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PROSITE entry PS00815


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General information about the entry

Entry name [info] AIPM_HOMOCIT_SYNTH_1
Accession [info] PS00815
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00643

Name and characterization of the entry

Description [info] Alpha-isopropylmalate and homocitrate synthases signature 1.
Pattern [info] 
L-R-[DE]-G-x-Q-x(4)-{L}-x(5)-K.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 443 in 443 different sequences
Number of true positive hits 429 in 429 different sequences
Number of 'unknown' hits 1
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 36
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 97.06 %
Recall (true positives / (true positives + false negatives)) 92.26 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 429 sequences 

AKSA_METAC  (Q8TKQ6), AKSA_METJA  (Q57926), AKSA_METKA  (Q8TW28), 

AKSA_METMA  (P58967), AKSA_METTH  (O27667), AMT7_ALTAL  (C9K7B8), 
CIMA_AQUAE  (O66682), CIMA_ARCFU  (O29305), CIMA_GEOSL  (Q74C76), 
CIMA_LEPIN  (Q8F3Q1), CIMA_METJA  (Q58787), CIMA_METKA  (Q8TYM1), 
CIMA_METMJ  (A3CUF2), CIMA_METPE  (B8GEI1), CIMA_METTH  (O26819), 
CIMA_STRCO  (O86511), CIMA_SULAC  (Q4J6H1), CIMA_SYNY3  (P74269), 
CIMA_THEMA  (Q9WZ22), FRBC_STRR3  (Q0ZQ46), GLOH_GLAL2  (S3D9F8), 
HOSA_THET2  (O87198), HOSC_YEAST  (P48570), HOSM_PENRW  (O94225), 
HOSM_SCHPO  (Q9Y823), HOSM_YARLI  (Q12726), HOSM_YEAST  (Q12122), 
HTYA_ASPRU  (K0E4E5), LEU11_ARATH (Q9LPR4), LEU11_CALS4 (Q8RDK3), 
LEU11_LEPIN (Q8F445), LEU12_ARATH (Q9C550), LEU12_BACP2 (A8FAK7), 
LEU12_CALS4 (Q8RCF9), LEU12_HYDCU (Q31EF5), LEU12_LEPIN (Q8F8T4), 
LEU12_RALN1 (Q8XSZ5), LEU1A_SOLPN (O04973), LEU1B_SOLPN (O04974), 
LEU1_ACESD  (E3PVH7), LEU1_ACET2  (A3DF94), LEU1_ACIET  (B9MA32), 
LEU1_ACIFD  (C7M0E4), LEU1_ACISJ  (A1W6T7), LEU1_AERHH  (A0KGM9), 
LEU1_AERS4  (A4SR62), LEU1_AFIC5  (B6JB87), LEU1_AGRFC  (Q8UD63), 
LEU1_ALBFT  (Q21VZ1), LEU1_ALCBS  (Q0VLR3), LEU1_ALIB4  (A8ES07), 
LEU1_ALIF1  (Q5E856), LEU1_ALIFM  (B5FGH4), LEU1_ALISL  (B6ELK0), 
