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Amos Bairoch

PROSITE entry PS00652


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PURL: https://purl.expasy.org/prosite/signature/PS00652

Direct ScanProsite submission
General information about the entry

Entry name [info] TNFR_NGFR_1
Accession [info] PS00652
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00561

Name and characterization of the entry

Description [info] TNFR/NGFR family cysteine-rich region signature.
Pattern [info] 
C-x(4,6)-[FYH]-x(5,10)-C-x(0,2)-C-x(2,3)-C-x(7,11)-C-x(4,6)-[DNEQSKP]-
{PD}-{CP}-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 179 in 118 different sequences
Number of true positive hits 139 in 79 different sequences
Number of 'unknown' hits 1
Number of false positive hits 39 in 38 different sequences
Number of false negative sequences 20
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 78.09 %
Recall (true positives / (true positives + false negatives)) 87.42 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] disulfide at position 1
Site [info] disulfide at position 5
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 11
Site [info] disulfide at position 16
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 79 sequences 

A53R_VACCW  (P24756), A53_VACCC   (P21071), CD27_HUMAN  (P26842), 

CD27_MOUSE  (P41272), CP530_TOXGM (S8G033), CRMB_CAMPM  (P68636), 
CRMB_CAMPS  (P68637), CRMB_CWPXG  (O73559), CRMB_MONPV  (P0DTN0), 
CRMB_VAR67  (P0DSV7), CRMB_VARV   (P0DSV8), TNF6B_HUMAN (O95407), 
TNR11_HUMAN (Q9Y6Q6), TNR11_MOUSE (O35305), TNR14_HUMAN (Q92956), 
TNR14_MOUSE (Q80WM9), TNR16_CHICK (P18519), TNR16_HUMAN (P08138), 
TNR16_MOUSE (Q9Z0W1), TNR16_RAT   (P07174), TNR19_HUMAN (Q9NS68), 
TNR19_MOUSE (Q9JLL3), TNR1A_BOVIN (O19131), TNR1A_HUMAN (P19438), 
TNR1A_MOUSE (P25118), TNR1A_PIG   (P50555), TNR1A_RAT   (P22934), 
TNR1B_HUMAN (P20333), TNR1B_MOUSE (P25119), TNR1B_RAT   (Q80WY6), 
TNR21_HUMAN (O75509), TNR21_MOUSE (Q9EPU5), TNR21_RAT   (D3ZF92), 
TNR22_MOUSE (Q9ER62), TNR23_MOUSE (Q9ER63), TNR25_HUMAN (Q93038), 
TNR26_MOUSE (P83626), TNR27_HUMAN (Q9HAV5), TNR27_MOUSE (Q8BX35), 
TNR3_HUMAN  (P36941), TNR3_MOUSE  (P50284), TNR4_HUMAN  (P43489), 
TNR4_MOUSE  (P47741), TNR4_RAT(P15725), TNR5_BOVIN  (Q28203), 
TNR5_CALJA  (Q3LRP1), TNR5_CANLF  (Q7YRL5), TNR5_HORSE  (Q3ZTK5), 
TNR5_HUMAN  (P25942), TNR5_MOUSE  (P27512), TNR5_PIG(Q8SQ34), 
TNR6_BOVIN  (P51867), TNR6_CERAT  (Q9BDN4), TNR6_HUMAN  (P25445), 
TNR6_MACFA  (Q9TSN4), TNR6_MACMU  (Q9BDP2), TNR6_MACNE  (Q9BDN0), 
TNR6_MOUSE  (P25446), TNR6_PIG(O77736), TNR6_RAT(Q63199), 
TNR8_HUMAN  (P28908), TNR8_MOUSE  (Q60846), TNR9_HUMAN  (Q07011), 
TNR9_MOUSE  (P20334), TR10A_HUMAN (O00220), TR10B_HUMAN (O14763), 
TR10B_MOUSE (Q9QZM4), TR10C_HUMAN (O14798), TR10D_HUMAN (Q9UBN6), 
TR11B_BOVIN (A5D7R1), TR11B_HUMAN (O00300), TR11B_MOUSE (O08712), 
TR11B_RAT   (O08727), TR13B_HUMAN (O14836), UL144_HCMVM (F5HAM0), 
UL144_HCMVO (Q68396), USP3_PINMG  (H2A0M8), VT2_MYXVL   (P29825), 
VT2_RFVKA   (P25943)
» more

UniProtKB/Swiss-Prot
False negative sequences		 20 sequences 

ACCR2_ARATH (O80963), C22L_VACCC  (P21106), CRI4_MAIZE  (O24585), 

EDAR_HUMAN  (Q9UNE0), EDAR_MOUSE  (Q9R187), EDAR_ORYLA  (Q90VY2), 
TNR12_HUMAN (Q9NP84), TNR12_MOUSE (Q9CR75), TNR17_HUMAN (Q02223), 
TNR17_MOUSE (O88472), TNR18_HUMAN (Q9Y5U5), TNR18_MOUSE (O35714), 
TNR8_RAT(P97525), TR13B_MOUSE (Q9ET35), TR13C_HUMAN (Q96RJ3), 
TR13C_MOUSE (Q9D8D0), TR19L_HUMAN (Q969Z4), TR19L_MACFA (Q9N092), 
TR19L_MOUSE (Q8BX43), WGN_DROME   (Q9VWS4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

