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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS01095


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PURL: https://purl.expasy.org/prosite/signature/PS01095

Direct ScanProsite submission
General information about the entry

Entry name [info] GH18_1
Accession [info] PS01095
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00839
Associated ProRule [info] PRU10053

Name and characterization of the entry

Description [info] Glycosyl hydrolases family 18 (GH18) active site signature.
Pattern [info]
[LIVMFY]-[DN]-G-[LIVMF]-[DN]-[LIVMF]-[DN]-x-E.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 114 in 113 different sequences
Number of true positive hits 102 in 101 different sequences
Number of 'unknown' hits 0
Number of false positive hits 12 in 12 different sequences
Number of false negative sequences 44
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 89.47 %
Recall (true positives / (true positives + false negatives)) 69.86 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
101 sequences

CHI10_DROME (Q9W5U2), CHI18_ENTFA (Q838S2), CHI1_APHAL  (P32470), 
CHI1_ARTBC  (D4AT07), CHI1_CANAL  (Q5AAH2), CHI1_CANAX  (P46876), 
CHI1_COCIM  (Q1E3R8), CHI1_COCP7  (C5P230), CHI1_COCPS  (P0CB51), 
CHI1_METAN  (O14456), CHI1_METRA  (E9ERT9), CHI1_PINMG  (H2A0L4), 
CHI1_RHINI  (P29025), CHI1_RHIOL  (P29026), CHI2_ARTBC  (D4AVJ0), 
CHI2_CANAL  (P40953), CHI2_COCIM  (Q1EAR5), CHI2_COCP7  (P54197), 
CHI2_METAN  (Q4U4T0), CHI2_METRA  (E9F9R9), CHI2_PINMG  (H2A0L5), 
CHI2_RHIOL  (P29027), CHI2_YEAST  (Q06350), CHI33_ARTBC (D4B4X4), 
CHI33_TRIHA (Q12713), CHI37_TRIHA (Q8NJQ5), CHI3_CANAL  (P40954), 
CHI3_METAN  (Q6QDR4), CHI3_METRA  (E9ENC6), CHI42_TRIHA (P48827), 
CHI46_TRIHA (A6N6J0), CHI4_CANAL  (Q5AM60), CHI4_METAN  (C9WJD0), 
CHI4_METRA  (E9F7R6), CHI52_PAEXY (A0A8G1A3Q5), CHIA1_ASPFM (Q873Y0), 
CHIA1_ASPFU (Q4WEP7), CHIA1_ASPNC (A2QUQ2), CHIA1_EMEND (Q92223), 
CHIA1_EMENI (G5EB30), CHIA1_NIACI (P20533), CHIA_ARATH  (P19172), 
CHIA_BOVIN  (Q95M17), CHIA_CICAR  (P36908), CHIA_CUCSA  (P17541), 
CHIA_FLAJ1  (A5FB63), CHIA_HUMAN  (Q9BZP6), CHIA_MOUSE  (Q91XA9), 
CHIA_PHAAN  (P29024), CHIA_PSEO7  (P32823), CHIA_RAT(Q6RY07), 
CHIA_SERMA  (P07254), CHIA_TOBAC  (P29060), CHIB1_ASPFM (Q873X9), 
CHIB1_ASPFU (E9QRF2), CHIB1_EMENI (G5EAZ3), CHIB_EMEND  (Q92222), 
CHIB_SERMA  (P11797), CHIB_TOBAC  (P29061), CHID_NIACI  (P27050), 
CHIE_BETVU  (P36910), CHIT1_HUMAN (Q13231), CHIT1_MOUSE (Q9D7Q1), 
CHIT1_TULSB (Q9SLP4), CHIT2_DROME (Q9W092), CHIT2_TULSB (Q7M443), 
CHIT3_VITVI (P51614), CHIT5_LOTJA (A0A1B1J8Z2), CHIT_BRUMA  (P29030), 
CHIT_CAEEL  (Q11174), CHIT_MANSE  (P36362), CHIT_NPVAC  (P41684), 
CHIT_NPVOP  (O10363), CHIT_PLAF7  (Q8I4R4), CHIT_PUNGR  (G1UH28), 
CHIT_STRLI  (P36909), CHIT_STRPL  (P11220), CHIT_YEAST  (P29029), 
CHIX_STROI  (Q05638), CHI_PINMA   (P86955), CHLY_HEVBR  (P23472), 
CHT5A_MEDTR (A0A072VEP0), CHT5B_MEDTR (A0A072UR65), DIAC_BOVIN  (Q01458), 
DIAC_HUMAN  (Q01459), DIAC_MOUSE  (Q8R242), DIAC_RAT(Q01460), 
EBA2_ELIME  (P36912), EBAG_FLAST  (P80036), EBAG_STRPL  (P04067), 
EBI1_BIFLS  (B7GPC7), ENDOS_STRP1 (Q99Y92), ENDS2_STRP9 (T1WGN1), 
ENDSD_STRDY (A0A191T6Q6), KTXA_KLULA  (P09805), LYS11_PENEN (A0A0A2J9B0), 
LYS12_PENEN (A0A0A2JP37), LYS18_PENEN (A0A0A2JVV3), NFH1_MEDTR  (U5N4E3), 
PPG1_CANAL  (Q5A6B6), YKVQ_BACSU  (O31682)
» more

