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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00738


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PURL: https://purl.expasy.org/prosite/signature/PS00738

Direct ScanProsite submission
General information about the entry

Entry name [info] ADOHCYASE_1
Accession [info] PS00738
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00603

Name and characterization of the entry

Description [info] S-adenosyl-L-homocysteine hydrolase signature 1.
Pattern [info] 
[GSAP]-[CS]-N-x-[FYLM]-S-[ST]-[QALKHD]-[DENG]-x-[AV]-[AVTS]-[ADERQ]-
[ACSG]-[LIVMCG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 252 in 252 different sequences
Number of true positive hits 250 in 250 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 99.21 %
Recall (true positives / (true positives + false negatives)) 99.21 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 250 sequences 

SAHH1_ARATH (O23255), SAHH2_ARATH (Q9LK36), SAHH2_DROME (Q9VZX9), 

SAHH2_HUMAN (O43865), SAHH2_MOUSE (Q80SW1), SAHH2_RAT   (B5DFN2), 
SAHH3_BOVIN (A6QLP2), SAHH3_DROME (P50245), SAHH3_HUMAN (Q96HN2), 
SAHH3_MOUSE (Q68FL4), SAHH3_PONAB (Q5R889), SAHHA_XENLA (P51893), 
SAHHB_XENLA (O93477), SAHH_ACIAD  (Q6FA43), SAHH_ACIET  (B9MD45), 
SAHH_ACISJ  (A1W3P0), SAHH_AERPE  (Q9YEF2), SAHH_AGRFC  (Q8UJ99), 
SAHH_ANOGA  (O76757), SAHH_AQUAE  (O67240), SAHH_ARCFU  (O28279), 
SAHH_AROAE  (Q5P6B7), SAHH_BACFR  (Q64MT2), SAHH_BACTN  (Q8A407), 
SAHH_BARHE  (Q6G584), SAHH_BARQU  (Q6G1D6), SAHH_BART1  (A9IL83), 
SAHH_BDEBA  (Q6MNC0), SAHH_BORBR  (Q7WQX5), SAHH_BORPA  (Q7W1Z7), 
SAHH_BORPD  (A9IGY5), SAHH_BORPE  (Q7VUL8), SAHH_BOVIN  (Q3MHL4), 
SAHH_BRADU  (Q89HP6), SAHH_BRAEL  (A0A087WNH6), SAHH_BRASB  (A5ENA7), 
SAHH_BRUA1  (B2S994), SAHH_BRUA2  (Q2YQX8), SAHH_BRUA4  (A6WX40), 
SAHH_BRUAB  (Q57AG3), SAHH_BRUC2  (A9M9T1), SAHH_BRUMB  (C0RFY3), 
SAHH_BRUME  (Q8YE49), SAHH_BRUO2  (A5VT52), SAHH_BRUSI  (B0CJJ7), 
SAHH_BRUSU  (Q8FXZ7), SAHH_BURM7  (A3MQW7), SAHH_BURM9  (A2S6W2), 
SAHH_BURMA  (Q62G22), SAHH_BURMS  (A1V8Z2), SAHH_BURP0  (A3P0L8), 
SAHH_BURP1  (Q3JY79), SAHH_BURP6  (A3NER1), SAHH_BURPS  (Q63PT2), 
SAHH_BURTA  (Q2STU0), SAHH_CAEEL  (P27604), SAHH_CANAL  (P83783), 
