PROSITE entry PS00720

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General information about the entry

Entry name [info]	RASGEF
Accession [info]	PS00720
Entry type [info]	PATTERN
Date [info]	01-DEC-1992 CREATED; 01-APR-2003 DATA UPDATE; 03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC00594

Name and characterization of the entry

Description [info]	Ras Guanine-nucleotide exchange factors domain signature.
Pattern [info]	[VI]-P-[FYWVI]-x-[GPSV]-x(2)-[LIVMFYK]-x-[DNE]-[LIVM]-x(13,35)-[IVL]-N- [FYME]-x-K.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.

Total number of hits	67 in 67 different sequences
Number of true positive hits	67 in 67 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	68
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	49.63 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

67 sequences

BUD5_YEAST  (P25300), C3G_DROME   (O77086), CDC25_CANAL (P43069),

CDC25_LACKL (Q02342), CDC25_YEAST (P04821), GEFB_DICDI  (Q8IS21), 
GEFC_DICDI  (Q8IS20), GEFK_DICDI  (Q54FF3), GEFS_DICDI  (Q8SSW7), 
GEFV_DICDI  (Q55FD8), GEFW_DICDI  (Q55GH9), GNDS_HUMAN  (Q12967), 
GNDS_MOUSE  (Q03385), GNDS_RAT(Q03386), LTE1_ASHGO  (Q75BH9), 
LTE1_CANGA  (Q6FT12), LTE1_KLULA  (Q6CY10), LTE1_YEAST  (P07866), 
RG1BA_DANRE (Q6DHR3), RG1BB_DANRE (Q6DBW1), RGF1B_BOVIN (A4IFE4), 
RGF1B_HUMAN (Q0VAM2), RGF1B_MOUSE (Q8JZL7), RGF1B_PONAB (Q5RC04), 
RGF1B_XENTR (Q28EC1), RGF1C_HUMAN (Q8N431), RGF1C_MACFA (Q95KH6), 
RGF1C_MOUSE (Q9D300), RGL1_DANRE  (Q6P112), RGL1_HUMAN  (Q9NZL6), 
RGL1_MOUSE  (Q60695), RGL2_CANLF  (Q5TJE5), RGL2_HUMAN  (O15211), 
RGL2_MOUSE  (Q61193), RGL3_HUMAN  (Q3MIN7), RGL3_MOUSE  (Q3UYI5), 
RGRF1_HUMAN (Q13972), RGRF1_MOUSE (P27671), RGRF1_RAT   (P28818), 
RGRF2_DANRE (A2CEA7), RGRF2_HUMAN (O14827), RGRF2_MOUSE (P70392), 
RGRF2_RAT   (Q99JE4), RPGF1_CAEEL (P34578), RPGF1_HUMAN (Q13905), 
RPGF3_HUMAN (O95398), RPGF3_MOUSE (Q8VCC8), RPGF3_RAT   (Q9Z1C8), 
RPGF4_HUMAN (Q8WZA2), RPGF4_MOUSE (Q9EQZ6), RPGF4_RAT   (Q9Z1C7), 
RPGF5_HUMAN (Q92565), RPGF5_MOUSE (Q8C0Q9), RPGF5_RAT   (P83900), 
RPGF_CAEEL  (G5EDB9), SDC25_YEAS1 (B3LTF3), SDC25_YEAS6 (B5VMS9), 
SDC25_YEAS7 (A7A0P0), SDC25_YEAS8 (C8ZCV7), SDC25_YEASX (P0CF32), 
SOS1_HUMAN  (Q07889), SOS1_MOUSE  (Q62245), SOS2_HUMAN  (Q07890), 
SOS2_MOUSE  (Q02384), SOS_DROME   (P26675), STE6_SCHPO  (P26674), 
YL016_YEAST (P0CF34)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

