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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00919


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PURL: https://purl.expasy.org/prosite/signature/PS00919

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General information about the entry

Entry name [info] DNASE_I_1
Accession [info] PS00919
Entry type [info] PATTERN
Date [info] 01-OCT-1993 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00711

Name and characterization of the entry

Description [info] Deoxyribonuclease I signature 1.
Pattern [info] 
[LIVM](2)-[AP]-[LQ]-H-[STA]-[STAE]-P-x(5)-E-[LIVM]-[DN]-x-L-x-[DE]-V.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 22 in 22 different sequences
Number of true positive hits 22 in 22 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 91.67 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 22 sequences 

DNAS1_BOVIN (P00639), DNAS1_CANLF (Q767J3), DNAS1_CHICK (Q9YGI5), 

DNAS1_HORSE (Q4AEE3), DNAS1_HUMAN (P24855), DNAS1_MOUSE (P49183), 
DNAS1_OREMO (O42446), DNAS1_PIG   (P11936), DNAS1_RABIT (O18998), 
DNAS1_RAT   (P21704), DNAS1_SHEEP (P11937), DNSL1_BOVIN (Q2QDE9), 
DNSL1_CHLAE (Q2QDF1), DNSL1_CRIGR (Q2QDE6), DNSL1_HUMAN (P49184), 
DNSL1_MOUSE (Q9D7J6), DNSL1_RAT   (Q2QDE7), DNSL2_HUMAN (Q92874), 
DNSL2_MOUSE (Q9D1G0), DNSL3_HUMAN (Q13609), DNSL3_MOUSE (O55070), 
DNSL3_RAT   (O89107)
» more

UniProtKB/Swiss-Prot
False negative sequences		 2 sequences 

DNAS1_THISK (D3SGB1), DNSL1_PIG   (Q2QDF0)


				
	

	

		PDB
[Detailed view]		
		
			17 PDB
			


			pdb_00001atn; pdb_00001dnk; pdb_00002a3z; pdb_00002a40; pdb_00002a41; pdb_00002a42; pdb_00002d1k; pdb_00002dnj; pdb_00003cjc; pdb_00003dni; pdb_00003w3d; pdb_00004awn; 
			
				pdb_00007kiu; pdb_00007nxv; pdb_00007nzm; pdb_00009fju; pdb_00009fjy
			
			

			» more