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PROSITE entry PS01047


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General information about the entry

Entry name [info] HMA_1
Accession [info] PS01047
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-APR-2006 DATA UPDATE;
03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00804

Name and characterization of the entry

Description [info] Heavy-metal-associated domain.
Pattern [info] 
[LIVNS]-x-{L}-[LIVMFA]-x-C-x-[STAGCDNH]-C-x(3)-[LIVFG]-{LV}-x(2)-[LIV]-
x(9,11)-[IVA]-x-[LVFYS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.


Total number of hits 222 in 153 different sequences
Number of true positive hits 207 in 138 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 63
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 93.24 %
Recall (true positives / (true positives + false negatives)) 76.67 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 6
Site [info] metal(?) at position 6
Site [info] metal(?) at position 9
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 138 sequences 

ATCS_SYNE7  (P37279    ), ATCS_SYNY3  (P73241    ), ATCU1_RHIME (P58341    ), 

ATCU2_RHIME (P58342    ), ATCU_SINMW  (Q9X5X3    ), ATOX1_BOVIN (Q3T0E0    ), 
ATOX1_CANLF (Q9TT99    ), ATOX1_HUMAN (O00244    ), ATOX1_MOUSE (O08997    ), 
ATOX1_RAT   (Q9WUC4    ), ATOX1_SHEEP (Q9XT28    ), ATP7A_CRIGR (P49015    ), 
ATP7A_HUMAN (Q04656    ), ATP7A_MOUSE (Q64430    ), ATP7A_RAT   (P70705    ), 
ATP7B_HUMAN (P35670    ), ATP7B_MOUSE (Q64446    ), ATP7B_RAT   (Q64535    ), 
ATP7B_SHEEP (Q9XT50    ), ATSY_SYNE7  (P37385    ), ATSY_SYNP6  (P07893    ), 
ATU2_SCHPO  (O59666    ), ATU2_YEAST  (P38995    ), ATX1_SCHPO  (O74735    ), 
ATX1_YEAST  (P38636    ), ATZN_SYNY3  (Q59998    ), CADA1_STAAU (P20021    ), 
CADA2_STAAU (P37386    ), CADA_ALKPO  (P30336    ), CADA_BACSU  (O32219    ), 
CADA_LISMN  (Q60048    ), CADA_LISMO  (P58414    ), CADA_STAAR  (Q6GIX1    ), 
COPA1_HELPX (P77871    ), COPA2_HELPX (Q59467    ), COPA3_HELPX (O08462    ), 
COPA_ARCFU  (O29777    ), COPA_BACSU  (O32220    ), COPA_ECO57  (Q8XD24    ), 
COPA_ECOLI  (Q59385    ), COPA_ENTHA  (P32113    ), COPA_HELFC  (O32619    ), 
COPA_HELPJ  (Q9ZM69    ), COPA_HELPY  (P55989    ), COPA_SALTI  (Q8Z8S4    ), 
COPA_SALTY  (Q8ZR95    ), COPA_STAA1  (A7X6S1    ), COPA_STAA2  (A6U4T8    ), 
COPA_STAA3  (Q2FDV0    ), COPA_STAA8  (Q2FV64    ), COPA_STAA9  (A5IVY3    ), 
