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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS01209


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PURL: https://purl.expasy.org/prosite/signature/PS01209

Direct ScanProsite submission
General information about the entry

Entry name [info] LDLRA_1
Accession [info] PS01209
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00929

Name and characterization of the entry

Description [info] LDL-receptor class A (LDLRA) domain signature.
Pattern [info] 
C-[VILMA]-x(5,6)-C-[DNH]-x(3)-[DENQHT]-C-x(3,4)-[STADEW]-[DEH]-[DE]-
x(1,5)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 828 in 166 different sequences
Number of true positive hits 827 in 165 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.88 %
Recall (true positives / (true positives + false negatives)) 98.22 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 31
Site [info] disulfide at position 1
Site [info] disulfide at position 4
Site [info] disulfide at position 8
Site [info] disulfide at position 14
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 165 sequences 

AEGP_HUMAN  (Q6UXC1), AEGP_MOUSE  (A2AJA7), AEGP_RAT(Q63191), 

CD320_BOVIN (A6QNY1), CD320_HUMAN (Q9NPF0), CD320_MOUSE (Q9Z1P5), 
CD320_RAT   (Q5HZW5), CDA1_BOMMO  (H9J9M0), CFAI_HUMAN  (P05156), 
CFAI_MOUSE  (Q61129), CFAI_PONAB  (Q5R5A4), CFAI_RAT(Q9WUW3), 
CO6_BOVIN   (Q29RU4), CO6_HUMAN   (P13671), CO6_MOUSE   (E9Q6D8), 
CO6_PANTR   (P61134), CO6_PONPY   (P61135), CO6_RAT (Q811M5), 
CO7_BOVIN   (Q29RQ1), CO7_HUMAN   (P10643), CO7_MOUSE   (D3YXF5), 
CO7_PIG (Q9TUQ3), CO7_PONAB   (Q5RAD0), CO8A_HUMAN  (P07357), 
CO8A_MOUSE  (Q8K182), CO8A_RABIT  (P98136), CO8B_HUMAN  (P07358), 
CO8B_MOUSE  (Q8BH35), CO8B_PAROL  (Q9PVW7), CO8B_RABIT  (P98137), 
CO8B_RAT(P55314), CO9_BOVIN   (Q3MHN2), CO9_HORSE   (P48770), 
CO9_HUMAN   (P02748), CO9_MOUSE   (P06683), CO9_ONCMY   (P06682), 
CO9_RABIT   (P48747), CO9_RAT (Q62930), CO9_TAKRU   (P79755), 
CORIN_HUMAN (Q9Y5Q5), CORIN_MOUSE (Q9Z319), CORIN_RAT   (Q80YN4), 
CPROH_CONVC (A0A0F7YYX3), CTX_ACAES   (B2DCR8), EGG1_CAEBR  (A8X765), 
EGG1_CAEEL  (Q09967), EGG1_CAERE  (E3LYX0), EGG2_CAEEL  (Q21629), 
ENTK_BOVIN  (P98072), ENTK_HUMAN  (P98073), ENTK_MOUSE  (P97435), 
ENTK_PIG(P98074), GLBL_LAMSP  (P16222), GLBL_TYLHE  (P18207), 
GLBM_TYLHE  (P18208), GR101_LYMST (P46023), IDD_HUMAN   (P98153), 
