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PROSITE entry PS00972


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General information about the entry

Entry name [info] USP_1
Accession [info] PS00972
Entry type [info] PATTERN
Date [info] 01-JUN-1994 CREATED;
01-DEC-2013 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00750
Associated ProRule [info] PRU10092

Name and characterization of the entry

Description [info] Ubiquitin specific protease (USP) domain signature 1.
Pattern [info] 
G-[LIVMFY]-x(1,3)-[AGCY]-[NASMQG]-x-C-[FYWC]-[LIVMFCA]-[NSTAD]-[SACV]-x-
[LIVMSF]-[QF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 296 in 296 different sequences
Number of true positive hits 296 in 296 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 29
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 91.08 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 296 sequences 

CREB_ASPCL  (A1CIL1), CREB_ASPFC  (B0Y4P5), CREB_ASPFN  (B8NSV5), 

CREB_ASPFU  (Q4WQI1), CREB_ASPNC  (A2Q9N1), CREB_ASPOR  (Q2UUG8), 
CREB_ASPTN  (Q0CT11), CREB_EMENI  (Q96V54), CREB_NEOFI  (A1CW53), 
CYLD_BOVIN  (Q1RMU2), CYLD_HUMAN  (Q9NQC7), CYLD_MOUSE  (Q80TQ2), 
CYLD_PONAB  (Q5RED8), CYLD_RAT(Q66H62), FAF_DROME   (P55824), 
FLA_ORYSJ   (Q2R4I5), NOT_DROME   (Q9VVR1), PUF_DROME   (Q9VC56), 
U17L5_HUMAN (A8MUK1), U17L6_HUMAN (Q6QN14), U17L8_HUMAN (P0C7I0), 
U17LA_HUMAN (C9JJH3), U17LB_HUMAN (C9JVI0), U17LC_MOUSE (G5E8I7), 
U17LD_HUMAN (C9JLJ4), U17LF_HUMAN (C9J2P7), U17LH_HUMAN (D6RBQ6), 
U17LI_HUMAN (D6R9N7), U17LJ_HUMAN (D6RCP7), U17LK_HUMAN (D6RJB6), 
U17LL_HUMAN (D6R901), U17LM_HUMAN (D6RA61), U17LN_HUMAN (D6RBM5), 
U17LO_HUMAN (Q0WX57), U17PA_MOUSE (Q61068), U17PB_MOUSE (E9Q9U0), 
U17PD_MOUSE (G5E8G2), U17PE_MOUSE (Q7M764), UB10A_XENLA (Q2NL57), 
UB10B_XENLA (Q7ZXR7), UB12A_XENLA (Q52KZ6), UB12B_XENLA (Q5M981), 
UB22A_XENLA (Q6GNI6), UB22B_XENLA (Q6DCJ1), UBP10_ARATH (Q9ZSB5), 
UBP10_BOVIN (A5PJS6), UBP10_CHICK (Q5ZJN4), UBP10_HUMAN (Q14694), 
UBP10_MOUSE (P52479), UBP10_RAT   (Q3KR59), UBP10_XENTR (Q6DIJ4), 
UBP11_ARATH (Q9MAQ3), UBP11_HUMAN (P51784), UBP11_MOUSE (Q99K46), 
UBP11_RAT   (Q5D006), UBP11_YEAST (P36026), UBP12_ARATH (Q9FPT1), 
UBP12_BOVIN (A5D9H7), UBP12_DANRE (A4FUN7), UBP12_HUMAN (O75317), 
UBP12_MOUSE (Q9D9M2), UBP12_SALSA (C0HB46), UBP12_SCHPO (O60079), 
UBP12_YEAST (P39538), UBP13_ARATH (Q84WU2), UBP13_BOVIN (E1BMF7), 
UBP13_CHICK (E1BY77), UBP13_HUMAN (Q92995), UBP13_MOUSE (Q5BKP2), 
UBP13_YEAST (P38187), UBP14_ARATH (Q8L6Y1), UBP14_BOVIN (Q0IIF7), 
