PROSITE logo

PROSITE entry PS01047


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] HMA_1
Accession [info] PS01047
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00804

Name and characterization of the entry

Description [info] Heavy-metal-associated domain.
Pattern [info] 
[LIVNS]-x-{L}-[LIVMFA]-x-C-x-[STAGCDNH]-C-x(3)-[LIVFG]-{LV}-x(2)-[LIV]-
x(9,11)-[IVA]-x-[LVFYS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 222 in 153 different sequences
Number of true positive hits 207 in 138 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 63
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 93.24 %
Recall (true positives / (true positives + false negatives)) 76.67 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 6
Site [info] metal(?) at position 6
Site [info] metal(?) at position 9
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 138 sequences 

ATCS_SYNE7  (P37279), ATCS_SYNY3  (P73241), ATCU1_RHIME (P58341), 

ATCU2_RHIME (P58342), ATCU_SINMW  (Q9X5X3), ATOX1_BOVIN (Q3T0E0), 
ATOX1_CANLF (Q9TT99), ATOX1_HUMAN (O00244), ATOX1_MOUSE (O08997), 
ATOX1_RAT   (Q9WUC4), ATOX1_SHEEP (Q9XT28), ATP7A_CRIGR (P49015), 
ATP7A_HUMAN (Q04656), ATP7A_MOUSE (Q64430), ATP7A_RAT   (P70705), 
ATP7B_HUMAN (P35670), ATP7B_MOUSE (Q64446), ATP7B_RAT   (Q64535), 
ATP7B_SHEEP (Q9XT50), ATSY_SYNE7  (P37385), ATSY_SYNP6  (P07893), 
ATU2_SCHPO  (O59666), ATU2_YEAST  (P38995), ATX1_SCHPO  (O74735), 
ATX1_YEAST  (P38636), ATZN_SYNY3  (Q59998), CADA1_STAAU (P20021), 
CADA2_STAAU (P37386), CADA_ALKPO  (P30336), CADA_BACSU  (O32219), 
CADA_LISMN  (Q60048), CADA_LISMO  (P58414), CADA_STAAR  (Q6GIX1), 
COPA1_HELPX (P77871), COPA2_HELPX (Q59467), COPA3_HELPX (O08462), 
COPA_ARCFU  (O29777), COPA_BACSU  (O32220), COPA_ECO57  (Q8XD24), 
COPA_ECOLI  (Q59385), COPA_ENTHA  (P32113), COPA_HELFC  (O32619), 
COPA_HELPJ  (Q9ZM69), COPA_HELPY  (P55989), COPA_SALTI  (Q8Z8S4), 
COPA_SALTY  (Q8ZR95), COPA_STAA1  (A7X6S1), COPA_STAA2  (A6U4T8), 
