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PROSITE entry PS00972


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PURL: https://purl.expasy.org/prosite/signature/PS00972

Direct ScanProsite submission
General information about the entry

Entry name [info] USP_1
Accession [info] PS00972
Entry type [info] PATTERN
Date [info] 01-JUN-1994 CREATED;
01-DEC-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00750
Associated ProRule [info] PRU10092

Name and characterization of the entry

Description [info] Ubiquitin specific protease (USP) domain signature 1.
Pattern [info] 
G-[LIVMFY]-x(1,3)-[AGCY]-[NASMQG]-x-C-[FYWC]-[LIVMFCA]-[NSTAD]-[SACV]-x-
[LIVMSF]-[QF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 298 in 298 different sequences
Number of true positive hits 298 in 298 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 29
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 91.13 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 298 sequences 

CREB_ASPCL  (A1CIL1), CREB_ASPFC  (B0Y4P5), CREB_ASPFN  (B8NSV5), 

CREB_ASPFU  (Q4WQI1), CREB_ASPNC  (A2Q9N1), CREB_ASPOR  (Q2UUG8), 
CREB_ASPTN  (Q0CT11), CREB_EMENI  (Q96V54), CREB_NEOFI  (A1CW53), 
CYLD_BOVIN  (Q1RMU2), CYLD_HUMAN  (Q9NQC7), CYLD_MOUSE  (Q80TQ2), 
CYLD_PONAB  (Q5RED8), CYLD_RAT(Q66H62), FAF_DROME   (P55824), 
FLA_ORYSJ   (Q2R4I5), NOT_DROME   (Q9VVR1), PUF_DROME   (Q9VC56), 
U17L5_HUMAN (A8MUK1), U17L6_HUMAN (Q6QN14), U17L8_HUMAN (P0C7I0), 
U17LA_HUMAN (C9JJH3), U17LB_HUMAN (C9JVI0), U17LC_MOUSE (G5E8I7), 
U17LD_HUMAN (C9JLJ4), U17LF_HUMAN (C9J2P7), U17LH_HUMAN (D6RBQ6), 
U17LI_HUMAN (D6R9N7), U17LJ_HUMAN (D6RCP7), U17LK_HUMAN (D6RJB6), 
U17LL_HUMAN (D6R901), U17LM_HUMAN (D6RA61), U17LN_HUMAN (D6RBM5), 
U17LO_HUMAN (Q0WX57), U17PA_MOUSE (Q61068), U17PB_MOUSE (E9Q9U0), 
U17PD_MOUSE (G5E8G2), U17PE_MOUSE (Q7M764), UB10A_XENLA (Q2NL57), 
UB10B_XENLA (Q7ZXR7), UB12A_XENLA (Q52KZ6), UB12B_XENLA (Q5M981), 
UB22A_XENLA (Q6GNI6), UB22B_XENLA (Q6DCJ1), UBP10_ARATH (Q9ZSB5), 
UBP10_BOVIN (A5PJS6), UBP10_CHICK (Q5ZJN4), UBP10_HUMAN (Q14694), 
UBP10_MOUSE (P52479), UBP10_RAT   (Q3KR59), UBP10_XENTR (Q6DIJ4), 
UBP11_ARATH (Q9MAQ3), UBP11_HUMAN (P51784), UBP11_MOUSE (Q99K46), 
UBP11_RAT   (Q5D006), UBP11_YEAST (P36026), UBP12_ARATH (Q9FPT1), 
UBP12_BOVIN (A5D9H7), UBP12_DANRE (A4FUN7), UBP12_HUMAN (O75317), 
UBP12_MOUSE (Q9D9M2), UBP12_RAT   (D0RB01), UBP12_SALSA (C0HB46), 
UBP12_SCHPO (O60079), UBP12_YEAST (P39538), UBP13_ARATH (Q84WU2), 
UBP13_BOVIN (E1BMF7), UBP13_CHICK (E1BY77), UBP13_HUMAN (Q92995), 
UBP13_MOUSE (Q5BKP2), UBP13_YEAST (P38187), UBP14_ARATH (Q8L6Y1), 
