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PROSITE entry PS00867


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PURL: https://purl.expasy.org/prosite/signature/PS00867

Direct ScanProsite submission
General information about the entry

Entry name [info] CPSASE_2
Accession [info] PS00867
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00676

Name and characterization of the entry

Description [info] Carbamoyl-phosphate synthase subdomain signature 2.
Pattern [info] 
[LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 726 in 486 different sequences
Number of true positive hits 582 in 342 different sequences
Number of 'unknown' hits 3 in 3 different sequences
Number of false positive hits 141 in 141 different sequences
Number of false negative sequences 2
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 80.50 %
Recall (true positives / (true positives + false negatives)) 99.66 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 342 sequences 

2OCS_HYDTT  (D3DJ42), ACACA_BOVIN (Q9TTS3), ACACA_HUMAN (Q13085), 

ACACA_MOUSE (Q5SWU9), ACACA_RAT   (P11497), ACACA_SHEEP (Q28559), 
ACACB_HUMAN (O00763), ACACB_MOUSE (E9Q4Z2), ACAC_CHICK  (P11029), 
ACAC_DICDI  (Q54J08), ACAC_SCHPO  (P78820), ACAC_YEAST  (Q00955), 
ACC1_ARATH  (Q38970), ACC1_ORYSJ  (Q8S6N5), ACC2_ARATH  (F4I1L3), 
ACC2_ORYSJ  (B9FK36), ACCA1_MYCBO (P0A509), ACCA1_MYCTO (P9WPQ2), 
ACCA1_MYCTU (P9WPQ3), ACCA3_MYCLE (P46392), ACCA3_MYCTU (P96890), 
ACCC1_BACSU (P49787), ACCC1_POPTR (B9HBA8), ACCC2_BACSU (O34544), 
ACCC2_POPTR (B9N843), ACCC_ALLVD  (O52058), ACCC_ARATH  (O04983), 
ACCC_ECO57  (Q8X9B6), ACCC_ECOLI  (P24182), ACCC_HAEIN  (P43873), 
ACCC_HALH5  (Q9KDS9), ACCC_NOSS1  (Q06862), ACCC_PSEAE  (P37798), 
CARB1_AQUAE (O67869), CARB1_METJA (Q58773), CARB1_METKA (Q8TWX0), 
CARB2_AQUAE (O67233), CARB2_METJA (Q58776), CARB2_METKA (Q8TUT7), 
CARB_ACIC5  (C1F1S6), CARB_AGARV  (C4ZEK2), CARB_AGRFC  (Q8UDE9), 
CARB_ARATH  (Q42601), CARB_ARCFU  (O28994), CARB_ARTS2  (A0JX72), 
CARB_BACAA  (C3P656), CARB_BACAC  (C3L740), CARB_BACAH  (A0RHQ8), 
CARB_BACAN  (Q81WF2), CARB_BACC0  (B7JJX3), CARB_BACC1  (Q732I3), 
CARB_BACC2  (B7IUP6), CARB_BACC3  (C1EPQ0), CARB_BACC4  (B7H6M2), 
