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PROSITE entry PS01209


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS01209
Entry name [info] LDLRA_1
Accession [info] PS01209
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00929

Name and characterization of the entry

Description [info] LDL-receptor class A (LDLRA) domain signature.
Pattern [info] 
C-[VILMA]-x(5,6)-C-[DNH]-x(3)-[DENQHT]-C-x(3,4)-[STADEW]-[DEH]-[DE]-
x(1,5)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 826 in 164 different sequences
Number of true positive hits 825 in 163 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.88 %
Recall (true positives / (true positives + false negatives)) 98.21 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 31
Site [info] disulfide at position 1
Site [info] disulfide at position 4
Site [info] disulfide at position 8
Site [info] disulfide at position 14
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 163 sequences 

AEGP_HUMAN  (Q6UXC1), AEGP_MOUSE  (A2AJA7), AEGP_RAT(Q63191), 

CD320_BOVIN (A6QNY1), CD320_HUMAN (Q9NPF0), CD320_MOUSE (Q9Z1P5), 
CD320_RAT   (Q5HZW5), CDA1_BOMMO  (H9J9M0), CFAI_HUMAN  (P05156), 
CFAI_MOUSE  (Q61129), CFAI_PONAB  (Q5R5A4), CFAI_RAT(Q9WUW3), 
CO6_BOVIN   (Q29RU4), CO6_HUMAN   (P13671), CO6_PANTR   (P61134), 
CO6_PONPY   (P61135), CO6_RAT (Q811M5), CO7_BOVIN   (Q29RQ1), 
CO7_HUMAN   (P10643), CO7_PIG (Q9TUQ3), CO7_PONAB   (Q5RAD0), 
CO8A_HUMAN  (P07357), CO8A_MOUSE  (Q8K182), CO8A_RABIT  (P98136), 
CO8B_HUMAN  (P07358), CO8B_MOUSE  (Q8BH35), CO8B_PAROL  (Q9PVW7), 
CO8B_RABIT  (P98137), CO8B_RAT(P55314), CO9_BOVIN   (Q3MHN2), 
CO9_HORSE   (P48770), CO9_HUMAN   (P02748), CO9_MOUSE   (P06683), 
CO9_ONCMY   (P06682), CO9_RABIT   (P48747), CO9_RAT (Q62930), 
CO9_TAKRU   (P79755), CORIN_HUMAN (Q9Y5Q5), CORIN_MOUSE (Q9Z319), 
CORIN_RAT   (Q80YN4), CPROH_CONVC (A0A0F7YYX3), CTX_SEPES   (B2DCR8), 
EGG1_CAEBR  (A8X765), EGG1_CAEEL  (Q09967), EGG1_CAERE  (E3LYX0), 
EGG2_CAEEL  (Q21629), ENTK_BOVIN  (P98072), ENTK_HUMAN  (P98073), 
ENTK_MOUSE  (P97435), ENTK_PIG(P98074), GLBL_LAMSP  (P16222), 
GLBL_TYLHE  (P18207), GLBM_TYLHE  (P18208), GR101_LYMST (P46023), 
IDD_HUMAN   (P98153), IDD_MOUSE   (P98154), LDLR1_XENLA (Q99087), 
LDLR2_XENLA (Q99088), LDLR_BOVIN  (P01131), LDLR_CRIGR  (P35950), 
LDLR_HUMAN  (P01130), LDLR_MOUSE  (P35951), LDLR_PIG(Q28832), 
LDLR_RABIT  (P20063), LDLR_RAT(P35952), LRAD1_HUMAN (Q5T700), 
LRAD3_HUMAN (Q86YD5), LRAD3_MOUSE (A2AR95), LRAD3_XENTR (A4IHY6), 
LRAD4_HUMAN (O15165), LRAD4_MOUSE (Q8BWJ4), LRP10_HUMAN (Q7Z4F1), 
LRP10_MOUSE (Q7TQH7), LRP11_HUMAN (Q86VZ4), LRP11_MOUSE (Q8CB67), 
LRP12_HUMAN (Q9Y561), LRP12_MACFA (Q9BE74), LRP12_MOUSE (Q8BUJ9), 
LRP12_PONAB (Q5R662), LRP1B_HUMAN (Q9NZR2), LRP1B_MOUSE (Q9JI18), 
LRP1_CHICK  (P98157), LRP1_HUMAN  (Q07954), LRP1_MOUSE  (Q91ZX7), 
LRP1_RAT(G3V928), LRP2_HUMAN  (P98164), LRP2_MOUSE  (A2ARV4), 
LRP2_PIG(C0HL13), LRP2_RAT(P98158), LRP3_HUMAN  (O75074), 
LRP3_RAT(O88204), LRP4_HUMAN  (O75096), LRP4_MOUSE  (Q8VI56), 
LRP4_RAT(Q9QYP1), LRP5_HUMAN  (O75197), LRP5_MOUSE  (Q91VN0), 
LRP6_HUMAN  (O75581), LRP6_MOUSE  (O88572), LRP8_CHICK  (Q98931), 
LRP8_HUMAN  (Q14114), LRP8_MOUSE  (Q924X6), LRP_CAEEL   (Q04833), 
LTK_DANRE   (F1QVU0), MALR1_HUMAN (Q5VYJ5), MALR1_MOUSE (A2AJX4), 
MFRP_HUMAN  (Q9BY79), MFRP_MOUSE  (Q8K480), MLRP1_ACRMI (B3EWZ5), 
MLRP2_ACRMI (B3EWZ6), MODSP_DROME (Q9VER6), NETO1_HUMAN (Q8TDF5), 
NETO1_MOUSE (Q8R4I7), NETO2_HUMAN (Q8NC67), NETO2_MOUSE (Q8BNJ6), 
NETO2_RAT   (C6K2K4), NUDEL_DROME (P98159), PGBM_HUMAN  (P98160), 
PGBM_MOUSE  (Q05793), PROH4_APIME (P85831), PROH4_CAMFO (E2AX35), 
RXFP1_HUMAN (Q9HBX9), RXFP1_MOUSE (Q6R6I7), RXFP1_PONAB (Q5R5V8), 
RXFP1_RAT   (Q6R6I6), RXFP2_CANLF (Q5XM32), RXFP2_HUMAN (Q8WXD0), 
RXFP2_MOUSE (Q91ZZ5), SORL_CHICK  (Q98930), SORL_HUMAN  (Q92673), 
SORL_MOUSE  (O88307), SORL_RABIT  (Q95209), SORL_RAT(P0DSP1), 
SPIT1_HUMAN (O43278), SPIT1_MOUSE (Q9R097), SSPO_BOVIN  (P98167), 
SSPO_CHICK  (Q2PC93), SSPO_HUMAN  (A2VEC9), SSPO_MOUSE  (Q8CG65), 
SSPO_RAT(Q700K0), ST14_BOVIN  (Q0IIH7), ST14_HUMAN  (Q9Y5Y6), 
ST14_MOUSE  (P56677), SVH1_CAEEL  (Q17800), TMPS2_HUMAN (O15393), 
TMPS2_MOUSE (Q9JIQ8), TMPS3_HUMAN (P57727), TMPS3_MOUSE (Q8K1T0), 
TMPS6_HUMAN (Q8IU80), TMPS6_MOUSE (Q9DBI0), TMPS7_HUMAN (Q7RTY8), 
TMPS7_MOUSE (Q8BIK6), TMPS7_RAT   (P86091), TMPS9_HUMAN (Q7Z410), 
TMPS9_MOUSE (P69525), TMPS9_RAT   (P69526), UNC52_CAEEL (Q06561), 
VGR_SOLIN   (Q6X0I2), VLDLR_CHICK (P98165), VLDLR_HUMAN (P98155), 
VLDLR_MOUSE (P98156), VLDLR_RABIT (P35953), VLDLR_RAT   (P98166), 
YL_DROME(P98163)
» more

