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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00859


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PURL: https://purl.expasy.org/prosite/signature/PS00859

Direct ScanProsite submission
General information about the entry

Entry name [info] GTP_CYCLOHYDROL_1_1
Accession [info] PS00859
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00672

Name and characterization of the entry

Description [info] GTP cyclohydrolase I signature 1.
Pattern [info] 
[DENGQST]-[LIVMPF]-[LIVM]-x(1,2)-[KRNQELD]-[DENKGS]-[LIVM]-x(3)-[STG]-x-
C-[EP]-H-H.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 365 in 365 different sequences
Number of true positive hits 365 in 365 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 6
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 98.38 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 365 sequences 

FOLKE_LACLA (Q9CGE3), FOLKE_LACLM (Q8GJP4), GCH11_NOSS1 (Q8YLL1), 

GCH11_PSEAE (Q9HYG8), GCH11_PSEPK (Q88LV4), GCH11_PSESM (Q887V1), 
GCH12_NOSS1 (Q8YN49), GCH12_PSEAE (Q9I351), GCH12_PSEPK (Q88JY1), 
GCH12_PSESM (Q884Q3), GCH1_ACET2  (A3DHH6), GCH1_ACTP2  (A3N0R3), 
GCH1_ACTP7  (B3GXP9), GCH1_ACTPJ  (B0BPI8), GCH1_AERHH  (A0KIN6), 
GCH1_AERS4  (A4SPE8), GCH1_AGRFC  (Q8UEK8), GCH1_ALIF1  (Q5E4E4), 
GCH1_ALIFM  (B5FF36), GCH1_ALISL  (B6EGN8), GCH1_ALKEH  (Q0A939), 
GCH1_ALLAM  (B9JWF1), GCH1_AQUAE  (O66603), GCH1_AZOC5  (A8HUG2), 
GCH1_AZOVD  (C1DHG2), GCH1_BACAA  (C3P598), GCH1_BACAC  (C3L8S8), 
GCH1_BACAH  (A0RBW5), GCH1_BACAN  (Q81SW2), GCH1_BACC0  (B7JGZ6), 
GCH1_BACC1  (Q73AY4), GCH1_BACC2  (B7IP89), GCH1_BACC3  (C1EN08), 
GCH1_BACC4  (B7HHR5), GCH1_BACC7  (B7HL21), GCH1_BACCN  (A7GN48), 
GCH1_BACCQ  (B9IVN3), GCH1_BACCR  (Q81FQ8), GCH1_BACCZ  (Q63DM1), 
GCH1_BACFN  (Q5L925), GCH1_BACFR  (Q64P85), GCH1_BACHK  (Q6HL44), 
GCH1_BACMK  (A9VMC0), GCH1_BACP2  (A8FEL2), GCH1_BACSU  (P19465), 
GCH1_BACTN  (Q8A0U0), GCH1_BACVZ  (A7Z630), GCH1_BARBK  (A1USJ5), 
GCH1_BARHE  (Q6G3J8), GCH1_BARQU  (Q6FZZ4), GCH1_BAUCH  (Q1LT77), 
GCH1_BEII9  (B2IBC4), GCH1_BIFLD  (B3DR12), GCH1_BIFLO  (Q8G3S1), 
GCH1_BLOFL  (Q7VRX3), GCH1_BLOPB  (Q492J7), GCH1_BRADU  (Q89IW2), 
GCH1_BREBN  (C0ZCC7), GCH1_BRUA1  (B2S5T0), GCH1_BRUA2  (Q2YQ03), 
GCH1_BRUA4  (A6X0X0), GCH1_BRUAB  (Q57D61), GCH1_BRUC2  (A9M586), 
GCH1_BRUMB  (C0RJ47), GCH1_BRUME  (Q8YH94), GCH1_BRUO2  (A5VQL0), 
GCH1_BRUSI  (B0CGM4), GCH1_BRUSU  (Q8G0L4), GCH1_BUCAP  (Q8KA05), 