LEU1_ANOFW  (B7GH19), LEU1_AQUAE  (O67862), LEU1_ARCFU  (O30020), 
LEU1_AROAE  (Q5NXN2), LEU1_ARTS2  (A0JX36), LEU1_AZOSB  (A1KBD3), 
LEU1_AZOVD  (C1DE40), LEU1_BACAA  (C3P4Z6), LEU1_BACAC  (C3L9Q7), 
LEU1_BACAH  (A0RBL2), LEU1_BACAN  (Q81T68), LEU1_BACC0  (B7JFY5), 
LEU1_BACC1  (Q73BA0), LEU1_BACC3  (C1EMA9), LEU1_BACCN  (A7GMU1), 
LEU1_BACCQ  (B9IUZ0), LEU1_BACCZ  (Q63DX8), LEU1_BACHK  (Q6HLF3), 
LEU1_BACLD  (Q65GI8), LEU1_BACMK  (A9VLG7), LEU1_BACP2  (A8FFW5), 
LEU1_BACSU  (P94565), LEU1_BACVZ  (A7Z7B8), LEU1_BIFLS  (B7GT76), 
LEU1_BLOFL  (Q7VQJ6), LEU1_BLOPB  (Q493R0), LEU1_BORPD  (A9HW07), 
LEU1_BRADU  (Q89GB0), LEU1_BRASB  (A5EP79), LEU1_BRASO  (A4YZ76), 
LEU1_BREBN  (C0Z9C8), LEU1_BRUME  (Q8YIJ3), LEU1_BRUSU  (Q8FZC4), 
LEU1_BUCAI  (Q9ZEY8), LEU1_BUCAP  (O85063), LEU1_BUCBP  (Q89A49), 
LEU1_BUCCC  (Q5WQ01), LEU1_BUCDN  (O85070), LEU1_BUCPS  (P58898), 
LEU1_BUCRP  (P48571), LEU1_BURA4  (B1YTR7), LEU1_BURCH  (A0K933), 
LEU1_BURCJ  (B4E5N2), LEU1_BURCM  (Q0BDB9), LEU1_BURL3  (Q39ED5), 
LEU1_BURM1  (A9AJN4), LEU1_BURO0  (B1JVQ1), LEU1_BURO1  (Q1BV03), 
LEU1_BURP0  (A3NT94), LEU1_BURP1  (Q3JUB9), LEU1_BURP6  (A3N7K7), 
LEU1_BURPS  (Q63VP3), LEU1_BURVG  (A4JGE0), LEU1_CAMC1  (A7ZES2), 
LEU1_CAMFF  (A0RQK7), LEU1_CAMHC  (A7I0N8), LEU1_CAMJ8  (A8FP35), 
LEU1_CAMJD  (A7H667), LEU1_CAMJE  (Q9PLV9), LEU1_CAMJJ  (A1W1X2), 
LEU1_CAMJR  (Q5HS76), LEU1_CARHZ  (Q3AEQ5), LEU1_CATAD  (C7QJN7), 
LEU1_CHRVO  (Q7P0H2), LEU1_CITK8  (A8ALM5), LEU1_CLAM3  (A5CRB9), 
LEU1_CLASE  (B0RCQ8), LEU1_CLOAB  (Q97MC5), LEU1_CLOK1  (B9E371), 
LEU1_CLOK5  (A5MZ76), LEU1_COREF  (Q8FU05), LEU1_CORGB  (A4QAP0), 
LEU1_CORGL  (P42455), LEU1_CROS5  (B1WQQ4), LEU1_CROS8  (A7MIC5), 
LEU1_CUPMC  (Q1LPX2), LEU1_CUPNH  (Q0KCT8), LEU1_CUPPJ  (Q473V1), 
LEU1_CUPTR  (B2AHM5), LEU1_DECAR  (Q47BI0), LEU1_DEIRA  (Q9RUA9), 
LEU1_DESAP  (B1I1Y1), LEU1_DESHY  (Q24PE3), LEU1_DESRM  (A4J181), 
LEU1_DICT6  (B5YEF4), LEU1_DICTD  (B8E2W9), LEU1_ECO24  (A7ZHG6), 
LEU1_ECO27  (B7UIC4), LEU1_ECO45  (B7MAJ9), LEU1_ECO55  (B7LFU5), 
LEU1_ECO57  (Q8X9Z8), LEU1_ECO5E  (B5YZB0), LEU1_ECO7I  (B7NHI2), 