COPA_STAA3  (Q2FDV0), COPA_STAA8  (Q2FV64), COPA_STAA9  (A5IVY3), 
COPA_STAAB  (Q2YWA3), COPA_STAAC  (Q5HCZ3), COPA_STAAE  (A6QK47), 
COPA_STAAM  (Q99R80), COPA_STAAN  (Q7A3E6), COPA_STAAR  (Q6GDP1), 
COPA_STAAS  (Q6G6B7), COPA_STAAT  (A8Z3F8), COPA_STAAW  (Q8NUQ9), 
COPA_STAEQ  (Q5HL56), COPA_STAES  (Q8CN02), COPA_STAHJ  (Q4L970), 
COPA_STAS1  (Q4A0G1), COPA_VIBCH  (Q9KPZ7), COPA_YERPE  (Q8ZCA7), 
COPP_HELFC  (O32620), COPP_HELPJ  (Q9ZM70), COPP_HELPY  (Q48271), 
COPZ_ARCFU  (O29901), COPZ_BACSU  (O32221), COPZ_ENTHA  (Q47840), 
COPZ_STAA1  (A7X6S3), COPZ_STAA2  (A6U4T9), COPZ_STAA3  (Q2FDU9), 
COPZ_STAA8  (Q2FV63), COPZ_STAA9  (A5IVY4), COPZ_STAAB  (P0C885), 
COPZ_STAAC  (Q5HCZ2), COPZ_STAAE  (A6QK48), COPZ_STAAM  (Q99R79), 
COPZ_STAAN  (Q7A3E5), COPZ_STAAR  (Q6GDP0), COPZ_STAAS  (Q6G6B6), 
COPZ_STAAT  (A8Z3F9), COPZ_STAAW  (Q79ZY4), COPZ_STAEQ  (Q5HL55), 
COPZ_STAES  (Q8CN01), COPZ_STAHJ  (Q4L971), COPZ_STAS1  (Q4A0G2), 
CTPA_MYCLE  (P46839), CTPA_MYCTO  (P9WPU0), CTPA_MYCTU  (P9WPU1), 
CTPB_MYCBO  (P59947), CTPB_MYCLE  (P46840), CTPB_MYCTO  (P9WPT8), 
CTPB_MYCTU  (P9WPT9), FIXI_BRADU  (Q59207), FIXI_RHILV  (O33533), 
FIXI_RHIME  (P18398), HIP24_ARATH (O81464), HIP45_ARATH (B3H6D0), 
HMA4_ORYSJ  (Q6H7M3), HMA5_ARATH  (Q9SH30), HMA5_ORYSJ  (A3AWA4), 
HMA6_ARATH  (Q9SZC9), HMA7_ARATH  (Q9S7J8), HMA9_ORYSJ  (A0A0P0X004), 
HMCT_HELPJ  (Q9ZL53), HMCT_HELPY  (Q59465), MEB2_ARATH  (F4KFS7), 
MERA_ACICA  (Q52109), MERA_ACIFR  (P17239), MERA_ALCSP  (P94188), 
MERA_BACCE  (P16171), MERA_ENTAG  (P94702), MERA_PSEAI  (P00392), 
MERA_PSEFL  (Q51772), MERA_SERMA  (P08662), MERA_SHEPU  (Q54465), 
MERA_SHIFL  (P08332), MERA_STAAU  (P0A0E5), MERA_STAES  (P0A0E4), 
MERP_ACICA  (Q52107), MERP_ALCSP  (P94186), MERP_ENTAG  (P0A217), 
MERP_ENTCL  (P0A218), MERP_PSEAI  (P04131), MERP_PSEFL  (Q51770), 
MERP_SALTI  (P0A216), MERP_SERMA  (P13113), MERP_SHEPU  (Q54463), 
MERP_SHIFL  (P04129), Y290_HAEIN  (P77868), Y291_HAEIN  (P43979), 
Y292_HAEIN  (O32622), ZNTA_ECOLI  (P37617), ZNTA_SHISS  (Q3YW59)
» more

