PROSITE logo

PROSITE entry PS01178


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] ANAPHYLATOXIN_2
Accession [info] PS01178
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00906
Associated ProRule [info] PRU00022

Name and characterization of the entry

Description [info] Anaphylatoxin domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7140000; R2=0.0113000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=551.3717041; R2=3.3716815; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=628; H_SCORE=2669; N_SCORE=7.8; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=513; H_SCORE=2281; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...
 
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='C';  M=-10,-12, 64,-18,-18,-20,-23,  6,-29,-22,-21,-15, -8,-31,-16,-20, -3, -8,-15,-44,-16,-18;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A';  M= 11,-11,-19,-15, -2,-13,-12, -9, -6, -7, -4,  2,-12,-15, -2,-10, -3, -4, -3,-19, -7, -3;
/M: SY='D';  M=  0, 16,-20, 20,  2,-23,-13, -9,-20, -8,-13,-15,  4,-12, -6,-13,  4,  7,-12,-31,-15, -2;
/M: SY='G';  M=  1,-11,-29,-11,-19,-29, 62,-20,-37,-19,-29,-19, -2,-16,-19,-20,  0,-19,-27,-21,-29,-19;
/M: SY='I';  M= -2,-19,-22,-25,-18, -7,-25,-13, 18,-14,  9, 17,-15,-20, -8,-13,-12, -7, 14,-23, -5,-15;
/M: SY='R';  M= -6, -3,-20, -8, -3,-17,-16, -1,-14,  1,-11, -4,  4,-18,  6, 10,  0, -1,-13,-26, -9,  0;
/M: SY='L';  M= -7,-12,-25,-11, -5,-12, -9,-13, -9, -9,  1,  1,-12,-20, -7, -7,-12,-11, -8,-13, -9, -6;
/M: SY='A';  M= 22,  0,-15,-10, -8,-17, -5,-11, -9, -8,-10, -9,  5,-15, -6,-11,  6, -1, -7,-26,-17, -7;
/I:         I=-6; MI=-32; MD=-32; IM=-32;
/M: SY='P';  M= -1, -3,-23, -5, -3,-19,-12,-12,-12, -1,-18,-11,  3, 12, -5, -7,  2,  0,-14,-27,-17, -5; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='E';  M=-11,  3,-26,  6, 23,-20,-19,  2,-15,  2, -8,  3, -3,-10, 12, -1, -6, -8,-17,-27,-11, 17;
/M: SY='G';  M= -8, -2,-30,  0, -2,-28, 11, -3,-27, -3,-25,-13,  2, -1,  3, -3, -3,-13,-27,-23,-17, -1;
/M: SY='E';  M=-15,  7,-29, 14, 23,-18,-20,  3,-24,  5,-16,-13,  0,-12, 12,  4, -6,-10,-24,-21, -3, 16;
/M: SY='T';  M= -2,  1,-18,  0, -1,-20, -1,-13,-23, -5,-21,-16,  4,-12, -4, -1, 15, 17,-14,-30,-17, -3;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M=  8,  0,-23,  2, 18,-27, -1, -8,-23, -2,-17,-14, -2, -9,  8, -8,  4, -7,-20,-26,-19, 13;
/M: SY='E';  M=  1, -4,-21, -5,  8,-20,-15, -8,-18,  2,-15,-10, -3, -8,  6,  4,  6,  4,-14,-25,-12,  6;
/M: SY='R';  M=-13,-12,-30,-10,  3,-17,-22, -9,-13,  4, -9, -7, -7,  3,  0, 17,-10, -9,-14,-25,-14, -2;
/M: SY='H';  M=  2, -3,-23, -2, -5,-17,-15, 15,-15,-10,-12, -8, -4, -6, -5,-12, -3, -6,-12,-24, -2, -7;
/I:         I=-4; MI=-22; MD=-22; IM=-22;
/M: SY='A';  M=  5, -2,-14, -5,  2,-15, -8, -6,-12,  4,-13, -5,  0, -9,  3,  3,  5,  2, -8,-19,-11,  2; D=-4;
/I:         I=-4; MI=-22; MD=-22; IM=-22; DM=-22;
/M: SY='Y';  M=-10,-10,-18,-12, -9,  5,-17,  3, -5, -3, -3, -2, -6,-17, -5,  5, -7, -3, -5, -5, 16, -9; D=-4;
/I:         I=-4; MI=-22; MD=-22; IM=-22; DM=-22;
/M: SY='I';  M= -4, -6,-15,-10, -9, -7,-10,-11,  9,-11, -1,  1, -1,-13, -9,-11, -5, -4,  7,-18, -8,-10; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-22;
/M: SY='G';  M=  1,  2,-23,  0, -7,-27, 30,-11,-30,-12,-29,-19, 11,-13, -6,-12, 12, -5,-24,-29,-24, -7;
/M: SY='D';  M=-12, 16,-28, 24, 13,-26,-14, -3,-27,  4,-25,-19,  7,  0,  2, -4,  1, -6,-24,-28,-10,  6;
/M: SY='S';  M=  1, -1,-20, -4,  2,-17,-11, -8,-11, -7, -9, -8,  2,-12, -1, -8,  3, -1,-10,-29,-15,  0;
/M: SY='C';  M= -3,-15, 84,-22,-16,-21,-25,-25,-28,-22,-19,-19,-16,-31,-21,-25, -6, -9,-11,-44,-27,-18;
/I:         I=-5; MI=0; IM=0;
/M: SY='V';  M= -1,-13,-21,-18,-13,-13,-17,-17,  0, -4, -6, -2, -8,-18, -8,  2, -4,  1,  4,-24,-11,-12;
/M: SY='T';  M= -5, -4,-22, -6,  2,-17,-20, -8, -7, -1,-10, -2, -3,-12,  2, -3,  2,  4, -6,-27,-10,  0;
/M: SY='F';  M=  9,-22,-16,-27,-19, 13,-19,-22,  3,-20,  6,  0,-19,-15,-23,-20, -8, -3,  9,-15, -3,-20;
/M: SY='F';  M=-15,-24,-23,-30,-22, 34,-30,-12,  8,-20,  6,  6,-19,-26,-17,-16,-16, -9,  5, -1, 22,-19;
/M: SY='K';  M=-11,-10,-26,-10,  1,-15,-23,-11,-12, 17, -3,  0, -9,-17,  0, 15,-14, -9, -9,-21, -8,  0;
/M: SY='Q';  M= -8,  3,-26,  6, 13,-28,-15,  3,-25,  9,-21,-11,  4,-12, 20, 17,  3, -5,-22,-27,-13, 15;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 41 in 32 different sequences
Number of true positive hits 41 in 32 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 97.62 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Anaphylatoxin-like
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 32 sequences 

