PROSITE entry PS01178

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PURL: https://purl.expasy.org/prosite/signature/PS01178

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General information about the entry

Entry name [info]	ANAPHYLATOXIN_2
Accession [info]	PS01178
Entry type [info]	MATRIX
Date [info]	01-NOV-1997 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00906
Associated ProRule [info]	PRU00022

Name and characterization of the entry

Description [info]

Anaphylatoxin domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7140000; R2=0.0113000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=551.3717041; R2=3.3716815; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=628; H_SCORE=2669; N_SCORE=7.8; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=513; H_SCORE=2281; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='C';  M=-10,-12, 64,-18,-18,-20,-23,  6,-29,-22,-21,-15, -8,-31,-16,-20, -3, -8,-15,-44,-16,-18;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A';  M= 11,-11,-19,-15, -2,-13,-12, -9, -6, -7, -4,  2,-12,-15, -2,-10, -3, -4, -3,-19, -7, -3;
/M: SY='D';  M=  0, 16,-20, 20,  2,-23,-13, -9,-20, -8,-13,-15,  4,-12, -6,-13,  4,  7,-12,-31,-15, -2;
/M: SY='G';  M=  1,-11,-29,-11,-19,-29, 62,-20,-37,-19,-29,-19, -2,-16,-19,-20,  0,-19,-27,-21,-29,-19;
/M: SY='I';  M= -2,-19,-22,-25,-18, -7,-25,-13, 18,-14,  9, 17,-15,-20, -8,-13,-12, -7, 14,-23, -5,-15;
/M: SY='R';  M= -6, -3,-20, -8, -3,-17,-16, -1,-14,  1,-11, -4,  4,-18,  6, 10,  0, -1,-13,-26, -9,  0;
/M: SY='L';  M= -7,-12,-25,-11, -5,-12, -9,-13, -9, -9,  1,  1,-12,-20, -7, -7,-12,-11, -8,-13, -9, -6;
/M: SY='A';  M= 22,  0,-15,-10, -8,-17, -5,-11, -9, -8,-10, -9,  5,-15, -6,-11,  6, -1, -7,-26,-17, -7;
/I:         I=-6; MI=-32; MD=-32; IM=-32;
/M: SY='P';  M= -1, -3,-23, -5, -3,-19,-12,-12,-12, -1,-18,-11,  3, 12, -5, -7,  2,  0,-14,-27,-17, -5; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='E';  M=-11,  3,-26,  6, 23,-20,-19,  2,-15,  2, -8,  3, -3,-10, 12, -1, -6, -8,-17,-27,-11, 17;
/M: SY='G';  M= -8, -2,-30,  0, -2,-28, 11, -3,-27, -3,-25,-13,  2, -1,  3, -3, -3,-13,-27,-23,-17, -1;
/M: SY='E';  M=-15,  7,-29, 14, 23,-18,-20,  3,-24,  5,-16,-13,  0,-12, 12,  4, -6,-10,-24,-21, -3, 16;
/M: SY='T';  M= -2,  1,-18,  0, -1,-20, -1,-13,-23, -5,-21,-16,  4,-12, -4, -1, 15, 17,-14,-30,-17, -3;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M=  8,  0,-23,  2, 18,-27, -1, -8,-23, -2,-17,-14, -2, -9,  8, -8,  4, -7,-20,-26,-19, 13;
/M: SY='E';  M=  1, -4,-21, -5,  8,-20,-15, -8,-18,  2,-15,-10, -3, -8,  6,  4,  6,  4,-14,-25,-12,  6;
/M: SY='R';  M=-13,-12,-30,-10,  3,-17,-22, -9,-13,  4, -9, -7, -7,  3,  0, 17,-10, -9,-14,-25,-14, -2;
/M: SY='H';  M=  2, -3,-23, -2, -5,-17,-15, 15,-15,-10,-12, -8, -4, -6, -5,-12, -3, -6,-12,-24, -2, -7;
/I:         I=-4; MI=-22; MD=-22; IM=-22;
/M: SY='A';  M=  5, -2,-14, -5,  2,-15, -8, -6,-12,  4,-13, -5,  0, -9,  3,  3,  5,  2, -8,-19,-11,  2; D=-4;
/I:         I=-4; MI=-22; MD=-22; IM=-22; DM=-22;
/M: SY='Y';  M=-10,-10,-18,-12, -9,  5,-17,  3, -5, -3, -3, -2, -6,-17, -5,  5, -7, -3, -5, -5, 16, -9; D=-4;
/I:         I=-4; MI=-22; MD=-22; IM=-22; DM=-22;
/M: SY='I';  M= -4, -6,-15,-10, -9, -7,-10,-11,  9,-11, -1,  1, -1,-13, -9,-11, -5, -4,  7,-18, -8,-10; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-22;
/M: SY='G';  M=  1,  2,-23,  0, -7,-27, 30,-11,-30,-12,-29,-19, 11,-13, -6,-12, 12, -5,-24,-29,-24, -7;
/M: SY='D';  M=-12, 16,-28, 24, 13,-26,-14, -3,-27,  4,-25,-19,  7,  0,  2, -4,  1, -6,-24,-28,-10,  6;
/M: SY='S';  M=  1, -1,-20, -4,  2,-17,-11, -8,-11, -7, -9, -8,  2,-12, -1, -8,  3, -1,-10,-29,-15,  0;
/M: SY='C';  M= -3,-15, 84,-22,-16,-21,-25,-25,-28,-22,-19,-19,-16,-31,-21,-25, -6, -9,-11,-44,-27,-18;
/I:         I=-5; MI=0; IM=0;
/M: SY='V';  M= -1,-13,-21,-18,-13,-13,-17,-17,  0, -4, -6, -2, -8,-18, -8,  2, -4,  1,  4,-24,-11,-12;
/M: SY='T';  M= -5, -4,-22, -6,  2,-17,-20, -8, -7, -1,-10, -2, -3,-12,  2, -3,  2,  4, -6,-27,-10,  0;
/M: SY='F';  M=  9,-22,-16,-27,-19, 13,-19,-22,  3,-20,  6,  0,-19,-15,-23,-20, -8, -3,  9,-15, -3,-20;
/M: SY='F';  M=-15,-24,-23,-30,-22, 34,-30,-12,  8,-20,  6,  6,-19,-26,-17,-16,-16, -9,  5, -1, 22,-19;
/M: SY='K';  M=-11,-10,-26,-10,  1,-15,-23,-11,-12, 17, -3,  0, -9,-17,  0, 15,-14, -9, -9,-21, -8,  0;
/M: SY='Q';  M= -8,  3,-26,  6, 13,-28,-15,  3,-25,  9,-21,-11,  4,-12, 20, 17,  3, -5,-22,-27,-13, 15;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	43 in 34 different sequences
Number of true positive hits	43 in 34 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	2

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	97.73 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	DOMAIN
Feature description [info]	Anaphylatoxin-like
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	34 sequences CO3_BOVIN (Q2UVX4), CO3_CAVPO (P12387), CO3_EPTBU (P98094), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	1 sequence FBLN1_CAEEL (O77469)
UniProtKB/Swiss-Prot 'Partial' sequences	2 sequences CO3_RABIT (P12247), CO3_XENLA (P23667)
PDB [Detailed view]	52 PDB 1C5A; 1CFA; 1KJS; 2A73; 3CU7; 3HQA; 3HQB; 3KLS; 3KM9; 3PRX; 3PVM; 4E0S; » more