 
KASC1_ARATH (P52410), KASC1_HORVU (P23902), KASC2_ARATH (Q9C9P4), 
KASM_ARATH  (Q8L3X9), LAN6_PYRDE  (P0DXV8), LCSC_PURLI  (A0A179H0J7), 
LECAS_PSEFF (P9WES9), LOVB_ASPTE  (Q9Y8A5), LOVB_ASPTN  (Q0C8M3), 
LOVF_ASPTE  (Q9Y7D5), LOVF_ASPTN  (Q0C8L6), LUC5_FUSSX  (A0A6J4B487), 
MACA_PENTR  (A0A2P1DP91), MCAS_MYCBO  (Q02251), MELA_PENEN  (A0A0A2KT65), 
MEN2_MENTH  (A0A6F9DYX9), MFMB_ANNMO  (P9WEG1), MLCA_PENCI  (Q8J0F7), 
MLCB_PENCI  (Q8J0F5), MLNS_PHANO  (A0A0A0RM07), MOKA_MONPI  (Q3S2T9), 
MOKB_MONPI  (Q3S2U6), MPAC2_PENBR (A0A0B5KU17), MPAC_PENBR  (F1DBA9), 
MPAC_PENRF  (W6QL47), MPAS_CLAUC  (A0A0R8YWJ7), MPSA_MACPH  (K2QYX5), 
MSAS_PENPA  (P22367), MSL3_MYCTU  (A0A089QRB9), MSL7_MYCBO  (Q7TXK8), 
MSL7_MYCMM  (B2HIL7), MYCA_BACIU  (Q9R9J1), MYCA_THET4  (G2Q9A5), 
NODE_RHILT  (P04684), NODE_RHILV  (P04683), NODE_RHIME  (P06230), 
NODE_RHIS3  (P72331), NOE4_RHIML  (P06231), NORA2_STRON (B4ER95), 
NORA_STRON  (B4ER92), NORB_STRON  (B4ER96), NORC_STRON  (B4ER97), 
NSCA_ARTBC  (D4AWH3), NSCA_ARTGP  (E4V2N2), NSCA_ARTOC  (C5FM57), 
NSCA_ASPFU  (Q4WA61), NSCA_NEOFI  (A1D8I9), NSCA_TRIEC  (F2PWS5), 
NSCA_TRIRC  (F2T0M0), NSCA_TRIT1  (F2S6Z9), NSCA_TRIVH  (D4CZZ2), 
NSRB_ASPN1  (A0A2I1C3X5), NTNH_NECSZ  (A0A455M2Y3), NVFA_ASPN1  (A0A2I1BSV9), 
OL56_STRAT  (Q07017), OLCA_PENCN  (P9WEQ0), OPDA_PENO1  (S7Z800), 
OPS1_BEAB2  (J4UHQ6), ORSA_EMENI  (Q5AUX1), OTAA_ASPC5  (A0A1R3RGK0), 
OTAA_ASPNC  (A2R6H1), OXSM_BOVIN  (Q0VCA7), OXSM_HUMAN  (Q9NWU1), 
OXSM_MOUSE  (Q9D404), PATK_ASPCL  (A1CFL8), PATK_PENEN  (A0A075TRC0), 
PFA1_THRS2  (A0A1B3PEI6), PFMAE_PESFW (W3X7U2), PGMA_ASPTN  (A0A1W7M1U5), 
PHAS_MYCBO  (Q7TVK8), PHAS_MYCBP  (A1KQG0), PHAS_MYCTA  (A5U9F4), 
PHAS_MYCTO  (P9WQE8), PHAS_MYCTU  (P9WQE9), PHIA_FUNX7  (A0A348HAX6), 
PHM1_PYRSX  (A0A2Z5XAL7), PHNA_PENHR  (A0A142C799), PIG15_CLAP2 (M1WG96), 
PIGJ_MONRU  (A0A1D5AG16), PIKA1_STRVZ (Q9ZGI5), PIKA2_STRVZ (Q9ZGI4), 
PIKA3_STRVZ (Q9ZGI3), PIKA4_STRVZ (Q9ZGI2), PKFA_EMENI  (Q5B8A0), 
PKGA_EMENI  (Q5AXA9), PKHA_EMENI  (Q5BBP8), PKIB_EMENI  (Q5B7V0), 
PKS10_DICDI (B0G103), PKS12_GIBZE (I1RF58), PKS12_MYCTU (I6XD69), 
PKS12_TALMA (D7RJN6), PKS12_TALMQ (B6QK81), PKS13_DICDI (Q559A9), 
PKS13_MYCTU (I6X8D2), PKS14_DICDI (Q558Y6), PKS15_MYCTU (P96284), 
PKS16_DICDI (Q869W9), PKS17_DICDI (Q869X2), PKS18_DICDI (Q54TW0), 
PKS19_DICDI (Q54T36), PKS19_PHANO (A0A0H4ADX3), PKS19_PYRO7 (G4N296), 
PKS1_AURME  (A0A172QE52), PKS1_DICDI  (Q55E72), PKS1_ELSFA  (A7UMW1), 
PKS1_METAF  (A0A0B4FTU6), PKS1_METAQ  (A0A2U8NEV6), PKS1_METAS  (A0A2U8NET4), 
PKS1_METBS  (A0A0B4ESU9), PKS1_METGA  (A0A0B4G9F9), PKS1_METMF  (A0A0B4H4F0), 
PKS1_METRA  (E9F646), PKS1_SARSH  (A5PHD6), PKS1_ZYMTI  (F9XMW3), 
PKS21_DICDI (B0G138), PKS22_DICDI (Q54QD3), PKS23_DICDI (Q54QD1), 
PKS24_BYSSP (P9WET9), PKS24_DICDI (Q54KU5), PKS25_DICDI (Q54KU3), 
