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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00659


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PURL: https://purl.expasy.org/prosite/signature/PS00659

Direct ScanProsite submission
General information about the entry

Entry name [info] GLYCOSYL_HYDROL_F5
Accession [info] PS00659
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00565

Name and characterization of the entry

Description [info] Glycosyl hydrolases family 5 signature.
Pattern [info] 
[LIV]-[LIVMFYWGA](2)-[DNEQG]-[LIVMGST]-{SENR}-N-E-[PV]-[RHDNSTLIVFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 190 in 190 different sequences
Number of true positive hits 85 in 85 different sequences
Number of 'unknown' hits 0
Number of false positive hits 105 in 105 different sequences
Number of false negative sequences 73
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 44.74 %
Recall (true positives / (true positives + false negatives)) 53.80 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site(?) at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 85 sequences 

CELDZ_THESZ (A0A0U4EBH5), CELE_ACET2  (P10477), EG5A_PHACH  (Q66NB7), 

EGCR1_ASPFM (H1AE13), EGCSE_CYANO (Q9GV16), EGCSE_HYDVU (Q6L6S1), 
EGH1_YEAST  (P40566), EXG1_CANAL  (P29717), EXG1_SCHPO  (Q9URU6), 
EXG1_WICAO  (O93939), EXG1_YEAST  (P23776), EXG2_CANAL  (Q5AIA1), 
EXG2_WICAO  (O93983), EXG2_YEAST  (P52911), EXG3_SCHPO  (O74799), 
EXG_CANOL   (Q8NKF9), EXG_KLULA   (Q12628), EXG_LACK1   (Q875R9), 
EXG_PICAN   (Q12626), EXG_SACU7   (Q876J3), EXG_SCHOC   (Q12700), 
EXG_YARLI   (Q12725), GUN1_ACIC1  (P54583), GUN1_BACIU  (P07983), 
GUN1_BUTFI  (P20847), GUN1_EVAC2  (P06566), GUN1_RUMAL  (P16216), 
GUN1_SAIFL  (Q04469), GUN2_BACSU  (P10475), GUN2_EVAC2  (P06565), 
GUN2_HYPJE  (P07982), GUN2_HYPJR  (A0A024SH20), GUN3_BACIU  (P23549), 
GUN3_EVAC2  (P19570), GUN3_FIBSS  (P14250), GUN4_RUMAL  (Q07940), 
GUN5_MICS2  (A0A8A1G1R1), GUN5_SALAG  (O85465), GUN5_THEFU  (Q01786), 
GUNA_BUTFI  (P22541), GUNA_CLOLO  (P54937), GUNA_PAEBA  (O08342), 
GUNA_RUMAL  (P23660), GUNA_RUMCH  (P17901), GUNA_RUMFL  (P16169), 
GUNA_STRLI  (P27035), GUNA_XANCP  (P19487), GUNB_ACET2  (P04956), 
GUNB_CALSA  (P10474), GUNB_CLOC7  (P28621), GUNB_NEOPA  (Q12647), 
GUNB_PAELA  (P23550), GUNB_RUMAL  (P23661), GUNC_ACET2  (A3DJ77), 
GUNC_ACETH  (P0C2S3), GUNC_CELJU  (P27033), GUNC_CLOSF  (P23340), 
GUND_CELFI  (P50400), GUND_CLOC7  (P28623), GUND_RUMCH  (P25472), 
GUNG_ACET2  (Q05332), GUNH_ACET2  (P16218), GUNN_PECAT  (Q59394), 
GUNV_PECCC  (Q47096), GUNW_PECPM  (Q59395), GUNZ_DICD3  (P07103), 
GUN_BACS6   (P19424), GUN_CLOSA   (P15704), GUN_HALA3   (P06564), 
GUN_MAREN   (A0A023VXA2), GUN_PAEPO   (P23548), GUN_RALN1   (P58599), 
GUN_RALSL   (P17974), GUN_ROBSP   (P23044), MAN1_ORYSJ  (Q0JKM9), 
MAN2_ORYSJ  (Q0JJD4), MAN5_CELJU  (B3PF24), MAN7_ORYSJ  (Q2RBB1), 
MAN8_ORYSJ  (Q0IQJ7), MANA_STRLI  (P51529), MANB_CALSA  (P22533), 
SPR1_SACU7  (Q876J2), SPR1_YEAST  (P32603), XYNA_THESA  (P36917), 
XYNX_ACETH  (P38535)
» more

