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PROSITE entry PS01248


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS01248
Entry name [info] EGF_LAM_1
Accession [info] PS01248
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00961

Name and characterization of the entry

Description [info] Laminin-type EGF-like (LE) domain signature.
Pattern [info] 
C-x(1,2)-C-x(5)-G-x(2)-C-x(2)-C-x(3,4)-[FYW]-x(3,15)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 584 in 139 different sequences
Number of true positive hits 527 in 95 different sequences
Number of 'unknown' hits 14 in 1 sequence
Number of false positive hits 43 in 43 different sequences
Number of false negative sequences 1
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 92.46 %
Recall (true positives / (true positives + false negatives)) 99.81 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 21
Site [info] disulfide at position 1
Site [info] disulfide at position 3
Site [info] disulfide at position 7
Site [info] disulfide at position 9
Site [info] disulfide at position 13
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 95 sequences 

AGRIN_CHICK (P31696), AGRIN_DIPOM (Q90404), AGRIN_HUMAN (O00468), 

AGRIN_MOUSE (A2ASQ1), AGRIN_RAT   (P25304), ATRN1_HUMAN (Q5VV63), 
ATRN1_MOUSE (Q6A051), ATRN_HUMAN  (O75882), ATRN_MOUSE  (Q9WU60), 
ATRN_RAT(Q99J86), CELR1_HUMAN (Q9NYQ6), CELR1_MOUSE (O35161), 
CELR2_HUMAN (Q9HCU4), CELR2_MOUSE (Q9R0M0), CELR2_RAT   (Q9QYP2), 
CELR3_HUMAN (Q9NYQ7), CELR3_MOUSE (Q91ZI0), CELR3_RAT   (O88278), 
CREL1_CAEEL (Q19267), CREL1_XENTR (A0A6I8RMG7), EPI1_CAEEL  (Q21313), 
LAM2_CAEEL  (Q18823), LAMA1_HUMAN (P25391), LAMA1_MOUSE (P19137), 
LAMA2_HUMAN (P24043), LAMA2_MOUSE (Q60675), LAMA3_HUMAN (Q16787), 
LAMA3_MOUSE (Q61789), LAMA4_HUMAN (Q16363), LAMA4_MOUSE (P97927), 
LAMA5_HUMAN (O15230), LAMA5_MOUSE (Q61001), LAMA_DROME  (Q00174), 
LAMB1_CHICK (Q01635), LAMB1_DROME (P11046), LAMB1_HUMAN (P07942), 
LAMB1_HYDVU (Q27262), LAMB1_MOUSE (P02469), LAMB2_HUMAN (P55268), 
LAMB2_MOUSE (Q61292), LAMB2_RAT   (P15800), LAMB3_HUMAN (Q13751), 
LAMB3_MOUSE (Q61087), LAMB4_DANRE (Q8JHV6), LAMB4_HUMAN (A4D0S4), 
LAMB_HIRME  (Q25092), LAMC1_DANRE (Q1LVF0), LAMC1_DROME (P15215), 
LAMC1_HUMAN (P11047), LAMC1_MOUSE (P02468), LAMC1_XENTR (A0JP86), 
LAMC2_HORSE (Q8HZI9), LAMC2_HUMAN (Q13753), LAMC2_MOUSE (Q61092), 
LAMC3_HUMAN (Q9Y6N6), LAMC3_MOUSE (Q9R0B6), MEGF8_HUMAN (Q7Z7M0), 
MEGF8_MOUSE (P60882), MEGF8_RAT   (Q9QYP0), MEGF9_HUMAN (Q9H1U4), 
MEGF9_MOUSE (Q8BH27), NET1_CHICK  (Q90922), NET1_HUMAN  (O95631), 
NET1_MOUSE  (O09118), NET1_PIG(Q2HXW4), NET1_RAT(Q924Z9), 
NET3_CHICK  (Q90923), NET3_HUMAN  (O00634), NET3_MOUSE  (Q9R1A3), 
NET4_HUMAN  (Q9HB63), NET4_MOUSE  (Q9JI33), NET4_PONAB  (Q5RB89), 
NET5_HUMAN  (Q8WTR8), NET5_MOUSE  (Q3UQ22), NET5_RAT(D3ZT86), 
NETA_DROME  (Q24567), NETB_DROME  (Q24568), NTNG1_HUMAN (Q9Y2I2), 
NTNG1_MOUSE (Q8R4G0), NTNG2_HUMAN (Q96CW9), NTNG2_MOUSE (Q8R4F1), 
PGBM_HUMAN  (P98160), PGBM_MOUSE  (Q05793), STAB1_HUMAN (Q9NY15), 
STAB1_MOUSE (Q8R4Y4), STAB2_HUMAN (Q8WWQ8), STAB2_MOUSE (Q8R4U0), 
STAB2_RAT   (Q8CFM6), STAN_DROME  (Q9V5N8), TAG53_CAEEL (Q19981), 
UNC52_CAEEL (Q06561), UNC6_CAEEL  (P34710), USH2A_HUMAN (O75445), 
USH2A_MOUSE (Q2QI47), USH2A_RAT   (Q8K3K1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 1 sequence 