UBP14_BOVIN (Q0IIF7), UBP14_CAEEL (Q17361), UBP14_HUMAN (P54578), 
UBP14_MOUSE (Q9JMA1), UBP14_PANTR (P60051), UBP14_RABIT (P40826), 
UBP14_SCHPO (Q11119), UBP14_YEAST (P38237), UBP15_ARATH (Q9FPS9), 
UBP15_BOVIN (Q2HJE4), UBP15_HUMAN (Q9Y4E8), UBP15_MOUSE (Q8R5H1), 
UBP15_ORYSJ (Q0E2F9), UBP15_RAT   (Q9R085), UBP15_XENTR (F6Z5C0), 
UBP15_YEAST (P50101), UBP16_ARATH (Q9SB51), UBP16_BOVIN (Q08DA3), 
UBP16_DANRE (A8HAL1), UBP16_EMENI (P0CAQ1), UBP16_HUMAN (Q9Y5T5), 
UBP16_MACFA (Q4R6X7), UBP16_MOUSE (Q99LG0), UBP16_RAT   (Q2KJ09), 
UBP16_SCHPO (O74442), UBP16_XENLA (Q6PAW2), UBP16_XENTR (Q0VA64), 
UBP16_YEAST (Q02863), UBP17_ARATH (Q9FKP5), UBP18_ARATH (Q67XW5), 
UBP18_HUMAN (Q9UMW8), UBP18_MOUSE (Q9WTV6), UBP18_PONAB (Q5RE63), 
UBP19_ARATH (Q9SJA1), UBP19_HUMAN (O94966), UBP19_MOUSE (Q3UJD6), 
UBP19_RAT   (Q6J1Y9), UBP1_ARATH  (Q9FPT5), UBP1_BOVIN  (Q29RP1), 
UBP1_HUMAN  (O94782), UBP1_MOUSE  (Q8BJQ2), UBP1_RAT(Q569C3), 
UBP1_SCHPO  (Q9USM5), UBP1_YEAST  (P25037), UBP20_ARATH (Q9FPS7), 
UBP20_BOVIN (A7Z056), UBP20_DANRE (A5PN09), UBP20_HUMAN (Q9Y2K6), 
UBP20_MOUSE (Q8C6M1), UBP20_PONAB (Q5R5Z6), UBP20_XENLA (B1WBD7), 
UBP20_XENTR (A0JM59), UBP21_ARATH (Q9FIQ1), UBP21_BOVIN (Q2KJ72), 
UBP21_HUMAN (Q9UK80), UBP21_MOUSE (Q9QZL6), UBP21_RAT   (B2GUX4), 
UBP22_ARATH (Q9LEW0), UBP22_BOVIN (P0C8Z3), UBP22_DANRE (A6H8I0), 
UBP22_HUMAN (Q9UPT9), UBP22_MOUSE (Q5DU02), UBP23_ARATH (Q9FPS4), 
UBP24_ARATH (Q9FPS3), UBP24_HUMAN (Q9UPU5), UBP24_MOUSE (B1AY13), 
UBP25_ARATH (Q9FPS2), UBP25_HUMAN (Q9UHP3), UBP25_MOUSE (P57080), 
UBP26_ARATH (Q9SCJ9), UBP26_HUMAN (Q9BXU7), UBP26_MOUSE (Q99MX1), 
UBP26_ORYSI (A2XDG4), UBP26_ORYSJ (A3AF13), UBP27_ARATH (Q9FPS0), 
UBP27_HUMAN (A6NNY8), UBP27_MOUSE (Q8CEG8), UBP28_CHICK (Q5ZID5), 
UBP28_HUMAN (Q96RU2), UBP28_MOUSE (Q5I043), UBP28_RAT   (D3ZJ96), 
UBP29_HUMAN (Q9HBJ7), UBP29_MOUSE (Q9ES63), UBP2_ARATH  (Q8W4N3), 
UBP2_BOVIN  (Q2KHV7), UBP2_CHICK  (O57429), UBP2_DROME  (Q8IQ27), 
UBP2_HUMAN  (O75604), UBP2_KLULA  (O42726), UBP2_MOUSE  (O88623), 
UBP2_RAT(Q5U349), UBP2_SCHPO  (Q9P3U0), UBP2_YEAST  (Q01476), 
UBP30_DANRE (A2BGT0), UBP30_HUMAN (Q70CQ3), UBP30_MOUSE (Q3UN04), 
UBP30_RAT   (D3ZPG5), UBP30_XENTR (A4QNN3), UBP31_HUMAN (Q70CQ4), 
UBP32_DROME (M9PD06), UBP32_HUMAN (Q8NFA0), UBP32_MOUSE (F8VPZ3), 
UBP33_BOVIN (A6QNM7), UBP33_DANRE (A5PMR2), UBP33_HUMAN (Q8TEY7), 
UBP33_MOUSE (Q8R5K2), UBP33_PONAB (Q5REG5), UBP33_XENTR (Q28CN3), 
UBP34_HUMAN (Q70CQ2), UBP34_MOUSE (Q6ZQ93), UBP35_HUMAN (Q9P2H5), 
UBP36_DROAN (B3M3M6), UBP36_DROER (B3NC86), UBP36_DROGR (B4IXE0), 