68 sequences

BCAR3_BOVIN (Q58DL5), BCAR3_HUMAN (O75815), BCAR3_MACFA (Q4R8R1),

BCAR3_MOUSE (Q9QZK2), BCAR3_RAT   (D3ZAZ5), BCAR3_XENLA (Q6INP9), 
BEM2_YEAST  (P39960), EFC25_SCHPO (Q9USU1), GBPC_DICDI  (Q8MVR1), 
GBPD_DICDI  (Q54S40), GEFA_DICDI  (Q54PQ4), GEFD_DICDI  (Q8IS19), 
GEFE_DICDI  (Q8IS18), GEFF_DICDI  (Q54C94), GEFG_DICDI  (Q8ST25), 
GEFH_DICDI  (Q8IS16), GEFI_DICDI  (Q8IS15), GEFJ_DICDI  (Q8IS14), 
GEFL_DICDI  (B0M0P8), GEFM_DICDI  (Q8SSQ3), GEFN_DICDI  (Q8IS12), 
GEFO_DICDI  (Q8IS11), GEFP_DICDI  (Q54TK8), GEFQ_DICDI  (Q86G47), 
GEFR_DICDI  (Q8SSQ0), GEFX_DICDI  (Q55EC7), GEFY_DICDI  (Q552M5), 
GRP1_HUMAN  (O95267), GRP1_MOUSE  (Q9Z1S3), GRP1_RAT(Q9R1K8), 
GRP1_XENLA  (Q6NTL4), GRP1_XENTR  (A4IJ06), GRP2A_XENLA (Q32N25), 
GRP2B_XENLA (Q6DCK3), GRP2_BOVIN  (A6N9I4), GRP2_HUMAN  (Q7LDG7), 
GRP2_MOUSE  (Q9QUG9), GRP2_RAT(P0C643), GRP4_BOVIN  (Q1LZ97), 
GRP4_HUMAN  (Q8TDF6), GRP4_MOUSE  (Q8BTM9), GRP4_RAT(Q8R5I4), 
KNDC1_HUMAN (Q76NI1), KNDC1_MOUSE (Q0KK55), PLCE1_HUMAN (Q9P212), 
PLCE1_MOUSE (Q8K4S1), PLCE1_RAT   (Q99P84), RGDSR_HUMAN (Q8IZJ4), 
RGF1A_HUMAN (Q8N9B8), RGF1A_XENTR (A0JM95), RGPS1_CHICK (Q5ZJK0), 
RGPS1_DANRE (B0UXH6), RGPS1_HUMAN (Q5JS13), RGPS1_MOUSE (A2AR50), 
RGPS2_HUMAN (Q86X27), RGPS2_MACFA (Q4R7W3), RGPS2_MOUSE (Q9ERD6), 
RPGF2_BOVIN (F1MSG6), RPGF2_CANLF (F1PBJ0), RPGF2_HUMAN (Q9Y4G8), 
RPGF2_MOUSE (Q8CHG7), RPGF2_RAT   (F1M386), RPGFL_HUMAN (Q9UHV5), 
RPGFL_MOUSE (Q68EF8), RPGFL_PONPY (Q5R9B2), SH2D3_HUMAN (Q8N5H7), 
SH2D3_MOUSE (Q9QZS8), SOS_CAEEL   (Q9N5D3)

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PDB
[Detailed view]

88 PDB

1BKD; 1NVU; 1NVV; 1NVW; 1NVX; 1XD2; 1XD4; 1XDV; 2BYV; 2II0; 2IJE; 3CF6; 3KSY; 4F7Z; 4JGW; 4MGI; 4MGK; 4MGY; 4MGZ; 4MH0; 4NYI; 4NYJ; 4NYM; 4URU; 4URV; 4URW; 4URX; 4URY; 4URZ; 4US0; 4US1; 4US2; 5CM8; 5CM9; 5OVD; 5OVE; 5OVF; 5OVG; 5OVH; 5OVI; 5WFO; 5WFP; 5WFQ; 5WFR; 6BVI; 6BVJ; 6BVK; 6BVL; 6BVM; 6CUO; 6CUP; 6CUR; 6D55; 6D56; 6D59; 6D5E; 6D5G; 6D5H; 6D5J; 6D5L; 6D5M; 6D5V; 6D5W; 6EIE; 6EPL; 6EPM; 6EPN; 6EPO; 6EPP; 6SCM; 6SFR; 6V94; 6V9F; 6V9J; 6V9L; 6V9M; 6V9N; 6V9O; 7AVI; 7AVL; 7AVS; 7AVT; 7AVU; 7AVV; 7KFZ; 7NZZ; 7UKR; 7UKS
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