SAHH_CATRO  (P35007), SAHH_CAUVC  (Q9ABH0), SAHH_CERSP  (O50562), 
SAHH_CHESB  (Q11CD0), SAHH_CHLCH  (Q3AQC2), SAHH_CHLL2  (B3EDY3), 
SAHH_CHLL3  (Q3B532), SAHH_CHLP8  (B3QMF5), SAHH_CHLPD  (A1BEZ2), 
SAHH_CHLPM  (A4SF77), SAHH_CHLTE  (Q8KEG8), SAHH_CHRFK  (A0M5W6), 
SAHH_CHRVO  (Q7NZF7), SAHH_CORDI  (P61456), SAHH_COREF  (Q8FRJ4), 
SAHH_CORGB  (A4QC87), SAHH_CORGL  (Q8NSC4), SAHH_COXB1  (B6J6H1), 
SAHH_COXB2  (B6J3R0), SAHH_COXBN  (A9KD88), SAHH_COXBU  (Q83A77), 
SAHH_CUPMC  (Q1LS20), SAHH_CUPNH  (Q0KF25), SAHH_CUPPJ  (Q476T8), 
SAHH_CUPTR  (B2AGG2), SAHH_DELAS  (A9C184), SAHH_DICDI  (P10819), 
SAHH_DROME  (Q27580), SAHH_ECTM1  (A4XPF3), SAHH_FLAJ1  (A5FJK3), 
SAHH_FLAPJ  (A6GW32), SAHH_GEOSL  (P61617), SAHH_GLOC7  (B7K8X6), 
SAHH_GLOVI  (Q7NGI6), SAHH_GRABC  (Q0BW40), SAHH_HAHCH  (Q2SLT4), 
SAHH_HALHL  (A1WXM7), SAHH_HALS3  (B0R7F2), SAHH_HALSA  (Q9HN50), 
SAHH_HALWC  (G0LFB0), SAHH_HALWD  (Q18EV6), SAHH_HERAR  (A4G975), 
SAHH_HUMAN  (P23526), SAHH_HYPNA  (Q0C427), SAHH_JANMA  (A6T2Y9), 
SAHH_LEIDO  (P36889), SAHH_LEPBJ  (Q04NN6), SAHH_LEPBL  (Q04WX0), 
SAHH_LEPCP  (B1Y647), SAHH_LEPIC  (Q75FU8), SAHH_LEPIN  (Q8EXV1), 
SAHH_LUPLU  (Q9SP37), SAHH_MACFA  (Q4R596), SAHH_MARMM  (Q0ALW1), 
SAHH_MARSD  (C6C1F4), SAHH_MEDSA  (P50246), SAHH_MESCR  (P93253), 
SAHH_METC4  (B7KSJ4), SAHH_METCA  (Q60CG8), SAHH_METEP  (A9VYP7), 
SAHH_METNO  (B8IPU4), SAHH_METPB  (B1ZLX0), SAHH_METPP  (A2SL00), 
SAHH_METS4  (B0UM37), SAHH_MOUSE  (P50247), SAHH_MYCBO  (Q7TWW7), 
SAHH_MYCBP  (A1KNQ0), SAHH_MYCBT  (C1AH22), SAHH_MYCLB  (B8ZQE9), 
SAHH_MYCLE  (Q9CCJ4), SAHH_MYCMM  (B2HEP6), SAHH_MYCPA  (Q73UK6), 
SAHH_MYCS2  (A4ZHR8), SAHH_MYCSJ  (A3PW97), SAHH_MYCSK  (A1UCK8), 
SAHH_MYCSS  (Q1BCD6), SAHH_MYCTA  (A5U7S2), SAHH_MYCTO  (P9WGV2), 
SAHH_MYCTU  (P9WGV3), SAHH_MYCUA  (A0PRF5), SAHH_MYXXD  (Q1CY84), 
SAHH_NICSY  (P68172), SAHH_NITEC  (Q0AEV8), SAHH_NITEU  (Q82WL1), 
SAHH_NITV2  (Q72EH1), SAHH_NITV4  (A1VFZ7), SAHH_NITV9  (B8DR41), 
SAHH_NOCFA  (Q5YQS7), SAHH_NOSS1  (Q8YX05), SAHH_OLEA2  (Q30WL8), 
SAHH_PARC0  (A1TUG3), SAHH_PARMW  (Q7U9Y3), SAHH_PARP8  (B2JIP4), 
SAHH_PARPJ  (B2T6X2), SAHH_PARXL  (Q13T36), SAHH_PELPB  (B4SD43), 