CARB_BACC7  (B7HLM0), CARB_BACCL  (P46537), CARB_BACCN  (A7GRL1), 
CARB_BACCQ  (B9IVW3), CARB_BACCR  (Q819S3), CARB_BACCZ  (Q636E0), 
CARB_BACHK  (Q6HES8), CARB_BACMK  (A9VTC6), CARB_BACSU  (P25994), 
CARB_BEUC1  (C5C687), CARB_BIFA0  (B8DTW3), CARB_BIFAA  (A1A0T4), 
CARB_BIFLD  (B3DQ32), CARB_BIFLO  (Q8G815), CARB_BIFLS  (B7GPW2), 
CARB_BRUME  (Q8YIC2), CARB_BRUSU  (Q8FZJ3), CARB_BUCAI  (P57244), 
CARB_BUCAP  (Q8K9Z7), CARB_BUCBP  (P59448), CARB_CALS4  (Q8RBK0), 
CARB_CAMJE  (Q9PIL7), CARB_CAUVC  (Q9A4D6), CARB_CLAM3  (A5CRX5), 
CARB_CLASE  (B0REV9), CARB_CLOAB  (Q97FT3), CARB_CLOB8  (A6LPD9), 
CARB_CLOBA  (B2UX86), CARB_CLOBB  (B2THH3), CARB_CLOBJ  (C1FNY3), 
CARB_CLOBL  (A7GE89), CARB_CLOBM  (B1KT07), CARB_CLOP1  (Q0TM79), 
CARB_CLOPE  (Q8XHB3), CARB_CLOPS  (Q0SPY4), CARB_COREF  (Q8FT42), 
CARB_CORGL  (P58939), CARB_CUTAK  (Q6A914), CARB_CUTCT  (P46056), 
CARB_DEIDV  (C1CXR4), CARB_DEIGD  (Q1IWM0), CARB_DEIRA  (Q9RWK0), 
CARB_DESAP  (B1I4M8), CARB_ECO57  (P63737), CARB_ECOL6  (Q8FLB0), 
CARB_ECOLI  (P00968), CARB_ENTFA  (Q834E2), CARB_EREGS  (Q75D66), 
CARB_EXIS2  (B1YIR9), CARB_EXISA  (C4L5W3), CARB_FUSNN  (Q8RG86), 
CARB_GEMAT  (C1A4I5), CARB_GEOSE  (O50302), CARB_HAEDU  (Q7VP67), 
CARB_HALER  (Q8RSS3), CARB_HALH5  (Q9K9V9), CARB_HALOH  (B8D1H3), 
CARB_HALSA  (Q9HP43), CARB_HELPJ  (Q9ZKT2), CARB_HELPY  (O25577), 
CARB_KINRD  (A6WCC6), CARB_KOCRD  (B2GI87), CARB_KORVE  (Q1IPK2), 
CARB_LACAC  (Q5FJC0), CARB_LACCB  (B3WEF5), CARB_LACDB  (Q047M8), 
CARB_LACH4  (A8YVZ3), CARB_LACJO  (Q74J34), CARB_LACLA  (Q9CFV2), 
CARB_LACLM  (O32771), CARB_LACLS  (Q02YG5), CARB_LACP3  (Q038Z2), 
CARB_LACP7  (A9KI94), CARB_LACPL  (P77886), CARB_LATSS  (Q38X24), 
CARB_LEPIC  (Q72NF1), CARB_LEPIN  (Q8F832), CARB_LEUCK  (B1MZ74), 
CARB_LEUMM  (Q03WW7), CARB_LIGS1  (Q1WVA9), CARB_LIMF3  (B2GD06), 
CARB_LIMRD  (A5VHN6), CARB_LIMRJ  (B2G564), CARB_LISIN  (Q92AH3), 
CARB_LISMC  (C1KWD4), CARB_LISMF  (Q71YI1), CARB_LISMH  (B8DDR7), 
CARB_LISMO  (Q8Y665), CARB_LISW6  (A0AJU0), CARB_LYSSC  (B1HQC1), 
CARB_MACCJ  (B9EB69), CARB_METAC  (Q8TNY4), CARB_METB6  (A7I6J1), 
CARB_METBA  (P13258), CARB_METBF  (Q469Z7), CARB_METHJ  (Q2FLD9), 