SCGR7_HUMAN (A0A286YF01)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			38 sequences
			


			
DEFI8_DROME (Q9VTT9), EPI1_CAEEL  (Q21313), GG3_ARATH   (Q6AWT8), 

			
IGFR1_BOVIN (A5PJC7), KR134_HYLAG (Q4W7H1), KR134_HYLLA (Q4W7H0), 
KR134_MACFA (Q4W7G9), KR134_MACFU (Q4W7G8), KR134_SAPAP (Q4W7G7), 
KR416_HUMAN (G5E9R7), KRA21_HUMAN (Q9BYU5), KRA22_HUMAN (Q9BYT5), 
KRA43_HUMAN (Q9BYR4), KRA44_HUMAN (Q9BYR3), KRA45_HUMAN (Q9BYR2), 
KRA47_HUMAN (Q9BYR0), KRA49_HUMAN (Q9BYQ8), KRA59_HUMAN (P26371), 
LAMA5_HUMAN (O15230), LAMA5_MOUSE (Q61001), M1BL1_HUMAN (P0DM35), 
MDFI_HUMAN  (Q99750), MEDEA_ARATH (O65312), MT4_HUMAN   (P47944), 
PTPR_CAEEL  (H2KZM6), SCGR2_HUMAN (A0A286YFB4), SCGR3_HUMAN (A0A286YF60), 
SCGR4_HUMAN (A0A286YEV6), SCGR5_HUMAN (A0A286YF46), SCGR6_HUMAN (A0A286YF77), 
SCGR8_HUMAN (A0A286YFG1), SCGR9_HUMAN (P0DSO2), STIG1_SOLLC (Q6EEH1), 
TRI42_HUMAN (Q8IWZ5), TRI42_MOUSE (Q9D2H5), UL32_EHV2   (Q66671), 
YL264_MIMIV (Q5UPU7), YL724_MIMIV (Q5UNX6)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			98 PDB
			


			pdb_00001d0g; pdb_00001d4v; pdb_00001du3; pdb_00001ext; pdb_00001ft4; pdb_00001jma; pdb_00001ncf; pdb_00001sg1; pdb_00001tnr; pdb_00001za3; pdb_00002aw2; pdb_00002h9g; 
			
				pdb_00002hev; pdb_00002hey; pdb_00003alq; pdb_00003buk; pdb_00003ij2; pdb_00003k51; pdb_00003me2; pdb_00003me4; pdb_00003mhd; pdb_00003mi8; pdb_00003qbq; pdb_00003qd6; 
				pdb_00003qo4; pdb_00003thm; pdb_00003tje; pdb_00003u3p; pdb_00003u3q; pdb_00003u3s; pdb_00003u3t; pdb_00003u3v; pdb_00003urf; pdb_00003x3f; pdb_00004e4d; pdb_00004fhq; 
				pdb_00004giq; pdb_00004i9x; pdb_00004j6g; pdb_00004kgg; pdb_00004kgq; pdb_00004msv; pdb_00004mxw; pdb_00004n90; pdb_00004od2; pdb_00004rsu; pdb_00004yn0; pdb_00005bnq; 
				pdb_00005cir; pdb_00005dmi; pdb_00005dmj; pdb_00005ihl; pdb_00005l36; pdb_00005t2q; pdb_00005t2r; pdb_00005tl5; pdb_00005tlj; pdb_00005tlk; pdb_00005wi8; pdb_00005wiw; 
				pdb_00005wjf; pdb_00006a3v; pdb_00006a3w; pdb_00006bwv; pdb_00006cpr; pdb_00006cu0; pdb_00006fax; pdb_00006mgp; pdb_00006mhr; pdb_00006mi2; pdb_00006mkz; pdb_00006ng3; 
				pdb_00006ogx; pdb_00006okm; pdb_00006okn; pdb_00006pe8; pdb_00006pe9; pdb_00006t3j; pdb_00006y8k; pdb_00007d4b; pdb_00007kp7; pdb_00007kp8; pdb_00007kpb; pdb_00007kx0; 
				pdb_00007msg; pdb_00007msj; pdb_00007p3i; pdb_00007yk4; pdb_00007yxu; pdb_00008ag1; pdb_00008dpx; pdb_00008ds5; pdb_00008gye; pdb_00008hlb; pdb_00008oz3; pdb_00008yx1; 
				pdb_00008yx9; pdb_00009cu8
			
			

			» more