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PROSITE entry PS00652


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00652
Entry name [info] TNFR_NGFR_1
Accession [info] PS00652
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00561

Name and characterization of the entry

Description [info] TNFR/NGFR family cysteine-rich region signature.
Pattern [info] 
C-x(4,6)-[FYH]-x(5,10)-C-x(0,2)-C-x(2,3)-C-x(7,11)-C-x(4,6)-[DNEQSKP]-
{PD}-{CP}-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 178 in 117 different sequences
Number of true positive hits 138 in 78 different sequences
Number of 'unknown' hits 1
Number of false positive hits 39 in 38 different sequences
Number of false negative sequences 20
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 77.97 %
Recall (true positives / (true positives + false negatives)) 87.34 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 16
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 78 sequences 

A53R_VACCW  (P24756), A53_VACCC   (P21071), CD27_HUMAN  (P26842), 

CD27_MOUSE  (P41272), CRMB_CAMPM  (P68636), CRMB_CAMPS  (P68637), 
CRMB_CWPXG  (O73559), CRMB_MONPV  (P0DTN0), CRMB_VAR67  (P0DSV7), 
CRMB_VARV   (P0DSV8), TNF6B_HUMAN (O95407), TNR11_HUMAN (Q9Y6Q6), 
TNR11_MOUSE (O35305), TNR14_HUMAN (Q92956), TNR14_MOUSE (Q80WM9), 
TNR16_CHICK (P18519), TNR16_HUMAN (P08138), TNR16_MOUSE (Q9Z0W1), 
TNR16_RAT   (P07174), TNR19_HUMAN (Q9NS68), TNR19_MOUSE (Q9JLL3), 
TNR1A_BOVIN (O19131), TNR1A_HUMAN (P19438), TNR1A_MOUSE (P25118), 
TNR1A_PIG   (P50555), TNR1A_RAT   (P22934), TNR1B_HUMAN (P20333), 
TNR1B_MOUSE (P25119), TNR1B_RAT   (Q80WY6), TNR21_HUMAN (O75509), 
TNR21_MOUSE (Q9EPU5), TNR21_RAT   (D3ZF92), TNR22_MOUSE (Q9ER62), 
TNR23_MOUSE (Q9ER63), TNR25_HUMAN (Q93038), TNR26_MOUSE (P83626), 
TNR27_HUMAN (Q9HAV5), TNR27_MOUSE (Q8BX35), TNR3_HUMAN  (P36941), 
TNR3_MOUSE  (P50284), TNR4_HUMAN  (P43489), TNR4_MOUSE  (P47741), 
TNR4_RAT(P15725), TNR5_BOVIN  (Q28203), TNR5_CALJA  (Q3LRP1), 
TNR5_CANLF  (Q7YRL5), TNR5_HORSE  (Q3ZTK5), TNR5_HUMAN  (P25942), 
TNR5_MOUSE  (P27512), TNR5_PIG(Q8SQ34), TNR6_BOVIN  (P51867), 
TNR6_CERAT  (Q9BDN4), TNR6_HUMAN  (P25445), TNR6_MACFA  (Q9TSN4), 
TNR6_MACMU  (Q9BDP2), TNR6_MACNE  (Q9BDN0), TNR6_MOUSE  (P25446), 
TNR6_PIG(O77736), TNR6_RAT(Q63199), TNR8_HUMAN  (P28908), 
TNR8_MOUSE  (Q60846), TNR9_HUMAN  (Q07011), TNR9_MOUSE  (P20334), 
TR10A_HUMAN (O00220), TR10B_HUMAN (O14763), TR10B_MOUSE (Q9QZM4), 
TR10C_HUMAN (O14798), TR10D_HUMAN (Q9UBN6), TR11B_BOVIN (A5D7R1), 
TR11B_HUMAN (O00300), TR11B_MOUSE (O08712), TR11B_RAT   (O08727), 
TR13B_HUMAN (O14836), UL144_HCMVM (F5HAM0), UL144_HCMVO (Q68396), 
USP3_PINMG  (H2A0M8), VT2_MYXVL   (P29825), VT2_RFVKA   (P25943)
» more