CO3_BOVIN   (Q2UVX4), CO3_CAVPO   (P12387), CO3_EPTBU   (P98094), 

CO3_HUMAN   (P01024), CO3_LETCA   (Q00685), CO3_MOUSE   (P01027), 
CO3_NAJNA   (Q01833), CO3_ONCMY   (P98093), CO3_PIG (P01025), 
CO3_RAT (P01026), CO4A_HUMAN  (P0C0L4), CO4B_HUMAN  (P0C0L5), 
CO4B_MOUSE  (P01029), CO4_BOVIN   (P01030), CO4_RAT (P08649), 
CO5_BOVIN   (P12082), CO5_HUMAN   (P01031), CO5_MOUSE   (P06684), 
CO5_PIG (P01032), CO5_RAT (P08650), FBLN1_CHICK (O73775), 
FBLN1_CHLAE (Q8MJJ9), FBLN1_DANRE (O42182), FBLN1_HUMAN (P23142), 
FBLN1_MOUSE (Q08879), FBLN2_HUMAN (P98095), FBLN2_MOUSE (P37889), 
VCO31_AUSSU (Q0ZZJ6), VCO32_AUSSU (A0RZC6), VCO3_CROAD  (J3S836), 
VCO3_NAJKA  (Q91132), VCO3_OPHHA  (I2C090)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

FBLN1_CAEEL (O77469)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			3 sequences
			


			
CO3_RABIT   (P12247), CO3_XENLA   (P23667), CO4_CAVPO   (P19069)


				
	

	

		PDB
[Detailed view]		
		
			48 PDB
			


			1C5A; 1CFA; 1KJS; 2A73; 3CU7; 3HQA; 3HQB; 3KLS; 3KM9; 3PRX; 3PVM; 4E0S; 
			
				4HW5; 4HWJ; 4I6O; 4P39; 4P3A; 4P3B; 4UU9; 4WB2; 4WB3; 5B4P; 5HCC; 5HCD; 
				5HCE; 5I5K; 5JPM; 5JPN; 6JV7; 6JV8; 6RQJ; 7AD6; 7AD7; 7NYC; 7NYD; 7Y64; 
				8AYH; 8B0F; 8B0G; 8B0H; 8CEM; 8HK2; 8HK5; 8HQC; 8I9L; 8IA2; 8JZZ; 8OQ3
			
			

			» more