SAHH_PETCR  (Q01781), SAHH_PHASS  (P50249), SAHH_PIG(Q710C4), 
SAHH_PLACU  (Q4XZZ5), SAHH_PLAF7  (P50250), SAHH_PLAYO  (Q7RKK8), 
SAHH_PNECA  (Q12663), SAHH_POLAQ  (A4T0E9), SAHH_POLNS  (B1XSH8), 
SAHH_PROM0  (A3PFB5), SAHH_PROM2  (A8G7D1), SAHH_PROM3  (A2C620), 
SAHH_PROM4  (A9BD69), SAHH_PROM9  (Q318B6), SAHH_PROMA  (Q7V9P3), 
SAHH_PROMM  (Q7V926), SAHH_PROMP  (Q7UZN3), SAHH_PSE14  (Q48PB5), 
SAHH_PSEA8  (B7V419), SAHH_PSEAB  (Q02TY0), SAHH_PSEAE  (Q9I685), 
SAHH_PSEE4  (Q1I3W5), SAHH_PSEF5  (Q4K4H7), SAHH_PSEFS  (C3K3G6), 
SAHH_PSEP1  (A5WA09), SAHH_PSEPF  (Q3K5D7), SAHH_PSEPG  (B0KM00), 
SAHH_PSEPW  (B1J2Y8), SAHH_PSESM  (Q87V73), SAHH_PSEU2  (Q4ZZ92), 
SAHH_PYRAB  (Q9UYK5), SAHH_PYRAE  (Q8ZTQ7), SAHH_PYRFU  (P50251), 
SAHH_PYRHO  (O58275), SAHH_RALN1  (Q8Y387), SAHH_RALPJ  (B2U774), 
SAHH_RAT(P10760), SAHH_RHIE6  (B3PVW2), SAHH_RHIEC  (Q2KE72), 
SAHH_RHIJ3  (Q1MNC6), SAHH_RHILO  (Q98CM3), SAHH_RHILW  (B5ZV80), 
SAHH_RHIME  (Q92TC1), SAHH_RHIR8  (B9JG53), SAHH_RHOBA  (Q7TTZ5), 
SAHH_RHOCB  (P28183), SAHH_RHOP2  (Q2IZR1), SAHH_RHOPA  (Q6N2N5), 
SAHH_RHOPS  (Q13AQ5), SAHH_RHOPT  (B3QJT3), SAHH_ROSDO  (Q9ZNA5), 
SAHH_SACS2  (P50252), SAHH_SCHPO  (O13639), SAHH_SINMW  (A6UEJ1), 
SAHH_SOLLC  (Q9SWF5), SAHH_SOLUE  (Q01VU1), SAHH_STRAA  (Q936D6), 
SAHH_STRAW  (Q82DC9), SAHH_STRAZ  (Q8GGL7), SAHH_STRCO  (Q9KZM1), 
SAHH_STRGG  (B1VUW6), SAHH_STUS1  (A4VRF7), SAHH_SULAC  (Q4JAZ7), 
SAHH_SULTO  (Q975T0), SAHH_SYNC1  (Q3A392), SAHH_SYNPW  (A5GI30), 
SAHH_SYNS3  (Q0IDX7), SAHH_SYNS9  (Q3B0K7), SAHH_SYNSC  (Q3ANF4), 
SAHH_SYNY3  (P74008), SAHH_THEAC  (Q9HKX4), SAHH_THEKO  (Q5JED2), 
SAHH_THEMA  (O51933), SAHH_THEVB  (Q8DGC8), SAHH_THEVO  (Q979Z4), 
SAHH_TOBAC  (P68173), SAHH_TRIVA  (P51540), SAHH_VARPS  (C5CM29), 
SAHH_WHEAT  (P32112), SAHH_XANAC  (Q8PP84), SAHH_XANC8  (Q4UQZ8), 
SAHH_XANCP  (Q8PCH5), SAHH_XANE5  (Q3BXC6), SAHH_XANOM  (Q2NZE3), 
SAHH_XANOP  (B2SPN6), SAHH_XYLF2  (B2I7N4), SAHH_XYLFA  (Q9PEJ1), 
SAHH_XYLFM  (B0U232), SAHH_XYLFT  (Q87EI8), SAHH_YEAST  (P39954), 
SAHH_ZYMMO  (Q5NR48), SIHH_METAC  (Q8TRA5), SIHH_METJA  (Q58783), 
SIHH_METKA  (P58855), SIHH_METMA  (Q8PUQ4), SIHH_METMP  (Q6LYR8), 
SIHH_METTH  (O27673)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