UBP14_CAEEL (Q17361), UBP14_HUMAN (P54578), UBP14_MOUSE (Q9JMA1), 
UBP14_PANTR (P60051), UBP14_RABIT (P40826), UBP14_SCHPO (Q11119), 
UBP14_YEAST (P38237), UBP15_ARATH (Q9FPS9), UBP15_BOVIN (Q2HJE4), 
UBP15_HUMAN (Q9Y4E8), UBP15_MOUSE (Q8R5H1), UBP15_ORYSJ (Q0E2F9), 
UBP15_RAT   (Q9R085), UBP15_XENTR (F6Z5C0), UBP15_YEAST (P50101), 
UBP16_ARATH (Q9SB51), UBP16_BOVIN (Q08DA3), UBP16_DANRE (A8HAL1), 
UBP16_EMENI (P0CAQ1), UBP16_HUMAN (Q9Y5T5), UBP16_MACFA (Q4R6X7), 
UBP16_MOUSE (Q99LG0), UBP16_RAT   (Q2KJ09), UBP16_SCHPO (O74442), 
UBP16_XENLA (Q6PAW2), UBP16_XENTR (Q0VA64), UBP16_YEAST (Q02863), 
UBP17_ARATH (Q9FKP5), UBP18_ARATH (Q67XW5), UBP18_HUMAN (Q9UMW8), 
UBP18_MOUSE (Q9WTV6), UBP18_PONAB (Q5RE63), UBP19_ARATH (Q9SJA1), 
UBP19_HUMAN (O94966), UBP19_MOUSE (Q3UJD6), UBP19_RAT   (Q6J1Y9), 
UBP1_ARATH  (Q9FPT5), UBP1_BOVIN  (Q29RP1), UBP1_HUMAN  (O94782), 
UBP1_MOUSE  (Q8BJQ2), UBP1_RAT(Q569C3), UBP1_SCHPO  (Q9USM5), 
UBP1_YEAST  (P25037), UBP20_ARATH (Q9FPS7), UBP20_BOVIN (A7Z056), 
UBP20_DANRE (A5PN09), UBP20_HUMAN (Q9Y2K6), UBP20_MOUSE (Q8C6M1), 
UBP20_PONAB (Q5R5Z6), UBP20_XENLA (B1WBD7), UBP20_XENTR (A0JM59), 
UBP21_ARATH (Q9FIQ1), UBP21_BOVIN (Q2KJ72), UBP21_HUMAN (Q9UK80), 
UBP21_MOUSE (Q9QZL6), UBP21_RAT   (B2GUX4), UBP22_ARATH (Q9LEW0), 
UBP22_BOVIN (P0C8Z3), UBP22_DANRE (A6H8I0), UBP22_HUMAN (Q9UPT9), 
UBP22_MOUSE (Q5DU02), UBP23_ARATH (Q9FPS4), UBP24_ARATH (Q9FPS3), 
UBP24_HUMAN (Q9UPU5), UBP24_MOUSE (B1AY13), UBP25_ARATH (Q9FPS2), 
UBP25_HUMAN (Q9UHP3), UBP25_MOUSE (P57080), UBP26_ARATH (Q9SCJ9), 
UBP26_HUMAN (Q9BXU7), UBP26_MOUSE (Q99MX1), UBP26_ORYSI (A2XDG4), 
UBP26_ORYSJ (A3AF13), UBP27_ARATH (Q9FPS0), UBP27_HUMAN (A6NNY8), 
UBP27_MOUSE (Q8CEG8), UBP28_CHICK (Q5ZID5), UBP28_HUMAN (Q96RU2), 
UBP28_MOUSE (Q5I043), UBP28_RAT   (D3ZJ96), UBP29_HUMAN (Q9HBJ7), 
UBP29_MOUSE (Q9ES63), UBP2_ARATH  (Q8W4N3), UBP2_BOVIN  (Q2KHV7), 
UBP2_CHICK  (O57429), UBP2_DROME  (Q8IQ27), UBP2_HUMAN  (O75604), 
UBP2_KLULA  (O42726), UBP2_MOUSE  (O88623), UBP2_RAT(Q5U349), 
UBP2_SCHPO  (Q9P3U0), UBP2_YEAST  (Q01476), UBP30_DANRE (A2BGT0), 
UBP30_HUMAN (Q70CQ3), UBP30_MOUSE (Q3UN04), UBP30_RAT   (D3ZPG5), 
UBP30_XENTR (A4QNN3), UBP31_HUMAN (Q70CQ4), UBP32_DROME (M9PD06), 
UBP32_HUMAN (Q8NFA0), UBP32_MOUSE (F8VPZ3), UBP33_BOVIN (A6QNM7), 
UBP33_DANRE (A5PMR2), UBP33_HUMAN (Q8TEY7), UBP33_MOUSE (Q8R5K2), 
UBP33_PONAB (Q5REG5), UBP33_XENTR (Q28CN3), UBP34_HUMAN (Q70CQ2), 
UBP34_MOUSE (Q6ZQ93), UBP35_HUMAN (Q9P2H5), UBP36_DROAN (B3M3M6), 
