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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00624


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PURL: https://purl.expasy.org/prosite/signature/PS00624

Direct ScanProsite submission
General information about the entry

Entry name [info] GMC_OXRED_2
Accession [info] PS00624
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2001 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00543

Name and characterization of the entry

Description [info] GMC oxidoreductases signature 2.
Pattern [info] 
[GS]-[PSTA]-x(2)-[ST]-[PS]-x-[LIVM](2)-x(2)-S-G-[LIVM]-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 174 in 174 different sequences
Number of true positive hits 173 in 173 different sequences
Number of 'unknown' hits 1
Number of false positive hits 0
Number of false negative sequences 39
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 81.60 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 173 sequences 

ACUG_ASPA1  (A0A1L9WN49), ALKJ_ECTOL  (Q00593), ALKJ_PSEPU  (Q9WWW2), 

ALOX_CANBO  (Q00922), ALOX_PICAN  (P04841), ARMD5_ARMGA (A0A2H3D1U1), 
ASC9_DIDFA  (A0A5C1RDA6), BETA1_CHRSD (Q1QXE1), BETA2_CHRSD (Q9L4K0), 
BETA_ACIAD  (Q6FDF9), BETA_ACIB3  (B7GYG5), BETA_ACIB5  (B7I895), 
BETA_ACIBC  (B2HV79), BETA_ACIBS  (B0VST3), BETA_ACIBY  (B0V945), 
BETA_AGRFC  (Q8UH55), BETA_BRUA4  (A6X2G7), BETA_BRUC2  (A9M9H8), 
BETA_BRUME  (Q8YFY2), BETA_BRUO2  (A5VPA6), BETA_BRUSI  (B0CKN4), 
BETA_BRUSU  (Q8G1Z8), BETA_BURA4  (B1Z034), BETA_BURCH  (A0B2F7), 
BETA_BURCJ  (B4EHJ2), BETA_BURCM  (Q0B711), BETA_BURL3  (Q39A44), 
BETA_BURM1  (A9AMZ9), BETA_BURMA  (Q62CH8), BETA_BURO0  (B1K707), 
BETA_BURO1  (Q1BQE2), BETA_BURP1  (Q3JLL7), BETA_BURPS  (Q63KK7), 
BETA_BURTA  (Q2T6D0), BETA_BURVG  (A4JJG6), BETA_CITK8  (A8AJN0), 
BETA_CROS8  (A7MFA8), BETA_ECO24  (A7ZI50), BETA_ECO27  (B7UJG4), 
BETA_ECO45  (B7MCD0), BETA_ECO55  (B7L439), BETA_ECO57  (Q8X6C6), 
BETA_ECO5E  (B5Z1R0), BETA_ECO8A  (B7M2V5), BETA_ECODH  (B1XE52), 
BETA_ECOHS  (A7ZWV4), BETA_ECOL5  (Q0TKW1), BETA_ECOL6  (Q8FKI9), 
BETA_ECOLC  (B1J0W6), BETA_ECOLI  (P17444), BETA_ECOLU  (B7N8L3), 
BETA_ECOSE  (B6I074), BETA_ECOSM  (B1LIJ7), BETA_ECOUT  (Q1RFM3), 
BETA_ECTM1  (A4XPI5), BETA_KLEP3  (B5Y008), BETA_KLEP7  (A6T613), 
BETA_PARP8  (B2JS89), BETA_PARPJ  (B2TCJ8), BETA_PARXL  (Q13NG7), 
BETA_PECAS  (Q6D6D9), BETA_PECCP  (C6DKY4), BETA_PHOPR  (Q6LGH5), 
BETA_PROMH  (B4EX94), BETA_PSE14  (Q48CM7), BETA_PSEA8  (B7V5R3), 