CARB_METLZ  (A2SQ53), CARB_METMA  (P58944), CARB_METMJ  (A3CU73), 
CARB_METPE  (B8GEA3), CARB_METS3  (A5UKG5), CARB_METTH  (O27077), 
CARB_METTP  (A0B8K9), CARB_MICLC  (C5CCF1), CARB_MYCBO  (Q7U054), 
CARB_MYCGI  (A4TBY6), CARB_MYCLE  (Q9CCR2), CARB_MYCSJ  (A3PZ65), 
CARB_MYCSK  (A1UFK4), CARB_MYCSS  (Q1B9F9), CARB_MYCTO  (P9WPK2), 
CARB_MYCTU  (P9WPK3), CARB_MYCVP  (A1T8H1), CARB_MYXXD  (Q1D6Y8), 
CARB_NATTJ  (B2A170), CARB_NEIGO  (Q59599), CARB_NEIMA  (Q9JW02), 
CARB_NEIMB  (Q9JXW8), CARB_NEUCR  (Q7SH52), CARB_NOSS1  (Q8YQL2), 
CARB_OENOB  (Q04H29), CARB_ORYSJ  (B9EXM2), CARB_PAEAT  (A1R6Z3), 
CARB_PASMU  (Q9CKV0), CARB_PEDPA  (Q03HB0), CARB_PELTS  (A5D508), 
CARB_PSEAE  (P38100), CARB_PSECP  (B8H8U5), CARB_PSELT  (A8F453), 
CARB_PSEPK  (Q88DU6), CARB_PSESM  (Q87WP4), CARB_PYRAE  (Q8ZY48), 
CARB_PYRFU  (Q8U085), CARB_RALN1  (Q8XZ83), CARB_RENSM  (A9WSA8), 
CARB_RHILO  (Q98I87), CARB_RHIME  (Q92PZ4), CARB_RHOBA  (Q7UJ58), 
CARB_RUBXD  (Q1AVY9), CARB_SACI1  (C3NH23), CARB_SACI2  (C3MQE3), 
CARB_SACI3  (C3N664), CARB_SACI4  (C3MW21), CARB_SACI6  (C4KHM7), 
CARB_SACI7  (C3NEM0), CARB_SACS2  (Q59969), CARB_SALTI  (Q8Z9L7), 
CARB_SALTY  (P14846), CARB_SCHPO  (O94313), CARB_SHIFL  (P63738), 
CARB_STAA1  (A7X1F4), CARB_STAA2  (A6U122), CARB_STAA3  (Q2FHN5), 
CARB_STAA8  (Q2FZ72), CARB_STAA9  (A5IS88), CARB_STAAB  (Q2YXG5), 
CARB_STAAC  (Q5HGM9), CARB_STAAE  (A6QGA4), CARB_STAAM  (P63739), 
CARB_STAAN  (P63740), CARB_STAAR  (Q6GHN2), CARB_STAAS  (Q6GA10), 
CARB_STAAT  (A8Z3P0), CARB_STAAW  (P58940), CARB_STACT  (B9DPN2), 
CARB_STAEQ  (Q5HPY8), CARB_STAES  (Q8CPJ4), CARB_STAHJ  (Q4L5Q5), 
CARB_STAS1  (Q49WY4), CARB_STRA1  (Q3K150), CARB_STRA3  (Q8E5F5), 
CARB_STRA5  (Q8DZQ7), CARB_STRAW  (Q827Q7), CARB_STRCO  (Q9KXR6), 
CARB_STRE4  (C0M756), CARB_STRGC  (A8AX83), CARB_STRGG  (B1W463), 
CARB_STRMU  (Q8DUP3), CARB_STRP1  (Q9A0C6), CARB_STRP2  (Q04K48), 
CARB_STRP3  (P0DA14), CARB_STRP4  (B5E512), CARB_STRP6  (Q5XCR6), 
CARB_STRP7  (C1C7Q3), CARB_STRP8  (P58941), CARB_STRPG  (A2RF60), 
CARB_STRPI  (B1IC65), CARB_STRPJ  (B8ZJT9), CARB_STRPN  (Q97QE4), 
CARB_STRPQ  (P0DA15), CARB_STRPS  (B2IQ67), CARB_STRPZ  (B5XKW2), 
