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PROSITE entry PS01047


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General information about the entry

Entry name [info] HMA_1
Accession [info] PS01047
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-APR-2006 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00804

Name and characterization of the entry

Description [info] Heavy-metal-associated domain.
Pattern [info] 
[LIVNS]-x-{L}-[LIVMFA]-x-C-x-[STAGCDNH]-C-x(3)-[LIVFG]-{LV}-x(2)-[LIV]-
x(9,11)-[IVA]-x-[LVFYS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 222 in 153 different sequences
Number of true positive hits 207 in 138 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 63
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 93.24 %
Recall (true positives / (true positives + false negatives)) 76.67 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 6
Site [info] metal(?) at position 6
Site [info] metal(?) at position 9
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 138 sequences 

ATCS_SYNE7  (P37279), ATCS_SYNY3  (P73241), ATCU1_RHIME (P58341), 

ATCU2_RHIME (P58342), ATCU_SINMW  (Q9X5X3), ATOX1_BOVIN (Q3T0E0), 
ATOX1_CANLF (Q9TT99), ATOX1_HUMAN (O00244), ATOX1_MOUSE (O08997), 
ATOX1_RAT   (Q9WUC4), ATOX1_SHEEP (Q9XT28), ATP7A_CRIGR (P49015), 
ATP7A_HUMAN (Q04656), ATP7A_MOUSE (Q64430), ATP7A_RAT   (P70705), 
ATP7B_HUMAN (P35670), ATP7B_MOUSE (Q64446), ATP7B_RAT   (Q64535), 
ATP7B_SHEEP (Q9XT50), ATSY_SYNE7  (P37385), ATSY_SYNP6  (P07893), 
ATU2_SCHPO  (O59666), ATU2_YEAST  (P38995), ATX1_SCHPO  (O74735), 
ATX1_YEAST  (P38636), ATZN_SYNY3  (Q59998), CADA1_STAAU (P20021), 
CADA2_STAAU (P37386), CADA_ALKPO  (P30336), CADA_BACSU  (O32219), 
CADA_LISMN  (Q60048), CADA_LISMO  (P58414), CADA_STAAR  (Q6GIX1), 
COPA1_HELPX (P77871), COPA2_HELPX (Q59467), COPA3_HELPX (O08462), 
COPA_ARCFU  (O29777), COPA_BACSU  (O32220), COPA_ECO57  (Q8XD24), 
COPA_ECOLI  (Q59385), COPA_ENTHA  (P32113), COPA_HELFC  (O32619), 
COPA_HELPJ  (Q9ZM69), COPA_HELPY  (P55989), COPA_SALTI  (Q8Z8S4), 
