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PROSITE entry PS00657


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00657
Entry name [info] FORK_HEAD_1
Accession [info] PS00657
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00564

Name and characterization of the entry

Description [info] Fork head domain signature 1.
Pattern [info] 
[KR]-P-[PTQ]-[FYLVQH]-S-[FY]-x(2)-[LIVM]-x(3,4)-[AC]-[LIM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 175 in 175 different sequences
Number of true positive hits 174 in 174 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 86
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.43 %
Recall (true positives / (true positives + false negatives)) 66.92 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 174 sequences 

CROC_DROME  (P32027), FD3_DROME   (Q02361), FD4_DROME   (P32028), 

FD5_DROME   (P32029), FKH02_CAEBR (A8XJN7), FKH02_CAEEL (Q22510), 
FKH1_YEAST  (P40466), FKH2_CANAL  (Q5A7S7), FKH2_SCHPO  (O60129), 
FKH2_YEAST  (P41813), FKH5_CAEEL  (Q19802), FKH6_CAEEL  (Q10924), 
FKHL1_YEAST (P39521), FKH_DROME   (P14734), FOXA1_HUMAN (P55317), 
FOXA1_MOUSE (P35582), FOXA1_RAT   (P23512), FOXA1_XENTR (Q8AWH1), 
FOXA2_DANRE (Q07342), FOXA2_HUMAN (Q9Y261), FOXA2_MOUSE (P35583), 
FOXA2_ORYLA (O42097), FOXA2_RAT   (P32182), FOXA2_XENTR (Q7T1R4), 
FOXA3_BOVIN (Q3Y598), FOXA3_HUMAN (P55318), FOXA3_MOUSE (P35584), 
FOXA3_RAT   (P32183), FOXA4_XENTR (Q6P839), FOXB1_HUMAN (Q99853), 
FOXB1_MOUSE (Q64732), FOXB1_XENLA (O93529), FOXB2_HUMAN (Q5VYV0), 
FOXB2_MOUSE (Q64733), FOXB2_XENLA (Q8JIT6), FOXC1_HUMAN (Q12948), 
FOXC1_MOUSE (Q61572), FOXC1_XENTR (Q68F77), FOXC2_HUMAN (Q99958), 
FOXC2_MOUSE (Q61850), FOXC2_RAT   (Q63246), FOXC2_XENTR (Q6NVT7), 
FOXD1_CHICK (Q98937), FOXD1_HUMAN (Q16676), FOXD1_MOUSE (Q61345), 
FOXD1_RAT   (Q63251), FOXD1_XENTR (Q6F2E4), FOXD2_HUMAN (O60548), 
FOXD2_MOUSE (O35392), FOXD3_CHICK (P79772), FOXD3_HUMAN (Q9UJU5), 
FOXD3_MOUSE (Q61060), FOXD3_RAT   (Q63245), FOXD3_XENTR (Q5M7L9), 
FOXD4_MOUSE (Q60688), FOXD4_RAT   (Q63249), FOXD5_XENTR (Q5WM45), 
FOXE1_HUMAN (O00358), FOXE1_MOUSE (Q8R2I0), FOXE3_HUMAN (Q13461), 
FOXE3_MOUSE (Q9QY14), FOXE3_RAT   (Q63250), FOXE4_XENLA (Q9PTK2), 
FOXF1_DANRE (A1L1S5), FOXF1_HUMAN (Q12946), FOXF1_MOUSE (Q61080), 
FOXF1_XENTR (Q28BS5), FOXF2_HUMAN (Q12947), FOXF2_MOUSE (O54743), 