LEU1_ECO81  (B7MNT2), LEU1_ECO8A  (B7M119), LEU1_ECOBW  (C4ZPZ7), 
LEU1_ECOHS  (A7ZW25), LEU1_ECOK1  (A1A7C2), LEU1_ECOL5  (Q0TLR5), 
LEU1_ECOL6  (Q8FL75), LEU1_ECOLC  (B1IRA4), LEU1_ECOLI  (P09151), 
LEU1_ECOLU  (B7N7U9), LEU1_ECOSE  (B6HZ24), LEU1_ECOSM  (B1LG11), 
LEU1_ECOUT  (Q1RGC3), LEU1_EDWI9  (C5B7R4), LEU1_ENDTX  (B1H0A7), 
LEU1_ENT38  (A4W6H9), LEU1_ERWT9  (B2VDA7), LEU1_ESCF3  (B7LWE2), 
LEU1_GEOKA  (Q5KWJ3), LEU1_GEOS4  (D3EBC1), LEU1_GEOSE  (Q8RL85), 
LEU1_GEOSW  (C5D5M0), LEU1_GEOTN  (A4IRH8), LEU1_GLOC7  (B7KJX8), 
LEU1_GLOVI  (Q7NI93), LEU1_HAEI8  (Q4QLS4), LEU1_HAEIE  (A5UD85), 
LEU1_HAEIN  (P43861), LEU1_HALH5  (Q9K8E8), LEU1_HALOH  (B8CX21), 
LEU1_HELHP  (Q7VH30), LEU1_HELMI  (B0TCR1), LEU1_HERSS  (D8J0Q1), 
LEU1_HISS1  (Q0I2G1), LEU1_HISS2  (B0USF6), LEU1_HYDCU  (Q31I16), 
LEU1_IGNH4  (A8AB61), LEU1_KINRD  (A6WDF2), LEU1_KLEP3  (B5Y1W2), 
LEU1_KLEP7  (A6T4L9), LEU1_KOCRD  (B2GHT7), LEU1_LACLA  (Q02141), 
LEU1_LACLS  (Q02YX5), LEU1_LEIXX  (Q6AED3), LEU1_LEPCP  (B1XYA8), 
LEU1_LEPIC  (Q72RL9), LEU1_LISIN  (Q92A28), LEU1_LISMC  (C1KWT1), 
LEU1_LISMF  (Q71Y35), LEU1_LISMH  (B8DBU4), LEU1_LISMO  (Q8Y5R9), 
LEU1_LISW6  (A0AK92), LEU1_LYSSC  (B1HR98), LEU1_MAGMM  (A0LBW3), 
LEU1_MARMS  (A6VSA9), LEU1_METAC  (Q8THA5), LEU1_METCA  (Q605K7), 
LEU1_METI4  (B3DX88), LEU1_METJA  (Q58595), LEU1_METKA  (Q8TYB1), 
LEU1_METMA  (P58968), LEU1_METNO  (B8IHS8), LEU1_METPB  (B1ZDN3), 
LEU1_METPP  (A2SHL8), LEU1_METTH  (O27525), LEU1_MICAE  (P94907), 
LEU1_MICAN  (B0JGK2), LEU1_MYCBO  (Q7TVV6), LEU1_MYCLE  (Q9CB76), 
LEU1_MYCTO  (P9WQB2), LEU1_MYCTU  (P9WQB3), LEU1_MYCUA  (A0PVE6), 
LEU1_NEIG1  (Q5F8D4), LEU1_NEIMA  (Q9JUK6), LEU1_NEIMB  (Q9JZG1), 
LEU1_NEIMF  (A1KTV6), LEU1_NITEC  (Q0AGN5), LEU1_NITEU  (Q820M0), 
LEU1_NITHX  (Q1QJV3), LEU1_NITMU  (Q2YBW0), LEU1_NITOC  (Q3J877), 
LEU1_NITSB  (A6Q4V5), LEU1_NITV9  (B8DM91), LEU1_NITWN  (Q3SQ49), 
LEU1_NOCFA  (Q5YVA5), LEU1_NOSS1  (P48575), LEU1_OCEIH  (Q8EN67), 
LEU1_OLSUV  (E1QWZ1), LEU1_PAEAT  (A1R6V4), LEU1_PARC0  (A1TRT4), 
LEU1_PARD8  (A6LDN1), LEU1_PARL1  (A7HP03), LEU1_PARMW  (Q7U892), 
LEU1_PARP8  (B2JDN6), LEU1_PARPJ  (B2SXZ9), LEU1_PARS2  (A8L551), 