COPA_SALTY  (Q8ZR95), COPA_STAA1  (A7X6S1), COPA_STAA2  (A6U4T8), 
COPA_STAA3  (Q2FDV0), COPA_STAA8  (Q2FV64), COPA_STAA9  (A5IVY3), 
COPA_STAAB  (Q2YWA3), COPA_STAAC  (Q5HCZ3), COPA_STAAE  (A6QK47), 
COPA_STAAM  (Q99R80), COPA_STAAN  (Q7A3E6), COPA_STAAR  (Q6GDP1), 
COPA_STAAS  (Q6G6B7), COPA_STAAT  (A8Z3F8), COPA_STAAW  (Q8NUQ9), 
COPA_STAEQ  (Q5HL56), COPA_STAES  (Q8CN02), COPA_STAHJ  (Q4L970), 
COPA_STAS1  (Q4A0G1), COPA_VIBCH  (Q9KPZ7), COPA_YERPE  (Q8ZCA7), 
COPP_HELFC  (O32620), COPP_HELPJ  (Q9ZM70), COPP_HELPY  (Q48271), 
COPZ_ARCFU  (O29901), COPZ_BACSU  (O32221), COPZ_ENTHA  (Q47840), 
COPZ_STAA1  (A7X6S3), COPZ_STAA2  (A6U4T9), COPZ_STAA3  (Q2FDU9), 
COPZ_STAA8  (Q2FV63), COPZ_STAA9  (A5IVY4), COPZ_STAAB  (P0C885), 
COPZ_STAAC  (Q5HCZ2), COPZ_STAAE  (A6QK48), COPZ_STAAM  (Q99R79), 
COPZ_STAAN  (Q7A3E5), COPZ_STAAR  (Q6GDP0), COPZ_STAAS  (Q6G6B6), 
COPZ_STAAT  (A8Z3F9), COPZ_STAAW  (Q79ZY4), COPZ_STAEQ  (Q5HL55), 
COPZ_STAES  (Q8CN01), COPZ_STAHJ  (Q4L971), COPZ_STAS1  (Q4A0G2), 
CTPA_MYCLE  (P46839), CTPA_MYCTO  (P9WPU0), CTPA_MYCTU  (P9WPU1), 
CTPB_MYCBO  (P59947), CTPB_MYCLE  (P46840), CTPB_MYCTO  (P9WPT8), 
CTPB_MYCTU  (P9WPT9), FIXI_BRADU  (Q59207), FIXI_RHILV  (O33533), 
FIXI_RHIME  (P18398), HIP24_ARATH (O81464), HIP45_ARATH (B3H6D0), 
HMA4_ORYSJ  (Q6H7M3), HMA5_ARATH  (Q9SH30), HMA5_ORYSJ  (A3AWA4), 
HMA6_ARATH  (Q9SZC9), HMA7_ARATH  (Q9S7J8), HMA9_ORYSJ  (A0A0P0X004), 
HMCT_HELPJ  (Q9ZL53), HMCT_HELPY  (Q59465), MEB2_ARATH  (F4KFS7), 
MERA_ACICA  (Q52109), MERA_ACIFR  (P17239), MERA_ALCSP  (P94188), 
MERA_BACCE  (P16171), MERA_ENTAG  (P94702), MERA_PSEAI  (P00392), 
MERA_PSEFL  (Q51772), MERA_SERMA  (P08662), MERA_SHEPU  (Q54465), 
MERA_SHIFL  (P08332), MERA_STAAU  (P0A0E5), MERA_STAES  (P0A0E4), 
MERP_ACICA  (Q52107), MERP_ALCSP  (P94186), MERP_ENTAG  (P0A217), 
MERP_ENTCL  (P0A218), MERP_PSEAI  (P04131), MERP_PSEFL  (Q51770), 
MERP_SALTI  (P0A216), MERP_SERMA  (P13113), MERP_SHEPU  (Q54463), 
MERP_SHIFL  (P04129), Y290_HAEIN  (P77868), Y291_HAEIN  (P43979), 
Y292_HAEIN  (O32622), ZNTA_ECOLI  (P37617), ZNTA_SHISS  (Q3YW59)
» more

