PROSITE entry PS00794

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00794
Entry name [info]	HPPK
Accession [info]	PS00794
Entry type [info]	PATTERN
Date [info]	01-DEC-1992 CREATED; 01-JUL-1999 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00631

Name and characterization of the entry

Description [info]	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature.
Pattern [info]	[KRHD]-x-[GA]-[PSAE]-R-x(2)-D-[LIV]-D-[LIVM](2).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	33 in 33 different sequences
Number of true positive hits	33 in 33 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	5
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	86.84 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

33 sequences

FOL1_DICDI  (Q54YD9), FOL1_PNECA  (P29251), FOL1_YEAST  (P53848),

FOLC_ARATH  (Q1ENB6), FOLKE_LACLA (Q9CGE3), FOLKE_LACLM (Q8GJP4), 
FOLKP_CHLMU (P82602), FOLKP_CHLTR (O84619), FOLM_ARATH  (Q9SZV3), 
FOLM_PEA(O04862), HPPK_AQUAE  (O66550), HPPK_BACSU  (P29252), 
HPPK_CAMJE  (Q9PJ54), HPPK_ECOLI  (P26281), HPPK_HAEIN  (P43777), 
HPPK_HELPJ  (Q9ZM35), HPPK_HELPY  (O25680), HPPK_METEA  (P71512), 
HPPK_MYCBO  (P64144), HPPK_MYCLE  (O69528), HPPK_MYCTO  (P9WNC6), 
HPPK_MYCTU  (P9WNC7), HPPK_PSEAE  (Q9HV71), HPPK_PSEPU  (O87790), 
HPPK_STRP1  (P0C0G3), HPPK_STRP3  (P0DB10), HPPK_STRP6  (Q5XCA6), 
HPPK_STRP8  (Q8P151), HPPK_STRPQ  (P0DB11), HPPK_STRPY  (P0C0G2), 
HPPK_SYNY3  (P72736), SULD_STRPN  (P22291), SULD_STRR6  (P59657)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

5 sequences

FOL1_SCHPO  (Q4LB35), FOLKP_CHLCV (Q821E2), FOLKP_CHLPN (Q9Z7E8),

HPPK_PORG3  (B2RI92), HPPK_PORGI  (P0C936)

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PDB
[Detailed view]

56 PDB

1CBK; 1DY3; 1EQ0; 1EQM; 1EX8; 1HKA; 1HQ2; 1IM6; 1Q0N; 1RAO; 1RB0; 1RTZ; 1RU1; 1RU2; 1TMJ; 1TMM; 2BMB; 2CG8; 2F63; 2F65; 3HCX; 3HD1; 3HD2; 3HSD; 3HSG; 3HSJ; 3HSZ; 3HT0; 3IP0; 3KUE; 3KUG; 3KUH; 3UD5; 3UDE; 3UDV; 4F7V; 4M5G; 4M5H; 4M5I; 4M5J; 4M5K; 4M5L; 4M5M; 4M5N; 5ETK; 5ETL; 5ETM; 5ETN; 5ETO; 5ETP; 6AN4; 6AN6; 7KDO; 7KDR; 7MPY; 8SIF
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