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PROSITE entry PS01248


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General information about the entry

Entry name [info] EGF_LAM_1
Accession [info] PS01248
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00961

Name and characterization of the entry

Description [info] Laminin-type EGF-like (LE) domain signature.
Pattern [info]
C-x(1,2)-C-x(5)-G-x(2)-C-x(2)-C-x(3,4)-[FYW]-x(3,15)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 584 in 139 different sequences
Number of true positive hits 527 in 95 different sequences
Number of 'unknown' hits 14 in 1 sequence
Number of false positive hits 43 in 43 different sequences
Number of false negative sequences 1
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 92.46 %
Recall (true positives / (true positives + false negatives)) 99.81 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 21
Site [info] disulfide at position 1
Site [info] disulfide at position 3
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 13
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
95 sequences

AGRIN_CHICK (P31696), AGRIN_DIPOM (Q90404), AGRIN_HUMAN (O00468), 
AGRIN_MOUSE (A2ASQ1), AGRIN_RAT   (P25304), ATRN1_HUMAN (Q5VV63), 
ATRN1_MOUSE (Q6A051), ATRN_HUMAN  (O75882), ATRN_MOUSE  (Q9WU60), 
ATRN_RAT(Q99J86), CELR1_HUMAN (Q9NYQ6), CELR1_MOUSE (O35161), 
CELR2_HUMAN (Q9HCU4), CELR2_MOUSE (Q9R0M0), CELR2_RAT   (Q9QYP2), 
CELR3_HUMAN (Q9NYQ7), CELR3_MOUSE (Q91ZI0), CELR3_RAT   (O88278), 
CREL1_CAEEL (Q19267), CREL1_XENTR (A0A6I8RMG7), EPI1_CAEEL  (Q21313), 
LAM2_CAEEL  (Q18823), LAMA1_HUMAN (P25391), LAMA1_MOUSE (P19137), 
LAMA2_HUMAN (P24043), LAMA2_MOUSE (Q60675), LAMA3_HUMAN (Q16787), 
LAMA3_MOUSE (Q61789), LAMA4_HUMAN (Q16363), LAMA4_MOUSE (P97927), 
LAMA5_HUMAN (O15230), LAMA5_MOUSE (Q61001), LAMA_DROME  (Q00174), 
LAMB1_CHICK (Q01635), LAMB1_DROME (P11046), LAMB1_HUMAN (P07942), 
LAMB1_HYDVU (Q27262), LAMB1_MOUSE (P02469), LAMB2_HUMAN (P55268), 
LAMB2_MOUSE (Q61292), LAMB2_RAT   (P15800), LAMB3_HUMAN (Q13751), 
LAMB3_MOUSE (Q61087), LAMB4_DANRE (Q8JHV6), LAMB4_HUMAN (A4D0S4), 
LAMB_HIRME  (Q25092), LAMC1_DANRE (Q1LVF0), LAMC1_DROME (P15215), 
LAMC1_HUMAN (P11047), LAMC1_MOUSE (P02468), LAMC1_XENTR (A0JP86), 
LAMC2_HORSE (Q8HZI9), LAMC2_HUMAN (Q13753), LAMC2_MOUSE (Q61092), 
LAMC3_HUMAN (Q9Y6N6), LAMC3_MOUSE (Q9R0B6), MEGF8_HUMAN (Q7Z7M0), 
MEGF8_MOUSE (P60882), MEGF8_RAT   (Q9QYP0), MEGF9_HUMAN (Q9H1U4), 
MEGF9_MOUSE (Q8BH27), NET1_CHICK  (Q90922), NET1_HUMAN  (O95631), 
NET1_MOUSE  (O09118), NET1_PIG(Q2HXW4), NET1_RAT(Q924Z9), 
NET3_CHICK  (Q90923), NET3_HUMAN  (O00634), NET3_MOUSE  (Q9R1A3), 
NET4_HUMAN  (Q9HB63), NET4_MOUSE  (Q9JI33), NET4_PONAB  (Q5RB89), 
NET5_HUMAN  (Q8WTR8), NET5_MOUSE  (Q3UQ22), NET5_RAT(D3ZT86), 
NETA_DROME  (Q24567), NETB_DROME  (Q24568), NTNG1_HUMAN (Q9Y2I2), 
NTNG1_MOUSE (Q8R4G0), NTNG2_HUMAN (Q96CW9), NTNG2_MOUSE (Q8R4F1), 
PGBM_HUMAN  (P98160), PGBM_MOUSE  (Q05793), STAB1_HUMAN (Q9NY15), 
STAB1_MOUSE (Q8R4Y4), STAB2_HUMAN (Q8WWQ8), STAB2_MOUSE (Q8R4U0), 
STAB2_RAT   (Q8CFM6), STAN_DROME  (Q9V5N8), TAG53_CAEEL (Q19981), 
UNC52_CAEEL (Q06561), UNC6_CAEEL  (P34710), USH2A_HUMAN (O75445), 
USH2A_MOUSE (Q2QI47), USH2A_RAT   (Q8K3K1)
» more

UniProtKB/Swiss-Prot
False negative sequences
1 sequence

SIGK_DICDI  (Q6TMJ6)

		
UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

LAMBV_CHICK (Q01636)

		
UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

LAM3_CAEEL  (G5ECE3)

		
UniProtKB/Swiss-Prot
False positive sequences
43 sequences

ADP1_YEAST  (P25371), CRE2A_XENLA (Q5XH36), CRE2B_XENLA (Q4V7M2), 
CREL1_BOVIN (Q5EA46), CREL1_HUMAN (Q96HD1), CREL1_MOUSE (Q91XD7), 
CREL1_RAT   (Q4V7F2), CREL2_BOVIN (Q2KIT5), CREL2_CRIGR (Q60438), 
CREL2_DANRE (Q7SXF6), CREL2_HUMAN (Q6UXH1), CREL2_MOUSE (Q9CYA0), 
CREL2_RAT   (Q4G063), POL_COYMV   (P19199), SRCH_HUMAN  (P23327), 
SRCH_RABIT  (P16230), TYRO_BOVIN  (Q8MIU0), TYRO_CANLF  (P54834), 
TYRO_CHICK  (P55024), TYRO_COTJA  (Q08410), TYRO_FELCA  (P55033), 
TYRO_GORGO  (Q9BDE0), TYRO_HUMAN  (P14679), TYRO_MOUSE  (P11344), 
TYRO_ORYLA  (P55025), TYRO_PELLE  (Q0MVP0), TYRO_PELNI  (Q04604), 
TYRO_PELSI  (P55026), TYRP1_AMBME (P55027), TYRP1_BOVIN (Q8WN57), 
TYRP1_CARAU (P55028), TYRP1_CHICK (O57405), TYRP1_FELCA (Q2VPW6), 
TYRP1_HUMAN (P17643), TYRP1_MOUSE (P07147), TYRP2_BOVIN (Q95119), 
TYRP2_CHICK (O93505), TYRP2_HUMAN (P40126), TYRP2_MOUSE (P29812), 
TYRP2_PIG   (Q4R1H1), WDR59_CHICK (Q5ZLG9), WDR59_HUMAN (Q6PJI9), 
WDR59_MOUSE (Q8C0M0)
» more

PDB
[Detailed view]
23 PDB

1KLO; 1NPE; 1TLE; 2Y38; 4AQS; 4AQT; 4OVE; 4PLM; 4PLN; 4PLO; 4URT; 4WNX; 5LF2; 6FKQ; 7LER; 7LRF; 7NDG; 7NE0; 7NE1; 8DMK; 8EDK; 8S9P; 8SNP
» more