BETA_PSEAB  (Q02DZ0), BETA_PSEAE  (Q9HTJ2), BETA_PSEE4  (Q1IG70), 
BETA_PSEF5  (Q4K4K7), BETA_PSEFS  (C3K3D3), BETA_PSEP1  (A5WA97), 
BETA_PSEP7  (A6VEI3), BETA_PSEPF  (Q3K5H3), BETA_PSEPG  (B0KN19), 
BETA_PSEPK  (Q88CW6), BETA_PSESM  (Q88AE7), BETA_PSEU2  (Q4ZM63), 
BETA_RHIE6  (B3PTE0), BETA_RHIEC  (Q2KB43), BETA_RHIJ3  (Q1MJU4), 
BETA_RHILO  (Q985M5), BETA_RHILW  (B5ZUG2), BETA_RHIME  (P54223), 
BETA_RHIR8  (B9JBA2), BETA_SERP5  (A8GBX9), BETA_SHIF8  (Q0T7N0), 
BETA_SINFN  (C3MIE4), BETA_SINMW  (A6U6Y8), BETA_STAA1  (A7X6Z3), 
BETA_STAA2  (A6U4Z2), BETA_STAA3  (Q2FDP9), BETA_STAA8  (Q2FV11), 
BETA_STAA9  (A5IW37), BETA_STAAB  (Q2YWJ5), BETA_STAAC  (Q5HCU1), 
BETA_STAAE  (A6QK99), BETA_STAAM  (P60336), BETA_STAAN  (P60337), 
BETA_STAAR  (Q6GDJ1), BETA_STAAS  (Q6G664), BETA_STAAT  (A8Z5A4), 
BETA_STAAW  (Q8NUM0), BETA_STAEQ  (Q5HL11), BETA_STAES  (Q8CMY2), 
BETA_STAHJ  (Q4L9D7), BETA_STAS1  (Q4A0Q1), BETA_STAXY  (Q9X2M2), 
BETA_STRM5  (B4SHV9), BETA_STRMK  (B2FQ89), BETA_XANAC  (Q8PPG8), 
BETA_XANC8  (Q4UYN5), BETA_XANCB  (B0RNU9), BETA_XANCP  (Q8P5D7), 
BETA_XANE5  (Q3BXK8), BETA_YERP3  (A7FKL6), BETA_YERPA  (Q1C932), 
BETA_YERPB  (B2K8U4), BETA_YERPE  (Q8ZGW0), BETA_YERPN  (Q1CFR7), 
BETA_YERPP  (A4TNP2), BETA_YERPS  (Q66D54), BETA_YERPY  (B1JSR0), 
CDH_PHACH   (Q01738), CHDH_HUMAN  (Q8NE62), CHDH_MOUSE  (Q8BJ64), 
CHDH_RAT(Q6UPE0), CHOX_ARTGO  (Q7X2H8), CICC_EMENI  (A0A1U8QYA8), 
CITC_MONPU  (A0A142PTM2), CITC_MONRU  (A0A161CEV4), DHGL_DROME  (P18173), 
DHGL_DROPS  (P18172), EO_BOMMO(H6AGY0), EO_SPOLI(Q95NZ0), 
ERIK_HERER  (P0DO29), FAP_CHLRE   (A8JHB7), FAP_CHLVA   (A0A248QE08), 
GMCH_MALS4  (M5EAX2), GMCH_MALSM  (Q5GMY3), GME62_PESMI (A0A5B8YW44), 
GOX1_PENEN  (A0A0A2JC26), GOX2_PENEN  (A0A0A2K2F6), GOX_ASPC5   (A0A1R3RM75), 
GOX_ASPNG   (P13006), GOX_PENAG   (P81156), GOX_PENCH   (K9L4P7), 
GOX_TALFL   (Q92452), GOX_TALVA   (Q70FC9), HTH_ARATH   (Q9S746), 
MDL1_PRUDU  (O24243), MDL1_PRUSE  (P52706), MDL2_PRUDU  (Q945K2), 
MDL2_PRUSE  (O50048), MDL3_PRUSE  (P52707), MDL4_PRUSE  (O82784), 
MDLL_ARATH  (Q9SSM2), PATE_ASPCL  (A1CFL2), PATE_PENEN  (A0A075TRK9), 
PKFF_EMENI  (Q5B8A1), PNO_MICLT   (Q9AJD6), SDH_GLUOY   (Q47944), 
XPTC_EMENI  (Q5AUN2), Y1279_MYCTO (P9WMV4), Y1279_MYCTU (P9WMV5), 
Y1310_MYCBO (P64264), Y492_MYCTO  (P9WMV6), Y492_MYCTU  (P9WMV7), 
YL128_MIMIV (Q5UPK7), YL894_MIMIV (Q5UQZ1), YR135_MIMIV (Q5UPL2), 
YR832_MIMIV (Q5UQH9), YTH2_RHOER  (P46371)
» more

