PROSITE entry PS00727

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PURL: https://purl.expasy.org/prosite/signature/PS00727

Direct ScanProsite submission

General information about the entry

Entry name [info]	AP_NUCLEASE_F1_2
Accession [info]	PS00727
Entry type [info]	PATTERN
Date [info]	01-DEC-1992 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00598

Name and characterization of the entry

Description [info]	AP endonucleases family 1 signature 2.
Pattern [info]	D-[ST]-[FY]-[RP]-[KHQ]-x(7,8)-[FYWD]-[ST]-[FYW](2).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	19 in 19 different sequences
Number of true positive hits	19 in 19 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	11
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	63.33 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

19 sequences

APEA_DICDI  (P51173), APEX1_BOVIN (P23196), APEX1_GORGO (A1YES6),

APEX1_HUMAN (P27695), APEX1_MOUSE (P28352), APEX1_PANPA (A1YFZ3), 
APEX1_PANTR (A2T6Y4), APEX1_PONPY (A2T7I6), APEX1_RAT   (P43138), 
APN2_SCHPO  (P87175), ARP_ARATH   (P45951), EX3_ECOLI   (P09030), 
EX3_HAEIN   (P44318), EX3_SALTI   (P0A1B0), EX3_SALTY   (P0A1A9), 
EXOA_BACSU  (P37454), EXOA_STRPN  (P0A2X3), EXOA_STRR6  (P0A2X4), 
RRP1_DROME  (P27864)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

11 sequences

APE1L_ARATH (Q5XF07), APE2_ARATH  (F4JNY0), APEX1_DANRE (A0MTA1),

APEX2_BOVIN (Q5E9N9), APEX2_HUMAN (Q9UBZ4), APEX2_MOUSE (Q68G58), 
APEX2_XENLA (Q6DDT4), APEX_PLABA  (A0A509ADV9), APEX_PLAF7  (O97240), 
APN2_YEAST  (P38207), UREND_METTH (O26314)

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PDB
[Detailed view]

70 PDB

pdb_00001ako; pdb_00001bix; pdb_00001de8; pdb_00001de9; pdb_00001dew; pdb_00001e9n; pdb_00001hd7; pdb_00002isi; pdb_00002o3h; pdb_00003u8u; pdb_00004iem; pdb_00004lnd; pdb_00004qh9; pdb_00004qhd; pdb_00004qhe; pdb_00005cfe; pdb_00005cfg; pdb_00005dff; pdb_00005dfh; pdb_00005dfi; pdb_00005dfj; pdb_00005dg0; pdb_00005wn0; pdb_00005wn1; pdb_00005wn2; pdb_00005wn4; pdb_00005wn5; pdb_00006boq; pdb_00006bor; pdb_00006bos; pdb_00006bot; pdb_00006bou; pdb_00006bov; pdb_00006bow; pdb_00006mk3; pdb_00006mkk; pdb_00006mkm; pdb_00006mko; pdb_00006p93; pdb_00006p94; pdb_00006w0q; pdb_00006w2p; pdb_00006w3l; pdb_00006w3n; pdb_00006w3q; pdb_00006w3u; pdb_00006w43; pdb_00006w4i; pdb_00006w4t; pdb_00007cd5; pdb_00007cd6; pdb_00007lpg; pdb_00007lph; pdb_00007lpi; pdb_00007lpj; pdb_00007mcr; pdb_00007mev; pdb_00007suv; pdb_00007svb; pdb_00007tc2; pdb_00007tc3; pdb_00007tr7; pdb_00007u50; pdb_00008ka3; pdb_00008ka4; pdb_00008ka5; pdb_00009dp1; pdb_00009dp2; pdb_00009dp3; pdb_00009dp4
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