LEU1_PARXL  (Q13WM0), LEU1_PASMU  (Q9CJN5), LEU1_PECAS  (Q6D0G8), 
LEU1_PECCP  (C6DEV8), LEU1_PELTS  (A5D4W0), LEU1_PHOLL  (Q7N129), 
LEU1_PHOPR  (Q6LV24), LEU1_PICP2  (B1XLQ9), LEU1_POLAQ  (A4SXR0), 
LEU1_POLNA  (A1VN06), LEU1_POLNS  (B1XUJ3), LEU1_POLSJ  (Q12B47), 
LEU1_PROM0  (A3PDH0), LEU1_PROM1  (A2C3L7), LEU1_PROM2  (A8G5D5), 
LEU1_PROM3  (A2C859), LEU1_PROM4  (A9BB43), LEU1_PROM5  (A2BX52), 
LEU1_PROM9  (Q31AF9), LEU1_PROMA  (Q7VBG1), LEU1_PROMH  (B4F194), 
LEU1_PROMM  (Q7TUV5), LEU1_PROMP  (Q7V121), LEU1_PROMS  (A2BRP4), 
LEU1_PROMT  (Q46K01), LEU1_PSE14  (Q48LY5), LEU1_PSEA6  (Q15QR4), 
LEU1_PSEA7  (A6V0X2), LEU1_PSEAE  (Q9HXK5), LEU1_PSECP  (B8H8Q9), 
LEU1_PSEE4  (Q1I5K2), LEU1_PSEF5  (Q4K6V7), LEU1_PSEFS  (C3K1K7), 
LEU1_PSEMY  (A4XY24), LEU1_PSEP1  (A5VZB6), LEU1_PSEPF  (Q3K7C3), 
LEU1_PSEPG  (B0KRD9), LEU1_PSEPK  (Q88P28), LEU1_PSEPW  (B1JDI2), 
LEU1_PSESM  (Q886Y1), LEU1_PSEU2  (Q4ZX14), LEU1_PSYIN  (A1SRG8), 
LEU1_PYRAB  (Q9UZ08), LEU1_PYRAE  (Q8ZW35), LEU1_PYRFU  (Q8U2A2), 
LEU1_RALN1  (Q8XXP1), LEU1_RALPJ  (B2UJY9), LEU1_RENSM  (A9WML8), 
LEU1_RHIJ3  (Q1MDH6), LEU1_RHILO  (Q98HN3), LEU1_RHIME  (Q9X7L2), 
LEU1_RHOBA  (Q7UI51), LEU1_RHOP2  (Q2IUT4), LEU1_RHOP5  (Q07PI3), 
LEU1_RHOPA  (Q6N858), LEU1_RHOPB  (Q212A9), LEU1_RHOPS  (Q138Z2), 
LEU1_RHOPT  (B3QCX5), LEU1_RHORT  (Q2RT17), LEU1_RIPO1  (B7JYP4), 
LEU1_RUMCH  (B8I1T7), LEU1_RUTMC  (A1AWA1), LEU1_SACS2  (Q97W36), 
LEU1_SALA4  (B5F7U9), LEU1_SALAR  (A9MQD8), LEU1_SALCH  (Q57TE6), 
LEU1_SALDC  (B5FI58), LEU1_SALEP  (B5R2K9), LEU1_SALG2  (B5RGE4), 
LEU1_SALHS  (B4TJ72), LEU1_SALNS  (B4SU36), LEU1_SALPA  (Q5PDG1), 
LEU1_SALPB  (A9MZK0), LEU1_SALPC  (C0Q5H1), LEU1_SALPK  (B5BLB5), 
LEU1_SALRM  (D5HB86), LEU1_SALSV  (B4TWW1), LEU1_SALTI  (Q8Z9I0), 
LEU1_SALTY  (P15875), LEU1_SCHPO  (O59736), LEU1_SEDSS  (E1R5X1), 
LEU1_SERP5  (A8G9R1), LEU1_SHEAM  (A1S2E0), LEU1_SHEB2  (B8E4K4), 
LEU1_SHEB5  (A3CZK5), LEU1_SHEB8  (A6WIB5), LEU1_SHEB9  (A9KY13), 
LEU1_SHEDO  (Q12SE7), LEU1_SHEFN  (Q07WG9), LEU1_SHEHH  (B0TQM0), 
LEU1_SHELP  (A3QIP0), LEU1_SHEON  (Q8E9N2), LEU1_SHEPA  (A8H9A1), 