UBP36_DROME (Q9VRP5), UBP36_DROMO (B4KXJ5), UBP36_DROPS (Q2LZB1), 
UBP36_DROSE (B4HUI5), UBP36_DROSI (B4QIS3), UBP36_DROVI (B4LG38), 
UBP36_DROWI (B4MLR8), UBP36_DROYA (B4PIW8), UBP36_HUMAN (Q9P275), 
UBP36_MOUSE (B1AQJ2), UBP37_BOVIN (F1N5V1), UBP37_CANLF (E2RK09), 
UBP37_CHICK (E1C213), UBP37_DANRE (E7F6T8), UBP37_HUMAN (Q86T82), 
UBP37_MOUSE (Q8C0R0), UBP37_PIG   (F1SRY5), UBP38_HUMAN (Q8NB14), 
UBP38_MOUSE (Q8BW70), UBP3_ARATH  (O24454), UBP3_HUMAN  (Q9Y6I4), 
UBP3_MOUSE  (Q91W36), UBP3_SCHPO  (O94269), UBP3_YEAST  (Q01477), 
UBP40_HUMAN (Q9NVE5), UBP40_MOUSE (Q8BWR4), UBP42_BOVIN (E1B9W9), 
UBP42_HUMAN (Q9H9J4), UBP42_MOUSE (B2RQC2), UBP42_RAT   (D3ZU96), 
UBP43_HUMAN (Q70EL4), UBP43_MOUSE (Q8BUM9), UBP44_AILME (D2HBJ8), 
UBP44_DANRE (Q7ZUM8), UBP44_HUMAN (Q9H0E7), UBP44_MOUSE (Q8C2S0), 
UBP44_XENTR (Q0V9G5), UBP45_DANRE (E9QG68), UBP45_HUMAN (Q70EL2), 
UBP45_MOUSE (Q8K387), UBP46_CAEEL (P34547), UBP46_DANRE (A5WWB0), 
UBP46_HUMAN (P62068), UBP46_MOUSE (P62069), UBP46_PONAB (Q5RBQ4), 
UBP46_RAT   (F1M625), UBP47_CHICK (E1C1R4), UBP47_HUMAN (Q96K76), 
UBP47_MOUSE (Q8BY87), UBP47_XENLA (Q5U252), UBP47_XENTR (A1A5G2), 
UBP48_CAEEL (G5ECC7), UBP49_HUMAN (Q70CQ1), UBP49_MOUSE (Q6P9L4), 
UBP4_ARATH  (Q8LAM0), UBP4_BOVIN  (A6QR55), UBP4_CANGA  (Q6FQF0), 
UBP4_EREGS  (Q754R5), UBP4_HUMAN  (Q13107), UBP4_KLULA  (Q9HFS7), 
UBP4_MOUSE  (P35123), UBP4_PONAB  (Q5RCD3), UBP4_RAT(B2GUZ1), 
UBP4_SCHPO  (O60139), UBP4_VANPO  (A7TGY3), UBP4_YEAS1  (B3LGK1), 
UBP4_YEAS7  (A6ZY34), UBP4_YEAST  (P32571), UBP50_HUMAN (Q70EL3), 
UBP50_MACFA (Q4R6D3), UBP50_MOUSE (Q6P8X6), UBP51_HUMAN (Q70EK9), 
UBP51_MOUSE (B1AY15), UBP5_ARATH  (O22207), UBP5_HUMAN  (P45974), 
UBP5_MOUSE  (P56399), UBP5_YEAST  (P39944), UBP64_DROME (Q9W4C3), 
UBP6_ARATH  (Q949Y0), UBP6_HUMAN  (P35125), UBP6_SCHPO  (Q92353), 
UBP6_YEAST  (P43593), UBP71_SCHPO (Q9UTT1), UBP72_SCHPO (Q09879), 
UBP7_ARATH  (Q84WC6), UBP7_CAEBR  (Q60MK8), UBP7_CAEEL  (Q7JKC3), 
UBP7_CHICK  (Q6U7I1), UBP7_DROME  (Q9VYQ8), UBP7_HUMAN  (Q93009), 
UBP7_MOUSE  (Q6A4J8), UBP7_RAT(Q4VSI4), UBP7_SCHPO  (Q9P7S5), 
UBP7_YEAST  (P40453), UBP8_ARATH  (Q9C585), UBP8_HUMAN  (P40818), 
UBP8_MOUSE  (Q80U87), UBP8_SCHPO  (Q09738), UBP8_YEAST  (P50102), 
UBP9_ARATH  (Q93Y01), UBP9_YEAST  (P39967), UBPA_DICDI  (P54201), 
UBPE_DROME  (Q24574), UBPL1_MIMIV (Q5UQR3), UBPY_CAEEL  (Q09931), 
UL17C_HUMAN (C9JPN9), UP44A_XENLA (Q6NTR6), UP44B_XENLA (Q5XGZ2), 
USP9X_HUMAN (Q93008), USP9X_MOUSE (P70398), USP9Y_HUMAN (O00507), 
USP9Y_MOUSE (F8VPU6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 29 sequences 