CARB_STRR6  (Q8CWR0), CARB_STRS7  (C0MEH1), CARB_STRSV  (A3CNI5), 
CARB_STRT1  (Q5M0W9), CARB_STRT2  (Q5M5F6), CARB_STRTD  (Q03LT8), 
CARB_STRU0  (B9DRV7), CARB_STRZJ  (C1CEM9), CARB_STRZP  (C1CL09), 
CARB_STRZT  (C1CR31), CARB_SULAC  (Q4J8E8), CARB_SULTO  (Q970U7), 
CARB_SYMTH  (Q67Q54), CARB_SYNY3  (Q55756), CARB_THEAC  (Q9HK17), 
CARB_THEMA  (Q9WZ27), CARB_THENN  (B9KB91), CARB_THEP1  (A5IJL8), 
CARB_THEP3  (B0KBW4), CARB_THEPX  (B0K4D7), CARB_THERP  (B9KXM5), 
CARB_THESQ  (B1L8T8), CARB_THET2  (P96495), CARB_THET8  (Q5SKN1), 
CARB_THEVO  (Q97AJ3), CARB_VIBCH  (Q9KPH9), CARB_VIBPA  (Q87SF3), 
CARB_VIBVU  (Q8DEM2), CARB_VIBVY  (Q7MNU0), CARB_XANAC  (P58942), 
CARB_XANCP  (P58943), CARB_XYLFA  (Q9PEC1), CARB_XYLFT  (Q87EB8), 
CARB_YEAST  (P03965), CARB_YERPE  (Q8ZIL4), CARB_ZYMMO  (O50236), 
CARY_BACSU  (P18185), CARY_GEOSE  (Q9ZB63), CARY_HALH5  (Q9K8V7), 
CARY_LACPL  (Q9RLS9), CPSM_AQUCT  (Q91293), CPSM_HUMAN  (P31327), 
CPSM_MOUSE  (Q8C196), CPSM_RAT(P07756), DMXL1_CRYX8 (A0A4P8DJE6), 
DUR1_LACKL  (A5H0J2), DUR1_YEAST  (P32528), EFNMT_DROME (Q9VIK9), 
HFA1_YEAS1  (B3LM95), HFA1_YEAS2  (C7GRE4), HFA1_YEAS7  (A6ZMR9), 
HFA1_YEAS8  (C8ZF72), HFA1_YEAST  (P32874), LAMA_EMENI  (P38095), 
MCCA_ARATH  (Q42523), MCCA_DICDI  (Q54KE6), MCCA_HUMAN  (Q96RQ3), 
MCCA_MOUSE  (Q99MR8), MCCA_ORYSJ  (Q2QMG2), MCCA_RAT(Q5I0C3), 
MCCA_SOYBN  (Q42777), MFND_METFA  (C7P8V7), PCCA_CAEBR  (Q612F5), 
PCCA_CAEEL  (Q19842), PCCA_HALMT  (I3R7G3), PCCA_HUMAN  (P05165), 
PCCA_MOUSE  (Q91ZA3), PCCA_PIG(P0DTA4), PCCA_RAT(P14882), 
PCCA_RUEPO  (Q5LUF3), PYC1_CAEEL  (O17732), PYC1_YEAST  (P11154), 
PYC2_YEAST  (P32327), PYCA_METJA  (Q58626), PYCA_METTH  (O27939), 
PYC_ASPNG   (Q9HES8), PYC_ASPTE   (O93918), PYC_ASPTN   (Q0CLK1), 
PYC_BACSU   (Q9KWU4), PYC_PICAN   (Q8X1T3), PYC_PICPA   (P78992), 
PYC_SCHPO   (Q9UUE1), PYC_STAAM   (A0A0H3JRU9), PYR1_CAEEL  (Q18990), 
PYR1_DICDI  (P20054), PYR1_DROME  (P05990), PYR1_EMENI  (O93937), 
PYR1_HUMAN  (P27708), PYR1_MESAU  (P08955), PYR1_MOUSE  (B2RQC6), 
PYR1_NEUCR  (Q7S8A6), PYR1_SCHPO  (Q09794), PYR1_SQUAC  (Q91437), 
PYR1_YEAST  (P07259), XRCC4_ARATH (Q682V0), Y4RH_SINFN  (P55641)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

