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PROSITE entry PS00661


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PURL: https://purl.expasy.org/prosite/signature/PS00661

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General information about the entry

Entry name [info] FERM_2
Accession [info] PS00661
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00566

Name and characterization of the entry

Description [info] FERM domain signature 2.
Pattern [info] 
[HYW]-x(9)-[DENQSTV]-[SA]-x(3)-[FYC]-[LIVM]-x(2,3)-[ACVWD]-x(2)-[LM]-
x(2)-[FY]-[GM]-x-[DENQSTH]-[LIVMFYS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 84 in 84 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 101
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 45.41 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 84 sequences 

E41L1_HUMAN (Q9H4G0), E41L1_MOUSE (Q9Z2H5), E41L1_RAT   (Q9WTP0), 

E41L2_HUMAN (O43491), E41L2_MOUSE (O70318), E41L3_HUMAN (Q9Y2J2), 
E41L3_MOUSE (Q9WV92), E41L5_BOVIN (Q58CU2), E41L5_CANLF (Q9MYU8), 
E41L5_HUMAN (Q9HCM4), E41L5_MOUSE (Q8BGS1), E41L5_RAT   (Q5FVG2), 
E41LA_DANRE (O57457), E41LA_HUMAN (Q9HCS5), E41LA_MOUSE (P52963), 
E41LB_HUMAN (Q9H329), E41LB_MOUSE (Q9JMC8), E41LB_RAT   (B2RYE5), 
EPB41_BOVIN (Q9N179), EPB41_CANLF (Q6Q7P4), EPB41_DROME (Q9V8R9), 
EPB41_HUMAN (P11171), EPB41_MOUSE (P48193), EPB41_XENLA (P11434), 
EZRI_BOVIN  (P31976), EZRI_HUMAN  (P15311), EZRI_MOUSE  (P26040), 
EZRI_RABIT  (Q8HZQ5), EZRI_RAT(P31977), FAK1_CHICK  (Q00944), 
FAK1_HUMAN  (Q05397), FAK1_MOUSE  (P34152), FAK1_RAT(O35346), 
FAK1_XENLA  (Q91738), FERM1_HUMAN (Q9BQL6), FERM1_MOUSE (P59113), 
FERM1_PONAB (Q5R8M5), FRM4A_HUMAN (Q9P2Q2), FRM4A_MOUSE (Q8BIE6), 
FRM4B_HUMAN (Q9Y2L6), FRM4B_MOUSE (Q920B0), MERL_HUMAN  (P35240), 
MERL_MOUSE  (P46662), MERL_PAPAN  (P59750), MERL_RAT(Q63648), 
MOEH_AEDAE  (Q170J7), MOEH_ANOGA  (Q7PS12), MOEH_CULQU  (B0WYY2), 
MOEH_DROME  (P46150), MOEH_DROPS  (Q29GR8), MOESA_DANRE (Q66I42), 
MOES_BOVIN  (Q2HJ49), MOES_HUMAN  (P26038), MOES_LYTVA  (P52962), 
MOES_MOUSE  (P26041), MOES_PIG(P26042), MOES_RAT(O35763), 
PTN14_HUMAN (Q15678), PTN14_MOUSE (Q62130), PTN21_HUMAN (Q16825), 
PTN21_MOUSE (Q62136), PTN21_RAT   (Q62728), PTN3_HUMAN  (P26045), 
PTN3_MOUSE  (A2ALK8), PTN4_HUMAN  (P29074), PTN4_MOUSE  (Q9WU22), 
PTP1_CAEEL  (P28191), RADI_BOVIN  (Q32LP2), RADI_CHICK  (Q9PU45), 
RADI_HUMAN  (P35241), RADI_MOUSE  (P26043), RADI_PIG(P26044), 
TALA1_DICDI (P0CE95), TALA_DICDI  (P0CE94), TLN1_CHICK  (P54939), 
TLN1_HUMAN  (Q9Y490), TLN1_MOUSE  (P26039), TLN2_HUMAN  (Q9Y4G6), 
TLN2_MOUSE  (Q71LX4), TLN_OSCPE   (A0A3G2LGI8), UN112_DROME (Q9VZI3), 
URP2_BOVIN  (Q32LP0), URP2_HUMAN  (Q86UX7), URP2_MOUSE  (Q8K1B8)
» more