PKS27_ASPFN (B8MYS6), PKS27_DICDI (Q54G30), PKS28_DICDI (B0G170), 
PKS29_DICDI (Q54FQ3), PKS2_COCH4  (N4WHA7), PKS2_DICDI  (Q55DM7), 
PKS2_METAF  (A0A0B4FLB2), PKS2_METAQ  (E9EHG2), PKS2_METBS  (A0A0B4H8J1), 
PKS2_METGA  (A0A0B4I1L1), PKS2_METMF  (A0A0B4I1J8), PKS2_METRA  (E9ET39), 
PKS30_DICDI (Q54FQ2), PKS31_DICDI (Q54FQ1), PKS32_DICDI (Q54FP8), 
PKS33_DICDI (Q54FN7), PKS34_DICDI (Q54FN2), PKS38_DICDI (Q54FD2), 
PKS39_DICDI (Q54FC8), PKS3_DICDI  (Q55CN6), PKS40_DICDI (Q54ED7), 
PKS41_DICDI (Q54ED6), PKS42_DICDI (Q54D44), PKS44_DICDI (Q54B51), 
PKS5_DICDI  (Q86JI5), PKS5_MYCS2  (A0R1E8), PKS5_MYCTU  (O53901), 
PKS6_DICDI  (B0G0Z9), PKS7_DICDI  (B0G100), PKS81_PSEFD (M3A326), 
PKS8_DICDI  (B0G101), PKS8_PESMI  (A0A1P8NTI3), PKS9_DICDI  (Q86AE3), 
PKSJ_BACSU  (P40806), PKSL_BACSU  (Q05470), PKSM_BACSU  (P40872), 
PKSN_BACSU  (O31782), PKSR_BACSU  (O31784), POXE_PENO1  (S7ZFK6), 
POXE_PENOX  (A0A1W5T1U1), PPSA_MYCBO  (Q7TXM0), PPSA_MYCTO  (P9WQE6), 
PPSA_MYCTU  (P9WQE7), PPSB_ASPOR  (Q2UB00), PPSB_MYCBO  (Q7TXL9), 
PPSB_MYCTO  (P9WQE4), PPSB_MYCTU  (P9WQE5), PPSC_MYCBO  (Q7TXL8), 
PPSC_MYCTU  (P96202), PPSD_MYCBO  (Q7TXL7), PPSD_MYCTO  (P9WQE2), 
PPSD_MYCTU  (P9WQE3), PPSE_MYCBO  (Q7TXL6), PPSE_MYCTO  (P9WQE0), 
PPSE_MYCTU  (P9WQE1), PREU1_PREIS (P9WET8), PREU2_PREIS (P9WET7), 
PREU4_PREIS (P9WET5), PREU7_PREIS (P9WET1), PREU8_PREIS (P9WET3), 
PRHL_PENBI  (A0A1E1FFN8), PRLS_FUNXX  (A0A089FSA4), PSOA_ASPFU  (Q4WAZ9), 
PTAA_PESFW  (A0A067XNI2), PVHA_TALVA  (A0A3T0QHT6), PYDA_ACRSP  (A0A8F4S6Z6), 
PYR2_ASPFU  (Q4WLD4), PYTA_ASPTE  (P9WEZ4), PYTA_ASPTN  (Q0CZH1), 
PYVA_ASPV1  (A0A2V5GX43), RADS2_FLOCH (C5H882), RDC1_METCM  (B3FWT6), 
RESH_ASPSL  (P0DXV7), RSTN3_ASPN3 (A0A0L1JG62), SDGA_EMENI  (A0A1U8QN18), 
SOL1_ALTSO  (D7UQ44), SORB_HYPJQ  (G0R6S9), SPKS1_STRTC (A0A384XH94), 
SPYA_ASPFU  (Q4WBH9), SQHKS_PHOSM (A0A3G1DJF3), SRDA_NEUCR  (Q7SHI6), 
STBA_STABI  (A0A193PS74), STCJ_EMENI  (Q00681), STHA_PHANO  (Q0UK48), 
STLB_DICDI  (Q54FI3), STMA_ASPUT  (A0A0C1E3C9), SUBA_METRA  (E9F5E7), 
TAS1_BOTB1  (A0A067MTM1), TAS1_CORMM  (G3J9P0), TAS1_GLOTA  (S7RK07), 
TAS1_PYRO7  (G4N137), TASS_HAPIR  (A0A0F7GFS4), TCMK_STRGA  (P16538), 
TERA_ASPTN  (Q0D1N9), THAG_BURTA  (Q2T4N1), THNA_TRIHA  (A0A0G0AID6), 
TOXH_COCCA  (S5NIA2), TPCC_ASPFU  (Q4WQZ5), TPEB_TALSN  (B8MV60), 
TRAA_PENCR  (A0A481WNP4), TROPA_TALSN (B8M9J9), TRT4_ASPTN  (Q0C8A4), 
TSTA_TALSN  (B8MKY6), TWMB_TALWO  (A0A2L0P0K3), USTP_USTVR  (A0A1B5L6A0), 
VALA_ASPTE  (P9WEV0), VDTA1_BYSSP (A0A443HK81), VERA_PENPO  (A0A1V6NYI6), 
VIRA_HYPVG  (G9N4B2), VRTA_PENAE  (D7PHZ2), W4931_FUSPC (K3VA96), 
WA_EMENI(Q03149), XENE_XENSI  (A0A7L9EYL1), XILA_PENCR  (A0A9P5GG56), 
XILA_PENRW  (B6H999), YANA_ASPNA  (G3Y419), ZEA1_GIBZE  (A0A098D6U0), 
ZEA2_GIBZE  (A0A098D8A0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 19 sequences 