UniProtKB/Swiss-Prot
False negative sequences		 73 sequences 

6GAL_HYPRU  (Q76FP5), EGCR1_CRYNH (H1AE12), EGCR1_RHIO9 (I1BTD7), 

EGCSE_RHOH1 (A0A3S5YBC7), EXG2_SCHPO  (Q10444), EXGA_ASPCL  (A1CRV0), 
EXGA_ASPFC  (B0XN12), EXGA_ASPFN  (B8N151), EXGA_ASPFU  (Q4WK60), 
EXGA_ASPNC  (A2RAR6), EXGA_ASPOR  (Q7Z9L3), EXGA_ASPTN  (Q0CR35), 
EXGA_EMENI  (Q5B5X8), EXGA_NEOFI  (A1D4Q5), EXGB_ASPFC  (B0XRX9), 
EXGB_ASPFN  (B8NBJ4), EXGB_ASPFU  (Q4X1N4), EXGB_ASPOR  (Q2TZQ9), 
EXGB_ASPTN  (Q0C8Z0), EXGB_EMENI  (Q5B6Q3), EXGB_NEOFI  (A1DGM6), 
EXGD_ASPCL  (A1CTI3), EXGD_ASPFC  (B0Y7W2), EXGD_ASPFN  (B8NNK9), 
EXGD_ASPFU  (Q4WMP0), EXGD_ASPNC  (A2QX52), EXGD_ASPOR  (Q2UMV7), 
EXGD_ASPTN  (Q0CHZ8), EXGD_EMENI  (Q5AVZ7), EXGD_NEOFI  (A1DMX4), 
EXG_BLUGR   (Q96V64), GUN3_HUMIN  (Q12624), MAN1_ARATH  (Q9FZ29), 
MAN1_SOLLC  (O48540), MAN2_ARATH  (Q7Y223), MAN2_SOLLC  (Q9FZ03), 
MAN3_ARATH  (Q9SG94), MAN3_ORYSJ  (Q0DM48), MAN3_SOLLC  (Q9FUQ6), 
MAN4_ARATH  (Q9SG95), MAN4_ORYSJ  (Q10B67), MAN4_SOLLC  (Q8L5J1), 
MAN5_ARATH  (Q9M0H6), MAN5_ORYSJ  (Q5W6G0), MAN5_SOLLC  (Q6YM50), 
MAN6_ARATH  (Q9LZV3), MAN6_ORYSJ  (Q0DCM5), MAN7_ARATH  (Q9FJZ3), 
MAN9_ORYSJ  (Q6Z310), MANA1_ASPTN (Q0CCD0), MANA2_ASPTN (Q0CUG5), 
MANA_ASPAC  (Q00012), MANA_ASPCL  (A1CGC6), MANA_ASPFN  (B8NVK8), 
MANA_ASPNC  (A2QKT4), MANA_ASPOR  (Q2TXJ2), MANA_CRYAT  (B4XC07), 
MANA_EMENI  (Q5B7X2), MANA_MYTED  (Q8WPJ2), MANA_NEOFI  (A1D8Y6), 
MANB_EMENI  (Q5B833), MANC_ASPTN  (Q0C8J3), MANC_EMENI  (Q5AZ53), 
MAND_EMENI  (Q5AVP1), MANF_ASPCL  (A1C8U0), MANF_ASPFC  (B0Y9E7), 
MANF_ASPFN  (B8NIV9), MANF_ASPFU  (Q4WBS1), MANF_ASPOR  (Q2U2I3), 
MANF_EMENI  (Q5AR04), MANF_NEOFI  (A1DBV1), MANP_ARATH  (Q9LW44), 
YBQ6_YEAST  (P38081)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