UniProtKB/Swiss-Prot
False negative sequences		 63 sequences 

ATOX1_ARATH (Q94BT9), ATOX1_DICDI (Q54PZ2), ATU1_YEAST  (P38360), 

CCH_ARATH   (O82089), CCS1_CANGA  (Q6FU61), CCS1_DEBHA  (Q6BK66), 
CCS1_EREGS  (Q75DD6), CCS1_KLULA  (Q6CIG2), CCS1_YARLI  (Q6BZU2), 
CCS1_YEAST  (P40202), CCS_ARATH   (Q9LD47), CCS_DICDI   (Q54F73), 
CCS_HUMAN   (O14618), CCS_MOUSE   (Q9WU84), CCS_ORYSJ   (Q7XTY9), 
CCS_RAT (Q9JK72), HIP15_ARATH (Q9CAK6), HIP17_ARATH (Q9FVS0), 
HIP18_ARATH (Q9T0K9), HIP19_ARATH (A0JPW5), HIP1_ARATH  (Q9ZUV1), 
HIP20_ARATH (Q9C9A3), HIP21_ARATH (Q9LF57), HIP22_ARATH (Q93VP2), 
HIP23_ARATH (O65657), HIP25_ARATH (O49613), HIP26_ARATH (Q9SZN7), 
HIP27_ARATH (Q67ZW1), HIP28_ARATH (F4IC29), HIP29_ARATH (Q9LP41), 
HIP2_ARATH  (Q8GWS3), HIP30_ARATH (F4IQG4), HIP31_ARATH (Q84K70), 
HIP32_ARATH (Q9M8K5), HIP33_ARATH (F4JZL7), HIP34_ARATH (Q0WV37), 
HIP35_ARATH (Q9C7J6), HIP36_ARATH (Q84J88), HIP37_ARATH (A2RVM8), 
HIP39_ARATH (O03982), HIP3_ARATH  (Q9FJH5), HIP41_ARATH (F4I1X0), 
HIP42_ARATH (Q9CAV5), HIP43_ARATH (Q9SFF7), HIP44_ARATH (F4JMB8), 
HIP4_ARATH  (Q9SHQ8), HIP5_ARATH  (Q9SJL2), HIP6_ARATH  (Q9LZF1), 
HIP7_ARATH  (Q9C5D3), HIP8_ARATH  (Q9M8T7), HIP9_ARATH  (Q9FLU5), 
HMA2_ARATH  (Q9SZW4), HMA2_ORYSJ  (A3BF39), HMA3A_ARATH (P0CW77), 
HMA3B_ARATH (P0CW78), HMA3_ORYSJ  (Q8H384), HMA4_ARATH  (O64474), 
HMCT_HELFE  (Q9RQB4), NAKR1_ARATH (Q8LDS4), NAKR2_ARATH (Q58FZ0), 
NAKR3_ARATH (Q8RXH8), PI21_ORYSI  (A2XT03), PI21_ORYSJ  (Q7XL73)
» more

UniProtKB/Swiss-Prot
False positive sequences		 15 sequences 

CSPL7_ORYSJ (Q6YT98), CYC6_GRATL  (Q6B941), CYC6_LIMMA  (P00118), 

CYC6_MICAE  (P00112), DDX47_DROME (Q9VIF6), GPI7_YEAST  (P40367), 
HMGB7_ARATH (Q8LDF9), NU5C_NEPOL  (Q9TKV7), QRIC2_MOUSE (Q3V2A7), 
R32DT_HUMAN (Q8NI28), RECO_LEIXX  (Q6AED5), SYFA_THEFY  (Q47N75), 
UD2A3_HUMAN (Q6UWM9), UD2A3_PONAB (Q5RFJ3), YAB4_ARATH  (Q9LDT3)
» more

PDB
[Detailed view]		 88 PDB

1AFI; 1AFJ; 1AW0; 1CC7; 1CC8; 1CPZ; 1FD8; 1FE0; 1FE4; 1FEE; 1FES; 1FVQ; 1FVS; 1JWW; 1K0V; 1KQK; 1KVI; 1KVJ; 1MWY; 1MWZ; 1OPZ; 1OQ3; 1OQ6; 1P6T; 1P8G; 1Q8L; 1S6O; 1S6U; 1TL4; 1TL5; 1Y3J; 1Y3K; 1YG0; 1YJR; 1YJT; 1YJU; 1YJV; 2AJ0; 2AJ1; 2AW0; 2EW9; 2G9O; 2GA7; 2GCF; 2GGP; 2HQI; 2K1R; 2KT2; 2KT3; 2LDI; 2LQ9; 2LQB; 2N7Y; 2OFG; 2OFH; 2QIF; 2RML; 2ROP; 2VOY; 2XMW; 3CJK; 3DXS; 3FRY; 3I9Z; 3IWL; 3IWX; 3K7R; 4A48; 4A4J; 4QOT; 4UMV; 4UMW; 4YDX; 4YEA; 5F0W; 5T7L; 5VDE; 5VDF; 6A71; 6A72; 6FF2; 7DC1; 7XUK; 7XUM; 7XUN; 7XUO; 7ZC3; 8IOY
» more