PROSITE entry PS00761

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

Entry name [info]	SPASE_I_3
Accession [info]	PS00761
Entry type [info]	PATTERN
Date [info]	01-DEC-1992 CREATED; 01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00418

Name and characterization of the entry

Description [info]	Signal peptidases I signature 3.
Pattern [info]	[LIVMFYW](2)-{NLPA}-{T}-G-D-[NH]-{PIEW}-x(2)-[SND]-x(2)-[SG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	112 in 112 different sequences
Number of true positive hits	90 in 90 different sequences
Number of 'unknown' hits	0
Number of false positive hits	22 in 22 different sequences
Number of false negative sequences	61
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	80.36 %
Recall (true positives / (true positives + false negatives))	59.60 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	90 sequences IMP1A_ARATH (Q6NLT8), IMP2L_BOVIN (Q2KI92), IMP2L_DANRE (Q6AZD4), IMP2L_HUMAN (Q96T52), IMP2L_MOUSE (Q8BPT6), IMP2L_XENLA (Q5PQ63), IMP2_YEAST (P46972), LEP1_BACAM (P41026), LEP1_SYNY3 (P72660), LEP2_BACAM (P41025), LEP2_SYNY3 (P73157), LEPP_BACNA (P37943), LEPQ_BACNA (Q57350), LEPS_BACSU (P28628), LEPT_BACSU (P71013), LEPU_BACSU (P42959), LEPV_BACSU (O07560), LEP_AQUAE (O67088), LEP_BACCL (P41027), LEP_BACLI (P42668), LEP_BUCAI (P57347), LEP_BUCAP (Q8K9R0), LEP_BUCBP (Q89AM6), LEP_ECOLI (P00803), LEP_HAEIN (P44454), LEP_HELPJ (Q9ZLQ5), LEP_HELPY (O25300), LEP_MYCLE (O33021), LEP_MYCTO (P9WKA0), LEP_MYCTU (P9WKA1), LEP_PHOLA (Q51876), LEP_PSEAE (Q9I5G7), LEP_PSEFL (P26844), LEP_RICAH (A8GM78), LEP_RICB8 (A8GYE1), LEP_RICBR (Q1RHA1), LEP_RICCK (A8EXI2), LEP_RICCN (Q92JB1), LEP_RICFE (Q4UKA7), LEP_RICM5 (A8F0M1), LEP_RICPR (Q9ZE32), LEP_RICRS (A8GQT7), LEP_RICTY (Q8L2J7), LEP_SALTI (P0A1W3), LEP_SALTY (P0A1W2), LEP_STAAC (Q5HHB9), LEP_STAAM (P0A067), LEP_STAAN (P0A068), LEP_STAAR (Q6GIC3), LEP_STAAS (Q6GAW1), LEP_STAAU (P0A070), LEP_STAAW (P0A069), PLSP1_ARATH (Q8H0W1), SC11A_BOVIN (P67810), SC11A_CANLF (P67811), SC11A_HUMAN (P67812), SC11A_MOUSE (Q9R0P6), SC11A_PONAB (Q5R9C7), SC11A_RAT (P42667), SC11B_HUMAN (P0C7V7), SC11C_CANLF (P13679), SC11C_HUMAN (Q9BY50), SC11C_MOUSE (Q9D8V7), SC11C_PONAB (Q5RC30), SC11C_RAT (Q9WTR7), SEC11_CANAL (Q5A869), SEC11_CANAW (C4YNJ0), SEC11_CANDC (B9WKT4), SEC11_CANTT (C5M4J6), SEC11_CLAL4 (C4Y3D4), SEC11_DEBHA (Q6BP15), SEC11_KOMPG (C4QXP7), SEC11_LODEL (A5DS09), SEC11_PICGU (A5DIZ8), SEC11_PICST (A3LXS1), SEC11_PLAF7 (Q8IE14), SEC11_SCHCM (D8Q7Q5), SEC11_YARLI (Q6CAG9), SEC11_YEAS1 (B3LTI7), SEC11_YEAS2 (C7GLT4), SEC11_YEAS7 (A6ZVU2), SEC11_YEAS8 (C8ZAS4), SEC11_YEASA (E7KDY6), SEC11_YEASB (E7Q587), SEC11_YEASL (E7KQ01), SEC11_YEAST (P15367), SEC11_YEASV (E7LVX4), SEC11_YEASZ (E7QG89), TPP1_ARATH (O04348), TPP2_ARATH (Q9M9Z2) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	61 sequences IMP1L_HUMAN (Q96LU5), IMP1L_MOUSE (Q9CQU8), IMP1L_XENTR (Q28I39), IMP1_YEAST (P28627), IMP2L_SCHPO (Q9UST2), LEPH_STAAC (Q5HHC0), LEPH_STAAM (P0A063), LEPH_STAAN (P0A064), LEPH_STAAR (Q6GIC4), LEPH_STAAS (Q6GAW2), LEPH_STAAU (P0A066), LEPH_STAAW (P0A065), LEP_STRPN (O07344), LEP_STRR6 (P59662), SEC11_AJEC8 (F0UDD2), SEC11_AJECG (C0NKT8), SEC11_AJECH (C6HB29), SEC11_AJECN (A6QX24), SEC11_AJEDR (C5G8L5), SEC11_ARTBC (D4ALL0), SEC11_ARTGP (E4V4X0), SEC11_ARTOC (C5FQ45), SEC11_ASPCL (A1CL29), SEC11_ASPFC (B0XWT3), SEC11_ASPFU (Q4WYF4), SEC11_ASPOR (Q2UBW3), SEC11_ASPTN (Q0CQC5), SEC11_BLAGS (C5JJG5), SEC11_CHAGB (Q2H1P3), SEC11_COCP7 (C5PA33), SEC11_COCPS (E9CXH2), SEC11_COLGM (E3QXY4), SEC11_EMENI (Q5B8K4), SEC11_EREGS (Q759W4), SEC11_FUSV7 (C7ZHK5), SEC11_GROCL (F0XJH4), SEC11_KLULA (Q6CMR5), SEC11_LACBS (B0D4L0), SEC11_LACTC (C5DDH1), SEC11_LEPMJ (E5A8D2), SEC11_METAQ (E9E796), SEC11_METRA (E9F8V9), SEC11_NEOFI (A1D6D8), SEC11_NEUCR (Q7RY44), SEC11_OGAPD (E7R7C4), SEC11_PARBA (C1GU90), SEC11_PARBD (C1FYD2), SEC11_PARBP (C0S3S0), SEC11_PENRW (B6HC89), SEC11_PODAN (B2B3T2), SEC11_PYRO7 (A4RGA1), SEC11_PYRTR (B2WEL2), SEC11_PYRTT (E3RR70), SEC11_SCLS1 (A7E716), SEC11_TALMQ (B6Q5G0), SEC11_TALSN (B8M5K5), SEC11_TRIVH (D4D5I1), SEC11_TUBMM (D5GNC3), SEC11_UNCRE (C4JYM4), SEC11_VERA1 (C9S8G0), SEC11_ZYGRC (C5E3W1) » more
UniProtKB/Swiss-Prot False positive sequences	22 sequences ACSA_PASMU (Q9CMW1), ADPRL_MIMIV (Q5UQP4), C508D_DICDI (Q1ZXA4), CBIK_SALTY (Q05592), CCDC9_MOUSE (Q8VC31), CT54_CONVE (Q9BPF7), DGOK_ECOLI (P31459), GLNA1_DICDI (Q86B00), HLDE_DICNV (A5EWS4), MYO7B_MOUSE (Q99MZ6), NACA_DICDI (Q54U07), OADC_PARXL (Q13Q00), PILR3_ARATH (O65679), PUM8_ARATH (Q9LM20), PURT_ACIAD (Q6FAM6), RECA_IDILO (Q5QUB8), SPT_CAUVN (A0A0H3C7E9), SYR_OCEIH (Q8EM45), TCPH_PLAF7 (O77323), THAL_ARATH (Q8L3P4), UBP15_ORYSJ (Q0E2F9), Y309_MYCGE (P47551) » more
PDB [Detailed view]	12 PDB 1B12; 1KN9; 1T7D; 3IIQ; 3S04; 4WVG; 4WVH; 4WVI; 4WVJ; 6B88; 7P2P; 7P2Q