PROSITE logo

PROSITE entry PS01121


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] CASPASE_HIS
Accession [info] PS01121
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00864

Name and characterization of the entry

Description [info] Caspase family histidine active site.
Pattern [info] 
H-x(2,4)-[SC]-x(2)-{A}-x-[LIVMF](2)-[ST]-H-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 69 in 69 different sequences
Number of true positive hits 58 in 58 different sequences
Number of 'unknown' hits 1
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 85.29 %
Recall (true positives / (true positives + false negatives)) 93.55 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 58 sequences 

CAS1A_XENLA (P55865), CAS1B_XENLA (P55867), CASP1_CANLF (Q9MZV7), 

CASP1_DROME (O02002), CASP1_FELCA (Q9MZV6), CASP1_HORSE (Q9TV13), 
CASP1_HUMAN (P29466), CASP1_MOUSE (P29452), CASP1_PIG   (Q9N2I1), 
CASP1_RAT   (P43527), CASP1_SPOFR (P89116), CASP2_CHICK (Q98943), 
CASP2_HUMAN (P42575), CASP2_MOUSE (P29594), CASP2_RAT   (P55215), 
CASP3_BOVIN (Q08DY9), CASP3_CANLF (Q8MKI5), CASP3_FELCA (Q8MJU1), 
CASP3_HUMAN (P42574), CASP3_MACFA (Q2PFV2), CASP3_MESAU (Q60431), 
CASP3_MOUSE (P70677), CASP3_PANTR (Q5IS54), CASP3_PIG   (Q95ND5), 
CASP3_RABIT (Q8MJC3), CASP3_RAT   (P55213), CASP3_SAIBB (Q5IS99), 
CASP3_XENLA (P55866), CASP4_BOVIN (Q5E9C1), CASP4_HUMAN (P49662), 
CASP4_MOUSE (P70343), CASP5_HUMAN (P51878), CASP6_BOVIN (Q3T0P5), 
CASP6_HUMAN (P55212), CASP6_MOUSE (O08738), CASP6_RAT   (O35397), 
CASP7_CHICK (F1NV61), CASP7_HUMAN (P55210), CASP7_MESAU (P55214), 
CASP7_MOUSE (P97864), CASP8_HUMAN (Q14790), CASP8_MOUSE (O89110), 
CASP8_RAT   (Q9JHX4), CASP9_HUMAN (P55211), CASP9_MOUSE (Q8C3Q9), 
CASPA_DANRE (Q9I9L7), CASPA_HUMAN (Q92851), CASPB_DANRE (Q504J1), 
CASPC_CANLF (Q075B4), CASPC_MACMU (Q153Z0), CASPC_MOUSE (O08736), 
CASPC_RAT   (Q920D5), CASPD_BOVIN (O75601), CED3_CAEEL  (P42573), 
CED3_CAERE  (P45436), CSP1_CAEEL  (G5EBM1), CSP2_CAEEL  (Q9TZP5), 
DRICE_DROME (O01382)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

CASP8_DROME (Q8IRY7), CASPE_HUMAN (P31944), CASPE_MOUSE (O89094), 

DRONC_DROME (Q9XYF4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

PHIA_FUNX7  (A0A348HAX6)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			10 sequences
			


			
ACCC_ALLVD  (O52058), CESAA_ARATH (Q9SKJ5), FENR_STAS1  (Q49ZU9), 

			
ICH_DROME   (Q9VHJ6), PARP2_HUMAN (Q9UGN5), PARP2_MOUSE (O88554), 
RN133_MACFA (Q95K04), RPOD_BUCAP  (P32001), SUGPH_MYCTU (Q6MWZ7), 
TDRD5_DANRE (Q1L981)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			266 PDB
			


			1BMQ; 1CP3; 1F1J; 1F9E; 1GFW; 1GQF; 1I3O; 1I4E; 1I4O; 1I51; 1IBC; 1ICE; 
			
