PROSITE entry PS00760

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General information about the entry

Entry name [info]	SPASE_I_2
Accession [info]	PS00760
Entry type [info]	PATTERN
Date [info]	01-DEC-1992 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00418
Associated ProRule [info]	PRU10098

Name and characterization of the entry

Description [info]	Signal peptidases I lysine active site.
Pattern [info]	K-R-[LIVMSTA](2)-[GA]-x-[PG]-G-[DEQ]-x-[LIVM]-x-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.

Total number of hits	46 in 46 different sequences
Number of true positive hits	44 in 44 different sequences
Number of 'unknown' hits	0
Number of false positive hits	2 in 2 different sequences
Number of false negative sequences	22
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	95.65 %
Recall (true positives / (true positives + false negatives))	66.67 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site at position 1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	44 sequences IMP1_SCHPO (O74800), IMP1_YEAST (P28627), LEP1_BACAM (P41026), LEP1_SYNY3 (P72660), LEP2_BACAM (P41025), LEP2_SYNY3 (P73157), LEPP_BACNA (P37943), LEPQ_BACNA (Q57350), LEPS_BACSU (P28628), LEPT_BACSU (P71013), LEPU_BACSU (P42959), LEPV_BACSU (O07560), LEP_AQUAE (O67088), LEP_BACCL (P41027), LEP_BACLI (P42668), LEP_BUCAI (P57347), LEP_BUCAP (Q8K9R0), LEP_BUCBP (Q89AM6), LEP_ECOLI (P00803), LEP_HAEIN (P44454), LEP_PHOLA (Q51876), LEP_PSEAE (Q9I5G7), LEP_PSEFL (P26844), LEP_RICAH (A8GM78), LEP_RICB8 (A8GYE1), LEP_RICBR (Q1RHA1), LEP_RICCK (A8EXI2), LEP_RICCN (Q92JB1), LEP_RICFE (Q4UKA7), LEP_RICM5 (A8F0M1), LEP_RICPR (Q9ZE32), LEP_RICRS (A8GQT7), LEP_RICTY (Q8L2J7), LEP_SALTI (P0A1W3), LEP_SALTY (P0A1W2), LEP_STAAC (Q5HHB9), LEP_STAAM (P0A067), LEP_STAAN (P0A068), LEP_STAAR (Q6GIC3), LEP_STAAS (Q6GAW1), LEP_STAAU (P0A070), LEP_STAAW (P0A069), LEP_STRPN (O07344), LEP_STRR6 (P59662) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	22 sequences IMP1L_HUMAN (Q96LU5), IMP1L_MOUSE (Q9CQU8), IMP1L_XENTR (Q28I39), IMP2L_BOVIN (Q2KI92), IMP2L_DANRE (Q6AZD4), IMP2L_HUMAN (Q96T52), IMP2L_MOUSE (Q8BPT6), IMP2L_SCHPO (Q9UST2), IMP2L_XENLA (Q5PQ63), IMP2_YEAST (P46972), LEPH_STAAC (Q5HHC0), LEPH_STAAM (P0A063), LEPH_STAAN (P0A064), LEPH_STAAR (Q6GIC4), LEPH_STAAS (Q6GAW2), LEPH_STAAU (P0A066), LEPH_STAAW (P0A065), LEP_HELPJ (Q9ZLQ5), LEP_HELPY (O25300), LEP_MYCLE (O33021), LEP_MYCTO (P9WKA0), LEP_MYCTU (P9WKA1) » more
UniProtKB/Swiss-Prot False positive sequences	2 sequences RL18_THEAN (Q4UFD5), RL18_THEPA (Q4N438)
PDB [Detailed view]	10 PDB 1B12; 1KN9; 1T7D; 3IIQ; 3S04; 4WVG; 4WVH; 4WVI; 4WVJ; 6B88