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PROSITE entry PS01095


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General information about the entry

Entry name [info] GH18_1
Accession [info] PS01095
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00839
Associated ProRule [info] PRU10053

Name and characterization of the entry

Description [info] Glycosyl hydrolases family 18 (GH18) active site signature.
Pattern [info]
[LIVMFY]-[DN]-G-[LIVMF]-[DN]-[LIVMF]-[DN]-x-E.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 114 in 113 different sequences
Number of true positive hits 102 in 101 different sequences
Number of 'unknown' hits 0
Number of false positive hits 12 in 12 different sequences
Number of false negative sequences 44
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 89.47 %
Recall (true positives / (true positives + false negatives)) 69.86 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
101 sequences

CHI10_DROME (Q9W5U2), CHI18_ENTFA (Q838S2), CHI1_APHAL  (P32470), 
CHI1_ARTBC  (D4AT07), CHI1_CANAL  (Q5AAH2), CHI1_CANAX  (P46876), 
CHI1_COCIM  (Q1E3R8), CHI1_COCP7  (C5P230), CHI1_COCPS  (P0CB51), 
CHI1_METAN  (O14456), CHI1_METRA  (E9ERT9), CHI1_PINMG  (H2A0L4), 
CHI1_RHINI  (P29025), CHI1_RHIOL  (P29026), CHI2_ARTBC  (D4AVJ0), 
CHI2_CANAL  (P40953), CHI2_COCIM  (Q1EAR5), CHI2_COCP7  (P54197), 
CHI2_METAN  (Q4U4T0), CHI2_METRA  (E9F9R9), CHI2_PINMG  (H2A0L5), 
CHI2_RHIOL  (P29027), CHI2_YEAST  (Q06350), CHI33_ARTBC (D4B4X4), 
CHI33_TRIHA (Q12713), CHI37_TRIHA (Q8NJQ5), CHI3_CANAL  (P40954), 
CHI3_METAN  (Q6QDR4), CHI3_METRA  (E9ENC6), CHI42_TRIHA (P48827), 
CHI46_TRIHA (A6N6J0), CHI4_CANAL  (Q5AM60), CHI4_METAN  (C9WJD0), 
CHI4_METRA  (E9F7R6), CHI52_PAEXY (A0A8G1A3Q5), CHIA1_ASPFM (Q873Y0), 
CHIA1_ASPFU (Q4WEP7), CHIA1_ASPNC (A2QUQ2), CHIA1_EMEND (Q92223), 
CHIA1_EMENI (G5EB30), CHIA1_NIACI (P20533), CHIA_ARATH  (P19172), 
CHIA_BOVIN  (Q95M17), CHIA_CICAR  (P36908), CHIA_CUCSA  (P17541), 
CHIA_FLAJ1  (A5FB63), CHIA_HUMAN  (Q9BZP6), CHIA_MOUSE  (Q91XA9), 
CHIA_PHAAN  (P29024), CHIA_PSEO7  (P32823), CHIA_RAT(Q6RY07), 
CHIA_SERMA  (P07254), CHIA_TOBAC  (P29060), CHIB1_ASPFM (Q873X9), 
CHIB1_ASPFU (E9QRF2), CHIB1_EMENI (G5EAZ3), CHIB_EMEND  (Q92222), 
CHIB_SERMA  (P11797), CHIB_TOBAC  (P29061), CHID_NIACI  (P27050), 
CHIE_BETVU  (P36910), CHIT1_HUMAN (Q13231), CHIT1_MOUSE (Q9D7Q1), 
CHIT1_TULSB (Q9SLP4), CHIT2_DROME (Q9W092), CHIT2_TULSB (Q7M443), 
CHIT3_VITVI (P51614), CHIT5_LOTJA (A0A1B1J8Z2), CHIT_BRUMA  (P29030), 
CHIT_CAEEL  (Q11174), CHIT_MANSE  (P36362), CHIT_NPVAC  (P41684), 
CHIT_NPVOP  (O10363), CHIT_PLAF7  (Q8I4R4), CHIT_PUNGR  (G1UH28), 
CHIT_STRLI  (P36909), CHIT_STRPL  (P11220), CHIT_YEAST  (P29029), 
CHIX_STROI  (Q05638), CHI_PINMA   (P86955), CHLY_HEVBR  (P23472), 
CHT5A_MEDTR (A0A072VEP0), CHT5B_MEDTR (A0A072UR65), DIAC_BOVIN  (Q01458), 
DIAC_HUMAN  (Q01459), DIAC_MOUSE  (Q8R242), DIAC_RAT(Q01460), 
EBA2_ELIME  (P36912), EBAG_FLAST  (P80036), EBAG_STRPL  (P04067), 
EBI1_BIFLS  (B7GPC7), ENDOS_STRP1 (Q99Y92), ENDS2_STRP9 (T1WGN1), 
ENDSD_STRDY (A0A191T6Q6), KTXA_KLULA  (P09805), LYS11_PENEN (A0A0A2J9B0), 
LYS12_PENEN (A0A0A2JP37), LYS18_PENEN (A0A0A2JVV3), NFH1_MEDTR  (U5N4E3), 
PPG1_CANAL  (Q5A6B6), YKVQ_BACSU  (O31682)
» more