COPA_STAAB  (Q2YWA3    ), COPA_STAAC  (Q5HCZ3    ), COPA_STAAE  (A6QK47    ), 
COPA_STAAM  (Q99R80    ), COPA_STAAN  (Q7A3E6    ), COPA_STAAR  (Q6GDP1    ), 
COPA_STAAS  (Q6G6B7    ), COPA_STAAT  (A8Z3F8    ), COPA_STAAW  (Q8NUQ9    ), 
COPA_STAEQ  (Q5HL56    ), COPA_STAES  (Q8CN02    ), COPA_STAHJ  (Q4L970    ), 
COPA_STAS1  (Q4A0G1    ), COPA_VIBCH  (Q9KPZ7    ), COPA_YERPE  (Q8ZCA7    ), 
COPP_HELFC  (O32620    ), COPP_HELPJ  (Q9ZM70    ), COPP_HELPY  (Q48271    ), 
COPZ_ARCFU  (O29901    ), COPZ_BACSU  (O32221    ), COPZ_ENTHA  (Q47840    ), 
COPZ_STAA1  (A7X6S3    ), COPZ_STAA2  (A6U4T9    ), COPZ_STAA3  (Q2FDU9    ), 
COPZ_STAA8  (Q2FV63    ), COPZ_STAA9  (A5IVY4    ), COPZ_STAAB  (P0C885    ), 
COPZ_STAAC  (Q5HCZ2    ), COPZ_STAAE  (A6QK48    ), COPZ_STAAM  (Q99R79    ), 
COPZ_STAAN  (Q7A3E5    ), COPZ_STAAR  (Q6GDP0    ), COPZ_STAAS  (Q6G6B6    ), 
COPZ_STAAT  (A8Z3F9    ), COPZ_STAAW  (Q79ZY4    ), COPZ_STAEQ  (Q5HL55    ), 
COPZ_STAES  (Q8CN01    ), COPZ_STAHJ  (Q4L971    ), COPZ_STAS1  (Q4A0G2    ), 
CTPA_MYCLE  (P46839    ), CTPA_MYCTO  (P9WPU0    ), CTPA_MYCTU  (P9WPU1    ), 
CTPB_MYCBO  (P59947    ), CTPB_MYCLE  (P46840    ), CTPB_MYCTO  (P9WPT8    ), 
CTPB_MYCTU  (P9WPT9    ), FIXI_BRADU  (Q59207    ), FIXI_RHILV  (O33533    ), 
FIXI_RHIME  (P18398    ), HIP24_ARATH (O81464    ), HIP45_ARATH (B3H6D0    ), 
HMA4_ORYSJ  (Q6H7M3    ), HMA5_ARATH  (Q9SH30    ), HMA5_ORYSJ  (A3AWA4    ), 
HMA6_ARATH  (Q9SZC9    ), HMA7_ARATH  (Q9S7J8    ), HMA9_ORYSJ  (A0A0P0X004), 
HMCT_HELPJ  (Q9ZL53    ), HMCT_HELPY  (Q59465    ), MEB2_ARATH  (F4KFS7    ), 
MERA_ACICA  (Q52109    ), MERA_ACIFR  (P17239    ), MERA_ALCSP  (P94188    ), 
MERA_BACCE  (P16171    ), MERA_ENTAG  (P94702    ), MERA_PSEAI  (P00392    ), 
MERA_PSEFL  (Q51772    ), MERA_SERMA  (P08662    ), MERA_SHEPU  (Q54465    ), 
MERA_SHIFL  (P08332    ), MERA_STAAU  (P0A0E5    ), MERA_STAES  (P0A0E4    ), 
MERP_ACICA  (Q52107    ), MERP_ALCSP  (P94186    ), MERP_ENTAG  (P0A217    ), 
MERP_ENTCL  (P0A218    ), MERP_PSEAI  (P04131    ), MERP_PSEFL  (Q51770    ), 
MERP_SALTI  (P0A216    ), MERP_SERMA  (P13113    ), MERP_SHEPU  (Q54463    ), 
MERP_SHIFL  (P04129    ), Y290_HAEIN  (P77868    ), Y291_HAEIN  (P43979    ), 
Y292_HAEIN  (O32622    ), ZNTA_ECOLI  (P37617    ), ZNTA_SHISS  (Q3YW59    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 63 sequences 

