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Entry: PS01121

General information about the entry

Entry name [info] CASPASE_HIS
Accession [info] PS01121
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED;
01-DEC-2004 DATA UPDATE;
22-FEB-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00864

Name and characterization of the entry

Description [info] Caspase family histidine active site.
Pattern [info] 
H-x(2,4)-[SC]-x(2)-{A}-x-[LIVMF](2)-[ST]-H-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_01 which contains 569'213 sequence entries.


Total number of hits 67 in 67 different sequences
Number of true positive hits 58 in 58 different sequences
Number of 'unknown' hits 0
Number of false positive hits 9 in 9 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 86.57 %
Recall (true positives / (true positives + false negatives)) 93.55 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 58 sequences 

CAS1A_XENLA (P55865    ), CAS1B_XENLA (P55867    ), CASP1_CANLF (Q9MZV7    ), 

CASP1_DROME (O02002    ), CASP1_FELCA (Q9MZV6    ), CASP1_HORSE (Q9TV13    ), 
CASP1_HUMAN (P29466    ), CASP1_MOUSE (P29452    ), CASP1_PIG   (Q9N2I1    ), 
CASP1_RAT   (P43527    ), CASP1_SPOFR (P89116    ), CASP2_CHICK (Q98943    ), 
CASP2_HUMAN (P42575    ), CASP2_MOUSE (P29594    ), CASP2_RAT   (P55215    ), 
CASP3_BOVIN (Q08DY9    ), CASP3_CANLF (Q8MKI5    ), CASP3_FELCA (Q8MJU1    ), 
CASP3_HUMAN (P42574    ), CASP3_MACFA (Q2PFV2    ), CASP3_MESAU (Q60431    ), 
CASP3_MOUSE (P70677    ), CASP3_PANTR (Q5IS54    ), CASP3_PIG   (Q95ND5    ), 
CASP3_RABIT (Q8MJC3    ), CASP3_RAT   (P55213    ), CASP3_SAIBB (Q5IS99    ), 
CASP3_XENLA (P55866    ), CASP4_BOVIN (Q5E9C1    ), CASP4_HUMAN (P49662    ), 
CASP4_MOUSE (P70343    ), CASP5_HUMAN (P51878    ), CASP6_BOVIN (Q3T0P5    ), 
CASP6_HUMAN (P55212    ), CASP6_MOUSE (O08738    ), CASP6_RAT   (O35397    ), 
CASP7_CHICK (F1NV61    ), CASP7_HUMAN (P55210    ), CASP7_MESAU (P55214    ), 
CASP7_MOUSE (P97864    ), CASP8_HUMAN (Q14790    ), CASP8_MOUSE (O89110    ), 
CASP8_RAT   (Q9JHX4    ), CASP9_HUMAN (P55211    ), CASP9_MOUSE (Q8C3Q9    ), 
CASPA_DANRE (Q9I9L7    ), CASPA_HUMAN (Q92851    ), CASPB_DANRE (Q504J1    ), 
CASPC_CANLF (Q075B4    ), CASPC_MACMU (Q153Z0    ), CASPC_MOUSE (O08736    ), 
CASPC_RAT   (Q920D5    ), CASPD_BOVIN (O75601    ), CED3_CAEEL  (P42573    ), 
CED3_CAERE  (P45436    ), CSP1_CAEEL  (G5EBM1    ), CSP2_CAEEL  (Q9TZP5    ), 
DRICE_DROME (O01382    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 4 sequences 

CASP8_DROME (Q8IRY7    ), CASPE_HUMAN (P31944    ), CASPE_MOUSE (O89094    ), 

DRONC_DROME (Q9XYF4    )
» more

UniProtKB/Swiss-Prot
False positive sequences		 9 sequences 

ACCC_ALLVD  (O52058    ), CESAA_ARATH (Q9SKJ5    ), FENR_STAS1  (Q49ZU9    ), 

PARP2_HUMAN (Q9UGN5    ), PARP2_MOUSE (O88554    ), RN133_MACFA (Q95K04    ), 
RPOD_BUCAP  (P32001    ), SUGPH_MYCTU (Q6MWZ7    ), TDRD5_DANRE (Q1L981    )
» more