UniProtKB/Swiss-Prot
False negative sequences
44 sequences

CH3L1_BOVIN (P30922), CH3L1_BUBBU (Q7YS85), CH3L1_CAPHI (Q8SPQ0), 
CH3L1_HUMAN (P36222), CH3L1_MOUSE (Q61362), CH3L1_PIG   (Q29411), 
CH3L1_PONAB (Q5RBP6), CH3L1_RAT   (Q9WTV1), CH3L1_SHEEP (Q6TMG6), 
CH3L2_HUMAN (Q15782), CHIA_ECOLI  (P13656), CHID1_BOVIN (Q5EAB4), 
CHID1_DANRE (Q7SYK0), CHID1_DICDI (Q54G42), CHID1_HUMAN (Q9BWS9), 
CHID1_MOUSE (Q922Q9), CHID1_PONAB (Q5RFF6), CHID1_RAT   (A0JPQ9), 
CHID1_XENLA (Q68EX9), CHID1_XENTR (Q66IL0), CHID_VIBFU  (P96156), 
CHITL_CAEEL (Q18143), CHIT_SACEN  (P14529), CHL18_DERFA (Q86R84), 
CHL18_DERPT (Q4JK71), CONB_CANEN  (P49347), DIAC1_DICDI (Q7KWW8), 
DIAC2_DICDI (Q8T293), EBA1_ELIME  (P36911), EBA3_ELIME  (P36913), 
OVGP1_BOVIN (Q28042), OVGP1_HUMAN (Q12889), OVGP1_MESAU (Q60557), 
OVGP1_MOUSE (Q62010), OVGP1_PAPAN (P36718), OVGP1_PIG   (Q28990), 
OVGP1_SHEEP (Q28542), XIP1_ORYSJ  (Q7GCM7), XIP1_WHEAT  (Q8L5C6), 
XIP2_ORYSJ  (Q53NL5), XIP_ORYSJ   (Q5WMW5), YDHD_BACSU  (O05495), 
YKZR_BACSU  (C0H404), YVBX_BACSU  (O32258)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
6 sequences

CAI_PHAVU   (P84708), CHI1_STROI  (P29115), CHI2_STROI  (P29116), 
CHIT_STRVL  (P84754), CHLY_PARTH  (P23473), NAHA1_PALCA (P85512)
» more

UniProtKB/Swiss-Prot
False positive sequences
12 sequences

CAPSD_CPVBM (Q6TS43), CAPSD_LDCPR (Q91IE1), CCNL2_XENTR (Q5BKF8), 
HISX_CALS4  (Q8R882), HSCB_ARATH  (Q8L7K4), NU4C_PROM0  (A3PAL7), 
NU4C_PROM2  (A8G2F5), NU4C_PROM5  (A2BUC6), NU4C_PROM9  (Q31D31), 
NU4C_PROMP  (Q7V3C8), SSUB2_RHIJ3 (Q1M7A6), TRPM2_HUMAN (O94759)
» more

PDB
[Detailed view]
114 PDB

1C3F; 1CTN; 1D2K; 1EDT; 1FFQ; 1FFR; 1GOI; 1GUV; 1H0G; 1H0I; 1HKI; 1HKJ; 1HKK; 1HKM; 1HVQ; 1ITX; 1K9T; 1LG1; 1LG2; 1LL4; 1LL6; 1LLO; 1LQ0; 1O6I; 1OGB; 1OGG; 1RD6; 1W9P; 1W9U; 1W9V; 1WAW; 1WB0; 1WNO; 1X6L; 1X6N; 2A3A; 2A3B; 2A3C; 2A3E; 2HVM; 2IUZ; 2UY2; 2UY3; 2UY4; 2UY5; 2WK2; 2WLY; 2WLZ; 2WM0; 2XUC; 2XVN; 2YBT; 2YBU; 3CH9; 3CHC; 3CHD; 3CHE; 3CHF; 3FXY; 3FY1; 3RM4; 3RM8; 3RM9; 3RME; 3WD0; 3WD1; 3WD2; 3WD3; 3WD4; 4NUY; 4TOQ; 4TXE; 4WJX; 4WK9; 4WKA; 4WKF; 4WKH; 4Z2G; 4Z2H; 4Z2I; 4Z2J; 4Z2K; 4Z2L; 5HBF; 5NR8; 5NRA; 5NRF; 6E58; 6EPB; 6JJR; 6JK6; 6JK9; 6JKF; 6LDU; 6LE7; 6LE8; 6MDS; 6MDV; 6VE1; 6ZE8; 7C34; 7C92; 7CB1; 7FD6; 7ZYA; 8FG5; 8FG7; 8FR9; 8FRA; 8FRB; 8FRC; 8FRD; 8FRG; 8GCA
» more