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| Entry: PS01178 |
General information about the entry
| Entry name [info] | ANAPHYLATOXIN_2 |
| Accession [info] | PS01178 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE; 12-AUG-2020 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00906 |
| Associated ProRule [info] | PRU00022 |
Name and characterization of the entry
| Description [info] | Anaphylatoxin domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=34; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7140000; R2=0.0113000; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=551.3717041; R2=3.3716815; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=628; H_SCORE=2669; N_SCORE=7.8; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=513; H_SCORE=2281; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='C'; M=-10,-12, 64,-18,-18,-20,-23, 6,-29,-22,-21,-15, -8,-31,-16,-20, -3, -8,-15,-44,-16,-18; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='A'; M= 11,-11,-19,-15, -2,-13,-12, -9, -6, -7, -4, 2,-12,-15, -2,-10, -3, -4, -3,-19, -7, -3; /M: SY='D'; M= 0, 16,-20, 20, 2,-23,-13, -9,-20, -8,-13,-15, 4,-12, -6,-13, 4, 7,-12,-31,-15, -2; /M: SY='G'; M= 1,-11,-29,-11,-19,-29, 62,-20,-37,-19,-29,-19, -2,-16,-19,-20, 0,-19,-27,-21,-29,-19; /M: SY='I'; M= -2,-19,-22,-25,-18, -7,-25,-13, 18,-14, 9, 17,-15,-20, -8,-13,-12, -7, 14,-23, -5,-15; /M: SY='R'; M= -6, -3,-20, -8, -3,-17,-16, -1,-14, 1,-11, -4, 4,-18, 6, 10, 0, -1,-13,-26, -9, 0; /M: SY='L'; M= -7,-12,-25,-11, -5,-12, -9,-13, -9, -9, 1, 1,-12,-20, -7, -7,-12,-11, -8,-13, -9, -6; /M: SY='A'; M= 22, 0,-15,-10, -8,-17, -5,-11, -9, -8,-10, -9, 5,-15, -6,-11, 6, -1, -7,-26,-17, -7; /I: I=-6; MI=-32; MD=-32; IM=-32; /M: SY='P'; M= -1, -3,-23, -5, -3,-19,-12,-12,-12, -1,-18,-11, 3, 12, -5, -7, 2, 0,-14,-27,-17, -5; D=-6; /I: I=-6; MI=-32; IM=-32; DM=-32; /M: SY='E'; M=-11, 3,-26, 6, 23,-20,-19, 2,-15, 2, -8, 3, -3,-10, 12, -1, -6, -8,-17,-27,-11, 17; /M: SY='G'; M= -8, -2,-30, 0, -2,-28, 11, -3,-27, -3,-25,-13, 2, -1, 3, -3, -3,-13,-27,-23,-17, -1; /M: SY='E'; M=-15, 7,-29, 14, 23,-18,-20, 3,-24, 5,-16,-13, 0,-12, 12, 4, -6,-10,-24,-21, -3, 16; /M: SY='T'; M= -2, 1,-18, 0, -1,-20, -1,-13,-23, -5,-21,-16, 4,-12, -4, -1, 15, 17,-14,-30,-17, -3; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='E'; M= 8, 0,-23, 2, 18,-27, -1, -8,-23, -2,-17,-14, -2, -9, 8, -8, 4, -7,-20,-26,-19, 13; /M: SY='E'; M= 1, -4,-21, -5, 8,-20,-15, -8,-18, 2,-15,-10, -3, -8, 6, 4, 6, 4,-14,-25,-12, 6; /M: SY='R'; M=-13,-12,-30,-10, 3,-17,-22, -9,-13, 4, -9, -7, -7, 3, 0, 17,-10, -9,-14,-25,-14, -2; /M: SY='H'; M= 2, -3,-23, -2, -5,-17,-15, 15,-15,-10,-12, -8, -4, -6, -5,-12, -3, -6,-12,-24, -2, -7; /I: I=-4; MI=-22; MD=-22; IM=-22; /M: SY='A'; M= 5, -2,-14, -5, 2,-15, -8, -6,-12, 4,-13, -5, 0, -9, 3, 3, 5, 2, -8,-19,-11, 2; D=-4; /I: I=-4; MI=-22; MD=-22; IM=-22; DM=-22; /M: SY='Y'; M=-10,-10,-18,-12, -9, 5,-17, 