LEU1_SHEPC  (A4Y2M0), LEU1_SHEPW  (B8CM39), LEU1_SHESA  (A0L1R0), 
LEU1_SHESH  (A8FQ83), LEU1_SHESM  (Q0HE65), LEU1_SHESR  (Q0HZT4), 
LEU1_SHESW  (A1REY0), LEU1_SHEWM  (B1KKZ4), LEU1_SHIB3  (B2U281), 
LEU1_SHIBS  (Q326G1), LEU1_SHIDS  (Q32K20), LEU1_SHIF8  (Q0T8C4), 
LEU1_SHIFL  (Q83SP0), LEU1_SHISS  (Q3Z5T6), LEU1_SHOC1  (Q5WEN3), 
LEU1_SODGM  (Q2NVW3), LEU1_SOLM1  (C4XPA8), LEU1_SOYBN  (Q39891), 
LEU1_STRAW  (Q82BV3), LEU1_STRCO  (O31046), LEU1_STRG3  (D3HCJ2), 
LEU1_STRM5  (B4SI67), LEU1_STRMK  (B2FT78), LEU1_STRRD  (D2ATJ4), 
LEU1_STUS1  (A4VNV6), LEU1_SULAC  (Q4JA78), LEU1_SULTO  (Q974X3), 
LEU1_SYNAS  (Q2LWJ3), LEU1_SYNPW  (A5GM47), LEU1_SYNR3  (A5GRZ0), 
LEU1_SYNS3  (Q0IBI3), LEU1_SYNS9  (Q3AYY2), LEU1_SYNSC  (Q3AIA2), 
LEU1_SYNY3  (P48576), LEU1_THEFY  (Q47RM9), LEU1_THEMA  (Q9WZ23), 
LEU1_THENN  (B9KB95), LEU1_THEP1  (A5IJM2), LEU1_THESQ  (B1L8U2), 
LEU1_THEVB  (Q8DJ32), LEU1_THIDA  (Q3SHE7), LEU1_TOLAT  (C4LAV7), 
LEU1_TRIEI  (Q112U2), LEU1_TRIV2  (Q3MBA3), LEU1_VARPS  (C5CYP2), 
LEU1_VEREI  (A1WNY5), LEU1_VESOH  (A5CWZ3), LEU1_VIBA3  (B7VIF2), 
LEU1_VIBCH  (Q9KP83), LEU1_VIBCM  (C3LR32), LEU1_VIBPA  (Q87SS7), 
LEU1_VIBVU  (Q8DEE1), LEU1_VIBVY  (Q7MP77), LEU1_WOLSU  (Q7M9W4), 
LEU1_XANAC  (P58900), LEU1_XANC8  (Q4UYG1), LEU1_XANCB  (B0RP28), 
LEU1_XANCP  (P58901), LEU1_XANE5  (Q3BPJ9), LEU1_XANOM  (Q2P761), 
LEU1_XANOP  (B2SNG9), LEU1_XANOR  (Q5H4C6), LEU1_XYLF2  (B2I596), 
LEU1_XYLFA  (Q9PCG3), LEU1_XYLFT  (Q87CL8), LEU1_YEAST  (P06208), 
LEU1_YERE8  (A1JJH7), LEU1_YERP3  (A7FM84), LEU1_YERPA  (Q1C1Z6), 
LEU1_YERPB  (B2K4C9), LEU1_YERPE  (Q8ZIG8), LEU1_YERPG  (A9R142), 
LEU1_YERPN  (Q1CMP5), LEU1_YERPP  (A4TQA2), LEU1_YERPS  (Q66EM1), 
LEU1_YERPY  (B1JK98), LEU9_YEAST  (Q12166), MAM11_EUTJA (P0DO77), 
MAM12_EUTJA (P0DO78), MAM1_ARATH  (Q9FG67), MAM2_ARATH  (Q8VX04), 
MAM3_ARATH  (Q9FN52), NIFV1_NOSS1 (Q44290), NIFV2_NOSS1 (P58637), 
NIFVA_CLOPA (Q00853), NIFV_AZOCH  (P23122), NIFV_AZOVI  (P05342), 
NIFV_CERSP  (Q01181), NIFV_ENTAG  (Q52070), NIFV_FRAAL  (Q47884), 
NIFV_FRASP  (P54610), NIFV_KLEPN  (P05345), NIFV_RHOCA  (Q07179)
» more

