PROSITE entry PS00726

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00726
Entry name [info]	AP_NUCLEASE_F1_1
Accession [info]	PS00726
Entry type [info]	PATTERN
Date [info]	01-DEC-1992 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00598

Name and characterization of the entry

Description [info]	AP endonucleases family 1 signature 1.
Pattern [info]	[APF]-D-[LIVMF](2)-{T}-[LIVM]-Q-E-{G}-K.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	25 in 25 different sequences
Number of true positive hits	25 in 25 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	5
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	83.33 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	metal(?) at position 7
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

25 sequences

APEA_DICDI  (P51173), APEX1_BOVIN (P23196), APEX1_DANRE (A0MTA1),

APEX1_GORGO (A1YES6), APEX1_HUMAN (P27695), APEX1_MOUSE (P28352), 
APEX1_PANPA (A1YFZ3), APEX1_PANTR (A2T6Y4), APEX1_PONPY (A2T7I6), 
APEX1_RAT   (P43138), APEX2_BOVIN (Q5E9N9), APEX2_HUMAN (Q9UBZ4), 
APEX2_MOUSE (Q68G58), APEX2_XENLA (Q6DDT4), APN2_SCHPO  (P87175), 
ARP_ARATH   (P45951), EX3_ECOLI   (P09030), EX3_HAEIN   (P44318), 
EX3_SALTI   (P0A1B0), EX3_SALTY   (P0A1A9), EXOA_BACSU  (P37454), 
EXOA_STRPN  (P0A2X3), EXOA_STRR6  (P0A2X4), RRP1_DROME  (P27864), 
UREND_METTH (O26314)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

5 sequences

APE1L_ARATH (Q5XF07), APE2_ARATH  (F4JNY0), APEX_PLABA  (A0A509ADV9),

APEX_PLAF7  (O97240), APN2_YEAST  (P38207)

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PDB
[Detailed view]

82 PDB

1AKO; 1BIX; 1DE8; 1DE9; 1DEW; 1E9N; 1HD7; 2ISI; 2O3C; 2O3H; 3FZI; 3G00; 3G0A; 3G0R; 3G1K; 3G2C; 3G2D; 3G38; 3G3C; 3G3Y; 3G4T; 3G8V; 3G91; 3GA6; 3U8U; 3W2X; 3W2Y; 4IEM; 4LND; 4QH9; 4QHD; 4QHE; 5CFE; 5CFG; 5DFF; 5DFH; 5DFI; 5DG0; 5WN0; 5WN1; 5WN3; 5WN4; 5WN5; 6BOQ; 6BOS; 6BOT; 6BOU; 6BOW; 6MK3; 6MKK; 6MKM; 6MKO; 6P94; 6W0Q; 6W2P; 6W3L; 6W3N; 6W3Q; 6W3U; 6W43; 6W4I; 6W4T; 6WCD; 7CD5; 7CD6; 7LPG; 7LPH; 7LPI; 7LPJ; 7MCR; 7MEV; 7TC2; 7TC3; 7TR7; 7U50; 8KA3; 8KA4; 8KA5; 9DP1; 9DP2; 9DP3; 9DP4
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