IDD_MOUSE   (P98154), LDLR1_XENLA (Q99087), LDLR2_XENLA (Q99088), 
LDLR_BOVIN  (P01131), LDLR_CRIGR  (P35950), LDLR_HUMAN  (P01130), 
LDLR_MOUSE  (P35951), LDLR_PIG(Q28832), LDLR_RABIT  (P20063), 
LDLR_RAT(P35952), LRAD1_HUMAN (Q5T700), LRAD3_HUMAN (Q86YD5), 
LRAD3_MOUSE (A2AR95), LRAD3_XENTR (A4IHY6), LRAD4_HUMAN (O15165), 
LRAD4_MOUSE (Q8BWJ4), LRP10_HUMAN (Q7Z4F1), LRP10_MOUSE (Q7TQH7), 
LRP11_HUMAN (Q86VZ4), LRP11_MOUSE (Q8CB67), LRP12_HUMAN (Q9Y561), 
LRP12_MACFA (Q9BE74), LRP12_MOUSE (Q8BUJ9), LRP12_PONAB (Q5R662), 
LRP1B_HUMAN (Q9NZR2), LRP1B_MOUSE (Q9JI18), LRP1_CHICK  (P98157), 
LRP1_HUMAN  (Q07954), LRP1_MOUSE  (Q91ZX7), LRP1_RAT(G3V928), 
LRP2_HUMAN  (P98164), LRP2_MOUSE  (A2ARV4), LRP2_PIG(C0HL13), 
LRP2_RAT(P98158), LRP3_HUMAN  (O75074), LRP3_RAT(O88204), 
LRP4_HUMAN  (O75096), LRP4_MOUSE  (Q8VI56), LRP4_RAT(Q9QYP1), 
LRP5_HUMAN  (O75197), LRP5_MOUSE  (Q91VN0), LRP6_HUMAN  (O75581), 
LRP6_MOUSE  (O88572), LRP8_CHICK  (Q98931), LRP8_HUMAN  (Q14114), 
LRP8_MOUSE  (Q924X6), LRP_CAEEL   (Q04833), LTK_DANRE   (F1QVU0), 
MALR1_HUMAN (Q5VYJ5), MALR1_MOUSE (A2AJX4), MFRP_HUMAN  (Q9BY79), 
MFRP_MOUSE  (Q8K480), MLRP1_ACRMI (B3EWZ5), MLRP2_ACRMI (B3EWZ6), 
MODSP_DROME (Q9VER6), NETO1_HUMAN (Q8TDF5), NETO1_MOUSE (Q8R4I7), 
NETO2_HUMAN (Q8NC67), NETO2_MOUSE (Q8BNJ6), NETO2_RAT   (C6K2K4), 
NUDEL_DROME (P98159), PGBM_HUMAN  (P98160), PGBM_MOUSE  (Q05793), 
PROH4_APIME (P85831), PROH4_CAMFO (E2AX35), RXFP1_HUMAN (Q9HBX9), 
RXFP1_MOUSE (Q6R6I7), RXFP1_PONAB (Q5R5V8), RXFP1_RAT   (Q6R6I6), 
RXFP2_CANLF (Q5XM32), RXFP2_HUMAN (Q8WXD0), RXFP2_MOUSE (Q91ZZ5), 
SORL_CHICK  (Q98930), SORL_HUMAN  (Q92673), SORL_MOUSE  (O88307), 
SORL_RABIT  (Q95209), SORL_RAT(P0DSP1), SPIT1_HUMAN (O43278), 
SPIT1_MOUSE (Q9R097), SSPO_BOVIN  (P98167), SSPO_CHICK  (Q2PC93), 
SSPO_HUMAN  (A2VEC9), SSPO_MOUSE  (Q8CG65), SSPO_RAT(Q700K0), 
ST14_BOVIN  (Q0IIH7), ST14_HUMAN  (Q9Y5Y6), ST14_MOUSE  (P56677), 
SVH1_CAEEL  (Q17800), TMPS2_HUMAN (O15393), TMPS2_MOUSE (Q9JIQ8), 
TMPS3_HUMAN (P57727), TMPS3_MOUSE (Q8K1T0), TMPS6_HUMAN (Q8IU80), 
TMPS6_MOUSE (Q9DBI0), TMPS7_HUMAN (Q7RTY8), TMPS7_MOUSE (Q8BIK6), 
TMPS7_RAT   (P86091), TMPS9_HUMAN (Q7Z410), TMPS9_MOUSE (P69525), 
TMPS9_RAT   (P69526), UNC52_CAEEL (Q06561), VGR_SOLIN   (Q6X0I2), 
VLDLR_CHICK (P98165), VLDLR_HUMAN (P98155), VLDLR_MOUSE (P98156), 
VLDLR_RABIT (P35953), VLDLR_RAT   (P98166), YL_DROME(P98163)
» more

