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PROSITE entry PS00697


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General information about the entry

Entry name [info] DNA_LIGASE_A1
Accession [info] PS00697
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00295
Associated ProRule [info] PRU10135

Name and characterization of the entry

Description [info] ATP-dependent DNA ligase AMP-binding site.
Pattern [info]
[EDQH]-{K}-K-{VEDI}-[DN]-G-{GLYN}-R-[GACIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 209 in 204 different sequences
Number of true positive hits 157 in 157 different sequences
Number of 'unknown' hits 0
Number of false positive hits 52 in 47 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 75.12 %
Recall (true positives / (true positives + false negatives)) 91.28 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site(?) at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
157 sequences

DNLI1_ARATH (Q42572), DNLI1_CAEEL (Q27474), DNLI1_DICDI (Q869E1), 
DNLI1_DROME (Q9W1H4), DNLI1_HALWD (Q18HT7), DNLI1_HUMAN (P18858), 
DNLI1_KORCO (B1L3K8), DNLI1_METAC (Q8TSR7), DNLI1_METBF (Q46C04), 
DNLI1_METMA (Q8PVR7), DNLI1_MOUSE (P37913), DNLI1_SCHPO (P12000), 
DNLI1_XENLA (P51892), DNLI1_YEAST (P04819), DNLI2_HALWD (Q18GX5), 
DNLI2_KORCO (B1L3V2), DNLI2_METAC (Q8TMT1), DNLI2_METBF (Q46BA3), 
DNLI2_METMA (Q8PTK1), DNLI2_THEPD (A1RY72), DNLI3_DICDI (Q54QM4), 
DNLI3_HUMAN (P49916), DNLI3_MOUSE (P97386), DNLI3_SCHPO (Q9C1W9), 
DNLI4_ARATH (Q9LL84), DNLI4_ASPFU (Q4WVG8), DNLI4_ASPOR (Q2U6A1), 
DNLI4_CANAL (P52496), DNLI4_CANGA (Q6FVD8), DNLI4_CHICK (Q90YB1), 
DNLI4_COCIM (Q1DKE7), DNLI4_COPC7 (A8N936), DNLI4_COPCI (Q7Z7W5), 
DNLI4_CRIGR (G3GTP0), DNLI4_CRYNB (P0CN09), DNLI4_CRYNJ (P0CN08), 
DNLI4_EMENI (Q5BH83), DNLI4_EREGS (Q75CA4), DNLI4_HUMAN (P49917), 
DNLI4_MOUSE (Q8BTF7), DNLI4_NEUCR (Q7SB49), DNLI4_ORYSJ (Q7X7E9), 
DNLI4_PHANO (Q0UCI9), DNLI4_PONAB (Q5R6L3), DNLI4_SCHPO (O74833), 
DNLI4_YEAST (Q08387), DNLI_ACIAM  (Q02093), DNLI_AERPE  (Q9YD18), 
DNLI_ANAD2  (B8JBM1), DNLI_ANADE  (Q2IH69), DNLI_ANADF  (A7HID3), 
DNLI_ANASK  (B4UIS1), DNLI_AQUAE  (O67398), DNLI_ARCFU  (O29632), 
DNLI_ASFB7  (P35970), DNLI_ASFK5  (P0C992), DNLI_ASFM2  (P26813), 
