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PROSITE entry PS01258


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS01258
Entry name [info] BH2
Accession [info] PS01258
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00829

Name and characterization of the entry

Description [info] Apoptosis regulator, Bcl-2 family BH2 motif signature.
Pattern [info] 
W-[LIM]-x(3)-[GR]-G-[WQ]-[DENSAV]-x-[FLGA]-[LIVFTC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 50 in 48 different sequences
Number of true positive hits 45 in 45 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 3 different sequences
Number of false negative sequences 17
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 90.00 %
Recall (true positives / (true positives + false negatives)) 72.58 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 45 sequences 

AR11_XENLA  (Q91828), AR1_XENLA   (Q91827), ARBH_ASFB7  (P42485), 

ARBH_ASFE4  (Q07818), ARBH_ASFK5  (P0C8H4), ARBH_ASFM2  (Q07819), 
ARBH_ASFP4  (P0C8H5), ARBH_ASFWA  (P0C8H6), B2CL1_CHICK (Q07816), 
B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), B2CL1_PIG   (O77737), 
B2CL1_RAT   (P53563), B2CL2_BOVIN (Q1RMX3), B2CL2_CANLF (Q45T69), 
B2CL2_HUMAN (Q92843), B2CL2_MOUSE (P70345), B2L10_HUMAN (Q9HD36), 
B2L10_RAT   (Q99M66), B2LA1_BOVIN (Q3C2I0), B2LA1_HUMAN (Q16548), 
B2LA1_MOUSE (Q07440), BAK_HUMAN   (Q16611), BAK_MOUSE   (O08734), 
BAX_BOVIN   (O02703), BAX_HUMAN   (Q07812), BAX_MOUSE   (Q07813), 
BAX_RAT (Q63690), BCL2_BOVIN  (O02718), BCL2_CANLF  (Q6R755), 
BCL2_CHICK  (Q00709), BCL2_CRIGR  (Q9JJV8), BCL2_HUMAN  (P10415), 
BCL2_MOUSE  (P10417), BCL2_RAT(P49950), EAR_EBVA8   (P0C6Z1), 
EAR_EBVB9   (P03182), EAR_EBVG(P0C736), MCL1_CANLF  (Q8HYS5), 
MCL1_FELCA  (Q7YRZ9), MCL1_HUMAN  (Q07820), MCL1_MOUSE  (P97287), 
MCL1_RAT(Q9Z1P3), NR13_CHICK  (Q90ZN1), NR13_COTJA  (Q90343)
» more

UniProtKB/Swiss-Prot
False negative sequences		 17 sequences 

ARBH_FOWPN  (Q9J5G4), B2L10_MOUSE (Q9Z0F3), B2L12_HUMAN (Q9HB09), 

B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), B2L14_BOVIN (Q5E9L4), 
B2L14_HUMAN (Q9BZR8), B2L14_MOUSE (Q9CPT0), B2L14_RAT   (Q6AYK4), 
BOKA_DANRE  (Q6DC66), BOKB_DANRE  (Q7T381), BOK_CHICK   (Q9I8I2), 
BOK_HUMAN   (Q9UMX3), BOK_MOUSE   (O35425), BOK_RAT (Q792S6), 
CED9_CAEBR  (P41957), CED9_CAEEL  (P41958)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

DLD3_YEAST  (P39976), FRS2_ARATH  (Q3EBQ3), LUCIF_LINPO (O77206)


				
	

	

		PDB
[Detailed view]		
		
			383 PDB
			


			1AF3; 1BXL; 1F16; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1MK3; 1O0L; 1PQ0; 1PQ1; 
			