UniProtKB/Swiss-Prot
False negative sequences		 101 sequences 

EXPA_DROME  (Q07436), FAK2_HUMAN  (Q14289), FAK2_MOUSE  (Q9QVP9), 

FAK2_RAT(P70600), FARP1_CHICK (F1P065), FARP1_HUMAN (Q9Y4F1), 
FARP1_MOUSE (F8VPU2), FARP1_PONAB (Q5RAB8), FARP1_RAT   (F1LYQ8), 
FARP2_HUMAN (O94887), FARP2_MOUSE (Q91VS8), FERM2_DANRE (F1Q8X5), 
FERM2_HUMAN (Q96AC1), FERM2_MOUSE (Q8CIB5), FR8P1_HUMAN (Q9BZ68), 
FRMA_DICDI  (Q54EW0), FRMB_DICDI  (Q55E74), FRMC_DICDI  (P0CD60), 
FRMD1_HUMAN (Q8N878), FRMD3_HUMAN (A2A2Y4), FRMD3_MOUSE (Q8BHD4), 
FRMD3_PONAB (Q5R803), FRMD3_XENTR (Q0P4Q4), FRMD5_HUMAN (Q7Z6J6), 
FRMD5_MOUSE (Q6P5H6), FRMD6_HUMAN (Q96NE9), FRMD6_MOUSE (Q8C0V9), 
FRMD6_RAT   (Q8VII0), FRMD7_HUMAN (Q6ZUT3), FRMD7_MOUSE (A2AD83), 
FRMD8_HUMAN (Q9BZ67), FRMD8_MOUSE (Q3UFK8), FRMD8_RAT   (Q5U2R3), 
FRMD8_XENLA (Q7ZWP1), FRMD8_XENTR (Q0IJ35), FRPD1_HUMAN (Q5SYB0), 
FRPD1_MOUSE (A2AKB4), FRPD2_HUMAN (Q68DX3), FRPD2_MOUSE (A0A140LI67), 
FRPD3_HUMAN (Q5JV73), FRPD4_HUMAN (Q14CM0), FRPD4_MOUSE (A2AFR3), 
HUM6_CAEBR  (Q622K8), HUM6_CAEEL  (P91443), JAK1_CYPCA  (Q09178), 
JAK1_DANRE  (O12990), JAK1_HUMAN  (P23458), JAK1_MOUSE  (P52332), 
JAK2_CHICK  (Q75R65), JAK2_HUMAN  (O60674), JAK2_MOUSE  (Q62120), 
JAK2_PIG(O19064), JAK2_PONAB  (Q5RB23), JAK2_RAT(Q62689), 
JAK3_HUMAN  (P52333), JAK3_MOUSE  (Q62137), JAK3_RAT(Q63272), 
JAK_DROME   (Q24592), KIN32_CAEEL (Q95YD4), KN14E_ARATH (Q9FHN8), 
KN14I_ORYSJ (Q7XPJ0), KRIT1_BOVIN (Q6TNJ1), KRIT1_DANRE (F1REV3), 
KRIT1_HUMAN (O00522), KRIT1_MOUSE (Q6S5J6), MERH_DROME  (Q24564), 
MYLIA_DANRE (Q6TEM9), MYLIB_DANRE (Q05AK5), MYLIP_HUMAN (Q8WY64), 
MYLIP_MOUSE (Q8BM54), MYLIP_RAT   (D3ZDI6), MYO10_BOVIN (P79114), 
MYO10_HUMAN (Q9HD67), MYO10_MOUSE (F8VQB6), MYO10_RAT   (D3ZJP6), 
MYO15_HUMAN (Q9UKN7), MYO15_MOUSE (Q9QZZ4), MYO7A_AEDAE (Q17LW0), 
MYO7A_DROME (Q9V3Z6), MYO7A_DROPS (Q29P71), MYO7A_HUMAN (Q13402), 
MYO7A_MOUSE (P97479), MYO7B_HUMAN (Q6PIF6), MYO7B_MOUSE (Q99MZ6), 
MYOG_DICDI  (Q86AC8), MYOI_DICDI  (Q9U1M8), PKHH1_DANRE (Q00IB7), 
PKHH1_HUMAN (Q9ULM0), PKHH1_MOUSE (Q80TI1), PKHH2_HUMAN (Q8IVE3), 
PKHH2_MOUSE (Q8C115), PKHH3_HUMAN (Q7Z736), PKHH3_MOUSE (Q8VCE9), 
PKHH3_RAT   (Q3B7L1), PTN13_HUMAN (Q12923), PTN13_MOUSE (Q64512), 
TALB_DICDI  (Q54K81), TYK2_HUMAN  (P29597), TYK2_MOUSE  (Q9R117), 
UN112_CAEEL (Q18685), Y34F_DROME  (Q9W5D0)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