U17L1_HUMAN (Q7RTZ2), U17L2_HUMAN (Q6R6M4), U17L3_HUMAN (A6NCW0), 

U17L4_HUMAN (A6NCW7), U17L7_HUMAN (P0C7H9), UBP10_SCHPO (Q9USR2), 
UBP10_YEAST (P53874), UBP11_SCHPO (Q9UUD6), UBP13_DANRE (F1QFS9), 
UBP13_XENTR (F6V6I0), UBP30_DROME (Q9W462), UBP39_HUMAN (Q53GS9), 
UBP39_MOUSE (Q3TIX9), UBP39_PONAB (Q5R761), UBP48_CHICK (Q5ZM45), 
UBP48_HUMAN (Q86UV5), UBP48_MOUSE (Q3V0C5), UBP48_RAT   (Q76LT8), 
UBP54_HUMAN (Q70EL1), UBP54_MOUSE (Q8BL06), UBP54_RAT   (Q6IE24), 
UBP5_PONAB  (Q5R407), UBP9_SCHPO  (Q9P7V9), UBPB_DICDI  (O96612), 
UBPH_CAEEL  (Q8WT44), UBPL2_MIMIV (Q5UPW7), USPL1_DANRE (Q6DRC5), 
USPL1_HUMAN (Q5W0Q7), USPL1_MOUSE (Q3ULM6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