UBP36_DROER (B3NC86), UBP36_DROGR (B4IXE0), UBP36_DROME (Q9VRP5), 
UBP36_DROMO (B4KXJ5), UBP36_DROPS (Q2LZB1), UBP36_DROSE (B4HUI5), 
UBP36_DROSI (B4QIS3), UBP36_DROVI (B4LG38), UBP36_DROWI (B4MLR8), 
UBP36_DROYA (B4PIW8), UBP36_HUMAN (Q9P275), UBP36_MOUSE (B1AQJ2), 
UBP37_BOVIN (F1N5V1), UBP37_CANLF (E2RK09), UBP37_CHICK (E1C213), 
UBP37_DANRE (E7F6T8), UBP37_HUMAN (Q86T82), UBP37_MOUSE (Q8C0R0), 
UBP37_PIG   (F1SRY5), UBP38_HUMAN (Q8NB14), UBP38_MOUSE (Q8BW70), 
UBP3_ARATH  (O24454), UBP3_HUMAN  (Q9Y6I4), UBP3_MOUSE  (Q91W36), 
UBP3_SCHPO  (O94269), UBP3_YEAST  (Q01477), UBP40_HUMAN (Q9NVE5), 
UBP40_MOUSE (Q8BWR4), UBP42_BOVIN (E1B9W9), UBP42_HUMAN (Q9H9J4), 
UBP42_MOUSE (B2RQC2), UBP42_RAT   (D3ZU96), UBP43_HUMAN (Q70EL4), 
UBP43_MOUSE (Q8BUM9), UBP44_AILME (D2HBJ8), UBP44_DANRE (Q7ZUM8), 
UBP44_HUMAN (Q9H0E7), UBP44_MOUSE (Q8C2S0), UBP44_XENTR (Q0V9G5), 
UBP45_DANRE (E9QG68), UBP45_HUMAN (Q70EL2), UBP45_MOUSE (Q8K387), 
UBP46_CAEEL (P34547), UBP46_DANRE (A5WWB0), UBP46_HUMAN (P62068), 
UBP46_MOUSE (P62069), UBP46_PONAB (Q5RBQ4), UBP46_RAT   (F1M625), 
UBP47_CHICK (E1C1R4), UBP47_HUMAN (Q96K76), UBP47_MOUSE (Q8BY87), 
UBP47_XENLA (Q5U252), UBP47_XENTR (A1A5G2), UBP48_CAEEL (G5ECC7), 
UBP49_HUMAN (Q70CQ1), UBP49_MOUSE (Q6P9L4), UBP4_ARATH  (Q8LAM0), 
UBP4_BOVIN  (A6QR55), UBP4_CANGA  (Q6FQF0), UBP4_EREGS  (Q754R5), 
UBP4_HUMAN  (Q13107), UBP4_KLULA  (Q9HFS7), UBP4_MOUSE  (P35123), 
UBP4_PONAB  (Q5RCD3), UBP4_RAT(B2GUZ1), UBP4_SCHPO  (O60139), 
UBP4_VANPO  (A7TGY3), UBP4_YEAS1  (B3LGK1), UBP4_YEAS7  (A6ZY34), 
UBP4_YEAST  (P32571), UBP50_HUMAN (Q70EL3), UBP50_MACFA (Q4R6D3), 
UBP50_MOUSE (Q6P8X6), UBP51_HUMAN (Q70EK9), UBP51_MOUSE (B1AY15), 
UBP5_ARATH  (O22207), UBP5_HUMAN  (P45974), UBP5_MOUSE  (P56399), 
UBP5_YEAST  (P39944), UBP64_DROME (Q9W4C3), UBP6_ARATH  (Q949Y0), 
UBP6_HUMAN  (P35125), UBP6_SCHPO  (Q92353), UBP6_YEAST  (P43593), 
UBP71_SCHPO (Q9UTT1), UBP72_SCHPO (Q09879), UBP7_ARATH  (Q84WC6), 
UBP7_CAEBR  (Q60MK8), UBP7_CAEEL  (Q7JKC3), UBP7_CHICK  (Q6U7I1), 
UBP7_DROME  (Q9VYQ8), UBP7_HUMAN  (Q93009), UBP7_MOUSE  (Q6A4J8), 
UBP7_RAT(Q4VSI4), UBP7_SCHPO  (Q9P7S5), UBP7_YEAST  (P40453), 
UBP8_ARATH  (Q9C585), UBP8_HUMAN  (P40818), UBP8_MOUSE  (Q80U87), 
UBP8_SCHPO  (Q09738), UBP8_YEAST  (P50102), UBP9_ARATH  (Q93Y01), 
UBP9_YEAST  (P39967), UBPA_DICDI  (P54201), UBPE_DROME  (Q24574), 
UBPL1_MIMIV (Q5UQR3), UBPY_CAEEL  (Q09931), UL17C_HUMAN (C9JPN9), 
UP44A_XENLA (Q6NTR6), UP44B_XENLA (Q5XGZ2), USP9X_HUMAN (Q93008), 
USP9X_MOUSE (P70398), USP9Y_HUMAN (O00507)
» more