EXG_PSEMZ   (P85924), GUN1_ACRSP  (P82288), GUNA_GLOTR  (P84194), 

GUNB_GLOTR  (P84196), GUN_SCHCO   (P81190)
» more

UniProtKB/Swiss-Prot
False positive sequences		 105 sequences 

AGAR_PSEAF  (P13734), AL4A1_DANRE (Q7SY23), AMPA_HELHP  (Q7VGF0), 

ARCA_PSEPK  (Q88P52), ARCA_PSEPU  (P41142), ASP39_ARATH (Q9S9K4), 
ATG4_EREGS  (Q75E61), ATPF1_NITHX (Q1QRI1), C27C1_AQUCT (P0DOX0), 
CDIN1_BOVIN (Q5E9S8), CDIN1_HUMAN (Q9Y2V0), CDIN1_MOUSE (Q3U4G0), 
CDIN1_XENLA (Q6NRW5), CDIN1_XENTR (Q28HL3), CNOT1_CAEEL (Q20937), 
COX1_BACP3  (P16262), CYAA_SCHPO  (P14605), F16A1_PARP8 (B2JEJ7), 
F16A1_PARXL (Q13V64), F16A3_PSET1 (Q3ICJ5), F16PA_ACIAD (Q6F982), 
F16PA_ACISJ (A1W9H6), F16PA_BURL3 (Q39IJ4), F16PA_CAUSK (B0T0R1), 
F16PA_CELJU (B3PGC8), F16PA_HERAR (A4G2P0), F16PA_HERSE (A2RQ29), 
F16PA_IDILO (Q5QVR9), F16PA_PARPJ (B2T699), F16PA_PSYA2 (Q4FUA6), 
F16PA_PSYCK (Q1QDE0), F16PA_RALN1 (Q8XXI7), F16PA_RALPJ (B2U8C4), 
F16PA_SHEAM (A1S351), F16PA_SHEB9 (A9L375), F16PA_SHEDO (Q12JW2), 
F16PA_SHEFN (Q088C3), F16PA_SHEHH (B0TTL6), F16PA_SHELP (A3QAZ7), 
F16PA_SHEON (Q8EAB6), F16PA_SHEPA (A8H0H1), F16PA_SHESA (A0KSW7), 
F16PA_SHESH (A8FRF1), F16PA_SHESM (Q0HMI8), F16PA_SHESR (Q0HRA0), 
F16PA_SHESW (A1RNR2), G6PI_PSEFL  (Q848I4), G6PI_PSEPF  (Q3K6Q4), 
GCSP_BACFN  (Q5LDN2), GCSP_BACFR  (Q64UQ7), HAP2_ARATH  (F4JP36), 
HEPHL_ACRMI (B3EWZ9), ILVB2_BRANA (P14874), JHD1_SCHPO  (O94603), 
K0754_HUMAN (O94854), K0754_MOUSE (Q69ZZ9), LTP_HHV7J   (P52362), 
L_TULV  (Q9YQR5), MACF1_HUMAN (Q9UPN3), MACF1_MOUSE (Q9QXZ0), 
MACF1_RAT   (D3ZHV2), MICA1_DANRE (E7F9T0), MLFA_ASPVC  (A0A319BQC1), 
MYOD_TOXGO  (Q9XYF6), NADL2_HUMAN (Q58DX5), OBSCN_HUMAN (Q5VST9), 
PAC_PRIMG   (Q60136), PAC_RHIVS   (P31956), PNPT1_HUMAN (Q8TCS8), 
PNPT1_MOUSE (Q8K1R3), PNPT1_PONAB (Q5RCW2), PROB_CLOAB  (Q97E63), 
PRUN1_BOVIN (Q5E9Y6), PRUN1_HUMAN (Q86TP1), PRUN1_MOUSE (Q8BIW1), 
PRUN1_RAT   (Q6AYG3), PSA_NAKMY   (C8XAQ3), PTCD3_DANRE (Q32LU7), 
PURL_SACS2  (Q9UX24), PXPA_BACSU  (P42963), PXPA_OCEIH  (Q8EN13), 
R213A_DANRE (A0A0R4IBK5), RECR_AZOC5  (A8IGX4), RFT1_CANGA  (Q6FPE8), 
RL25_RUEPO  (Q5LV90), RNH2_THEPD  (A1RYM0), RPPH_BORBR  (Q7WFP0), 
RPPH_BORPA  (Q7W482), RPPH_BORPE  (Q7VTZ7), RPPH_NITMU  (Q2YBW4), 
RUVC_THIDA  (Q3SGT0), SC15A_ARATH (Q9LXX6), SDK2_MOUSE  (Q6V4S5), 
SP100_MUSCR (O35893), SYFB_PROMP  (Q7V1J8), TAF14_ARATH (F4IPK2), 
TM1R_SOLLC  (A7M6E7), TM1S_SOLLC  (A7M6E8), Y1530_RUBXD (Q1AVT6), 
Y2148_CALS8 (A4XLE5), Y526_SYNWW  (Q0AZJ4), Y5392_ARATH (Q9FID6), 
YB0G_SCHPO  (P87157), YBX7_SCHPO  (Q10201), YL786_MIMIV (Q5UPR9)
» more

PDB
[Detailed view]		 55 PDB

pdb_00001a3h; pdb_00001cec; pdb_00001cz1; pdb_00001e5j; pdb_00001ece; pdb_00001edg; pdb_00001egz; pdb_00001eqc; pdb_00001eqp; pdb_00001g01; pdb_00001g0c; pdb_00001h11; pdb_00001h2j; pdb_00001h4p; pdb_00001h5v; pdb_00001hf6; pdb_00001ocq; pdb_00001qhz; pdb_00001qi0; pdb_00001qi2; pdb_00001vrx; pdb_00001w3k; pdb_00001w3l; pdb_00002a3h; pdb_00002ckr; pdb_00002cks; pdb_00002pb1; pdb_00002pbo; pdb_00002pc8; pdb_00002pf0; pdb_00002v38; pdb_00003a3h; pdb_00003n9k; pdb_00003ndy; pdb_00003ndz; pdb_00003o6a; pdb_00003pzt; pdb_00003pzu; pdb_00003pzv; pdb_00003qr3; pdb_00004a3h; pdb_00004im4; pdb_00004m80; pdb_00004m81; pdb_00004m82; pdb_00004tuf; pdb_00004u3a; pdb_00004u5i; pdb_00004u5k; pdb_00005a3h; pdb_00005byw; pdb_00005fip; pdb_00006a3h; pdb_00007a3h; pdb_00008a3h
» more