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PROSITE entry PS00652


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General information about the entry

Entry name [info] TNFR_NGFR_1
Accession [info] PS00652
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00561

Name and characterization of the entry

Description [info] TNFR/NGFR family cysteine-rich region signature.
Pattern [info] 
C-x(4,6)-[FYH]-x(5,10)-C-x(0,2)-C-x(2,3)-C-x(7,11)-C-x(4,6)-[DNEQSKP]-
{PD}-{CP}-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.


Total number of hits 178 in 117 different sequences
Number of true positive hits 138 in 78 different sequences
Number of 'unknown' hits 1
Number of false positive hits 39 in 38 different sequences
Number of false negative sequences 20
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 77.97 %
Recall (true positives / (true positives + false negatives)) 87.34 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 16
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 78 sequences 

A53R_VACCW  (P24756    ), A53_VACCC   (P21071    ), CD27_HUMAN  (P26842    ), 

CD27_MOUSE  (P41272    ), CRMB_CAMPM  (P68636    ), CRMB_CAMPS  (P68637    ), 
CRMB_CWPXG  (O73559    ), CRMB_MONPV  (P0DTN0    ), CRMB_VAR67  (P0DSV7    ), 
CRMB_VARV   (P0DSV8    ), TNF6B_HUMAN (O95407    ), TNR11_HUMAN (Q9Y6Q6    ), 
TNR11_MOUSE (O35305    ), TNR14_HUMAN (Q92956    ), TNR14_MOUSE (Q80WM9    ), 
TNR16_CHICK (P18519    ), TNR16_HUMAN (P08138    ), TNR16_MOUSE (Q9Z0W1    ), 
TNR16_RAT   (P07174    ), TNR19_HUMAN (Q9NS68    ), TNR19_MOUSE (Q9JLL3    ), 
TNR1A_BOVIN (O19131    ), TNR1A_HUMAN (P19438    ), TNR1A_MOUSE (P25118    ), 
TNR1A_PIG   (P50555    ), TNR1A_RAT   (P22934    ), TNR1B_HUMAN (P20333    ), 
TNR1B_MOUSE (P25119    ), TNR1B_RAT   (Q80WY6    ), TNR21_HUMAN (O75509    ), 
TNR21_MOUSE (Q9EPU5    ), TNR21_RAT   (D3ZF92    ), TNR22_MOUSE (Q9ER62    ), 
TNR23_MOUSE (Q9ER63    ), TNR25_HUMAN (Q93038    ), TNR26_MOUSE (P83626    ), 
TNR27_HUMAN (Q9HAV5    ), TNR27_MOUSE (Q8BX35    ), TNR3_HUMAN  (P36941    ), 
TNR3_MOUSE  (P50284    ), TNR4_HUMAN  (P43489    ), TNR4_MOUSE  (P47741    ), 
TNR4_RAT    (P15725    ), TNR5_BOVIN  (Q28203    ), TNR5_CALJA  (Q3LRP1    ), 
TNR5_CANLF  (Q7YRL5    ), TNR5_HORSE  (Q3ZTK5    ), TNR5_HUMAN  (P25942    ), 
TNR5_MOUSE  (P27512    ), TNR5_PIG    (Q8SQ34    ), TNR6_BOVIN  (P51867    ), 
TNR6_CERAT  (Q9BDN4    ), TNR6_HUMAN  (P25445    ), TNR6_MACFA  (Q9TSN4    ), 
TNR6_MACMU  (Q9BDP2    ), TNR6_MACNE  (Q9BDN0    ), TNR6_MOUSE  (P25446    ), 
TNR6_PIG    (O77736    ), TNR6_RAT    (Q63199    ), TNR8_HUMAN  (P28908    ), 
TNR8_MOUSE  (Q60846    ), TNR9_HUMAN  (Q07011    ), TNR9_MOUSE  (P20334    ), 
TR10A_HUMAN (O00220    ), TR10B_HUMAN (O14763    ), TR10B_MOUSE (Q9QZM4    ), 
TR10C_HUMAN (O14798    ), TR10D_HUMAN (Q9UBN6    ), TR11B_BOVIN (A5D7R1    ), 
TR11B_HUMAN (O00300    ), TR11B_MOUSE (O08712    ), TR11B_RAT   (O08727    ), 
TR13B_HUMAN (O14836    ), UL144_HCMVM (F5HAM0    ), UL144_HCMVO (Q68396    ), 
USP3_PINMG  (H2A0M8    ), VT2_MYXVL   (P29825    ), VT2_RFVKA   (P25943    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 20 sequences 