UniProtKB/Swiss-Prot
False negative sequences		 15 sequences 

ALK_HUMAN   (Q9UM73), ALK_MOUSE   (P97793), GLU2B_BOVIN (Q28034), 

GLU2B_HUMAN (P14314), GLU2B_MOUSE (O08795), MIG13_CAEEL (G5EF33), 
PKD1_HUMAN  (P98161), PKD1_MOUSE  (O08852), RSVR_COTJA  (P98162), 
SCD2_CAEEL  (O76411), TMPS4_HUMAN (Q9NRS4), TMPS4_MOUSE (Q8VCA5), 
TMPSD_HUMAN (Q9BYE2), TMPSD_MOUSE (Q5U405), YL54_CAEEL  (P34434)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

MYCB2_DANRE (F1RD40)


				
	

	

		PDB
[Detailed view]		
		
			128 PDB
			


			pdb_00001ajj; pdb_00001cr8; pdb_00001d2j; pdb_00001d2l; pdb_00001f5y; pdb_00001f8z; pdb_00001j8e; pdb_00001ldl; pdb_00001ldr; pdb_00001n7d; pdb_00001v9u; pdb_00001xfe; 
			
				pdb_00002fcw; pdb_00002fyj; pdb_00002fyl; pdb_00002i1p; pdb_00002jm4; pdb_00002knx; pdb_00002kny; pdb_00002kri; pdb_00002lgp; pdb_00002m0p; pdb_00002m7p; pdb_00002m96; 
				pdb_00002xrc; pdb_00003a7q; pdb_00003dpr; pdb_00003m0c; pdb_00003ojy; pdb_00003p5c; pdb_00003t5o; pdb_00004a5w; pdb_00004e0s; pdb_00004zrp; pdb_00004zrq; pdb_00005b4x; 
				pdb_00005b4y; pdb_00005fmw; pdb_00005h7v; pdb_00005o32; pdb_00005oy9; pdb_00005oyl; pdb_00006byv; pdb_00006cxo; pdb_00006dlw; pdb_00006h03; pdb_00006h04; pdb_00007f56; 
				pdb_00007f57; pdb_00007f59; pdb_00007f5a; pdb_00007f5b; pdb_00007fff; pdb_00007ffl; pdb_00007ffn; pdb_00007meq; pdb_00007n1h; pdb_00007nyc; pdb_00007nyd; pdb_00007qbd; 
				pdb_00007qbe; pdb_00007qbf; pdb_00007qbg; pdb_00007tmw; pdb_00007wqx; pdb_00007xyd; pdb_00007y0e; pdb_00007y0f; pdb_00008b0f; pdb_00008b0g; pdb_00008b0h; pdb_00008de6; 
				pdb_00008em4; pdb_00008em7; pdb_00008hd8; pdb_00008ihp; pdb_00008jhz; pdb_00008ji0; pdb_00008jut; pdb_00008juu; pdb_00008jx8; pdb_00008jx9; pdb_00008jxa; pdb_00008jxb; 
				pdb_00008jxc; pdb_00008jxd; pdb_00008jxe; pdb_00008jxf; pdb_00008jxg; pdb_00008jxh; pdb_00008jxi; pdb_00008jxj; pdb_00008s0l; pdb_00008s0m; pdb_00008s0n; pdb_00008s9p; 
				pdb_00008ua4; pdb_00008ua8; pdb_00008ufb; pdb_00008ufc; pdb_00008vgt; pdb_00008x0k; pdb_00008x0l; pdb_00008x0m; pdb_00008xi4; pdb_00008xi5; pdb_00008y1d; pdb_00008y1e; 
				pdb_00008y7x; pdb_00008y7y; pdb_00008y87; pdb_00008y88; pdb_00008y89; pdb_00008y8a; pdb_00008y8b; pdb_00008yoy; pdb_00008yqq; pdb_00008ys2; pdb_00008ys4; pdb_00008yvz; 
				pdb_00008yw0; pdb_00008yw1; pdb_00008yw2; pdb_00009bd8; pdb_00009bde; pdb_00009bdt; pdb_00009coo; pdb_00009izn
			
			

			» more