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PROSITE entry PS01121


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS01121
Entry name [info] CASPASE_HIS
Accession [info] PS01121
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00864

Name and characterization of the entry

Description [info] Caspase family histidine active site.
Pattern [info] 
H-x(2,4)-[SC]-x(2)-{A}-x-[LIVMF](2)-[ST]-H-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 69 in 69 different sequences
Number of true positive hits 58 in 58 different sequences
Number of 'unknown' hits 1
Number of false positive hits 10 in 10 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 85.29 %
Recall (true positives / (true positives + false negatives)) 93.55 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 58 sequences 

CAS1A_XENLA (P55865), CAS1B_XENLA (P55867), CASP1_CANLF (Q9MZV7), 

CASP1_DROME (O02002), CASP1_FELCA (Q9MZV6), CASP1_HORSE (Q9TV13), 
CASP1_HUMAN (P29466), CASP1_MOUSE (P29452), CASP1_PIG   (Q9N2I1), 
CASP1_RAT   (P43527), CASP1_SPOFR (P89116), CASP2_CHICK (Q98943), 
CASP2_HUMAN (P42575), CASP2_MOUSE (P29594), CASP2_RAT   (P55215), 
CASP3_BOVIN (Q08DY9), CASP3_CANLF (Q8MKI5), CASP3_FELCA (Q8MJU1), 
CASP3_HUMAN (P42574), CASP3_MACFA (Q2PFV2), CASP3_MESAU (Q60431), 
CASP3_MOUSE (P70677), CASP3_PANTR (Q5IS54), CASP3_PIG   (Q95ND5), 
CASP3_RABIT (Q8MJC3), CASP3_RAT   (P55213), CASP3_SAIBB (Q5IS99), 
CASP3_XENLA (P55866), CASP4_BOVIN (Q5E9C1), CASP4_HUMAN (P49662), 
CASP4_MOUSE (P70343), CASP5_HUMAN (P51878), CASP6_BOVIN (Q3T0P5), 
CASP6_HUMAN (P55212), CASP6_MOUSE (O08738), CASP6_RAT   (O35397), 
CASP7_CHICK (F1NV61), CASP7_HUMAN (P55210), CASP7_MESAU (P55214), 
CASP7_MOUSE (P97864), CASP8_HUMAN (Q14790), CASP8_MOUSE (O89110), 
CASP8_RAT   (Q9JHX4), CASP9_HUMAN (P55211), CASP9_MOUSE (Q8C3Q9), 
CASPA_DANRE (Q9I9L7), CASPA_HUMAN (Q92851), CASPB_DANRE (Q504J1), 
CASPC_CANLF (Q075B4), CASPC_MACMU (Q153Z0), CASPC_MOUSE (O08736), 
CASPC_RAT   (Q920D5), CASPD_BOVIN (O75601), CED3_CAEEL  (P42573), 
CED3_CAERE  (P45436), CSP1_CAEEL  (G5EBM1), CSP2_CAEEL  (Q9TZP5), 
DRICE_DROME (O01382)
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

CASP8_DROME (Q8IRY7), CASPE_HUMAN (P31944), CASPE_MOUSE (O89094), 

DRONC_DROME (Q9XYF4)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

PHIA_FUNX7  (A0A348HAX6)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			10 sequences
			


			
ACCC_ALLVD  (O52058), CESAA_ARATH (Q9SKJ5), FENR_STAS1  (Q49ZU9), 

			
ICH_DROME   (Q9VHJ6), PARP2_HUMAN (Q9UGN5), PARP2_MOUSE (O88554), 
RN133_MACFA (Q95K04), RPOD_BUCAP  (P32001), SUGPH_MYCTU (Q6MWZ7), 
TDRD5_DANRE (Q1L981)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			273 PDB
			


			1BMQ; 1CP3; 1F1J; 1F9E; 1GFW; 1GQF; 1I3O; 1I4E; 1I4O; 1I51; 1IBC; 1ICE; 
			