CARB_HYPBU  (A2BJL3), PYCA_ARCFU  (O30019)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
ACCC_POPEU  (P84546)


				
	

	

		UniProtKB/Swiss-Prot
'Unknown' sequences		
		
			3 sequences
			


			
ARLY2_RHILO (Q981V0), R1AB_SARS2  (P0DTD1), R1A_SARS2   (P0DTC1)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			141 sequences
			


			
AATE_METLZ  (A2SST2), ABAA_ASPOR  (C0STD9), ACH1_CANAL  (P83773), 

			
ACH1_YARLI  (Q6C3Z9), AKAP9_HUMAN (Q99996), AKAP9_MOUSE (Q70FJ1), 
AL121_ARATH (Q8VZC3), ALDH_LINUS  (Q40255), AP2B_YEAST  (P27351), 
ARGB_PELUB  (Q4FNF2), ARMX5_HUMAN (Q6P1M9), ARMX5_PONAB (Q5RDG2), 
ATC1_DICDI  (P54678), ATG12_PICAN (A7KAJ7), BTRJ_NIACI  (Q4H4E7), 
CAP6_ARATH  (Q8VYT2), CENPC_YEAST (P35201), CH60_PHATC  (A0T0H6), 
CMOB_NAUPA  (B9L8G5), COBT_METC4  (Q9X7F4), CRNS1_CHICK (D3KCC4), 
CRNS1_HUMAN (A5YM72), CRNS1_MOUSE (Q6ZPS2), CTRO_HUMAN  (O14578), 
CTRO_MOUSE  (P49025), CTRO_RAT(E9PSL7), CTXL_ACRMI  (B7W114), 
CUTI_DIDRA  (P29292), CYSH_VIBVU  (Q8CWK6), CYSH_VIBVY  (Q7MHA7), 
DAPB_BDEBA  (Q6MRM8), DMD_SACS2   (Q97UL5), DPO3_STRA3  (P63983), 
DPO3_STRA5  (P63984), DYH9_HUMAN  (Q9NYC9), EABN2_BACSU (P42293), 
F16PC_LACCB (B3W9A8), F16PC_LACP3 (Q036S2), F200A_MACFA (Q4R6P1), 
FUJ1_GIBF5  (S0EET5), GCSH3_ARATH (Q9LQL0), GGLO_BOVIN  (Q3ZC33), 
GLB1_MAIZE  (P15590), GLB63_ORYSJ (Q75GX9), GLS24_STRP1 (Q99ZE5), 
GLS24_STRP3 (P0CZ86), GLS24_STRP6 (Q5XBW6), GLS24_STRP8 (Q7CN70), 
GLS24_STRPM (Q48TA2), GLS24_STRPQ (P0CZ87), GLYA_PICTO  (Q6L1F6), 
GPI7_YARLI  (Q6C7Q6), GUAD_DICDI  (Q86AW9), GUNG_ACET2  (Q05332), 
HLDE_SERP5  (A8GJU3), HMW2_MYCGA  (Q7NBF8), HRDA_STRCO  (P18182), 
INVSB_XENLA (Q71S21), IORB_METTM  (P80911), KAD_MESFL   (Q6F1X3), 
KIN17_DICDI (Q55D16), LAA1_YEAST  (P39526), MDH1_AQUAE  (O67655), 
MDH_MYXXA   (Q6ZZC6), MDH_PYRAE   (Q8ZVB2), MDH_PYRIL   (A1RS58), 
MDH_SYNC1   (Q3A5S0), MDH_THET7   (A0A0S3QTC6), MED10_CANAL (Q5A3K2), 
MFND_METJA  (Q58225), MINE_VIBCH  (Q9KQN7), MINE_VIBPA  (Q87RC5), 
MINE_VIBVU  (Q8DFS2), MINE_VIBVY  (Q7MML2), MMS36_MAGGM (Q6NE78), 
MSMJL_METJA (Q58543), MTAD_HALWD  (Q18EV7), NEUBH_CAMJE (Q0P8T1), 
NU3M_WICCA  (P48913), OBG_GLAP5   (B8F871), OPDA_PENO1  (S7Z800), 
PARP2_HUMAN (Q9UGN5), PARP2_MOUSE (O88554), PEPT_ALIF1  (Q5E0X3), 
PHM1_PYRSX  (A0A2Z5XAL7), PRLS_FUNXX  (A0A089FSA4), PRP5_PYRO7  (A4RN46), 
PSTB_BORAP  (Q0SNU4), PSTB_BORGP  (Q662E6), PSUG_GEMAT  (C1AA54), 
PURCE_DICDI (Q54QE4), RECR_RHOP5  (Q07H54), RLMF_FLAJ1  (A5FHX5), 
RPOC_NITMU  (Q2YB04), RPOD_COXBU  (Q83BB6), RPOD_RICBR  (Q1RKH7), 
RPOD_RICCN  (Q92FZ8), RPOD_RICFE  (Q4UJT1), RPOD_RICPR  (P33451), 
RPOD_RICTY  (Q68VQ5), RPOS_COXBU  (Q9KI19), RPSB_CORDI  (P33118), 
SEC39_YEAST (Q12745), SGO1_SCHPO  (Q9P7A0), SIGA2_SYNE7 (Q31ME3), 
SIGA3_SYNE7 (Q31QG5), SIGA_MYCBO  (P0A603), SIGA_MYCTO  (P9WGI0), 
SIGA_MYCTU  (P9WGI1), SIGA_STRCO  (P18183), SIGA_STRGG  (B1VXR4), 
SIGA_STRGR  (P77951), SIGA_THEAQ  (Q9EZJ8), SIGA_THET2  (Q72L95), 
SIGB_MYCTO  (P9WGI4), SIGB_MYCTU  (P9WGI5), SUZ2_DROME  (P25172), 
SYI_ANAMM   (Q5PAL9), SYV_BUCAI   (P57447), TMN3_ARATH  (Q9ZPS7), 
TORD_COLP3  (Q484F1), TSAE_RICBR  (Q1RGZ7), TSAE_RICPR  (Q9ZED0), 
TSAE_RICTY  (Q68XZ1), TTC12_HUMAN (Q9H892), TTC12_MACFA (Q95LY5), 
UBP28_HUMAN (Q96RU2), UBP28_MOUSE (Q5I043), UBP28_RAT   (D3ZJ96), 
VIT3_DROME  (P06607), XB35_ORYSJ  (Q7EZ44), Y2393_NOSS1 (P46079), 
Y449_MYCGE  (P47687), Y874_METJA  (Q58284), Y952_ARCFU  (O29310), 
YECD_ECO57  (P0ADI8), YECD_ECOLI  (P0ADI7), YGIN_ECO57  (P0ADU3), 
YGIN_ECOLI  (P0ADU2), YGIN_SHIFL  (P0ADU4), YPF15_PLAF7 (Q8IBB8)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			102 PDB
			