DNLI_ASFP4  (P0C990), DNLI_ASFWA  (P0C991), DNLI_BEUC1  (C5BW79), 
DNLI_BPT3   (P07717), DNLI_BPT4   (P00970), DNLI_BPT6   (P19088), 
DNLI_BPT7   (P00969), DNLI_CALMQ  (A8MDU6), DNLI_CENSY  (A0RWD6), 
DNLI_DICT6  (B5YD88), DNLI_DICTD  (B8DZX8), DNLI_FOWPN  (Q67480), 
DNLI_HALLT  (B9LUZ9), DNLI_HALMA  (Q5V4R0), DNLI_HALS3  (B0R4C9), 
DNLI_HALSA  (Q9HR35), DNLI_HALVD  (D4GYZ4), DNLI_HYPBU  (A2BJX6), 
DNLI_IGNH4  (A8AB20), DNLI_KINRD  (A6WG40), DNLI_KORVE  (Q1II25), 
DNLI_META3  (A6UVC4), DNLI_METBU  (Q12X08), DNLI_METJA  (Q57635), 
DNLI_METKA  (Q8TWN3), DNLI_METM5  (A4FY19), DNLI_METM6  (A9AAX4), 
DNLI_METM7  (A6VFQ9), DNLI_METMP  (Q6LYM1), DNLI_METS5  (A4YD25), 
DNLI_METST  (Q2NHF9), DNLI_METTF  (P54875), DNLI_METTH  (Q50566), 
DNLI_METTP  (A0B7F9), DNLI_METVS  (A6UNY0), DNLI_MONPV  (A0A7H0DNE6), 
DNLI_MYCA1  (A0QJL0), DNLI_MYCBO  (Q7TTR7), DNLI_MYCBP  (A1KN60), 
DNLI_MYCBT  (C1AGI1), DNLI_MYCGI  (A4TDS2), DNLI_MYCMM  (B2HHE1), 
DNLI_MYCPA  (Q73V97), DNLI_MYCS2  (A0QUP1), DNLI_MYCSJ  (A3PXE2), 
DNLI_MYCSK  (A1UDY9), DNLI_MYCSS  (Q1BB26), DNLI_MYCTA  (A5U776), 
DNLI_MYCTO  (P9WNV4), DNLI_MYCTU  (P9WNV5), DNLI_MYCUA  (A0PTC0), 
DNLI_MYCVP  (A1T6P2), DNLI_NATPD  (Q3IPX0), DNLI_NITMS  (A9A3K1), 
DNLI_NOCFA  (Q5YNY7), DNLI_NOCSJ  (A1SKL2), DNLI_NPVLD  (Q9YMV2), 
DNLI_OPITP  (B1ZZL9), DNLI_PERMH  (C0QSL7), DNLI_PSECP  (B8HCE1), 
DNLI_PYRAB  (P0CL75), DNLI_PYRAE  (O93723), DNLI_PYRAR  (A4WH24), 
DNLI_PYRAY  (P0CL74), DNLI_PYRCJ  (A3MS62), DNLI_PYRFU  (P56709), 
DNLI_PYRHO  (O59288), DNLI_PYRIL  (A1RTK4), DNLI_PYRNV  (B1YA52), 
DNLI_RHOJR  (Q0SG75), DNLI_RHOOB  (C1AX87), DNLI_SACEN  (A4F870), 
DNLI_SACS2  (Q980T8), DNLI_SACSH  (Q9P9K9), DNLI_SORC5  (A9GU24), 
DNLI_STAMF  (A3DP49), DNLI_STRAW  (Q826P6), DNLI_STRCO  (Q9FCB1), 
DNLI_STRGG  (B1W5J2), DNLI_SULAC  (Q4JAM1), DNLI_SULIA  (C3MZR1), 
DNLI_SULIK  (C4KIZ2), DNLI_SULIL  (C3MJ14), DNLI_SULIM  (C3MYD2), 
DNLI_SULIN  (C3NF77), DNLI_SULIY  (C3N834), DNLI_SULTO  (Q976G4), 
DNLI_SULZI  (D2CJS7), DNLI_THEFM  (Q9HH07), DNLI_THEKO  (Q9HHC4), 
DNLI_THEON  (B6YTR4), DNLI_VACCA  (O57250), DNLI_VACCC  (P20492), 
DNLI_VACCW  (P16272), DNLI_VAR67  (P0DOO3), DNLI_VARV   (P0DOO4), 
LIG6_ARATH  (F4HPZ9), LIGC1_MYCS2 (A0R5T2), ROQA_PENRW  (B6HJU6), 
Y1287_AQUAE (O67319)
» more