GCH1_CAEEL  (Q19980), GCH1_CALS4  (Q8R7N2), GCH1_CAMC1  (A7ZB36), 
GCH1_CAMC5  (A7GW42), GCH1_CAMJ8  (A8FJZ5), GCH1_CAMJD  (A7H1R1), 
GCH1_CAMJE  (P51594), GCH1_CAMJJ  (A1VXS2), GCH1_CAMJR  (Q5HWX4), 
GCH1_CAMLR  (B9KDZ8), GCH1_CARHZ  (Q3ADI2), GCH1_CAUVC  (Q9AAY3), 
GCH1_CHESB  (Q11JM4), GCH1_CHICK  (P50141), GCH1_CHLCH  (Q3ATN0), 
GCH1_CHLPM  (A4SF37), GCH1_CHLTE  (Q8KEA8), GCH1_CHRSD  (Q1QV64), 
GCH1_CHRVO  (Q7NYZ2), GCH1_CITK8  (A8AE79), GCH1_CLOAB  (Q97D54), 
GCH1_CLOB1  (A7FU67), GCH1_CLOB6  (C3KVW3), GCH1_CLOB8  (A6LWG6), 
GCH1_CLOBH  (A5I231), GCH1_CLOBJ  (C1FN26), GCH1_CLOBK  (B1IL94), 
GCH1_CLOBL  (A7GDP1), GCH1_CLOBM  (B1L1S1), GCH1_CLOD6  (Q18BW7), 
GCH1_CLOK1  (B9E092), GCH1_CLOK5  (A5N6S3), GCH1_CLONN  (A0Q2L7), 
GCH1_CLOP1  (Q0TRM0), GCH1_CLOPE  (Q8XLM2), GCH1_CLOPS  (Q0STY9), 
GCH1_CORA7  (C3PJE8), GCH1_COREF  (Q8FMG3), GCH1_CORGB  (A4QH94), 
GCH1_CORGL  (Q8NM84), GCH1_COXBN  (A9KFF3), GCH1_COXBR  (A9NDB3), 
GCH1_COXBU  (Q83DE3), GCH1_DEHM1  (Q3Z782), GCH1_DEHMB  (A5FQD3), 
GCH1_DEHMC  (Q3ZYB5), GCH1_DEIRA  (Q9RYB4), GCH1_DESRM  (A4J5D0), 
GCH1_DICDI  (Q94465), GCH1_DROME  (P48596), GCH1_ECO24  (A7ZNX6), 
GCH1_ECO27  (B7UFG9), GCH1_ECO45  (B7MF66), GCH1_ECO55  (B7LAH4), 
GCH1_ECO57  (P0A6T7), GCH1_ECO5E  (B5YWU3), GCH1_ECO7I  (B7NMB8), 
GCH1_ECO81  (B7MXG6), GCH1_ECO8A  (B7M4Z9), GCH1_ECOBW  (C4ZU03), 
GCH1_ECODH  (B1X7P1), GCH1_ECOHS  (A8A214), GCH1_ECOK1  (A1AD13), 
GCH1_ECOL5  (Q0TFT7), GCH1_ECOL6  (P0A6T6), GCH1_ECOLC  (B1IYB6), 
GCH1_ECOLI  (P0A6T5), GCH1_ECOLU  (B7NCI3), GCH1_ECOSE  (B6I8K3), 
GCH1_ECOSM  (B1LKQ0), GCH1_ECOUT  (Q1R9R9), GCH1_EDWI9  (C5BCL9), 
GCH1_ENT38  (A4WCI8), GCH1_ENTFA  (Q82Z12), GCH1_ERWT9  (B2VII2), 
GCH1_ESCF3  (B7LVB3), GCH1_FINM2  (B0S1R1), GCH1_FLAJ1  (A5FHM7), 
GCH1_FUSNN  (Q8RH43), GCH1_GEOKA  (Q5KXT7), GCH1_GEOSW  (C5D3E8), 
GCH1_GLOVI  (Q7NK98), GCH1_HAEDU  (Q7VM90), GCH1_HAEI8  (Q4QKH4), 
GCH1_HAEIE  (A5UC59), GCH1_HAEIG  (A5UEW4), GCH1_HAEIN  (P43866), 
GCH1_HAHCH  (Q2SPJ2), GCH1_HALH5  (Q9KCC7), GCH1_HELHP  (Q7VFG4), 
GCH1_HELP2  (B6JME9), GCH1_HELPG  (B5Z7T2), GCH1_HELPH  (Q1CSU6), 
GCH1_HELPJ  (Q9ZKS2), GCH1_HELPS  (B2UU76), GCH1_HELPY  (P56462), 
GCH1_HISS1  (Q0I3F6), GCH1_HISS2  (B0UUA9), GCH1_HUMAN  (P30793), 
GCH1_HYDS0  (B4U640), GCH1_HYPNA  (Q0BXB5), GCH1_JANMA  (A6SZ52), 
GCH1_KLEP3  (B5XP57), GCH1_KLEP7  (A6TBN8), GCH1_LACPL  (Q88ST4), 
GCH1_LATSS  (Q38WN0), GCH1_LEIXX  (Q6ACQ1), GCH1_LEPBA  (B0S8X8), 