				1JXQ; 1K86; 1K88; 1KMC; 1M72; 1NME; 1NMQ; 1NMS; 1NW9; 1PAU; 1PYO; 1QDU; 
				1QTN; 1QX3; 1RE1; 1RHJ; 1RHK; 1RHM; 1RHQ; 1RHR; 1RHU; 1RWK; 1RWM; 1RWN; 
				1RWO; 1RWP; 1RWV; 1RWW; 1RWX; 1SC1; 1SC3; 1SC4; 1SHJ; 1SHL; 2AR9; 2C1E; 
				2C2K; 2C2M; 2C2O; 2C2Z; 2CDR; 2CJX; 2CJY; 2CNK; 2CNL; 2CNN; 2CNO; 2DKO; 
				2FQQ; 2FUN; 2H48; 2H4W; 2H4Y; 2H51; 2H54; 2H5I; 2H5J; 2H65; 2HBQ; 2HBR; 
				2HBY; 2HBZ; 2J30; 2J31; 2J32; 2J33; 2K7Z; 2P2C; 2QL5; 2QL7; 2QL9; 2QLB; 
				2QLF; 2QLJ; 2WDP; 2XYG; 2XYH; 2XYP; 2XZD; 2XZT; 2Y0B; 2Y1L; 3D6F; 3D6H; 
				3D6M; 3DEH; 3DEI; 3DEJ; 3DEK; 3E4C; 3EDQ; 3EDR; 3GJQ; 3GJR; 3GJS; 3GJT; 
				3H0E; 3H11; 3H1P; 3IBC; 3IBF; 3ITN; 3K7E; 3KJF; 3KJN; 3KJQ; 3NKF; 3NR2; 
				3NS7; 3OD5; 3P45; 3P4U; 3PCX; 3PD0; 3PD1; 3QNW; 3R5J; 3R5K; 3R6G; 3R6L; 
				3R7B; 3R7N; 3R7S; 3RJM; 3S70; 3S8E; 3SIP; 3SIR; 3V3K; 3V6L; 3V6M; 4DCJ; 
				4DCO; 4DCP; 4EHA; 4EHD; 4EHF; 4EHH; 4EHK; 4EHL; 4EHN; 4EJF; 4FDL; 4FEA; 
				4FXO; 4HQ0; 4HQR; 4HVA; 4JB8; 4JJ7; 4JJ8; 4JJE; 4JQY; 4JQZ; 4JR0; 4JR1; 
				4JR2; 4LSZ; 4M9R; 4N5D; 4N6G; 4N7J; 4N7M; 4NBK; 4NBL; 4NBN; 4PRY; 4PRZ; 
				4PS0; 4PS1; 4QTX; 4QTY; 4QU0; 4QU5; 4QU8; 4QU9; 4QUA; 4QUB; 4QUD; 4QUE; 
				4QUG; 4QUH; 4QUI; 4QUJ; 4QUL; 4ZVO; 4ZVP; 4ZVQ; 4ZVR; 4ZVS; 4ZVT; 4ZVU; 
				5I9B; 5I9T; 5IAB; 5IAE; 5IAG; 5IAJ; 5IAK; 5IAN; 5IAR; 5IAS; 5IBC; 5IBP; 
				5IBR; 5IC4; 5IC6; 5K20; 5MMV; 5MTK; 5V6U; 5V6Z; 6BZ9; 6DEU; 6DEV; 6F6R; 
				6KMT; 6KMU; 6KMV; 6KMZ; 6KN0; 6KN1; 6NRY; 6NS7; 6PX9; 6PZP; 6VIE; 7WR0; 
				7WR1; 7WR4; 7WR5; 7WR6; 7WZS; 7XN4; 7XN5; 7XN6; 8DGZ; 8DJ3; 8EG5; 8EG6; 
				8F78; 8F96; 8F97; 8F98; 8F99; 8F9A; 8F9B; 8F9C; 8F9D; 8FBV; 8J6K; 8JOL; 
				8SPB; 8WRA
			
			

			» more