UniProtKB/Swiss-Prot
False negative sequences		 29 sequences 

U17L1_HUMAN (Q7RTZ2), U17L2_HUMAN (Q6R6M4), U17L3_HUMAN (A6NCW0), 

U17L4_HUMAN (A6NCW7), U17L7_HUMAN (P0C7H9), UBP10_SCHPO (Q9USR2), 
UBP10_YEAST (P53874), UBP11_SCHPO (Q9UUD6), UBP13_DANRE (F1QFS9), 
UBP13_XENTR (F6V6I0), UBP30_DROME (Q9W462), UBP39_HUMAN (Q53GS9), 
UBP39_MOUSE (Q3TIX9), UBP39_PONAB (Q5R761), UBP48_CHICK (Q5ZM45), 
UBP48_HUMAN (Q86UV5), UBP48_MOUSE (Q3V0C5), UBP48_RAT   (Q76LT8), 
UBP54_HUMAN (Q70EL1), UBP54_MOUSE (Q8BL06), UBP54_RAT   (Q6IE24), 
UBP5_PONAB  (Q5R407), UBP9_SCHPO  (Q9P7V9), UBPB_DICDI  (O96612), 
UBPH_CAEEL  (Q8WT44), UBPL2_MIMIV (Q5UPW7), USPL1_DANRE (Q6DRC5), 
USPL1_HUMAN (Q5W0Q7), USPL1_MOUSE (Q3ULM6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

UBP11_CANLF (Q01988)


				
	

	

		PDB
[Detailed view]		
		
			124 PDB
			


			1NB8; 1NBF; 1VJV; 2AYN; 2AYO; 2F1Z; 2GFO; 2HD5; 2IBI; 2VHF; 2Y5B; 2Y6E; 
			
				3I3T; 3IHP; 3M99; 3MHH; 3MHS; 3MTN; 3N3K; 3NHE; 3V6C; 3V6E; 4FIP; 4FJC; 
				4FK5; 4M5W; 4M5X; 4WA6; 5A5B; 5CHT; 5CHV; 5CVM; 5CVN; 5CVO; 5FWI; 5GJQ; 
				5J7T; 5JTJ; 5JTV; 5K16; 5K1A; 5K1B; 5K1C; 5KYB; 5KYC; 5KYD; 5KYE; 5KYF; 
				5L8H; 5L8W; 5MPC; 5N9R; 5N9T; 5NGE; 5NGF; 5O71; 5OHK; 5OHN; 5UQV; 5UQX; 
				5VS6; 5VSB; 5VSK; 5WCH; 5WHC; 5XU8; 6CPM; 6CRN; 6DGF; 6F5H; 6GH9; 6GHA; 
				6H4H; 6H4I; 6H4J; 6HEH; 6HEI; 6HEJ; 6HEK; 6HEL; 6IIK; 6IIL; 6IIM; 6IIN; 
				6JLQ; 6M1K; 6ML1; 6T9L; 6VN2; 6VN3; 6VN4; 6VN5; 6VN6; 7AY0; 7AY2; 7CM2; 
				7QO4; 7QO5; 7R2G; 7TUO; 7W37; 7W38; 7W39; 7W3A; 7W3B; 7W3C; 7W3F; 7W3G; 
				7W3H; 7W3I; 7W3J; 7W3K; 7W3M; 7W3R; 7W3U; 7XHH; 7XHK; 7YXX; 7YXY; 8BS3; 
				8BS9; 8D0A; 8D1T; 8HJE
			
			

			» more