UniProtKB/Swiss-Prot
False negative sequences		 15 sequences 

ALK_HUMAN   (Q9UM73), ALK_MOUSE   (P97793), GLU2B_BOVIN (Q28034), 

GLU2B_HUMAN (P14314), GLU2B_MOUSE (O08795), MIG13_CAEEL (G5EF33), 
PKD1_HUMAN  (P98161), PKD1_MOUSE  (O08852), RSVR_COTJA  (P98162), 
SCD2_CAEEL  (O76411), TMPS4_HUMAN (Q9NRS4), TMPS4_MOUSE (Q8VCA5), 
TMPSD_HUMAN (Q9BYE2), TMPSD_MOUSE (Q5U405), YL54_CAEEL  (P34434)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

MYCB2_DANRE (F1RD40)


				
	

	

		PDB
[Detailed view]		
		
			128 PDB
			


			1AJJ; 1CR8; 1D2J; 1D2L; 1F5Y; 1F8Z; 1J8E; 1LDL; 1LDR; 1N7D; 1V9U; 1XFE; 
			
				2FCW; 2FYJ; 2FYL; 2I1P; 2JM4; 2KNX; 2KNY; 2KRI; 2LGP; 2M0P; 2M7P; 2M96; 
				2XRC; 3A7Q; 3DPR; 3M0C; 3OJY; 3P5C; 3T5O; 4A5W; 4E0S; 4ZRP; 4ZRQ; 5B4X; 
				5B4Y; 5FMW; 5H7V; 5O32; 5OY9; 5OYL; 6BYV; 6CXO; 6DLW; 6H03; 6H04; 7F56; 
				7F57; 7F59; 7F5A; 7F5B; 7FFF; 7FFL; 7FFN; 7MEQ; 7N1H; 7NYC; 7NYD; 7QBD; 
				7QBE; 7QBF; 7QBG; 7TMW; 7WQX; 7XYD; 7Y0E; 7Y0F; 8B0F; 8B0G; 8B0H; 8DE6; 
				8EM4; 8EM7; 8HD8; 8IHP; 8JHZ; 8JI0; 8JUT; 8JUU; 8JX8; 8JX9; 8JXA; 8JXB; 
				8JXC; 8JXD; 8JXE; 8JXF; 8JXG; 8JXH; 8JXI; 8JXJ; 8S0L; 8S0M; 8S0N; 8S9P; 
				8UA4; 8UA8; 8UFB; 8UFC; 8VGT; 8X0K; 8X0L; 8X0M; 8XI4; 8XI5; 8Y1D; 8Y1E; 
				8Y7X; 8Y7Y; 8Y87; 8Y88; 8Y89; 8Y8A; 8Y8B; 8YOY; 8YQQ; 8YS2; 8YS4; 8YVZ; 
				8YW0; 8YW1; 8YW2; 9BD8; 9BDE; 9BDT; 9COO; 9IZN
			
			

			» more