GCH1_LEPBJ  (Q04P36), GCH1_LEPBL  (Q056J8), GCH1_LEPBP  (B0SRX6), 
GCH1_LEPIC  (Q72LY8), GCH1_LEPIN  (Q8EYG1), GCH1_LISIN  (Q92A75), 
GCH1_LISMC  (C1KWN3), GCH1_LISMF  (Q71Y82), GCH1_LISMH  (B8DBZ3), 
GCH1_LISMO  (Q8Y5X1), GCH1_LISW6  (A0AK45), GCH1_LYSSC  (B1HTA3), 
GCH1_MANSM  (Q65TR0), GCH1_METCA  (Q607T5), GCH1_METS4  (B0U881), 
GCH1_MOUSE  (Q05915), GCH1_MYCA1  (A0QA85), GCH1_MYCA9  (B1MGU9), 
GCH1_MYCBO  (P64208), GCH1_MYCBP  (A1KPU4), GCH1_MYCBT  (C1AI67), 
GCH1_MYCGI  (A4T5P2), GCH1_MYCLB  (B8ZU42), GCH1_MYCLE  (O69531), 
GCH1_MYCMM  (B2HJ53), GCH1_MYCPA  (Q743Z2), GCH1_MYCTA  (A5U8T4), 
GCH1_MYCTO  (P9WN56), GCH1_MYCTU  (P9WN57), GCH1_MYCUA  (A0PV57), 
GCH1_MYCVP  (A1TG42), GCH1_NEUCR  (P51599), GCH1_NOSP7  (B2J1L7), 
GCH1_ONCMY  (P51596), GCH1_OSTOS  (O61573), GCH1_PARD8  (A6LFE8), 
GCH1_PASMU  (P57865), GCH1_PECAS  (Q6D3N3), GCH1_PECCP  (C6DEM6), 
GCH1_PELTS  (A5D2D8), GCH1_PELUB  (Q4FL89), GCH1_PERMH  (C0QPU5), 
GCH1_PHOLL  (Q7N6K7), GCH1_PHOPR  (Q6LQL4), GCH1_PHYBL  (P51600), 
GCH1_PORG3  (B2RIJ1), GCH1_PORGI  (Q7MWI5), GCH1_PSEA6  (Q15YG1), 
GCH1_PSET1  (Q3IF89), GCH1_PYRAE  (Q8ZWW5), GCH1_PYRNV  (B1YCT7), 
GCH1_RALN1  (Q8XZK8), GCH1_RAT(P22288), GCH1_RHILO  (Q98LQ6), 
GCH1_RHIME  (Q92QB4), GCH1_RHOBA  (Q7UJJ7), GCH1_RHOP2  (Q2IY20), 
GCH1_RHOPA  (Q6N4E7), GCH1_RHOPB  (Q212N0), GCH1_RHOPS  (Q134L7), 
GCH1_RHOPT  (B3QE25), GCH1_RICAE  (C3PNA0), GCH1_RICAH  (A8GN89), 
GCH1_RICB8  (A8GUB6), GCH1_RICBR  (Q1RID0), GCH1_RICCN  (Q92I93), 
GCH1_RICFE  (Q4ULX3), GCH1_RICM5  (A8F1F2), GCH1_RICPR  (Q9ZDE8), 
GCH1_RICPU  (C4K2D8), GCH1_RICRO  (B0BXB8), GCH1_RICRS  (A8GRW0), 
GCH1_RICTY  (Q68WZ4), GCH1_RUMCH  (B8I184), GCH1_SACI1  (C3NGB7), 
GCH1_SACI2  (C3MR62), GCH1_SACI3  (C3MZ97), GCH1_SACI4  (C3MXF1), 
GCH1_SACI6  (C4KIH5), GCH1_SACI7  (C3N7B7), GCH1_SACS2  (Q980E8), 
GCH1_SALA4  (B5EYP3), GCH1_SALAR  (A9MK63), GCH1_SALCH  (Q57ME6), 
GCH1_SALDC  (B5FNJ7), GCH1_SALEP  (B5R163), GCH1_SALG2  (B5RC32), 
GCH1_SALHS  (B4TAL5), GCH1_SALNS  (B4SY26), GCH1_SALPA  (Q5PE52), 
GCH1_SALPB  (A9N6K0), GCH1_SALPC  (C0Q0U7), GCH1_SALPK  (B5BE43), 
GCH1_SALSV  (B4TNQ0), GCH1_SALTI  (P64210), GCH1_SALTY  (P64209), 
GCH1_SCHPO  (O13774), GCH1_SERP5  (A8GC24), GCH1_SHEAM  (A1S2C7), 
GCH1_SHEB2  (B8E4J0), GCH1_SHEB5  (A3CZJ1), GCH1_SHEB8  (A6WIA1), 
GCH1_SHEB9  (A9KXZ9), GCH1_SHEDO  (Q12SG0), GCH1_SHELP  (A3QIQ4), 
GCH1_SHEON  (Q8E9L6), GCH1_SHEPC  (A4Y2K7), GCH1_SHESA  (A0L1S4), 
