We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00973
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PURL: https://purl.expasy.org/prosite/signature/PS00973
Direct ScanProsite submission
General information about the entry
| Entry name [info] | USP_2 |
| Accession [info] | PS00973 |
| Entry type [info] | PATTERN |
| Date [info] |
01-JUN-1994 CREATED;
01-DEC-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00750 |
| Associated ProRule [info] | PRU10093 |
Name and characterization of the entry
| Description [info] | Ubiquitin specific protease (USP) domain signature 2. |
| Pattern [info] |
[YMF]-x-[LK]-x-[SAGNC]-[LIVMFT]-x(2)-H-x-G-x(4,6)-G-H-[YF]. |
Numerical results [info]
| Total number of hits | 299 in 299 different sequences |
| Number of true positive hits | 299 in 299 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 28 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 91.44 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 13 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
299 sequences
CREB_ASPCL (A1CIL1), CREB_ASPFC (B0Y4P5), CREB_ASPFN (B8NSV5), CREB_ASPFU (Q4WQI1), CREB_ASPNC (A2Q9N1), CREB_ASPOR (Q2UUG8), CREB_ASPTN (Q0CT11), CREB_EMENI (Q96V54), CREB_NEOFI (A1CW53), FAF_DROME (P55824), NOT_DROME (Q9VVR1), PUF_DROME (Q9VC56), U17L1_HUMAN (Q7RTZ2), U17L2_HUMAN (Q6R6M4), U17L3_HUMAN (A6NCW0), U17L5_HUMAN (A8MUK1), U17L6_HUMAN (Q6QN14), U17L7_HUMAN (P0C7H9), U17LA_HUMAN (C9JJH3), U17LB_HUMAN (C9JVI0), U17LC_MOUSE (G5E8I7), U17LD_HUMAN (C9JLJ4), U17LF_HUMAN (C9J2P7), U17LH_HUMAN (D6RBQ6), U17LI_HUMAN (D6R9N7), U17LJ_HUMAN (D6RCP7), U17LK_HUMAN (D6RJB6), U17LL_HUMAN (D6R901), U17LM_HUMAN (D6RA61), U17LO_HUMAN (Q0WX57), U17PA_MOUSE (Q61068), U17PB_MOUSE (E9Q9U0), U17PD_MOUSE (G5E8G2), U17PE_MOUSE (Q7M764), UB10A_XENLA (Q2NL57), UB10B_XENLA (Q7ZXR7), UB12A_XENLA (Q52KZ6), UB12B_XENLA (Q5M981), UB22A_XENLA (Q6GNI6), UB22B_XENLA (Q6DCJ1), UBP10_ARATH (Q9ZSB5), UBP10_BOVIN (A5PJS6), UBP10_HUMAN (Q14694), UBP10_MOUSE (P52479), UBP10_RAT (Q3KR59), UBP10_XENTR (Q6DIJ4), UBP10_YEAST (P53874), UBP11_ARATH (Q9MAQ3), UBP11_CANLF (Q01988), UBP11_HUMAN (P51784), UBP11_MOUSE (Q99K46), UBP11_RAT (Q5D006), UBP11_SCHPO (Q9UUD6), UBP11_YEAST (P36026), UBP12_ARATH (Q9FPT1), UBP12_BOVIN (A5D9H7), UBP12_DANRE (A4FUN7), UBP12_DROME (Q9VCT9), UBP12_HUMAN (O75317), UBP12_MOUSE (Q9D9M2), UBP12_RAT (D0RB01), UBP12_SALSA (C0HB46), UBP12_SCHPO (O60079), UBP12_YEAST (P39538), UBP13_ARATH (Q84WU2), UBP13_BOVIN (E1BMF7), UBP13_CHICK (E1BY77), UBP13_DANRE (F1QFS9), UBP13_HUMAN (Q92995), UBP13_MOUSE (Q5BKP2), UBP13_XENTR (F6V6I0), UBP13_YEAST (P38187), UBP14_ARATH (Q8L6Y1), UBP14_BOVIN (Q0IIF7), UBP14_CAEEL (Q17361), UBP14_HUMAN (P54578), UBP14_MOUSE (Q9JMA1), UBP14_PANTR (P60051), UBP14_RABIT (P40826), UBP14_SCHPO (Q11119), UBP14_YEAST (P38237), UBP15_BOVIN (Q2HJE4), UBP15_HUMAN (Q9Y4E8), UBP15_MOUSE (Q8R5H1), UBP15_RAT (Q9R085), UBP15_XENTR (F6Z5C0), UBP15_YEAST (P50101), UBP16_BOVIN (Q08DA3), UBP16_DANRE (A8HAL1), UBP16_EMENI (P0CAQ1), UBP16_HUMAN (Q9Y5T5), UBP16_MACFA (Q4R6X7), UBP16_MOUSE (Q99LG0), UBP16_RAT (Q2KJ09), UBP16_SCHPO (O74442), UBP16_XENLA (Q6PAW2), UBP16_XENTR (Q0VA64), UBP16_YEAST (Q02863), UBP18_HUMAN (Q9UMW8), UBP18_MOUSE (Q9WTV6), UBP18_PONAB (Q5RE63), UBP19_HUMAN (O94966), UBP19_MOUSE (Q3UJD6), UBP19_RAT (Q6J1Y9), UBP1_ARATH (Q9FPT5), UBP1_BOVIN (Q29RP1), UBP1_HUMAN (O94782), UBP1_MOUSE (Q8BJQ2), UBP1_RAT(Q569C3), UBP1_SCHPO (Q9USM5), UBP1_YEAST (P25037), UBP20_ARATH (Q9FPS7), UBP20_BOVIN (A7Z056), UBP20_DANRE (A5PN09), UBP20_HUMAN (Q9Y2K6), UBP20_MOUSE (Q8C6M1), UBP20_PONAB (Q5R5Z6), UBP20_XENLA (B1WBD7), UBP20_XENTR (A0JM59), UBP21_ARATH (Q9FIQ1), UBP21_BOVIN (Q2KJ72), UBP21_HUMAN (Q9UK80), UBP21_MOUSE (Q9QZL6), UBP21_RAT (B2GUX4), UBP22_BOVIN (P0C8Z3), UBP22_DANRE (A6H8I0), UBP22_HUMAN (Q9UPT9), UBP22_MOUSE (Q5DU02), UBP23_ARATH (Q9FPS4), UBP24_ARATH (Q9FPS3), UBP24_HUMAN (Q9UPU5), UBP24_MOUSE (B1AY13), UBP25_ARATH (Q9FPS2), UBP25_HUMAN (Q9UHP3), UBP25_MOUSE (P57080), UBP26_ARATH (Q9SCJ9), UBP26_HUMAN (Q9BXU7), UBP26_MOUSE (Q99MX1), UBP26_ORYSI (A2XDG4), UBP26_ORYSJ (A3AF13), UBP27_HUMAN (A6NNY8), UBP27_MOUSE (Q8CEG8), UBP28_CHICK (Q5ZID5), UBP28_HUMAN (Q96RU2), UBP28_MOUSE (Q5I043), UBP28_RAT (D3ZJ96), UBP29_HUMAN (Q9HBJ7), UBP29_MOUSE (Q9ES63), UBP2_ARATH (Q8W4N3), UBP2_BOVIN (Q2KHV7), UBP2_CHICK (O57429), UBP2_DROME (Q8IQ27), UBP2_HUMAN (O75604), UBP2_KLULA (O42726), UBP2_MOUSE (O88623), UBP2_RAT(Q5U349), UBP2_SCHPO (Q9P3U0), UBP2_YEAST (Q01476), UBP30_DANRE (A2BGT0), UBP30_DROME (Q9W462), UBP30_HUMAN (Q70CQ3), UBP30_MOUSE (Q3UN04), UBP30_RAT (D3ZPG5), UBP30_XENTR (A4QNN3), UBP31_HUMAN (Q70CQ4), UBP32_DROME (M9PD06), UBP32_HUMAN (Q8NFA0), UBP32_MOUSE (F8VPZ3), UBP33_BOVIN (A6QNM7), UBP33_DANRE (A5PMR2), UBP33_HUMAN (Q8TEY7), UBP33_MOUSE (Q8R5K2), UBP33_PONAB (Q5REG5), UBP33_XENTR (Q28CN3), UBP34_HUMAN (Q70CQ2), UBP34_MOUSE (Q6ZQ93), UBP35_HUMAN (Q9P2H5), UBP36_DROAN (B3M3M6), UBP36_DROER (B3NC86), UBP36_DROGR (B4IXE0), UBP36_DROME (Q9VRP5), UBP36_DROMO (B4KXJ5), UBP36_DROPS (Q2LZB1), UBP36_DROSE (B4HUI5), UBP36_DROSI (B4QIS3), UBP36_DROVI (B4LG38), UBP36_DROWI (B4MLR8), UBP36_DROYA (B4PIW8), UBP36_HUMAN (Q9P275), UBP36_MOUSE (B1AQJ2), UBP37_BOVIN (F1N5V1), UBP37_CANLF (E2RK09), UBP37_CHICK (E1C213), UBP37_DANRE (E7F6T8), UBP37_HUMAN (Q86T82), UBP37_MOUSE (Q8C0R0), UBP37_PIG (F1SRY5), UBP38_HUMAN (Q8NB14), UBP38_MOUSE (Q8BW70), UBP3_ARATH (O24454), UBP3_HUMAN (Q9Y6I4), UBP3_MOUSE (Q91W36), UBP3_SCHPO (O94269), UBP3_YEAST (Q01477), UBP40_HUMAN (Q9NVE5), UBP40_MOUSE (Q8BWR4), UBP42_BOVIN (E1B9W9), UBP42_HUMAN (Q9H9J4), UBP42_MOUSE (B2RQC2), UBP42_RAT (D3ZU96), UBP43_HUMAN (Q70EL4), UBP43_MOUSE (Q8BUM9), UBP44_AILME (D2HBJ8), UBP44_DANRE (Q7ZUM8), UBP44_HUMAN (Q9H0E7), UBP44_MOUSE (Q8C2S0), UBP44_XENTR (Q0V9G5), UBP45_DANRE (E9QG68), UBP45_HUMAN (Q70EL2), UBP45_MOUSE (Q8K387), UBP46_CAEEL (P34547), UBP46_DANRE (A5WWB0), UBP46_HUMAN (P62068), UBP46_MOUSE (P62069), UBP46_PONAB (Q5RBQ4), UBP46_RAT (F1M625), UBP47_CHICK (E1C1R4), UBP47_HUMAN (Q96K76), UBP47_MOUSE (Q8BY87), UBP47_XENLA (Q5U252), UBP47_XENTR (A1A5G2), UBP48_CAEEL (G5ECC7), UBP48_CHICK (Q5ZM45), UBP48_DANRE (A0A0R4IB93), UBP48_HUMAN (Q86UV5), UBP48_MOUSE (Q3V0C5), UBP48_RAT (Q76LT8), UBP49_HUMAN (Q70CQ1), UBP49_MOUSE (Q6P9L4), UBP4_ARATH (Q8LAM0), UBP4_BOVIN (A6QR55), UBP4_EREGS (Q754R5), UBP4_HUMAN (Q13107), UBP4_KLULA (Q9HFS7), UBP4_MOUSE (P35123), UBP4_PONAB (Q5RCD3), UBP4_RAT(B2GUZ1), UBP4_SCHPO (O60139), UBP4_VANPO (A7TGY3), UBP4_YEAS1 (B3LGK1), UBP4_YEAS7 (A6ZY34), UBP4_YEAST (P32571), UBP50_HUMAN (Q70EL3), UBP50_MACFA (Q4R6D3), UBP50_MOUSE (Q6P8X6), UBP51_HUMAN (Q70EK9), UBP51_MOUSE (B1AY15), UBP5_ARATH (O22207), UBP5_HUMAN (P45974), UBP5_MOUSE (P56399), UBP5_PONAB (Q5R407), UBP5_YEAST (P39944), UBP64_DROME (Q9W4C3), UBP6_ARATH (Q949Y0), UBP6_HUMAN (P35125), UBP6_SCHPO (Q92353), UBP6_YEAST (P43593), UBP71_SCHPO (Q9UTT1), UBP72_SCHPO (Q09879), UBP7_ARATH (Q84WC6), UBP7_CAEBR (Q60MK8), UBP7_CAEEL (Q7JKC3), UBP7_CHICK (Q6U7I1), UBP7_DROME (Q9VYQ8), UBP7_HUMAN (Q93009), UBP7_MOUSE (Q6A4J8), UBP7_RAT(Q4VSI4), UBP7_SCHPO (Q9P7S5), UBP7_YEAST (P40453), UBP8_ARATH (Q9C585), UBP8_HUMAN (P40818), UBP8_MOUSE (Q80U87), UBP8_SCHPO (Q09738), UBP8_YEAST (P50102), UBP9_ARATH (Q93Y01), UBP9_SCHPO (Q9P7V9), UBP9_YEAST (P39967), UBPA_DICDI (P54201), UBPB_DICDI (O96612), UBPE_DROME (Q24574), UBPL1_MIMIV (Q5UQR3), UBPY_CAEEL (Q09931), UL17C_HUMAN (C9JPN9), UP44A_XENLA (Q6NTR6), UP44B_XENLA (Q5XGZ2), USP9X_HUMAN (Q93008), USP9X_MOUSE (P70398), USP9Y_HUMAN (O00507), USP9Y_MOUSE (F8VPU6)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
28 sequences