UniProtKB/Swiss-Prot
False negative sequences
15 sequences

DNLI1_RAT   (Q9JHY8), DNLI1_THEPD (A1RXA6), DNLI_HAEIN  (P44121), 
DNLI_METAR  (Q0W0X1), DNLI_METB6  (A7IAA9), DNLI_METHJ  (Q2FTH4), 
DNLI_METLZ  (A2SR38), DNLI_METMJ  (A3CWP1), DNLI_METPE  (B8GGB8), 
DNLI_METS3  (A5UKX2), DNLI_NANEQ  (Q74M64), DNLI_PICTO  (Q6L195), 
DNLI_THEAC  (Q9HJ26), DNLI_THEVO  (Q979A1), LIGD_BACSU  (O34398)
» more

UniProtKB/Swiss-Prot
False positive sequences
47 sequences

ACVS_AMYLA  (P27743), ACVS_STRCL  (Q01757), ALN_ORYSJ   (B9FDB8), 
AMBB_PSEAE  (Q9I1H0), BDP1_HUMAN  (A6H8Y1), BDP1_MOUSE  (Q571C7), 
BUAA_PETAA  (A0A411L027), CCTN_TALIS  (A0A0U1LQE6), CITS_BACSU  (O34427), 
COX20_YEAST (Q04935), CPG1_PORG3  (B2RM93), DDHA_RHOSU  (Q8GPG4), 
DHOM_LACLA  (Q9CGD8), DHOM_LACLC  (P52985), DLTA_LACLA  (Q9CG49), 
DSBC_BORBR  (Q7WEL4), DSBC_BORPA  (Q7W396), DSBC_BORPE  (Q7VU58), 
ERF99_ARATH (Q8L9K1), FABH_PROMM  (Q7V4F6), FAU1_SULAC  (Q4J9H1), 
FAU1_THEKO  (Q5JHN3), FOLD_BUCAI  (P57557), HAGA1_PORGI (P59915), 
HAGA2_PORGN (Q51845), HEPHL_ACRMI (B3EWZ9), HYUC_RHIML  (Q6DTN4), 
INO80_USTMA (Q4PGL2), KGP38_PORGN (P72194), KGP66_PORGN (P72197), 
KGP83_PORGN (Q51817), KGP_PORG3   (B2RLK2), KUP_ANADF   (A7H902), 
LCSA_PURLI  (A0A179H164), MNME_SULNB  (A6QAL0), NLSA_EMENI  (Q5BDY8), 
NRPS1_ASPFU (Q4WT66), NRPS4_GIBZE (I1RF49), NRPS8_ASPFU (Q4WVN4), 
PAL2_SOLTU  (P31426), PDXB_PORGI  (Q7MV70), PKS1_DICDI  (Q55E72), 
QUEA_DEHM1  (Q3Z8C1), QUEA_STRGC  (A8AYK5), RIMM_SYNR3  (A5GQ79), 
U518_AEDAE  (Q17AI4), U518_ANOGA  (Q7PZ36)
» more

PDB
[Detailed view]
52 PDB

1A0I; 1X9N; 2CFM; 2HIV; 2HIX; 3GDE; 3L2P; 3VNN; 3W1B; 3W1G; 3W5O; 6BKF; 6BKG; 6DT1; 6IMJ; 6IMK; 6IML; 6IMN; 6P09; 6P0A; 6P0B; 6P0C; 6P0D; 6P0E; 6Q1V; 7KR3; 7KR4; 7L34; 7L35; 7LSY; 7LT3; 7NFC; 7NFE; 7QNZ; 7QO1; 7RPO; 7RPW; 7RPX; 7SUM; 7SX5; 7SXE; 8BH3; 8BHV; 8BHY; 8BOT; 8EZA; 8EZB; 8VDN; 8VDS; 8VDT; 8VZL; 8VZM
» more