UniProtKB/Swiss-Prot
False negative sequences
44 sequences

CH3L1_BOVIN (P30922), CH3L1_BUBBU (Q7YS85), CH3L1_CAPHI (Q8SPQ0), 
CH3L1_HUMAN (P36222), CH3L1_MOUSE (Q61362), CH3L1_PIG   (Q29411), 
CH3L1_PONAB (Q5RBP6), CH3L1_RAT   (Q9WTV1), CH3L1_SHEEP (Q6TMG6), 
CH3L2_HUMAN (Q15782), CHIA_ECOLI  (P13656), CHID1_BOVIN (Q5EAB4), 
CHID1_DANRE (Q7SYK0), CHID1_DICDI (Q54G42), CHID1_HUMAN (Q9BWS9), 
CHID1_MOUSE (Q922Q9), CHID1_PONAB (Q5RFF6), CHID1_RAT   (A0JPQ9), 
CHID1_XENLA (Q68EX9), CHID1_XENTR (Q66IL0), CHID_VIBFU  (P96156), 
CHITL_CAEEL (Q18143), CHIT_SACEN  (P14529), CHL18_DERFA (Q86R84), 
CHL18_DERPT (Q4JK71), CONB_CANEN  (P49347), DIAC1_DICDI (Q7KWW8), 
DIAC2_DICDI (Q8T293), EBA1_ELIME  (P36911), EBA3_ELIME  (P36913), 
OVGP1_BOVIN (Q28042), OVGP1_HUMAN (Q12889), OVGP1_MESAU (Q60557), 
OVGP1_MOUSE (Q62010), OVGP1_PAPAN (P36718), OVGP1_PIG   (Q28990), 
OVGP1_SHEEP (Q28542), XIP1_ORYSJ  (Q7GCM7), XIP1_WHEAT  (Q8L5C6), 
XIP2_ORYSJ  (Q53NL5), XIP_ORYSJ   (Q5WMW5), YDHD_BACSU  (O05495), 
YKZR_BACSU  (C0H404), YVBX_BACSU  (O32258)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
6 sequences

CAI_PHAVU   (P84708), CHI1_STROI  (P29115), CHI2_STROI  (P29116), 
CHIT_STRVL  (P84754), CHLY_PARTH  (P23473), NAHA1_PALCA (P85512)
» more

UniProtKB/Swiss-Prot
False positive sequences
12 sequences

CAPSD_CPVBM (Q6TS43), CAPSD_LDCPR (Q91IE1), CCNL2_XENTR (Q5BKF8), 
HISX_CALS4  (Q8R882), HSCB_ARATH  (Q8L7K4), NU4C_PROM0  (A3PAL7), 
NU4C_PROM2  (A8G2F5), NU4C_PROM5  (A2BUC6), NU4C_PROM9  (Q31D31), 
NU4C_PROMP  (Q7V3C8), SSUB2_RHIJ3 (Q1M7A6), TRPM2_HUMAN (O94759)
» more

PDB
[Detailed view]
114 PDB

pdb_00001c3f; pdb_00001ctn; pdb_00001d2k; pdb_00001edt; pdb_00001ffq; pdb_00001ffr; pdb_00001goi; pdb_00001guv; pdb_00001h0g; pdb_00001h0i; pdb_00001hki; pdb_00001hkj; pdb_00001hkk; pdb_00001hkm; pdb_00001hvq; pdb_00001itx; pdb_00001k9t; pdb_00001lg1; pdb_00001lg2; pdb_00001ll4; pdb_00001ll6; pdb_00001llo; pdb_00001lq0; pdb_00001o6i; pdb_00001ogb; pdb_00001ogg; pdb_00001rd6; pdb_00001w9p; pdb_00001w9u; pdb_00001w9v; pdb_00001waw; pdb_00001wb0; pdb_00001wno; pdb_00001x6l; pdb_00001x6n; pdb_00002a3a; pdb_00002a3b; pdb_00002a3c; pdb_00002a3e; pdb_00002hvm; pdb_00002iuz; pdb_00002uy2; pdb_00002uy3; pdb_00002uy4; pdb_00002uy5; pdb_00002wk2; pdb_00002wly; pdb_00002wlz; pdb_00002wm0; pdb_00002xuc; pdb_00002xvn; pdb_00002ybt; pdb_00002ybu; pdb_00003ch9; pdb_00003chc; pdb_00003chd; pdb_00003che; pdb_00003chf; pdb_00003fxy; pdb_00003fy1; pdb_00003rm4; pdb_00003rm8; pdb_00003rm9; pdb_00003rme; pdb_00003wd0; pdb_00003wd1; pdb_00003wd2; pdb_00003wd3; pdb_00003wd4; pdb_00004nuy; pdb_00004toq; pdb_00004txe; pdb_00004wjx; pdb_00004wk9; pdb_00004wka; pdb_00004wkf; pdb_00004wkh; pdb_00004z2g; pdb_00004z2h; pdb_00004z2i; pdb_00004z2j; pdb_00004z2k; pdb_00004z2l; pdb_00005hbf; pdb_00005nr8; pdb_00005nra; pdb_00005nrf; pdb_00006e58; pdb_00006epb; pdb_00006jjr; pdb_00006jk6; pdb_00006jk9; pdb_00006jkf; pdb_00006ldu; pdb_00006le7; pdb_00006le8; pdb_00006mds; pdb_00006mdv; pdb_00006ve1; pdb_00006ze8; pdb_00007c34; pdb_00007c92; pdb_00007cb1; pdb_00007fd6; pdb_00007zya; pdb_00008fg5; pdb_00008fg7; pdb_00008fr9; pdb_00008fra; pdb_00008frb; pdb_00008frc; pdb_00008frd; pdb_00008frg; pdb_00008gca
» more