PDB
[Detailed view]		 240 PDB

1BMQ; 1CP3; 1F1J; 1F9E; 1GFW; 1GQF; 1I3O; 1I4E; 1I4O; 1I51; 1IBC; 1ICE; 1JXQ; 1K86; 1K88; 1KMC; 1M72; 1NME; 1NMQ; 1NMS; 1NW9; 1PAU; 1PYO; 1QDU; 1QTN; 1QX3; 1RE1; 1RHJ; 1RHK; 1RHM; 1RHQ; 1RHR; 1RHU; 1RWK; 1RWM; 1RWN; 1RWO; 1RWP; 1RWV; 1RWW; 1RWX; 1SC1; 1SC3; 1SC4; 1SHJ; 1SHL; 2AR9; 2C1E; 2C2K; 2C2M; 2C2O; 2C2Z; 2CDR; 2CJX; 2CJY; 2CNK; 2CNL; 2CNN; 2CNO; 2DKO; 2FQQ; 2FUN; 2H48; 2H4W; 2H4Y; 2H51; 2H54; 2H5I; 2H5J; 2H65; 2HBQ; 2HBR; 2HBY; 2HBZ; 2J30; 2J31; 2J32; 2J33; 2K7Z; 2P2C; 2QL5; 2QL7; 2QL9; 2QLB; 2QLF; 2QLJ; 2WDP; 2XYG; 2XYH; 2XYP; 2XZD; 2XZT; 2Y0B; 2Y1L; 3D6F; 3D6H; 3D6M; 3DEH; 3DEI; 3DEJ; 3DEK; 3E4C; 3EDQ; 3EDR; 3GJQ; 3GJR; 3GJS; 3GJT; 3H0E; 3H11; 3H1P; 3IBC; 3IBF; 3ITN; 3K7E; 3KJF; 3KJN; 3KJQ; 3NKF; 3NR2; 3NS7; 3OD5; 3P45; 3P4U; 3PCX; 3PD0; 3PD1; 3QNW; 3R5J; 3R5K; 3R6G; 3R6L; 3R7B; 3R7N; 3R7S; 3RJM; 3S70; 3S8E; 3SIP; 3SIR; 3V3K; 3V6L; 3V6M; 4DCJ; 4DCO; 4DCP; 4EHA; 4EHD; 4EHF; 4EHH; 4EHK; 4EHL; 4EHN; 4EJF; 4FDL; 4FEA; 4FXO; 4HQ0; 4HQR; 4HVA; 4JB8; 4JJ7; 4JJ8; 4JJE; 4JQY; 4JQZ; 4JR0; 4JR1; 4JR2; 4LSZ; 4M9R; 4N5D; 4N6G; 4N7J; 4N7M; 4NBK; 4NBL; 4NBN; 4PRY; 4PRZ; 4PS0; 4PS1; 4QTX; 4QTY; 4QU0; 4QU5; 4QU8; 4QU9; 4QUA; 4QUB; 4QUD; 4QUE; 4QUG; 4QUH; 4QUI; 4QUJ; 4QUL; 4ZVO; 4ZVP; 4ZVQ; 4ZVR; 4ZVS; 4ZVT; 4ZVU; 5I9B; 5I9T; 5IAB; 5IAE; 5IAG; 5IAJ; 5IAK; 5IAN; 5IAR; 5IAS; 5IBC; 5IBP; 5IBR; 5IC4; 5IC6; 5K20; 5MMV; 5MTK; 5V6U; 5V6Z; 6BZ9; 6DEU; 6DEV; 6F6R; 6KMT; 6KMU; 6KMV; 6KMZ; 6KN0; 6KN1; 6NRY; 6NS7; 6PX9; 6PZP; 6VIE; 7WZS
» more

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