UBP11_CANLF (Q01988)


				
	

	

		PDB
[Detailed view]		
		
			149 PDB
			


			pdb_00001nb8; pdb_00001nbf; pdb_00001vjv; pdb_00002ayn; pdb_00002ayo; pdb_00002f1z; pdb_00002gfo; pdb_00002hd5; pdb_00002ibi; pdb_00002vhf; pdb_00002y5b; pdb_00002y6e; 
			
				pdb_00003i3t; pdb_00003ihp; pdb_00003m99; pdb_00003mhh; pdb_00003mhs; pdb_00003mtn; pdb_00003n3k; pdb_00003nhe; pdb_00003v6c; pdb_00003v6e; pdb_00004fip; pdb_00004fjc; 
				pdb_00004fk5; pdb_00004m5w; pdb_00004m5x; pdb_00004wa6; pdb_00005a5b; pdb_00005cht; pdb_00005chv; pdb_00005cvm; pdb_00005cvn; pdb_00005cvo; pdb_00005fwi; pdb_00005gjq; 
				pdb_00005j7t; pdb_00005jtj; pdb_00005jtv; pdb_00005k16; pdb_00005k1a; pdb_00005k1b; pdb_00005k1c; pdb_00005kyb; pdb_00005kyc; pdb_00005kyd; pdb_00005kye; pdb_00005kyf; 
				pdb_00005l8h; pdb_00005l8w; pdb_00005mpc; pdb_00005n9r; pdb_00005n9t; pdb_00005nge; pdb_00005ngf; pdb_00005o71; pdb_00005ohk; pdb_00005ohn; pdb_00005uqv; pdb_00005uqx; 
				pdb_00005vs6; pdb_00005vsb; pdb_00005vsk; pdb_00005wch; pdb_00005whc; pdb_00005xu8; pdb_00006cpm; pdb_00006crn; pdb_00006dgf; pdb_00006f5h; pdb_00006gh9; pdb_00006gha; 
				pdb_00006h4h; pdb_00006h4i; pdb_00006h4j; pdb_00006heh; pdb_00006hei; pdb_00006hej; pdb_00006hek; pdb_00006hel; pdb_00006iik; pdb_00006iil; pdb_00006iim; pdb_00006iin; 
				pdb_00006jlq; pdb_00006m1k; pdb_00006ml1; pdb_00006t9l; pdb_00006vn2; pdb_00006vn3; pdb_00006vn4; pdb_00006vn5; pdb_00006vn6; pdb_00007ay0; pdb_00007ay2; pdb_00007cm2; 
				pdb_00007qo4; pdb_00007qo5; pdb_00007r2g; pdb_00007tuo; pdb_00007w37; pdb_00007w38; pdb_00007w39; pdb_00007w3a; pdb_00007w3b; pdb_00007w3c; pdb_00007w3f; pdb_00007w3g; 
				pdb_00007w3h; pdb_00007w3i; pdb_00007w3j; pdb_00007w3k; pdb_00007w3m; pdb_00007w3r; pdb_00007w3u; pdb_00007xhh; pdb_00007xhk; pdb_00007yxx; pdb_00007yxy; pdb_00008bs3; 
				pdb_00008bs9; pdb_00008d0a; pdb_00008d1t; pdb_00008d4z; pdb_00008hje; pdb_00008p14; pdb_00008p19; pdb_00008p1p; pdb_00008p1q; pdb_00008wg5; pdb_00008xpn; pdb_00009dek; 
				pdb_00009del; pdb_00009dem; pdb_00009den; pdb_00009deo; pdb_00009dep; pdb_00009ebs; pdb_00009fio; pdb_00009fip; pdb_00009fiq; pdb_00009fir; pdb_00009fis; pdb_00009fit; 
				pdb_00009fiu; pdb_00009fiv; pdb_00009hnw; pdb_00009iju; pdb_00009iml
			
			

			» more