				1JXQ; 1K86; 1K88; 1KMC; 1M72; 1NME; 1NMQ; 1NMS; 1NW9; 1PAU; 1PYO; 1QDU; 
				1QTN; 1QX3; 1RE1; 1RHJ; 1RHK; 1RHM; 1RHQ; 1RHR; 1RHU; 1RWK; 1RWM; 1RWN; 
				1RWO; 1RWP; 1RWV; 1RWW; 1RWX; 1SC1; 1SC3; 1SC4; 1SHJ; 1SHL; 2AR9; 2C1E; 
				2C2K; 2C2M; 2C2O; 2C2Z; 2CDR; 2CJX; 2CJY; 2CNK; 2CNL; 2CNN; 2CNO; 2DKO; 
				2FQQ; 2FUN; 2H48; 2H4W; 2H4Y; 2H51; 2H54; 2H5I; 2H5J; 2H65; 2HBQ; 2HBR; 
				2HBY; 2HBZ; 2J30; 2J31; 2J32; 2J33; 2K7Z; 2P2C; 2QL5; 2QL7; 2QL9; 2QLB; 
				2QLF; 2QLJ; 2WDP; 2XYG; 2XYH; 2XYP; 2XZD; 2XZT; 2Y0B; 2Y1L; 3D6F; 3D6H; 
				3D6M; 3DEH; 3DEI; 3DEJ; 3DEK; 3E4C; 3EDQ; 3EDR; 3GJQ; 3GJR; 3GJS; 3GJT; 
				3H0E; 3H11; 3H1P; 3IBC; 3IBF; 3ITN; 3K7E; 3KJF; 3KJN; 3KJQ; 3NKF; 3NR2; 
				3NS7; 3OD5; 3P45; 3P4U; 3PCX; 3PD0; 3PD1; 3QNW; 3R5J; 3R5K; 3R6G; 3R6L; 
				3R7B; 3R7N; 3R7S; 3RJM; 3S70; 3S8E; 3SIP; 3SIR; 3V3K; 3V6L; 3V6M; 4DCJ; 
				4DCO; 4DCP; 4EHA; 4EHD; 4EHF; 4EHH; 4EHK; 4EHL; 4EHN; 4EJF; 4FDL; 4FEA; 
				4FXO; 4HQ0; 4HQR; 4HVA; 4JB8; 4JJ7; 4JJ8; 4JJE; 4JQY; 4JQZ; 4JR0; 4JR1; 
				4JR2; 4LSZ; 4M9R; 4N5D; 4N6G; 4N7J; 4N7M; 4NBK; 4NBL; 4NBN; 4PRY; 4PRZ; 
				4PS0; 4PS1; 4QTX; 4QTY; 4QU0; 4QU5; 4QU8; 4QU9; 4QUA; 4QUB; 4QUD; 4QUE; 
				4QUG; 4QUH; 4QUI; 4QUJ; 4QUL; 4ZVO; 4ZVP; 4ZVQ; 4ZVR; 4ZVS; 4ZVT; 4ZVU; 
				5I9B; 5I9T; 5IAB; 5IAE; 5IAG; 5IAJ; 5IAK; 5IAN; 5IAR; 5IAS; 5IBC; 5IBP; 
				5IBR; 5IC4; 5IC6; 5K20; 5MMV; 5MTK; 5V6U; 5V6Z; 6BZ9; 6DEU; 6DEV; 6F6R; 
				6KMT; 6KMU; 6KMV; 6KMZ; 6KN0; 6KN1; 6NRY; 6NS7; 6PX9; 6PZP; 6VIE; 7WR0; 
				7WR1; 7WR4; 7WR5; 7WR6; 7WZS; 7XN4; 7XN5; 7XN6; 8DGZ; 8DJ3; 8EG5; 8EG6; 
				8F78; 8F96; 8F97; 8F98; 8F99; 8F9A; 8F9B; 8F9C; 8F9D; 8FBV; 8J6K; 8JOL; 
				8SPB; 8SV1; 8WRA; 8YBX; 8YNI; 8YNK; 8YNL; 8YNM; 8YNN
			
			

			» more