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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00661


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PURL: https://purl.expasy.org/prosite/signature/PS00661

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General information about the entry

Entry name [info] FERM_2
Accession [info] PS00661
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00566

Name and characterization of the entry

Description [info] FERM domain signature 2.
Pattern [info] 
[HYW]-x(9)-[DENQSTV]-[SA]-x(3)-[FYC]-[LIVM]-x(2,3)-[ACVWD]-x(2)-[LM]-
x(2)-[FY]-[GM]-x-[DENQSTH]-[LIVMFYS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 84 in 84 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 101
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 45.41 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 84 sequences 

E41L1_HUMAN (Q9H4G0), E41L1_MOUSE (Q9Z2H5), E41L1_RAT   (Q9WTP0), 

E41L2_HUMAN (O43491), E41L2_MOUSE (O70318), E41L3_HUMAN (Q9Y2J2), 
E41L3_MOUSE (Q9WV92), E41L5_BOVIN (Q58CU2), E41L5_CANLF (Q9MYU8), 
E41L5_HUMAN (Q9HCM4), E41L5_MOUSE (Q8BGS1), E41L5_RAT   (Q5FVG2), 
E41LA_DANRE (O57457), E41LA_HUMAN (Q9HCS5), E41LA_MOUSE (P52963), 
E41LB_HUMAN (Q9H329), E41LB_MOUSE (Q9JMC8), E41LB_RAT   (B2RYE5), 
EPB41_BOVIN (Q9N179), EPB41_CANLF (Q6Q7P4), EPB41_DROME (Q9V8R9), 
EPB41_HUMAN (P11171), EPB41_MOUSE (P48193), EPB41_XENLA (P11434), 
EZRI_BOVIN  (P31976), EZRI_HUMAN  (P15311), EZRI_MOUSE  (P26040), 
EZRI_RABIT  (Q8HZQ5), EZRI_RAT(P31977), FAK1_CHICK  (Q00944), 
FAK1_HUMAN  (Q05397), FAK1_MOUSE  (P34152), FAK1_RAT(O35346), 
FAK1_XENLA  (Q91738), FERM1_HUMAN (Q9BQL6), FERM1_MOUSE (P59113), 
FERM1_PONAB (Q5R8M5), FRM4A_HUMAN (Q9P2Q2), FRM4A_MOUSE (Q8BIE6), 
FRM4B_HUMAN (Q9Y2L6), FRM4B_MOUSE (Q920B0), MERL_HUMAN  (P35240), 
MERL_MOUSE  (P46662), MERL_PAPAN  (P59750), MERL_RAT(Q63648), 
MOEH_AEDAE  (Q170J7), MOEH_ANOGA  (Q7PS12), MOEH_CULQU  (B0WYY2), 
MOEH_DROME  (P46150), MOEH_DROPS  (Q29GR8), MOESA_DANRE (Q66I42), 
MOES_BOVIN  (Q2HJ49), MOES_HUMAN  (P26038), MOES_LYTVA  (P52962), 
MOES_MOUSE  (P26041), MOES_PIG(P26042), MOES_RAT(O35763), 
PTN14_HUMAN (Q15678), PTN14_MOUSE (Q62130), PTN21_HUMAN (Q16825), 
PTN21_MOUSE (Q62136), PTN21_RAT   (Q62728), PTN3_HUMAN  (P26045), 
PTN3_MOUSE  (A2ALK8), PTN4_HUMAN  (P29074), PTN4_MOUSE  (Q9WU22), 
PTP1_CAEEL  (P28191), RADI_BOVIN  (Q32LP2), RADI_CHICK  (Q9PU45), 
RADI_HUMAN  (P35241), RADI_MOUSE  (P26043), RADI_PIG(P26044), 
TALA1_DICDI (P0CE95), TALA_DICDI  (P0CE94), TLN1_CHICK  (P54939), 
TLN1_HUMAN  (Q9Y490), TLN1_MOUSE  (P26039), TLN2_HUMAN  (Q9Y4G6), 
TLN2_MOUSE  (Q71LX4), TLN_OSCPE   (A0A3G2LGI8), UN112_DROME (Q9VZI3), 
URP2_BOVIN  (Q32LP0), URP2_HUMAN  (Q86UX7), URP2_MOUSE  (Q8K1B8)
» more

