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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00658


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PURL: https://purl.expasy.org/prosite/signature/PS00658

Direct ScanProsite submission
General information about the entry

Entry name [info] FORK_HEAD_2
Accession [info] PS00658
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00564

Name and characterization of the entry

Description [info] Fork head domain signature 2.
Pattern [info] 
W-[QKR]-[NSD]-[SA]-[LIV]-R-H.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 261 in 261 different sequences
Number of true positive hits 260 in 260 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.62 %
Recall (true positives / (true positives + false negatives)) 97.38 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 260 sequences 

CROC_DROME  (P32027), FAST3_XENLA (Q8JIT7), FD3_DROME   (Q02361), 

FD4_DROME   (P32028), FD5_DROME   (P32029), FKH02_CAEBR (A8XJN7), 
FKH02_CAEEL (Q22510), FKH1_YEAST  (P40466), FKH2_CANAL  (Q5A7S7), 
FKH2_SCHPO  (O60129), FKH2_YEAST  (P41813), FKH3_CAEEL  (A0A078BQN7), 
FKH4_CAEEL  (O17617), FKH5_CAEEL  (Q19802), FKH6_CAEEL  (Q10924), 
FKH9_CAEEL  (Q21187), FKHL1_YEAST (P39521), FKH_DROME   (P14734), 
FOXA1_HUMAN (P55317), FOXA1_MOUSE (P35582), FOXA1_RAT   (P23512), 
FOXA1_XENTR (Q8AWH1), FOXA2_DANRE (Q07342), FOXA2_HUMAN (Q9Y261), 
FOXA2_MOUSE (P35583), FOXA2_ORYLA (O42097), FOXA2_RAT   (P32182), 
FOXA2_XENTR (Q7T1R4), FOXA3_BOVIN (Q3Y598), FOXA3_HUMAN (P55318), 
FOXA3_MOUSE (P35584), FOXA3_RAT   (P32183), FOXA4_XENTR (Q6P839), 
FOXB1_HUMAN (Q99853), FOXB1_MOUSE (Q64732), FOXB1_XENLA (O93529), 
FOXB2_HUMAN (Q5VYV0), FOXB2_MOUSE (Q64733), FOXB2_XENLA (Q8JIT6), 
FOXC1_HUMAN (Q12948), FOXC1_MOUSE (Q61572), FOXC1_XENTR (Q68F77), 
FOXC2_HUMAN (Q99958), FOXC2_MOUSE (Q61850), FOXC2_RAT   (Q63246), 
FOXC2_XENTR (Q6NVT7), FOXD1_CHICK (Q98937), FOXD1_HUMAN (Q16676), 
FOXD1_MOUSE (Q61345), FOXD1_RAT   (Q63251), FOXD1_XENLA (Q9PSY4), 
FOXD1_XENTR (Q6F2E4), FOXD2_HUMAN (O60548), FOXD2_MOUSE (O35392), 
FOXD2_XENLA (Q90WN4), FOXD3_CHICK (P79772), FOXD3_HUMAN (Q9UJU5), 
FOXD3_MOUSE (Q61060), FOXD3_RAT   (Q63245), FOXD3_XENTR (Q5M7L9), 
FOXD4_HUMAN (Q12950), FOXD4_MOUSE (Q60688), FOXD4_RAT   (Q63249), 
FOXD5_XENTR (Q5WM45), FOXE1_HUMAN (O00358), FOXE1_MOUSE (Q8R2I0), 
FOXE1_XENLA (Q5J3Q5), FOXE3_HUMAN (Q13461), FOXE3_MOUSE (Q9QY14), 
FOXE3_RAT   (Q63250), FOXE4_XENLA (Q9PTK2), FOXF1_DANRE (A1L1S5), 
FOXF1_HUMAN (Q12946), FOXF1_MOUSE (Q61080), FOXF1_XENTR (Q28BS5), 
FOXF2_HUMAN (Q12947), FOXF2_MOUSE (O54743), FOXF_CAEEL  (P91278), 
FOXF_DROME  (Q9VS05), FOXG1_CEBCA (Q1A1A6), FOXG1_CERSI (Q1A1A1), 
FOXG1_CHICK (Q90964), FOXG1_CHLPG (Q1A1A5), FOXG1_EPOGA (Q1A1A3), 
FOXG1_EQUQB (Q1A1A2), FOXG1_HUMAN (P55316), FOXG1_MNELE (Q8ITI5), 
FOXG1_MOUSE (Q60987), FOXG1_PIPRU (Q1A1A4), FOXG1_RAT   (Q00939), 
FOXG1_XENLA (Q9YHC5), FOXH1_DANRE (Q9I9E1), FOXH1_HUMAN (O75593), 
FOXH1_MOUSE (O88621), FOXH1_XENLA (P70056), FOXH1_XENTR (Q28GC4), 
FOXI1_HUMAN (Q12951), FOXI1_MOUSE (Q922I5), FOXI1_XENTR (Q6P2Z3), 
FOXI2_HUMAN (Q6ZQN5), FOXI2_MOUSE (Q3I5G5), FOXI2_RAT   (Q63248), 
FOXI2_XENTR (Q28HT3), FOXI3_CANLF (B5RHS5), FOXI3_CHICK (A0A8V0YY16), 
FOXI3_HUMAN (A8MTJ6), FOXI3_MOUSE (D3Z120), FOXJ1_HUMAN (Q92949), 
FOXJ1_MOUSE (Q61660), FOXJ1_RAT   (Q63247), FOXJ1_XENTR (Q5M7N6), 