UniProtKB/Swiss-Prot
False negative sequences		 36 sequences 

CIMA_METAC  (Q8TJJ1), CIMA_METMA  (P58966), HOSA_PYRAB  (Q9V1J1), 

HOSA_PYRHO  (O59390), HOSA_SACS2  (Q97ZE0), HOSA_SULAC  (Q4J989), 
HOSA_SULIA  (C3N5A3), HOSA_SULIK  (C4KGW9), HOSA_SULIL  (C3MPM7), 
HOSA_SULIM  (C3MYM1), HOSA_SULIN  (C3NHU6), HOSA_SULIY  (C3NDV7), 
HOSA_SULTO  (Q971S5), LEU1_CAUSK  (B0T0G9), LEU1_CAUVC  (Q9A823), 
LEU1_CAUVN  (B8H607), LEU1_STAA1  (A7X4N1), LEU1_STAA2  (A6U3E2), 
LEU1_STAA3  (Q2FF67), LEU1_STAA8  (Q2FWK3), LEU1_STAA9  (A5IUK3), 
LEU1_STAAB  (Q2YUF2), LEU1_STAAC  (Q5HEE4), LEU1_STAAE  (A6QIQ3), 
LEU1_STAAM  (P63476), LEU1_STAAN  (P63477), LEU1_STAAR  (Q6GF16), 
LEU1_STAAS  (Q6G7Q1), LEU1_STAAT  (A8Z4W0), LEU1_STAAW  (P58899), 
LEU1_STACT  (B9DMJ6), LEU1_STAEQ  (Q5HMF9), LEU1_STAES  (Q8CNL3), 
LEU1_STAHJ  (Q4L7U0), LEU1_STAS1  (Q49Z12), NIFV_AZOBR  (P70728)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

LEU1_BUCML  (Q9EVG4), LEU1_BUCUE  (Q9EVH6), LEU1_BUCUM  (Q9EVH0), 

LEU1_BUCUN  (Q9EVI8), LEU1_THETH  (Q56216)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

DESPB_DANRE (A0A8M9PQ61)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			13 sequences
			


			
ASAP3_HUMAN (Q8TDY4), CHLN_TETOB  (Q1KVX6), MNME_ACIAD  (Q6F6L1), 

			
MNME_ACIBT  (A3M8Y8), MNME_ACIBY  (B0V5S5), MNME_ALKEH  (Q0A4L6), 
MNME_METFK  (Q1GXL7), MNME_POLAQ  (A4T0N1), MNME_RHORT  (Q2RN77), 
RPOA_BORAP  (Q0SN05), UDA1_CAEEL  (Q9XU84), WRT1_CAEEL  (Q94128), 
ZEP3_HUMAN  (Q5T1R4)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			20 PDB
			


			1SR9; 2ZTJ; 2ZTK; 2ZYF; 3A9I; 3BLE; 3BLF; 3BLI; 3EWB; 3FIG; 3HPS; 3HPX; 
			
				3HPZ; 3HQ1; 3IVS; 3IVT; 3IVU; 3MI3; 3RMJ; 3U6W
			
			

			» more