ACCR2_ARATH (O80963    ), C22L_VACCC  (P21106    ), CRI4_MAIZE  (O24585    ), 

EDAR_HUMAN  (Q9UNE0    ), EDAR_MOUSE  (Q9R187    ), EDAR_ORYLA  (Q90VY2    ), 
TNR12_HUMAN (Q9NP84    ), TNR12_MOUSE (Q9CR75    ), TNR17_HUMAN (Q02223    ), 
TNR17_MOUSE (O88472    ), TNR18_HUMAN (Q9Y5U5    ), TNR18_MOUSE (O35714    ), 
TNR8_RAT    (P97525    ), TR13B_MOUSE (Q9ET35    ), TR13C_HUMAN (Q96RJ3    ), 
TR13C_MOUSE (Q9D8D0    ), TR19L_HUMAN (Q969Z4    ), TR19L_MACFA (Q9N092    ), 
TR19L_MOUSE (Q8BX43    ), WGN_DROME   (Q9VWS4    )
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

SCGR7_HUMAN (A0A286YF01)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			38 sequences
			


			
DEFI8_DROME (Q9VTT9    ), EPI1_CAEEL  (Q21313    ), GG3_ARATH   (Q6AWT8    ), 

			
IGFR1_BOVIN (A5PJC7    ), KR134_HYLAG (Q4W7H1    ), KR134_HYLLA (Q4W7H0    ), 
KR134_MACFA (Q4W7G9    ), KR134_MACFU (Q4W7G8    ), KR134_SAPAP (Q4W7G7    ), 
KR416_HUMAN (G5E9R7    ), KRA21_HUMAN (Q9BYU5    ), KRA22_HUMAN (Q9BYT5    ), 
KRA43_HUMAN (Q9BYR4    ), KRA44_HUMAN (Q9BYR3    ), KRA45_HUMAN (Q9BYR2    ), 
KRA47_HUMAN (Q9BYR0    ), KRA49_HUMAN (Q9BYQ8    ), KRA59_HUMAN (P26371    ), 
LAMA5_HUMAN (O15230    ), LAMA5_MOUSE (Q61001    ), M1BL1_HUMAN (P0DM35    ), 
MDFI_HUMAN  (Q99750    ), MEDEA_ARATH (O65312    ), MT4_HUMAN   (P47944    ), 
PTPR_CAEEL  (H2KZM6    ), SCGR2_HUMAN (A0A286YFB4), SCGR3_HUMAN (A0A286YF60), 
SCGR4_HUMAN (A0A286YEV6), SCGR5_HUMAN (A0A286YF46), SCGR6_HUMAN (A0A286YF77), 
SCGR8_HUMAN (A0A286YFG1), SCGR9_HUMAN (P0DSO2    ), STIG1_SOLLC (Q6EEH1    ), 
TRI42_HUMAN (Q8IWZ5    ), TRI42_MOUSE (Q9D2H5    ), UL32_EHV2   (Q66671    ), 
YL264_MIMIV (Q5UPU7    ), YL724_MIMIV (Q5UNX6    )


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			88 PDB
			


			1D0G; 1D4V; 1DU3; 1EXT; 1FT4; 1JMA; 1NCF; 1SG1; 1TNR; 1ZA3; 2AW2; 2H9G; 
			
				2HEV; 2HEY; 3ALQ; 3BUK; 3IJ2; 3K51; 3ME2; 3ME4; 3MHD; 3MI8; 3QBQ; 3QD6; 
				3QO4; 3THM; 3TJE; 3U3P; 3U3Q; 3U3S; 3U3T; 3U3V; 3URF; 3X3F; 4E4D; 4FHQ; 
				4GIQ; 4I9X; 4J6G; 4KGG; 4KGQ; 4MSV; 4MXW; 4N90; 4OD2; 4RSU; 4YN0; 5BNQ; 
				5CIR; 5DMI; 5DMJ; 5IHL; 5L36; 5T2Q; 5T2R; 5TL5; 5TLJ; 5TLK; 5WI8; 5WIW; 
				5WJF; 6A3V; 6A3W; 6BWV; 6CPR; 6CU0; 6FAX; 6MGP; 6MHR; 6MI2; 6MKZ; 6NG3; 
				6OGX; 6OKM; 6OKN; 6PE8; 6PE9; 6T3J; 6Y8K; 7D4B; 7KP7; 7KP8; 7KPB; 7KX0; 
				7MSG; 7MSJ; 7P3I; 8DS5
			
			

			» more