FOXJ2_HUMAN (Q9P0K8), FOXJ2_MOUSE (Q9ES18), FOXJ2_XENLA (Q68EZ2), 
FOXJ2_XENTR (Q28EM1), FOXJ3_HUMAN (Q9UPW0), FOXJ3_MOUSE (Q8BUR3), 
FOXK1_HUMAN (P85037), FOXK1_MOUSE (P42128), FOXK2_HUMAN (Q01167), 
FOXK2_MOUSE (Q3UCQ1), FOXK2_XENLA (Q7ZX03), FOXL1_DROME (Q02360), 
FOXL1_HUMAN (Q12952), FOXL1_MOUSE (Q64731), FOXL2_BOVIN (Q6VFT7), 
FOXL2_BRALU (Q4VUF1), FOXL2_CAPHI (Q8MIP2), FOXL2_HUMAN (P58012), 
FOXL2_MOUSE (O88470), FOXL2_PIG   (Q6VFT6), FOXL2_RABIT (Q6VFT5), 
FOXL3_HUMAN (A0A1W2PRP0), FOXM1_HUMAN (Q08050), FOXM1_MOUSE (O08696), 
FOXM1_RAT   (P97691), FOXM1_XENLA (Q5W1J6), FOXN1_HUMAN (O15353), 
FOXN1_MOUSE (Q61575), FOXN2_HUMAN (P32314), FOXN2_XENLA (Q66J77), 
FOXN2_XENTR (Q28F43), FOXN3_HUMAN (O00409), FOXN3_MOUSE (Q499D0), 
FOXN3_PIG   (Q33BP8), FOXN3_XENLA (Q3BJS3), FOXN3_XENTR (Q28G71), 
FOXN4_DANRE (A2BGM5), FOXN4_HUMAN (Q96NZ1), FOXN4_MOUSE (Q8K3Q3), 
FOXN4_XENLA (Q3BJS1), FOXO1_BOVIN (E1BPQ1), FOXO1_HUMAN (Q12778), 
FOXO1_ICTTR (Q810W5), FOXO1_MOUSE (Q9R1E0), FOXO1_PIG   (A4L7N3), 
FOXO1_RAT   (G3V7R4), FOXO1_XENLA (Q6EUW2), FOXO1_XENTR (Q66JJ0), 
FOXO3_HUMAN (O43524), FOXO3_MOUSE (Q9WVH4), FOXO3_XENLA (Q6EUW1), 
FOXO4_HUMAN (P98177), FOXO4_MOUSE (Q9WVH3), FOXO6_HUMAN (A8MYZ6), 
FOXO6_MOUSE (Q70KY4), FOXO_CAEEL  (O16850), FOXO_DROAN  (B3LYS5), 
FOXO_DROER  (B3P0K6), FOXO_DROGR  (B4JSC2), FOXO_DROME  (Q95V55), 
FOXO_DROMO  (B4KBF6), FOXO_DROPE  (B4G4S8), FOXO_DROPS  (Q298W7), 
FOXO_DROSE  (B4HF64), FOXO_DROVI  (B4MB78), FOXO_DROWI  (B4NFR1), 
FOXO_DROYA  (B4PTD3), FOXP1_BOVIN (A4IFD2), FOXP1_CHICK (Q58NQ4), 
FOXP1_HUMAN (Q9H334), FOXP1_MOUSE (P58462), FOXP1_RAT   (Q498D1), 
FOXP1_XENLA (Q5W1J5), FOXP2_GORGO (Q8MJ99), FOXP2_HUMAN (O15409), 
FOXP2_HYLLA (Q5QL03), FOXP2_MACMU (Q8MJ97), FOXP2_MOUSE (P58463), 
FOXP2_PANPA (Q8HZ00), FOXP2_PANTR (Q8MJA0), FOXP2_PONPY (Q8MJ98), 
FOXP2_RAT   (P0CF24), FOXP2_XENLA (Q4VYS1), FOXP3_HUMAN (Q9BZS1), 
FOXP3_MACFA (Q6U8D7), FOXP3_MOUSE (Q99JB6), FOXP4_HUMAN (Q8IVH2), 
FOXP4_MOUSE (Q9DBY0), FOXP4_XENLA (Q4VYR7), FOXQ1_HUMAN (Q9C009), 
FOXQ1_MOUSE (O70220), FOXQ1_RAT   (Q63244), FOXS1_HUMAN (O43638), 
FOXS1_MOUSE (Q61574), FX1AA_DANRE (A3RK74), FX1AB_DANRE (A3RK75), 
FX4L1_HUMAN (Q9NU39), FX4L3_HUMAN (Q6VB84), FX4L4_HUMAN (Q8WXT5), 
FX4L5_HUMAN (Q5VV16), FX4L6_HUMAN (Q3SYB3), FXA1A_XENLA (Q6LD29), 
FXA1B_XENLA (P32315), FXA2A_XENLA (Q91765), FXA2B_XENLA (P84961), 
FXA4A_XENLA (P33205), FXA4B_XENLA (P33206), FXC1A_DANRE (Q9DE25), 
FXC1A_XENLA (Q9PVZ3), FXC1B_DANRE (Q9DE24), FXC1B_XENLA (Q32NP8), 
FXC2A_XENLA (Q9PVY9), FXC2B_XENLA (Q9PVY8), FXD3A_XENLA (Q9DEN4), 
FXD3B_XENLA (Q9DEN3), FXD5A_XENLA (Q9PRJ8), FXD5B_XENLA (Q9PT68), 
FXD5C_XENLA (Q9PT67), FXF1A_XENLA (Q9W706), FXF1B_XENLA (Q9W707), 
FXI1A_XENLA (Q91904), FXI1B_XENLA (Q91905), FXI1C_XENLA (Q8JIT5), 
FXI1C_XENTR (Q28D67), FXI1E_XENLA (Q7ZYQ0), FXI1E_XENTR (Q6P8A3), 
FXI2A_XENLA (Q5NDM2), FXI2B_XENLA (Q63ZH2), FXI3A_DANRE (A3KNJ3), 
FXI3B_DANRE (Q7T1C0), FXJ12_XENLA (Q32NH9), FXJ12_XENTR (Q66IG8), 
FXJ1A_DANRE (F1QDF8), FXJ1A_XENLA (Q708W2), FXJ1B_DANRE (F1R8Z9), 
FXJ1B_XENLA (Q708W1), FXP1B_DANRE (Q2LE08), HCM1_YEAST  (P25364), 
LIN31_CAEEL (P34683), MEI4_SCHPO  (O13606), PES1_CAEBR  (Q9GZ14), 
PES1_CAEEL  (G5EGC9), PHA4_CAEEL  (Q17381), QIN_AVIS3   (P56260), 
SEP1_SCHPO  (O43058), SGF1_BOMMO  (Q17241), SLP1_DROME  (P32030), 
SLP2_DROME  (P32031), UN130_CAEEL (Q18694)
» more