BEKAS_PSEAE (Q9HYV7), FPY1_FUSMA  (A0A1L7U3D7), KASA_MYCBO  (P63455), 

KASA_MYCLE  (Q9CBS7), KASA_MYCTE  (H8ESN0), KASA_MYCTO  (P9WQD8), 
KASA_MYCTU  (P9WQD9), KASB_MYCBO  (P63457), KASB_MYCLE  (O69473), 
KASB_MYCTO  (P9WQD6), KASB_MYCTU  (P9WQD7), MEN1_MENTH  (A0A6F9DXA0), 
ORYA_ASPOR  (Q2TXF0), PIGJ_SERS3  (Q5W262), PKS1_CALOD  (P9WES1), 
PKS26_DICDI (Q54IX3), PKS45_DICDI (Q54B49), PKS4_CALOD  (P9WES2), 
TPEA_TALSN  (B8MV59)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

FAS_CAPHI   (P08757), FAS_RABIT   (P07855)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			11 sequences
			


			
CLAG_PENCR  (A0A481WQK1), GLPB_HAEDU  (Q7VM49), KDSB_MYXXD  (Q1DDB3), 

			
MDH_PSYIN   (A1SRP8), MNMG_ERYLH  (Q2N6I8), NEUA_BOVIN  (Q3SZM5), 
NEUA_HUMAN  (Q8NFW8), NEUA_PONAB  (Q5R6R5), PUS5_ORYSJ  (Q0DST9), 
Y1105_ARATH (O04086), YOGA_LEPMJ  (E5AE42)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			126 PDB
			


			1B3N; 1DD8; 1E5M; 1FJ4; 1FJ8; 1G5X; 1H4F; 1KAS; 1TQY; 1W0I; 2AQ7; 2AQB; 
			
				2BUH; 2BUI; 2BYW; 2BYX; 2BYY; 2BYZ; 2BZ3; 2BZ4; 2C9H; 2CDH; 2GFW; 2GFY; 
				2GQD; 2HG4; 2IWY; 2IWZ; 2IX4; 2PFF; 2QO3; 2UV8; 2VB7; 2VB8; 2VB9; 2VBA; 
				2VKZ; 3HHD; 3HMJ; 4JRH; 4JRM; 4LS5; 4LS6; 4LS7; 4LS8; 4NA1; 5BP1; 5KOF; 
				5MY0; 5MY2; 6C9U; 6FIJ; 6FIK; 6JSH; 6JSI; 6KOG; 6OKC; 6OKF; 6OKG; 6OLT; 
				6QL5; 6QL6; 6QL7; 6QL9; 6ROP; 6TA1; 6U5V; 6U5W; 6WC7; 7CPX; 7CPY; 7L4E; 
				7L4L; 7M7E; 7M7F; 7M7G; 7M7H; 7M7I; 7M7J; 7S6C; 7S6D; 7SQI; 7SZ9; 7TUI; 
				8BY8; 8CG5; 8CG6; 8EE0; 8EE1; 8G4U; 8IN9; 8PRV; 8PRW; 8PS1; 8PS2; 8PS8; 
				8PS9; 8PSA; 8PSF; 8PSG; 8PSJ; 8PSK; 8PSL; 8PSM; 8PSP; 8SMS; 8TJN; 8TJO; 
				8TJP; 8TPW; 8TPX; 8VF7; 8VG4; 8VLE; 8VLO; 8VLP; 8VM0; 8VM5; 8VM6; 8VM7; 
				8VMC; 8VMD; 9B7Z; 9F48; 9MJ9; 9NJU
			
			

			» more