FOXF_CAEEL  (P91278), FOXG1_CEBCA (Q1A1A6), FOXG1_CERSI (Q1A1A1), 
FOXG1_CHICK (Q90964), FOXG1_CHLPG (Q1A1A5), FOXG1_EPOGA (Q1A1A3), 
FOXG1_EQUQB (Q1A1A2), FOXG1_HUMAN (P55316), FOXG1_MOUSE (Q60987), 
FOXG1_PIPRU (Q1A1A4), FOXG1_RAT   (Q00939), FOXG1_XENLA (Q9YHC5), 
FOXI1_HUMAN (Q12951), FOXI1_MOUSE (Q922I5), FOXI1_XENTR (Q6P2Z3), 
FOXI2_HUMAN (Q6ZQN5), FOXI2_MOUSE (Q3I5G5), FOXI2_RAT   (Q63248), 
FOXI2_XENTR (Q28HT3), FOXI3_CANLF (B5RHS5), FOXI3_CHICK (A0A8V0YY16), 
FOXI3_HUMAN (A8MTJ6), FOXI3_MOUSE (D3Z120), FOXJ1_HUMAN (Q92949), 
FOXJ1_MOUSE (Q61660), FOXJ1_RAT   (Q63247), FOXJ1_XENTR (Q5M7N6), 
FOXJ2_XENLA (Q68EZ2), FOXJ2_XENTR (Q28EM1), FOXJ3_HUMAN (Q9UPW0), 
FOXJ3_MOUSE (Q8BUR3), FOXK1_HUMAN (P85037), FOXK1_MOUSE (P42128), 
FOXK2_HUMAN (Q01167), FOXK2_MOUSE (Q3UCQ1), FOXK2_XENLA (Q7ZX03), 
FOXL1_DROME (Q02360), FOXL1_HUMAN (Q12952), FOXL1_MOUSE (Q64731), 
FOXL2_BOVIN (Q6VFT7), FOXL2_BRALU (Q4VUF1), FOXL2_CAPHI (Q8MIP2), 
FOXL2_HUMAN (P58012), FOXL2_MOUSE (O88470), FOXL2_PIG   (Q6VFT6), 
FOXL2_RABIT (Q6VFT5), FOXM1_HUMAN (Q08050), FOXM1_MOUSE (O08696), 
FOXM1_RAT   (P97691), FOXM1_XENLA (Q5W1J6), FOXN2_HUMAN (P32314), 
FOXN2_XENLA (Q66J77), FOXN2_XENTR (Q28F43), FOXN3_HUMAN (O00409), 
FOXN3_MOUSE (Q499D0), FOXN3_PIG   (Q33BP8), FOXN3_XENTR (Q28G71), 
FOXQ1_HUMAN (Q9C009), FOXQ1_MOUSE (O70220), FOXQ1_RAT   (Q63244), 
FOXS1_HUMAN (O43638), FOXS1_MOUSE (Q61574), FX4L1_HUMAN (Q9NU39), 
FX4L3_HUMAN (Q6VB84), FX4L4_HUMAN (Q8WXT5), FX4L5_HUMAN (Q5VV16), 
FX4L6_HUMAN (Q3SYB3), FXA1A_XENLA (Q6LD29), FXA1B_XENLA (P32315), 
FXA2A_XENLA (Q91765), FXA2B_XENLA (P84961), FXA4A_XENLA (P33205), 
FXA4B_XENLA (P33206), FXC1A_DANRE (Q9DE25), FXC1A_XENLA (Q9PVZ3), 
FXC1B_DANRE (Q9DE24), FXC1B_XENLA (Q32NP8), FXC2A_XENLA (Q9PVY9), 
FXC2B_XENLA (Q9PVY8), FXD5A_XENLA (Q9PRJ8), FXD5B_XENLA (Q9PT68), 
FXD5C_XENLA (Q9PT67), FXF1A_XENLA (Q9W706), FXF1B_XENLA (Q9W707), 
FXI1B_XENLA (Q91905), FXI1C_XENLA (Q8JIT5), FXI1C_XENTR (Q28D67), 
FXI1E_XENLA (Q7ZYQ0), FXI1E_XENTR (Q6P8A3), FXI2A_XENLA (Q5NDM2), 
FXI3A_DANRE (A3KNJ3), FXI3B_DANRE (Q7T1C0), FXJ12_XENLA (Q32NH9), 
FXJ12_XENTR (Q66IG8), FXJ1A_DANRE (F1QDF8), FXJ1A_XENLA (Q708W2), 
FXJ1B_DANRE (F1R8Z9), FXJ1B_XENLA (Q708W1), HCM1_YEAST  (P25364), 
LIN31_CAEEL (P34683), PHA4_CAEEL  (Q17381), QIN_AVIS3   (P56260), 
SGF1_BOMMO  (Q17241), SLP1_DROME  (P32030), SLP2_DROME  (P32031)
» more