ATOX1_ARATH (Q94BT9    ), ATOX1_DICDI (Q54PZ2    ), ATU1_YEAST  (P38360    ), 

CCH_ARATH   (O82089    ), CCS1_ASHGO  (Q75DD6    ), CCS1_CANGA  (Q6FU61    ), 
CCS1_DEBHA  (Q6BK66    ), CCS1_KLULA  (Q6CIG2    ), CCS1_YARLI  (Q6BZU2    ), 
CCS1_YEAST  (P40202    ), CCS_ARATH   (Q9LD47    ), CCS_DICDI   (Q54F73    ), 
CCS_HUMAN   (O14618    ), CCS_MOUSE   (Q9WU84    ), CCS_ORYSJ   (Q7XTY9    ), 
CCS_RAT     (Q9JK72    ), HIP15_ARATH (Q9CAK6    ), HIP17_ARATH (Q9FVS0    ), 
HIP18_ARATH (Q9T0K9    ), HIP19_ARATH (A0JPW5    ), HIP1_ARATH  (Q9ZUV1    ), 
HIP20_ARATH (Q9C9A3    ), HIP21_ARATH (Q9LF57    ), HIP22_ARATH (Q93VP2    ), 
HIP23_ARATH (O65657    ), HIP25_ARATH (O49613    ), HIP26_ARATH (Q9SZN7    ), 
HIP27_ARATH (Q67ZW1    ), HIP28_ARATH (F4IC29    ), HIP29_ARATH (Q9LP41    ), 
HIP2_ARATH  (Q8GWS3    ), HIP30_ARATH (F4IQG4    ), HIP31_ARATH (Q84K70    ), 
HIP32_ARATH (Q9M8K5    ), HIP33_ARATH (F4JZL7    ), HIP34_ARATH (Q0WV37    ), 
HIP35_ARATH (Q9C7J6    ), HIP36_ARATH (Q84J88    ), HIP37_ARATH (A2RVM8    ), 
HIP39_ARATH (O03982    ), HIP3_ARATH  (Q9FJH5    ), HIP41_ARATH (F4I1X0    ), 
HIP42_ARATH (Q9CAV5    ), HIP43_ARATH (Q9SFF7    ), HIP44_ARATH (F4JMB8    ), 
HIP4_ARATH  (Q9SHQ8    ), HIP5_ARATH  (Q9SJL2    ), HIP6_ARATH  (Q9LZF1    ), 
HIP7_ARATH  (Q9C5D3    ), HIP8_ARATH  (Q9M8T7    ), HIP9_ARATH  (Q9FLU5    ), 
HMA2_ARATH  (Q9SZW4    ), HMA2_ORYSJ  (A3BF39    ), HMA3A_ARATH (P0CW77    ), 
HMA3B_ARATH (P0CW78    ), HMA3_ORYSJ  (Q8H384    ), HMA4_ARATH  (O64474    ), 
HMCT_HELFE  (Q9RQB4    ), NAKR1_ARATH (Q8LDS4    ), NAKR2_ARATH (Q58FZ0    ), 
NAKR3_ARATH (Q8RXH8    ), PI21_ORYSI  (A2XT03    ), PI21_ORYSJ  (Q7XL73    )
» more

UniProtKB/Swiss-Prot
False positive sequences		 15 sequences 

CSPL7_ORYSJ (Q6YT98    ), CYC6_GRATL  (Q6B941    ), CYC6_LIMMA  (P00118    ), 

CYC6_MICAE  (P00112    ), DDX47_DROME (Q9VIF6    ), GPI7_YEAST  (P40367    ), 
HMGB7_ARATH (Q8LDF9    ), NU5C_NEPOL  (Q9TKV7    ), QRIC2_MOUSE (Q3V2A7    ), 
R32DT_HUMAN (Q8NI28    ), RECO_LEIXX  (Q6AED5    ), SYFA_THEFY  (Q47N75    ), 
UD2A3_HUMAN (Q6UWM9    ), UD2A3_PONAB (Q5RFJ3    ), YAB4_ARATH  (Q9LDT3    )
» more

PDB
[Detailed view]		 83 PDB

1AFI; 1AFJ; 1AW0; 1CC7; 1CC8; 1CPZ; 1FD8; 1FE0; 1FE4; 1FEE; 1FES; 1FVQ; 1FVS; 1JWW; 1K0V; 1KQK; 1KVI; 1KVJ; 1MWY; 1MWZ; 1OPZ; 1OQ3; 1OQ6; 1P6T; 1P8G; 1Q8L; 1S6O; 1S6U; 1TL4; 1TL5; 1Y3J; 1Y3K; 1YG0; 1YJR; 1YJT; 1YJU; 1YJV; 2AJ0; 2AJ1; 2AW0; 2EW9; 2G9O; 2GA7; 2GCF; 2GGP; 2HQI; 2K1R; 2KT2; 2KT3; 2LDI; 2LQ9; 2LQB; 2N7Y; 2OFG; 2OFH; 2QIF; 2RML; 2ROP; 2VOY; 2XMW; 3CJK; 3DXS; 3FRY; 3I9Z; 3IWL; 3IWX; 3K7R; 4A48; 4A4J; 4QOT; 4UMV; 4UMW; 4YDX; 4YEA; 5F0W; 5T7L; 5VDE; 5VDF; 6A71; 6A72; 6FF2; 7DC1; 7ZC3
» more