CYLD_BOVIN (Q1RMU2), CYLD_HUMAN (Q9NQC7), CYLD_MOUSE (Q80TQ2), CYLD_PONAB (Q5RED8), CYLD_RAT(Q66H62), FLA_ORYSJ (Q2R4I5), U17L4_HUMAN (A6NCW7), U17L8_HUMAN (P0C7I0), UBP10_SCHPO (Q9USR2), UBP15_ARATH (Q9FPS9), UBP15_ORYSJ (Q0E2F9), UBP16_ARATH (Q9SB51), UBP17_ARATH (Q9FKP5), UBP18_ARATH (Q67XW5), UBP19_ARATH (Q9SJA1), UBP22_ARATH (Q9LEW0), UBP27_ARATH (Q9FPS0), UBP39_HUMAN (Q53GS9), UBP39_MOUSE (Q3TIX9), UBP39_PONAB (Q5R761), UBP54_HUMAN (Q70EL1), UBP54_MOUSE (Q8BL06), UBP54_RAT (Q6IE24), UBPH_CAEEL (Q8WT44), UBPL2_MIMIV (Q5UPW7), USPL1_DANRE (Q6DRC5), USPL1_HUMAN (Q5W0Q7), USPL1_MOUSE (Q3ULM6)» more |
| PDB [Detailed view] |
162 PDB
pdb_00001nb8; pdb_00001nbf; pdb_00001vjv; pdb_00002ayn; pdb_00002ayo; pdb_00002f1z; pdb_00002gfo; pdb_00002hd5; pdb_00002ibi; pdb_00002y5b; pdb_00002y6e; pdb_00003i3t; pdb_00003ihp; pdb_00003m99; pdb_00003mhh; pdb_00003mhs; pdb_00003mtn; pdb_00003n3k; pdb_00003nhe; pdb_00003v6c; pdb_00003v6e; pdb_00004fip; pdb_00004fjc; pdb_00004fk5; pdb_00004m5w; pdb_00004m5x; pdb_00004wa6; pdb_00004zux; pdb_00005a5b; pdb_00005cht; pdb_00005chv; pdb_00005cvm; pdb_00005cvn; pdb_00005cvo; pdb_00005fwi; pdb_00005gjq; pdb_00005j7t; pdb_00005jtj; pdb_00005jtv; pdb_00005k16; pdb_00005k1a; pdb_00005k1b; pdb_00005k1c; pdb_00005kyb; pdb_00005kyc; pdb_00005kyd; pdb_00005kye; pdb_00005kyf; pdb_00005l8h; pdb_00005l8w; pdb_00005mpc; pdb_00005n9r; pdb_00005n9t; pdb_00005nge; pdb_00005ngf; pdb_00005o71; pdb_00005ohk; pdb_00005ohn; pdb_00005ohp; pdb_00005txk; pdb_00005uqv; pdb_00005uqx; pdb_00005vs6; pdb_00005vsb; pdb_00005vsk; pdb_00005wch; pdb_00005whc; pdb_00005xu8; pdb_00005xve; pdb_00006aqr; pdb_00006cpm; pdb_00006crn; pdb_00006dgf; pdb_00006f5h; pdb_00006gh9; pdb_00006gha; pdb_00006h4h; pdb_00006h4i; pdb_00006h4j; pdb_00006heh; pdb_00006hei; pdb_00006hej; pdb_00006hek; pdb_00006hel; pdb_00006iik; pdb_00006iil; pdb_00006iim; pdb_00006iin; pdb_00006jlq; pdb_00006lvs; pdb_00006m1k; pdb_00006ml1; pdb_00006t9l; pdb_00006vn2; pdb_00006vn3; pdb_00006vn4; pdb_00006vn5; pdb_00006vn6; pdb_00007ay0; pdb_00007ay1; pdb_00007ay2; pdb_00007cm2; pdb_00007qo4; pdb_00007qo5; pdb_00007r2g; pdb_00007tuo; pdb_00007w37; pdb_00007w38; pdb_00007w39; pdb_00007w3a; pdb_00007w3b; pdb_00007w3c; pdb_00007w3f; pdb_00007w3g; pdb_00007w3h; pdb_00007w3i; pdb_00007w3j; pdb_00007w3k; pdb_00007w3m; pdb_00007w3r; pdb_00007w3u; pdb_00007xhh; pdb_00007xhk; pdb_00007yxx; pdb_00007yxy; pdb_00007zh3; pdb_00007zh4; pdb_00008a9j; pdb_00008a9k; pdb_00008bs3; pdb_00008bs9; pdb_00008d0a; pdb_00008d1t; pdb_00008d4z; pdb_00008hje; pdb_00008oyp; pdb_00008p14; pdb_00008p19; pdb_00008p1p; pdb_00008p1q; pdb_00008wg5; pdb_00008xpn; pdb_00009dek; pdb_00009del; pdb_00009dem; pdb_00009den; pdb_00009deo; pdb_00009dep; pdb_00009ebs; pdb_00009fci; pdb_00009fcj; pdb_00009fio; pdb_00009fip; pdb_00009fiq; pdb_00009fir; pdb_00009fis; pdb_00009fit; pdb_00009fiu; pdb_00009fiv; pdb_00009hnw; pdb_00009iju; pdb_00009iml » more |