UniProtKB/Swiss-Prot
False negative sequences		 39 sequences 

4PADH_RHILO (Q988C9), AFLK_ASPPU  (Q12062), BETA_VIBC1  (A7N2P9), 

BETA_VIBVU  (Q8D3K2), BETA_VIBVY  (Q7MF12), CGLYO_ARTG1 (H0QPM2), 
CGLYO_MICSX (P0DXE4), CGLYO_MICTR (A0A0M2HFA3), CHOD_BREST  (P22637), 
CHOD_MYCTO  (P9WMV8), CHOD_MYCTU  (P9WMV9), CHOD_STRS0  (P12676), 
FAO1_ARATH  (Q9ZWB9), FAO1_LOTJA  (B5WWZ8), FAO2_LOTJA  (B5WWZ9), 
FAO3_ARATH  (Q9LW56), FAO4A_ARATH (O65709), FAO4B_ARATH (Q94BP3), 
FDHL_GLUJA  (M1VMF7), GADH1_PANCY (O34214), LIVQ_STRLV  (Q2MF66), 
MPDB_MYCAO  (Q3YAT3), NEOG_STRFR  (Q53U15), NINAG_DROME (Q9VGP2), 
P2OX_EMENI  (Q5B2E9), P2OX_LYOSH  (Q75ZP8), P2OX_PENSG  (Q8J136), 
P2OX_PHACH  (Q6QWR1), P2OX_PHLGI  (Q6UG02), P2OX_TRAHI  (P59097), 
P2OX_TRAPU  (Q5G234), P2OX_TRAVE  (P79076), P2OX_TRIMT  (Q8J2V8), 
PDH1_AGABI  (Q3L1D1), PDH1_AGACM  (V5NDL4), PDH1_AGAXA  (V5NC32), 
PDH1_LEUMG  (Q3L245), PDH2_LEUMG  (Q3L243), PDH3_LEUMG  (Q0R4L2)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

NEC3_NESMA  (P0DO52)


				
	

	

		PDB
[Detailed view]		
		
			41 PDB
			


			pdb_00001cf3; pdb_00001gal; pdb_00001gpe; pdb_00001ju2; pdb_00001kdg; pdb_00001naa; pdb_00002jbv; pdb_00003gdn; pdb_00003gdp; pdb_00003ljp; pdb_00003nne; pdb_00003qvp; 
			
				pdb_00003qvr; pdb_00004mjw; pdb_00004z24; pdb_00004z25; pdb_00004z26; pdb_00005eb4; pdb_00005eb5; pdb_00005ncc; pdb_00005nit; pdb_00005niw; pdb_00006jby; pdb_00006lqy; 
				pdb_00006lr8; pdb_00006yru; pdb_00006yrv; pdb_00006yrx; pdb_00006yrz; pdb_00006ys1; pdb_00006ys2; pdb_00006zh7; pdb_00007av4; pdb_00007bwp; pdb_00007cgs; pdb_00007r33; 
				pdb_00007r34; pdb_00007r35; pdb_00007r36; pdb_00007yx3; pdb_00008bxl
			
			

			» more