				1Q59; 1R2D; 1R2E; 1R2G; 1R2H; 1R2I; 1WSX; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 
				2B48; 2BZW; 2IMS; 2IMT; 2JCN; 2JM6; 2K7W; 2KBW; 2LP8; 2LPC; 2LR1; 2M03; 
				2M04; 2M5B; 2ME8; 2ME9; 2MEJ; 2MHS; 2NL9; 2NLA; 2O1Y; 2O21; 2O22; 2O2F; 
				2O2M; 2O2N; 2P1L; 2PON; 2PQK; 2ROC; 2ROD; 2V6Q; 2VM6; 2VOF; 2VOG; 2VOH; 
				2VOI; 2W3L; 2WH6; 2XA0; 2XPX; 2Y6W; 2YJ1; 2YQ6; 2YQ7; 2YV6; 2YXJ; 3CVA; 
				3D7V; 3FDL; 3FDM; 3I1H; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 
				3INQ; 3IO8; 3IO9; 3KJ0; 3KJ1; 3KJ2; 3KZ0; 3MK8; 3MQP; 3PK1; 3PL7; 3QKD; 
				3R85; 3SP7; 3SPF; 3WIX; 3WIY; 3WIZ; 3ZK6; 3ZLN; 3ZLO; 3ZLR; 4A1U; 4A1W; 
				4AQ3; 4BD2; 4BD6; 4BD7; 4BD8; 4BPI; 4BPJ; 4BPK; 4C52; 4C5D; 4CIM; 4CIN; 
				4EHR; 4G35; 4HNJ; 4HW2; 4HW3; 4HW4; 4IEH; 4K5A; 4K5B; 4LVT; 4LXD; 4MAN; 
				4OQ5; 4OQ6; 4OYD; 4PPI; 4QNQ; 4QVE; 4QVF; 4QVX; 4S0O; 4S0P; 4TUH; 4U2U; 
				4WGI; 4WMR; 4WMS; 4WMT; 4WMU; 4WMV; 4WMW; 4WMX; 4YJ4; 4YK9; 4Z9V; 4ZBF; 
				4ZBI; 4ZEQ; 4ZIE; 4ZIF; 4ZIG; 4ZIH; 4ZII; 5AGW; 5AGX; 5B1Z; 5C3F; 5C3G; 
				5C6H; 5FC4; 5FCG; 5FDO; 5FDR; 5FMI; 5FMJ; 5FMK; 5IEZ; 5IF4; 5JSB; 5JSN; 
				5KU9; 5LOF; 5MES; 5MEV; 5UA4; 5UA5; 5UUK; 5UUL; 5UUM; 5UUP; 5VAU; 5VAX; 
				5VAY; 5VKC; 5VWV; 5VWW; 5VWX; 5VWY; 5VWZ; 5VX0; 5VX1; 5VX2; 5VX3; 5W5X; 
				5W5Z; 5W60; 5W61; 5W62; 5W89; 5W8F; 5WHH; 5WHI; 6B4L; 6B4U; 6BF2; 6BW2; 
				6BW8; 6DCN; 6DCO; 6DM8; 6E3I; 6E3J; 6EB6; 6FS0; 6FS1; 6FS2; 6GL8; 6HJL; 
				6IJQ; 6IWB; 6LHD; 6MBB; 6MBC; 6MBD; 6MBE; 6MCY; 6NE5; 6O0K; 6O0L; 6O0M; 
				6O0O; 6O0P; 6O4U; 6O6F; 6O6G; 6OQB; 6OQC; 6OQD; 6OQN; 6OVC; 6P3P; 6QB3; 
				6QB4; 6QB6; 6QFC; 6QFI; 6QFM; 6QFQ; 6QGD; 6QXJ; 6QYK; 6QYL; 6QYN; 6QYO; 
				6QYP; 6QZ5; 6QZ6; 6QZ7; 6QZ8; 6QZB; 6RJP; 6RNU; 6ST2; 6STJ; 6TZC; 6U63; 
				6U64; 6U65; 6U67; 6U6F; 6UA3; 6UAB; 6UD2; 6UDI; 6UDT; 6UDU; 6UDV; 6UDX; 
				6UDY; 6UVC; 6UVD; 6UVE; 6UVF; 6UVG; 6UVH; 6VBX; 6VO4; 6VWC; 6YBG; 6YBJ; 
				6YBK; 6YBL; 6YLI; 6ZHC; 6ZIE; 7CA4; 7JGV; 7JGW; 7K02; 7LH7; 7LHB; 7LK4; 
				7M5A; 7M5B; 7NB4; 7NB7; 7P33; 7P9W; 7WJH; 7XGE; 7XGF; 7XGG; 7Y8D; 7Y90; 
				7Y99; 7YA5; 7YAA; 8AV9; 8CZF; 8CZG; 8CZH; 8EKX; 8EL0; 8EL1; 8FY0; 8FY1; 
				8FY2; 8G3S; 8G3T; 8G3U; 8G3W; 8G3X; 8G3Y; 8GSV; 8H7B; 8HLL; 8HLM; 8HLN; 
				8HOG; 8HOH; 8HOI; 8HTR; 8HTS; 8IGC; 8IQK; 8IQL; 8IQM; 8IVB; 8QSO; 8RPO; 
				8SM5; 8SVY; 8T6F; 8U27; 8UKY; 8VJP; 8VWX; 8VWZ; 8VXM; 8VXN; 8WLS; 8XP5; 
				9AQZ; 9BCG; 9CKN; 9FKY; 9FKZ; 9FL0; 9GIP; 9GIQ; 9GIR; 9GIS; 9GIT
			
			

			» more