SIGK_DICDI  (Q6TMJ6)


				
	

	

		UniProtKB/Swiss-Prot
'Partial' sequences		
		
			1 sequence
			


			
LAMBV_CHICK (Q01636)


				
	

	

		UniProtKB/Swiss-Prot
'Unknown' sequences		
		
			1 sequence
			


			
LAM3_CAEEL  (G5ECE3)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			43 sequences
			


			
ADP1_YEAST  (P25371), CRE2A_XENLA (Q5XH36), CRE2B_XENLA (Q4V7M2), 

			
CREL1_BOVIN (Q5EA46), CREL1_HUMAN (Q96HD1), CREL1_MOUSE (Q91XD7), 
CREL1_RAT   (Q4V7F2), CREL2_BOVIN (Q2KIT5), CREL2_CRIGR (Q60438), 
CREL2_DANRE (Q7SXF6), CREL2_HUMAN (Q6UXH1), CREL2_MOUSE (Q9CYA0), 
CREL2_RAT   (Q4G063), POL_COYMV   (P19199), SRCH_HUMAN  (P23327), 
SRCH_RABIT  (P16230), TYRO_BOVIN  (Q8MIU0), TYRO_CANLF  (P54834), 
TYRO_CHICK  (P55024), TYRO_COTJA  (Q08410), TYRO_FELCA  (P55033), 
TYRO_GORGO  (Q9BDE0), TYRO_HUMAN  (P14679), TYRO_MOUSE  (P11344), 
TYRO_ORYLA  (P55025), TYRO_PELLE  (Q0MVP0), TYRO_PELNI  (Q04604), 
TYRO_PELSI  (P55026), TYRP1_AMBME (P55027), TYRP1_BOVIN (Q8WN57), 
TYRP1_CARAU (P55028), TYRP1_CHICK (O57405), TYRP1_FELCA (Q2VPW6), 
TYRP1_HUMAN (P17643), TYRP1_MOUSE (P07147), TYRP2_BOVIN (Q95119), 
TYRP2_CHICK (O93505), TYRP2_HUMAN (P40126), TYRP2_MOUSE (P29812), 
TYRP2_PIG   (Q4R1H1), WDR59_CHICK (Q5ZLG9), WDR59_HUMAN (Q6PJI9), 
WDR59_MOUSE (Q8C0M0)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			25 PDB
			


			1KLO; 1NPE; 1TLE; 2Y38; 4AQS; 4AQT; 4OVE; 4PLM; 4PLN; 4PLO; 4URT; 4WNX; 
			
				5LF2; 6FKQ; 7LER; 7LRF; 7NDG; 7NE0; 7NE1; 8DMK; 8EDK; 8S9P; 8SNP; 8TSM; 
				9D77
			
			

			» more