EPB41_CHICK (P12264), EZRI_MESAU  (P86232)


				
	

	

		PDB
[Detailed view]		
		
			168 PDB
			


			pdb_00001e5w; pdb_00001ef1; pdb_00001gc6; pdb_00001gc7; pdb_00001gg3; pdb_00001h4r; pdb_00001isn; pdb_00001j19; pdb_00001mix; pdb_00001miz; pdb_00001mk7; pdb_00001mk9; 
			
				pdb_00001mp8; pdb_00001ni2; pdb_00001sgh; pdb_00001y19; pdb_00002d10; pdb_00002d11; pdb_00002d2q; pdb_00002ems; pdb_00002emt; pdb_00002etm; pdb_00002he7; pdb_00002ijm; 
				pdb_00002j0j; pdb_00002j0k; pdb_00002j0l; pdb_00002j0m; pdb_00002jkk; pdb_00002jkm; pdb_00002jko; pdb_00002jkq; pdb_00002yvc; pdb_00002zpy; pdb_00003bin; pdb_00003bz3; 
				pdb_00003g9w; pdb_00003ivf; pdb_00003pxk; pdb_00003qij; pdb_00003u8z; pdb_00003wa0; pdb_00003x23; pdb_00004brx; pdb_00004c7t; pdb_00004d4r; pdb_00004d4s; pdb_00004d4v; 
				pdb_00004d4y; pdb_00004d55; pdb_00004d58; pdb_00004d5h; pdb_00004d5k; pdb_00004ebv; pdb_00004ebw; pdb_00004f7g; pdb_00004gu6; pdb_00004gu9; pdb_00004i4e; pdb_00004i4f; 
				pdb_00004k8a; pdb_00004k9y; pdb_00004kab; pdb_00004kao; pdb_00004p7i; pdb_00004q9s; pdb_00004rm8; pdb_00004rm9; pdb_00004rma; pdb_00004yl8; pdb_00004zri; pdb_00004zrj; 
				pdb_00004zrk; pdb_00005rym; pdb_00005ryn; pdb_00005ryo; pdb_00005ryp; pdb_00005ryq; pdb_00005ryr; pdb_00005rys; pdb_00005ryt; pdb_00005ryu; pdb_00005ryv; pdb_00005ryw; 
				pdb_00005ryx; pdb_00005ryy; pdb_00005ryz; pdb_00005rz0; pdb_00005rz1; pdb_00005rz2; pdb_00005rz3; pdb_00005rz4; pdb_00005rz5; pdb_00005rz6; pdb_00005rz7; pdb_00005rz8; 
				pdb_00005rz9; pdb_00005rza; pdb_00005rzb; pdb_00005rzc; pdb_00005rzd; pdb_00005rze; pdb_00005rzf; pdb_00005rzg; pdb_00005rzh; pdb_00005rzi; pdb_00005rzj; pdb_00005rzk; 
				pdb_00005rzl; pdb_00005rzm; pdb_00005rzn; pdb_00005rzo; pdb_00005rzp; pdb_00005rzq; pdb_00005rzr; pdb_00005rzs; pdb_00005rzt; pdb_00005rzu; pdb_00005rzv; pdb_00005rzw; 
				pdb_00005rzx; pdb_00005rzy; pdb_00005rzz; pdb_00005s00; pdb_00006cds; pdb_00006gcr; pdb_00006gcw; pdb_00006gcx; pdb_00006i8z; pdb_00006ibe; pdb_00006mfs; pdb_00006r9t; 
				pdb_00006t36; pdb_00006txq; pdb_00006txs; pdb_00006ty3; pdb_00006ty4; pdb_00006u4k; pdb_00006v97; pdb_00006v9g; pdb_00006vgu; pdb_00006yoj; pdb_00006yq1; pdb_00006yr9; 
				pdb_00006yt6; pdb_00006yvs; pdb_00006yvy; pdb_00006yxv; pdb_00007c3m; pdb_00007lwh; pdb_00007pi4; pdb_00008cir; pdb_00008cis; pdb_00008cit; pdb_00008ciu; pdb_00008fse; 
				pdb_00008fso; pdb_00008ftb; pdb_00008gvl; pdb_00008gxe; pdb_00008s4y; pdb_00008t0a; pdb_00008t0d; pdb_00008vdo; pdb_00008vdp; pdb_00008vdq; pdb_00008vdr; pdb_00008y8y
			
			

			» more