UniProtKB/Swiss-Prot
False negative sequences		 86 sequences 

FAST3_XENLA (Q8JIT7), FKH3_CAEEL  (A0A078BQN7), FKH4_CAEEL  (O17617), 

FKHL1_SCHPO (O14270), FOXD1_XENLA (Q9PSY4), FOXD2_XENLA (Q90WN4), 
FOXD4_HUMAN (Q12950), FOXE1_XENLA (Q5J3Q5), FOXF_DROME  (Q9VS05), 
FOXG1_MNELE (Q8ITI5), FOXH1_DANRE (Q9I9E1), FOXH1_HUMAN (O75593), 
FOXH1_MOUSE (O88621), FOXH1_XENLA (P70056), FOXH1_XENTR (Q28GC4), 
FOXJ2_HUMAN (Q9P0K8), FOXJ2_MOUSE (Q9ES18), FOXN1_HUMAN (O15353), 
FOXN1_MOUSE (Q61575), FOXN3_XENLA (Q3BJS3), FOXN4_DANRE (A2BGM5), 
FOXN4_HUMAN (Q96NZ1), FOXN4_MOUSE (Q8K3Q3), FOXN4_XENLA (Q3BJS1), 
FOXN5_XENLA (Q3BJS0), FOXN5_XENTR (Q28H65), FOXO1_HUMAN (Q12778), 
FOXO1_ICTTR (Q810W5), FOXO1_MOUSE (Q9R1E0), FOXO1_XENLA (Q6EUW2), 
FOXO1_XENTR (Q66JJ0), FOXO3_HUMAN (O43524), FOXO3_MOUSE (Q9WVH4), 
FOXO3_XENLA (Q6EUW1), FOXO4_HUMAN (P98177), FOXO4_MOUSE (Q9WVH3), 
FOXO6_HUMAN (A8MYZ6), FOXO6_MOUSE (Q70KY4), FOXO_CAEEL  (O16850), 
FOXO_DROAN  (B3LYS5), FOXO_DROER  (B3P0K6), FOXO_DROGR  (B4JSC2), 
FOXO_DROME  (Q95V55), FOXO_DROMO  (B4KBF6), FOXO_DROPE  (B4G4S8), 
FOXO_DROPS  (Q298W7), FOXO_DROSE  (B4HF64), FOXO_DROVI  (B4MB78), 
FOXO_DROWI  (B4NFR1), FOXO_DROYA  (B4PTD3), FOXP1_BOVIN (A4IFD2), 
FOXP1_CHICK (Q58NQ4), FOXP1_HUMAN (Q9H334), FOXP1_MOUSE (P58462), 
FOXP1_RAT   (Q498D1), FOXP1_XENLA (Q5W1J5), FOXP2_GORGO (Q8MJ99), 
FOXP2_HUMAN (O15409), FOXP2_HYLLA (Q5QL03), FOXP2_MACMU (Q8MJ97), 
FOXP2_MOUSE (P58463), FOXP2_PANPA (Q8HZ00), FOXP2_PANTR (Q8MJA0), 
FOXP2_PONPY (Q8MJ98), FOXP2_RAT   (P0CF24), FOXP2_XENLA (Q4VYS1), 
FOXP3_HUMAN (Q9BZS1), FOXP3_MACFA (Q6U8D7), FOXP3_MOUSE (Q99JB6), 
FOXP4_HUMAN (Q8IVH2), FOXP4_MOUSE (Q9DBY0), FOXP4_XENLA (Q4VYR7), 
FOXR1_HUMAN (Q6PIV2), FOXR1_MOUSE (Q3UTB7), FOXR2_HUMAN (Q6PJQ5), 
FOXR2_MOUSE (Q3UM89), FXD3A_XENLA (Q9DEN4), FXD3B_XENLA (Q9DEN3), 
FXI1A_XENLA (Q91904), FXI2B_XENLA (Q63ZH2), FXP1B_DANRE (Q2LE08), 
MEI4_SCHPO  (O13606), PES1_CAEBR  (Q9GZ14), PES1_CAEEL  (G5EGC9), 
SEP1_SCHPO  (O43058), UN130_CAEEL (Q18694)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

DDUB_DICDI  (Q55B97)


				
	

	

		PDB
[Detailed view]		
		
			29 PDB
			


			1D5V; 1JXS; 1KQ8; 1VTN; 2A3S; 2C6Y; 2D2W; 2HDC; 2HFH; 3G73; 5X07; 6AKO; 
			
				6AKP; 6LBM; 6NCE; 6NCM; 6O3T; 7CBY; 7FJ2; 7VOU; 7VOV; 7VOX; 7YZE; 7YZF; 
				8BZM; 8VFY; 8VFZ; 8VG1; 8VG2
			
			

			» more