UniProtKB/Swiss-Prot
False negative sequences		 63 sequences 

ATOX1_ARATH (Q94BT9), ATOX1_DICDI (Q54PZ2), ATU1_YEAST  (P38360), 

CCH_ARATH   (O82089), CCS1_CANGA  (Q6FU61), CCS1_DEBHA  (Q6BK66), 
CCS1_EREGS  (Q75DD6), CCS1_KLULA  (Q6CIG2), CCS1_YARLI  (Q6BZU2), 
CCS1_YEAST  (P40202), CCS_ARATH   (Q9LD47), CCS_DICDI   (Q54F73), 
CCS_HUMAN   (O14618), CCS_MOUSE   (Q9WU84), CCS_ORYSJ   (Q7XTY9), 
CCS_RAT (Q9JK72), HIP15_ARATH (Q9CAK6), HIP17_ARATH (Q9FVS0), 
HIP18_ARATH (Q9T0K9), HIP19_ARATH (A0JPW5), HIP1_ARATH  (Q9ZUV1), 
HIP20_ARATH (Q9C9A3), HIP21_ARATH (Q9LF57), HIP22_ARATH (Q93VP2), 
HIP23_ARATH (O65657), HIP25_ARATH (O49613), HIP26_ARATH (Q9SZN7), 
HIP27_ARATH (Q67ZW1), HIP28_ARATH (F4IC29), HIP29_ARATH (Q9LP41), 
HIP2_ARATH  (Q8GWS3), HIP30_ARATH (F4IQG4), HIP31_ARATH (Q84K70), 
HIP32_ARATH (Q9M8K5), HIP33_ARATH (F4JZL7), HIP34_ARATH (Q0WV37), 
HIP35_ARATH (Q9C7J6), HIP36_ARATH (Q84J88), HIP37_ARATH (A2RVM8), 
HIP39_ARATH (O03982), HIP3_ARATH  (Q9FJH5), HIP41_ARATH (F4I1X0), 
HIP42_ARATH (Q9CAV5), HIP43_ARATH (Q9SFF7), HIP44_ARATH (F4JMB8), 
HIP4_ARATH  (Q9SHQ8), HIP5_ARATH  (Q9SJL2), HIP6_ARATH  (Q9LZF1), 
HIP7_ARATH  (Q9C5D3), HIP8_ARATH  (Q9M8T7), HIP9_ARATH  (Q9FLU5), 
HMA2_ARATH  (Q9SZW4), HMA2_ORYSJ  (A3BF39), HMA3A_ARATH (P0CW77), 
HMA3B_ARATH (P0CW78), HMA3_ORYSJ  (Q8H384), HMA4_ARATH  (O64474), 
HMCT_HELFE  (Q9RQB4), NAKR1_ARATH (Q8LDS4), NAKR2_ARATH (Q58FZ0), 
NAKR3_ARATH (Q8RXH8), PI21_ORYSI  (A2XT03), PI21_ORYSJ  (Q7XL73)
» more

UniProtKB/Swiss-Prot
False positive sequences		 15 sequences 

CSPL7_ORYSJ (Q6YT98), CYC6_GRATL  (Q6B941), CYC6_LIMMA  (P00118), 

CYC6_MICAE  (P00112), DDX47_DROME (Q9VIF6), GPI7_YEAST  (P40367), 
HMGB7_ARATH (Q8LDF9), NU5C_NEPOL  (Q9TKV7), QRIC2_MOUSE (Q3V2A7), 
R32DT_HUMAN (Q8NI28), RECO_LEIXX  (Q6AED5), SYFA_THEFY  (Q47N75), 
UD2A3_HUMAN (Q6UWM9), UD2A3_PONAB (Q5RFJ3), YAB4_ARATH  (Q9LDT3)
» more

PDB
[Detailed view]		 88 PDB

1AFI; 1AFJ; 1AW0; 1CC7; 1CC8; 1CPZ; 1FD8; 1FE0; 1FE4; 1FEE; 1FES; 1FVQ; 1FVS; 1JWW; 1K0V; 1KQK; 1KVI; 1KVJ; 1MWY; 1MWZ; 1OPZ; 1OQ3; 1OQ6; 1P6T; 1P8G; 1Q8L; 1S6O; 1S6U; 1TL4; 1TL5; 1Y3J; 1Y3K; 1YG0; 1YJR; 1YJT; 1YJU; 1YJV; 2AJ0; 2AJ1; 2AW0; 2EW9; 2G9O; 2GA7; 2GCF; 2GGP; 2HQI; 2K1R; 2KT2; 2KT3; 2LDI; 2LQ9; 2LQB; 2N7Y; 2OFG; 2OFH; 2QIF; 2RML; 2ROP; 2VOY; 2XMW; 3CJK; 3DXS; 3FRY; 3I9Z; 3IWL; 3IWX; 3K7R; 4A48; 4A4J; 4QOT; 4UMV; 4UMW; 4YDX; 4YEA; 5F0W; 5T7L; 5VDE; 5VDF; 6A71; 6A72; 6FF2; 7DC1; 7XUK; 7XUM; 7XUN; 7XUO; 7ZC3; 8IOY
» more