GCH1_SHESM  (Q0HE51), GCH1_SHESR  (Q0HZU8), GCH1_SHESW  (A1REU0), 
GCH1_SHIB3  (B2TVT9), GCH1_SHIBS  (Q31YW1), GCH1_SHIDS  (Q32EN8), 
GCH1_SHIF8  (Q0T2X1), GCH1_SHIFL  (P0A6T8), GCH1_SHISS  (Q3Z053), 
GCH1_SINFN  (C3MB45), GCH1_SINMW  (A6U8C2), GCH1_SODGM  (Q2NUE3), 
GCH1_STRA1  (Q3K0Y1), GCH1_STRA3  (Q8E549), GCH1_STRA5  (Q8DZI5), 
GCH1_STRAW  (Q82EE8), GCH1_STRCO  (Q9X8I3), GCH1_STRGC  (A8AZD8), 
GCH1_STRGG  (B1VSG4), GCH1_STRMU  (Q8DUG2), GCH1_STRP1  (P0C0C2), 
GCH1_STRP2  (Q04MF9), GCH1_STRP3  (P0DB30), GCH1_STRP4  (B5E6W5), 
GCH1_STRP6  (Q5XCA9), GCH1_STRP7  (C1CB65), GCH1_STRP8  (P0A3E9), 
GCH1_STRPG  (A2REL9), GCH1_STRPI  (B1I918), GCH1_STRPJ  (B8ZL26), 
GCH1_STRPN  (P51595), GCH1_STRPQ  (P0DB31), GCH1_STRPS  (B2ISL9), 
GCH1_STRPY  (P0C0C1), GCH1_STRPZ  (B5XLE8), GCH1_STRR6  (P59656), 
GCH1_STRS2  (A4W1S9), GCH1_STRSV  (A3CKF4), GCH1_STRSY  (A4VVH1), 
GCH1_STRT1  (Q5LYM8), GCH1_STRT2  (Q5M391), GCH1_STRZJ  (C1CC81), 
GCH1_STRZP  (C1CIH2), GCH1_STRZT  (C1CPG4), GCH1_SULAC  (Q4J8S2), 
GCH1_SULSY  (B2V9P4), GCH1_SULTO  (Q971G9), GCH1_SYNE7  (Q54769), 
GCH1_SYNJA  (Q2JR69), GCH1_SYNJB  (Q2JPT8), GCH1_SYNP6  (Q5N623), 
GCH1_SYNY3  (Q55759), GCH1_TERTT  (C5BL73), GCH1_THEFY  (Q47KU5), 
GCH1_THEP3  (B0KCE5), GCH1_THEPX  (B0K5C1), GCH1_THEVB  (Q8DJB8), 
GCH1_THEYD  (B5YJV0), GCH1_TOLAT  (C4LDE6), GCH1_VIBC1  (A7N6L2), 
GCH1_VIBCH  (Q9KLX5), GCH1_VIBPA  (Q87GZ6), GCH1_VIBVU  (Q8D6I7), 
GCH1_VIBVY  (Q7MDE5), GCH1_WIGBR  (Q8D2N7), GCH1_WOLSU  (Q7M933), 
GCH1_XANAC  (Q8PEP3), GCH1_XANCP  (Q8P3B0), GCH1_XANE5  (Q3BM80), 
GCH1_XYLF2  (B2I4L2), GCH1_XYLFA  (Q9PC02), GCH1_XYLFM  (B0U794), 
GCH1_XYLFT  (Q87D63), GCH1_YEAST  (P51601), GCH1_YERE8  (A1JU09), 
GCH1_YERP3  (A7FJL1), GCH1_YERPB  (B2JZ02), GCH1_YERPE  (Q8ZG15), 
GCH1_YERPG  (A9R1B1), GCH1_YERPY  (B1JQJ4)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

GCH1_CALMQ  (A8MC60), GCH1_HAMD5  (C4K3L4), GCH1_HELAH  (Q17WX5), 

GCH1_HYPBU  (A2BL58), GCH1_MARMM  (Q0AM02), GCH1_NITMU  (Q2Y6B3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

GCH1_BACPU  (P48063), GCH1_EUGGR  (P51597), GCH1_MUCPU  (P51598)


				
	

	

		PDB
[Detailed view]		
		
			19 PDB
			


			pdb_00001fb1; pdb_00001fbx; pdb_00001gtp; pdb_00001is7; pdb_00001is8; pdb_00001n3t; pdb_00001wpl; pdb_00004du6; pdb_00004uqf; pdb_00006z80; pdb_00006z85; pdb_00006z86; 
			
				pdb_00006z87; pdb_00006z88; pdb_00006z89; pdb_00007ala; pdb_00007alb; pdb_00007alc; pdb_00007alq
			
			

			» more