UniProtKB/Swiss-Prot
False negative sequences		 7 sequences 

FKHL1_SCHPO (O14270), FOXN5_XENLA (Q3BJS0), FOXN5_XENTR (Q28H65), 

FOXR1_HUMAN (Q6PIV2), FOXR1_MOUSE (Q3UTB7), FOXR2_HUMAN (Q6PJQ5), 
FOXR2_MOUSE (Q3UM89)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

QUEC_LAWIP  (Q1MQ73)


				
	

	

		PDB
[Detailed view]		
		
			58 PDB
			


			pdb_00001d5v; pdb_00001e17; pdb_00001jxs; pdb_00001kq8; pdb_00001vtn; pdb_00002a07; pdb_00002a3s; pdb_00002as5; pdb_00002c6y; pdb_00002d2w; pdb_00002hdc; pdb_00002hfh; 
			
				pdb_00002k86; pdb_00002kiu; pdb_00002uzk; pdb_00003co6; pdb_00003co7; pdb_00003coa; pdb_00003g73; pdb_00003l2c; pdb_00003qrf; pdb_00004lg0; pdb_00004wk8; pdb_00005dui; 
				pdb_00005ocn; pdb_00005x07; pdb_00006ako; pdb_00006akp; pdb_00006el8; pdb_00006lbi; pdb_00006lbm; pdb_00006nce; pdb_00006ncm; pdb_00006o3t; pdb_00006qvw; pdb_00006xat; 
				pdb_00007cby; pdb_00007fj2; pdb_00007tdw; pdb_00007tdx; pdb_00007vou; pdb_00007vov; pdb_00007vox; pdb_00007yz7; pdb_00007yza; pdb_00007yzb; pdb_00007yzc; pdb_00007yzd; 
				pdb_00007yze; pdb_00007yzf; pdb_00007yzg; pdb_00008bzm; pdb_00008sro; pdb_00008srp; pdb_00008vfy; pdb_00008vfz; pdb_00008vg1; pdb_00008vg2
			
			

			» more