3, -5, -3, -3, -2, -6,-17, -5, 5, -7, -3, -5, -5, 16, -9; D=-4; /I: I=-4; MI=-22; MD=-22; IM=-22; DM=-22; /M: SY='I'; M= -4, -6,-15,-10, -9, -7,-10,-11, 9,-11, -1, 1, -1,-13, -9,-11, -5, -4, 7,-18, -8,-10; D=-4; /I: I=-4; MI=0; IM=0; DM=-22; /M: SY='G'; M= 1, 2,-23, 0, -7,-27, 30,-11,-30,-12,-29,-19, 11,-13, -6,-12, 12, -5,-24,-29,-24, -7; /M: SY='D'; M=-12, 16,-28, 24, 13,-26,-14, -3,-27, 4,-25,-19, 7, 0, 2, -4, 1, -6,-24,-28,-10, 6; /M: SY='S'; M= 1, -1,-20, -4, 2,-17,-11, -8,-11, -7, -9, -8, 2,-12, -1, -8, 3, -1,-10,-29,-15, 0; /M: SY='C'; M= -3,-15, 84,-22,-16,-21,-25,-25,-28,-22,-19,-19,-16,-31,-21,-25, -6, -9,-11,-44,-27,-18; /I: I=-5; MI=0; IM=0; /M: SY='V'; M= -1,-13,-21,-18,-13,-13,-17,-17, 0, -4, -6, -2, -8,-18, -8, 2, -4, 1, 4,-24,-11,-12; /M: SY='T'; M= -5, -4,-22, -6, 2,-17,-20, -8, -7, -1,-10, -2, -3,-12, 2, -3, 2, 4, -6,-27,-10, 0; /M: SY='F'; M= 9,-22,-16,-27,-19, 13,-19,-22, 3,-20, 6, 0,-19,-15,-23,-20, -8, -3, 9,-15, -3,-20; /M: SY='F'; M=-15,-24,-23,-30,-22, 34,-30,-12, 8,-20, 6, 6,-19,-26,-17,-16,-16, -9, 5, -1, 22,-19; /M: SY='K'; M=-11,-10,-26,-10, 1,-15,-23,-11,-12, 17, -3, 0, -9,-17, 0, 15,-14, -9, -9,-21, -8, 0; /M: SY='Q'; M= -8, 3,-26, 6, 13,-28,-15, 3,-25, 9,-21,-11, 4,-12, 20, 17, 3, -5,-22,-27,-13, 15; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 41 in 32 different sequences |
| Number of true positive hits | 41 in 32 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 1 |
| Number of 'partial' sequences | 3 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 97.62 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 3 |
| Feature key [info] | DOMAIN |
| Feature description [info] | Anaphylatoxin-like |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
32 sequences
CO3_BOVIN (Q2UVX4 ), CO3_CAVPO (P12387 ), CO3_EPTBU (P98094 ), CO3_HUMAN (P01024 ), CO3_LETCA (Q00685 ), CO3_MOUSE (P01027 ), CO3_NAJNA (Q01833 ), CO3_ONCMY (P98093 ), CO3_PIG (P01025 ), CO3_RAT (P01026 ), CO4A_HUMAN (P0C0L4 ), CO4B_HUMAN (P0C0L5 ), CO4B_MOUSE (P01029 ), CO4_BOVIN (P01030 ), CO4_RAT (P08649 ), CO5_BOVIN (P12082 ), CO5_HUMAN (P01031 ), CO5_MOUSE (P06684 ), CO5_PIG (P01032 ), CO5_RAT (P08650 ), FBLN1_CHICK (O73775 ), FBLN1_CHLAE (Q8MJJ9 ), FBLN1_DANRE (O42182 ), FBLN1_HUMAN (P23142 ), FBLN1_MOUSE (Q08879 ), FBLN2_HUMAN (P98095 ), FBLN2_MOUSE (P37889 ), VCO31_AUSSU (Q0ZZJ6 ), VCO32_AUSSU (A0RZC6 ), VCO3_CROAD (J3S836 ), VCO3_NAJKA (Q91132 ), VCO3_OPHHA (I2C090 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
1 sequence
FBLN1_CAEEL (O77469 ) |
| UniProtKB/Swiss-Prot 'Partial' sequences |
3 sequences
CO3_RABIT (P12247 ), CO3_XENLA (P23667 ), CO4_CAVPO (P19069 ) |
| PDB [Detailed view] |
34 PDB
1C5A; 1CFA; 1KJS; 2A73; 2B39; 3CU7; 3HQA; 3HQB; 3KLS; 3KM9; 3PRX; 3PVM; 4E0S; 4FXG; 4FXK; 4HW5; 4HWJ; 4I6O; 4P39; 4P3A; 4P3B; 4UU9; 4WB2; 4WB3; 5B4P; 5HCC; 5HCD; 5HCE; 5I5K; 5JPM; 5JPN; 6I2X; 6JV7; 6JV8 » more |
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