SAHH_NOVAD  (Q2G6T1), SAHH_SPHAL  (Q1GWT5)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			3 sequences
			


			
SAHH1_POPEU (P84533), SAHH2_POPEU (P84532), SAHH_STRFR  (P26799)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			2 sequences
			


			
BRE1A_ORYSI (A2XW69), BRE1A_ORYSJ (Q7XU27)


				
	

	

		PDB
[Detailed view]		
		
			101 PDB
			


			pdb_00001a7a; pdb_00001b3r; pdb_00001d4f; pdb_00001k0u; pdb_00001ky4; pdb_00001ky5; pdb_00001li4; pdb_00001v8b; pdb_00001xwf; pdb_00002h5l; pdb_00002ziz; pdb_00002zj0; 
			
				pdb_00002zj1; pdb_00003ce6; pdb_00003d64; pdb_00003dhy; pdb_00003glq; pdb_00003gvp; pdb_00003mtg; pdb_00003n58; pdb_00003nj4; pdb_00003ond; pdb_00003one; pdb_00003onf; 
				pdb_00003x2e; pdb_00003x2f; pdb_00004lvc; pdb_00004pfj; pdb_00004pgf; pdb_00004yvf; pdb_00005axa; pdb_00005axb; pdb_00005axc; pdb_00005axd; pdb_00005m5k; pdb_00005m65; 
				pdb_00005m66; pdb_00005m67; pdb_00005tov; pdb_00005tow; pdb_00005w49; pdb_00005w4b; pdb_00006exi; pdb_00006f3n; pdb_00006f3o; pdb_00006f3p; pdb_00006f3q; pdb_00007o5l; 
				pdb_00007o5m; pdb_00007r37; pdb_00007r38; pdb_00007r39; pdb_00007r3a; pdb_00007zd0; pdb_00007zd1; pdb_00007zd2; pdb_00007zd3; pdb_00007zd4; pdb_00007zd7; pdb_00007zd8; 
				pdb_00007zd9; pdb_00008ajs; pdb_00008ajt; pdb_00008aju; pdb_00008ajv; pdb_00008ajw; pdb_00008azf; pdb_00008cfb; pdb_00008cfc; pdb_00008cfd; pdb_00008cfe; pdb_00008cfg; 
				pdb_00008cfh; pdb_00008cfi; pdb_00008cfj; pdb_00008cfk; pdb_00008cfl; pdb_00008cfm; pdb_00008cfn; pdb_00008cfo; pdb_00008cfp; pdb_00008cfq; pdb_00008cfr; pdb_00008cfs; 
				pdb_00008cft; pdb_00008cfu; pdb_00008cfv; pdb_00008cfw; pdb_00008cfx; pdb_00008cfy; pdb_00008cfz; pdb_00008cg0; pdb_00008cg1; pdb_00008cg2; pdb_00008cod; pdb_00008qno; 
				pdb_00009hkv; pdb_00009hkw; pdb_00009hkx; pdb_00009hky; pdb_00009hkz
			
			

			» more