UniProtKB/Swiss-Prot
False negative sequences		 20 sequences 

ACCR2_ARATH (O80963), C22L_VACCC  (P21106), CRI4_MAIZE  (O24585), 

EDAR_HUMAN  (Q9UNE0), EDAR_MOUSE  (Q9R187), EDAR_ORYLA  (Q90VY2), 
TNR12_HUMAN (Q9NP84), TNR12_MOUSE (Q9CR75), TNR17_HUMAN (Q02223), 
TNR17_MOUSE (O88472), TNR18_HUMAN (Q9Y5U5), TNR18_MOUSE (O35714), 
TNR8_RAT(P97525), TR13B_MOUSE (Q9ET35), TR13C_HUMAN (Q96RJ3), 
TR13C_MOUSE (Q9D8D0), TR19L_HUMAN (Q969Z4), TR19L_MACFA (Q9N092), 
TR19L_MOUSE (Q8BX43), WGN_DROME   (Q9VWS4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

SCGR7_HUMAN (A0A286YF01)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			38 sequences
			


			
DEFI8_DROME (Q9VTT9), EPI1_CAEEL  (Q21313), GG3_ARATH   (Q6AWT8), 

			
IGFR1_BOVIN (A5PJC7), KR134_HYLAG (Q4W7H1), KR134_HYLLA (Q4W7H0), 
KR134_MACFA (Q4W7G9), KR134_MACFU (Q4W7G8), KR134_SAPAP (Q4W7G7), 
KR416_HUMAN (G5E9R7), KRA21_HUMAN (Q9BYU5), KRA22_HUMAN (Q9BYT5), 
KRA43_HUMAN (Q9BYR4), KRA44_HUMAN (Q9BYR3), KRA45_HUMAN (Q9BYR2), 
KRA47_HUMAN (Q9BYR0), KRA49_HUMAN (Q9BYQ8), KRA59_HUMAN (P26371), 
LAMA5_HUMAN (O15230), LAMA5_MOUSE (Q61001), M1BL1_HUMAN (P0DM35), 
MDFI_HUMAN  (Q99750), MEDEA_ARATH (O65312), MT4_HUMAN   (P47944), 
PTPR_CAEEL  (H2KZM6), SCGR2_HUMAN (A0A286YFB4), SCGR3_HUMAN (A0A286YF60), 
SCGR4_HUMAN (A0A286YEV6), SCGR5_HUMAN (A0A286YF46), SCGR6_HUMAN (A0A286YF77), 
SCGR8_HUMAN (A0A286YFG1), SCGR9_HUMAN (P0DSO2), STIG1_SOLLC (Q6EEH1), 
TRI42_HUMAN (Q8IWZ5), TRI42_MOUSE (Q9D2H5), UL32_EHV2   (Q66671), 
YL264_MIMIV (Q5UPU7), YL724_MIMIV (Q5UNX6)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			98 PDB
			


			1D0G; 1D4V; 1DU3; 1EXT; 1FT4; 1JMA; 1NCF; 1SG1; 1TNR; 1ZA3; 2AW2; 2H9G; 
			
				2HEV; 2HEY; 3ALQ; 3BUK; 3IJ2; 3K51; 3ME2; 3ME4; 3MHD; 3MI8; 3QBQ; 3QD6; 
				3QO4; 3THM; 3TJE; 3U3P; 3U3Q; 3U3S; 3U3T; 3U3V; 3URF; 3X3F; 4E4D; 4FHQ; 
				4GIQ; 4I9X; 4J6G; 4KGG; 4KGQ; 4MSV; 4MXW; 4N90; 4OD2; 4RSU; 4YN0; 5BNQ; 
				5CIR; 5DMI; 5DMJ; 5IHL; 5L36; 5T2Q; 5T2R; 5TL5; 5TLJ; 5TLK; 5WI8; 5WIW; 
				5WJF; 6A3V; 6A3W; 6BWV; 6CPR; 6CU0; 6FAX; 6MGP; 6MHR; 6MI2; 6MKZ; 6NG3; 
				6OGX; 6OKM; 6OKN; 6PE8; 6PE9; 6T3J; 6Y8K; 7D4B; 7KP7; 7KP8; 7KPB; 7KX0; 
				7MSG; 7MSJ; 7P3I; 7YK4; 7YXU; 8AG1; 8DPX; 8DS5; 8GYE; 8HLB; 8OZ3; 8YX1; 
				8YX9; 9CU8
			
			

			» more