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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00918


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PURL: https://purl.expasy.org/prosite/signature/PS00918

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General information about the entry

Entry name [info] DNASE_I_2
Accession [info] PS00918
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00711

Name and characterization of the entry

Description [info] Deoxyribonuclease I signature 2.
Pattern [info] 
G-D-F-N-A-x-C-[SAK].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 21 in 21 different sequences
Number of true positive hits 21 in 21 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 87.50 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] disulfide at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 21 sequences 

DNAS1_BOVIN (P00639), DNAS1_CANLF (Q767J3), DNAS1_CHICK (Q9YGI5), 

DNAS1_HORSE (Q4AEE3), DNAS1_HUMAN (P24855), DNAS1_MOUSE (P49183), 
DNAS1_OREMO (O42446), DNAS1_PIG   (P11936), DNAS1_RAT   (P21704), 
DNAS1_SHEEP (P11937), DNSL1_CHLAE (Q2QDF1), DNSL1_CRIGR (Q2QDE6), 
DNSL1_HUMAN (P49184), DNSL1_MOUSE (Q9D7J6), DNSL1_PIG   (Q2QDF0), 
DNSL1_RAT   (Q2QDE7), DNSL2_HUMAN (Q92874), DNSL2_MOUSE (Q9D1G0), 
DNSL3_HUMAN (Q13609), DNSL3_MOUSE (O55070), DNSL3_RAT   (O89107)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

DNAS1_RABIT (O18998), DNAS1_THISK (D3SGB1), DNSL1_BOVIN (Q2QDE9)


				
	

	

		PDB
[Detailed view]		
		
			17 PDB
			


			pdb_00001atn; pdb_00001dnk; pdb_00002a3z; pdb_00002a40; pdb_00002a41; pdb_00002a42; pdb_00002d1k; pdb_00002dnj; pdb_00003cjc; pdb_00003dni; pdb_00003w3d; pdb_00004awn; 
			
				pdb_00007kiu; pdb_00007nxv; pdb_00007nzm; pdb_00009fju; pdb_00009fjy
			
			

			» more