UniProtKB/Swiss-Prot
False negative sequences		 101 sequences 

EXPA_DROME  (Q07436), FAK2_HUMAN  (Q14289), FAK2_MOUSE  (Q9QVP9), 

FAK2_RAT(P70600), FARP1_CHICK (F1P065), FARP1_HUMAN (Q9Y4F1), 
FARP1_MOUSE (F8VPU2), FARP1_PONAB (Q5RAB8), FARP1_RAT   (F1LYQ8), 
FARP2_HUMAN (O94887), FARP2_MOUSE (Q91VS8), FERM2_DANRE (F1Q8X5), 
FERM2_HUMAN (Q96AC1), FERM2_MOUSE (Q8CIB5), FR8P1_HUMAN (Q9BZ68), 
FRMA_DICDI  (Q54EW0), FRMB_DICDI  (Q55E74), FRMC_DICDI  (P0CD60), 
FRMD1_HUMAN (Q8N878), FRMD3_HUMAN (A2A2Y4), FRMD3_MOUSE (Q8BHD4), 
FRMD3_PONAB (Q5R803), FRMD3_XENTR (Q0P4Q4), FRMD5_HUMAN (Q7Z6J6), 
FRMD5_MOUSE (Q6P5H6), FRMD6_HUMAN (Q96NE9), FRMD6_MOUSE (Q8C0V9), 
FRMD6_RAT   (Q8VII0), FRMD7_HUMAN (Q6ZUT3), FRMD7_MOUSE (A2AD83), 
FRMD8_HUMAN (Q9BZ67), FRMD8_MOUSE (Q3UFK8), FRMD8_RAT   (Q5U2R3), 
FRMD8_XENLA (Q7ZWP1), FRMD8_XENTR (Q0IJ35), FRPD1_HUMAN (Q5SYB0), 
FRPD1_MOUSE (A2AKB4), FRPD2_HUMAN (Q68DX3), FRPD2_MOUSE (A0A140LI67), 
FRPD3_HUMAN (Q5JV73), FRPD4_HUMAN (Q14CM0), FRPD4_MOUSE (A2AFR3), 
HUM6_CAEBR  (Q622K8), HUM6_CAEEL  (P91443), JAK1_CYPCA  (Q09178), 
JAK1_DANRE  (O12990), JAK1_HUMAN  (P23458), JAK1_MOUSE  (P52332), 
JAK2_CHICK  (Q75R65), JAK2_HUMAN  (O60674), JAK2_MOUSE  (Q62120), 
JAK2_PIG(O19064), JAK2_PONAB  (Q5RB23), JAK2_RAT(Q62689), 
JAK3_HUMAN  (P52333), JAK3_MOUSE  (Q62137), JAK3_RAT(Q63272), 
JAK_DROME   (Q24592), KIN32_CAEEL (Q95YD4), KN14E_ARATH (Q9FHN8), 
KN14I_ORYSJ (Q7XPJ0), KRIT1_BOVIN (Q6TNJ1), KRIT1_DANRE (F1REV3), 
KRIT1_HUMAN (O00522), KRIT1_MOUSE (Q6S5J6), MERH_DROME  (Q24564), 
MYLIA_DANRE (Q6TEM9), MYLIB_DANRE (Q05AK5), MYLIP_HUMAN (Q8WY64), 
MYLIP_MOUSE (Q8BM54), MYLIP_RAT   (D3ZDI6), MYO10_BOVIN (P79114), 
MYO10_HUMAN (Q9HD67), MYO10_MOUSE (F8VQB6), MYO10_RAT   (D3ZJP6), 
MYO15_HUMAN (Q9UKN7), MYO15_MOUSE (Q9QZZ4), MYO7A_AEDAE (Q17LW0), 
MYO7A_DROME (Q9V3Z6), MYO7A_DROPS (Q29P71), MYO7A_HUMAN (Q13402), 
MYO7A_MOUSE (P97479), MYO7B_HUMAN (Q6PIF6), MYO7B_MOUSE (Q99MZ6), 
MYOG_DICDI  (Q86AC8), MYOI_DICDI  (Q9U1M8), PKHH1_DANRE (Q00IB7), 
PKHH1_HUMAN (Q9ULM0), PKHH1_MOUSE (Q80TI1), PKHH2_HUMAN (Q8IVE3), 
PKHH2_MOUSE (Q8C115), PKHH3_HUMAN (Q7Z736), PKHH3_MOUSE (Q8VCE9), 
PKHH3_RAT   (Q3B7L1), PTN13_HUMAN (Q12923), PTN13_MOUSE (Q64512), 
TALB_DICDI  (Q54K81), TYK2_HUMAN  (P29597), TYK2_MOUSE  (Q9R117), 
UN112_CAEEL (Q18685), Y34F_DROME  (Q9W5D0)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