			1A9X; 1BNC; 1BXR; 1C30; 1C3O; 1CE8; 1CS0; 1DV1; 1JDB; 1KEE; 1M6V; 1T36; 
			
				1W93; 1W96; 2C00; 2GPS; 2GPW; 2HJW; 2J9G; 2V58; 2V59; 2V5A; 2VQD; 2VR1; 
				2W6M; 2W6N; 2W6O; 2W6P; 2W6Q; 2W6Z; 2W70; 2W71; 2YL2; 3BG5; 3G8C; 3G8D; 
				3GID; 3GLK; 3HB9; 3HBL; 3HO8; 3JRW; 3JRX; 3JZF; 3JZI; 3N6R; 3RUP; 3RV3; 
				3RV4; 4HNT; 4HNU; 4HNV; 4HQ6; 4HR7; 4MV1; 4MV3; 4MV4; 4MV6; 4MV7; 4MV8; 
				4MV9; 4RZQ; 5CSK; 5CSL; 5DOT; 5DOU; 5KKN; 5MLK; 6G2D; 6G2H; 6G2I; 6OI8; 
				6OI9; 6OJH; 6UEL; 6W2J; 7KBL; 7KC7; 7KCT; 7T9W; 7YBU; 8J4Z; 8J78; 8J7D; 
				8J99; 8JAK; 8JAW; 8JXL; 8JXM; 8JXN; 8K2V; 8UZ2; 8XKZ; 8XL0; 8XL1; 8XL2; 
				8XL3; 8XL4; 8XL5; 8XL6; 8XL7; 8XL8
			
			

			» more