EPB41_CHICK (P12264), EZRI_MESAU  (P86232)


				
	

	

		PDB
[Detailed view]		
		
			168 PDB
			


			pdb_00001e5w; pdb_00001ef1; pdb_00001gc6; pdb_00001gc7; pdb_00001gg3; pdb_00001h4r; pdb_00001isn; pdb_00001j19; pdb_00001mix; pdb_00001miz; pdb_00001mk7; pdb_00001mk9; 
			
				pdb_00001mp8; pdb_00001ni2; pdb_00001sgh; pdb_00001y19; pdb_00002d10; pdb_00002d11; pdb_00002d2q; pdb_00002ems; pdb_00002emt; pdb_00002etm; pdb_00002he7; pdb_00002ijm; 
				pdb_00002j0j; pdb_00002j0k; pdb_00002j0l; pdb_00002j0m; pdb_00002jkk; pdb_00002jkm; pdb_00002jko; pdb_00002jkq; pdb_00002yvc; pdb_00002zpy; pdb_00003bin; pdb_00003bz3; 
				pdb_00003g9w; pdb_00003ivf; pdb_00003pxk; pdb_00003qij; pdb_00003u8z; pdb_00003wa0; pdb_00003x23; pdb_00004brx; pdb_00004c7t; pdb_00004d4r; pdb_00004d4s; pdb_00004d4v; 
				pdb_00004d4y; pdb_00004d55; pdb_00004d58; pdb_00004d5h; pdb_00004d5k; pdb_00004ebv; pdb_00004ebw; pdb_00004f7g; pdb_00004gu6; pdb_00004gu9; pdb_00004i4e; pdb_00004i4f; 
				pdb_00004k8a; pdb_00004k9y; pdb_00004kab; pdb_00004kao; pdb_00004p7i; pdb_00004q9s; pdb_00004rm8; pdb_00004rm9; pdb_00004rma; pdb_00004yl8; pdb_00004zri; pdb_00004zrj; 
				pdb_00004zrk; pdb_00005rym; pdb_00005ryn; pdb_00005ryo; pdb_00005ryp; pdb_00005ryq; pdb_00005ryr; pdb_00005rys; pdb_00005ryt; pdb_00005ryu; pdb_00005ryv; pdb_00005ryw; 
				pdb_00005ryx; pdb_00005ryy; pdb_00005ryz; pdb_00005rz0; pdb_00005rz1; pdb_00005rz2; pdb_00005rz3; pdb_00005rz4; pdb_00005rz5; pdb_00005rz6; pdb_00005rz7; pdb_00005rz8; 
				pdb_00005rz9; pdb_00005rza; pdb_00005rzb; pdb_00005rzc; pdb_00005rzd; pdb_00005rze; pdb_00005rzf; pdb_00005rzg; pdb_00005rzh; pdb_00005rzi; pdb_00005rzj; pdb_00005rzk; 
				pdb_00005rzl; pdb_00005rzm; pdb_00005rzn; pdb_00005rzo; pdb_00005rzp; pdb_00005rzq; pdb_00005rzr; pdb_00005rzs; pdb_00005rzt; pdb_00005rzu; pdb_00005rzv; pdb_00005rzw; 
				pdb_00005rzx; pdb_00005rzy; pdb_00005rzz; pdb_00005s00; pdb_00006cds; pdb_00006gcr; pdb_00006gcw; pdb_00006gcx; pdb_00006i8z; pdb_00006ibe; pdb_00006mfs; pdb_00006r9t; 
				pdb_00006t36; pdb_00006txq; pdb_00006txs; pdb_00006ty3; pdb_00006ty4; pdb_00006u4k; pdb_00006v97; pdb_00006v9g; pdb_00006vgu; pdb_00006yoj; pdb_00006yq1; pdb_00006yr9; 
				pdb_00006yt6; pdb_00006yvs; pdb_00006yvy; pdb_00006yxv; pdb_00007c3m; pdb_00007lwh; pdb_00007pi4; pdb_00008cir; pdb_00008cis; pdb_00008cit; pdb_00008ciu; pdb_00008fse; 
				pdb_00008fso; pdb_00008ftb; pdb_00008gvl; pdb_00008gxe; pdb_00008s4y; pdb_00008t0a; pdb_00008t0d; pdb_00008vdo; pdb_00008vdp; pdb_00008vdq; pdb_00008vdr; pdb_00008y8y
			
			

			» more