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PROSITE entry PS01258


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PURL: https://purl.expasy.org/prosite/signature/PS01258

Direct ScanProsite submission
General information about the entry

Entry name [info] BH2
Accession [info] PS01258
Entry type [info] PATTERN
Date [info] 01-NOV-1997 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00829

Name and characterization of the entry

Description [info] Apoptosis regulator, Bcl-2 family BH2 motif signature.
Pattern [info] 
W-[LIM]-x(3)-[GR]-G-[WQ]-[DENSAV]-x-[FLGA]-[LIVFTC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 50 in 48 different sequences
Number of true positive hits 45 in 45 different sequences
Number of 'unknown' hits 0
Number of false positive hits 5 in 3 different sequences
Number of false negative sequences 17
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 90.00 %
Recall (true positives / (true positives + false negatives)) 72.58 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 3
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 45 sequences 

AR11_XENLA  (Q91828), AR1_XENLA   (Q91827), ARBH_ASFB7  (P42485), 

ARBH_ASFE4  (Q07818), ARBH_ASFK5  (P0C8H4), ARBH_ASFM2  (Q07819), 
ARBH_ASFP4  (P0C8H5), ARBH_ASFWA  (P0C8H6), B2CL1_CHICK (Q07816), 
B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), B2CL1_PIG   (O77737), 
B2CL1_RAT   (P53563), B2CL2_BOVIN (Q1RMX3), B2CL2_CANLF (Q45T69), 
B2CL2_HUMAN (Q92843), B2CL2_MOUSE (P70345), B2L10_HUMAN (Q9HD36), 
B2L10_RAT   (Q99M66), B2LA1_BOVIN (Q3C2I0), B2LA1_HUMAN (Q16548), 
B2LA1_MOUSE (Q07440), BAK_HUMAN   (Q16611), BAK_MOUSE   (O08734), 
BAX_BOVIN   (O02703), BAX_HUMAN   (Q07812), BAX_MOUSE   (Q07813), 
BAX_RAT (Q63690), BCL2_BOVIN  (O02718), BCL2_CANLF  (Q6R755), 
BCL2_CHICK  (Q00709), BCL2_CRIGR  (Q9JJV8), BCL2_HUMAN  (P10415), 
BCL2_MOUSE  (P10417), BCL2_RAT(P49950), EAR_EBVA8   (P0C6Z1), 
EAR_EBVB9   (P03182), EAR_EBVG(P0C736), MCL1_CANLF  (Q8HYS5), 
MCL1_FELCA  (Q7YRZ9), MCL1_HUMAN  (Q07820), MCL1_MOUSE  (P97287), 
MCL1_RAT(Q9Z1P3), NR13_CHICK  (Q90ZN1), NR13_COTJA  (Q90343)
» more

UniProtKB/Swiss-Prot
False negative sequences		 17 sequences 

ARBH_FOWPN  (Q9J5G4), B2L10_MOUSE (Q9Z0F3), B2L12_HUMAN (Q9HB09), 

B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), B2L14_BOVIN (Q5E9L4), 
B2L14_HUMAN (Q9BZR8), B2L14_MOUSE (Q9CPT0), B2L14_RAT   (Q6AYK4), 
BOKA_DANRE  (Q6DC66), BOKB_DANRE  (Q7T381), BOK_CHICK   (Q9I8I2), 
BOK_HUMAN   (Q9UMX3), BOK_MOUSE   (O35425), BOK_RAT (Q792S6), 
CED9_CAEBR  (P41957), CED9_CAEEL  (P41958)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

DLD3_YEAST  (P39976), FRS2_ARATH  (Q3EBQ3), LUCIF_LINPO (O77206)


				
	

	

		PDB
[Detailed view]		
		
			387 PDB
			


			pdb_00001af3; pdb_00001bxl; pdb_00001f16; pdb_00001g5j; pdb_00001g5m; pdb_00001gjh; pdb_00001lxl; pdb_00001maz; pdb_00001mk3; pdb_00001o0l; pdb_00001pq0; pdb_00001pq1; 
			
				pdb_00001q59; pdb_00001r2d; pdb_00001r2e; pdb_00001r2g; pdb_00001r2h; pdb_00001r2i; pdb_00001wsx; pdb_00001ysg; pdb_00001ysi; pdb_00001ysn; pdb_00001ysw; pdb_00001zy3; 
				pdb_00002b48; pdb_00002bzw; pdb_00002ims; pdb_00002imt; pdb_00002jcn; pdb_00002jm6; pdb_00002k7w; pdb_00002kbw; pdb_00002lp8; pdb_00002lpc; pdb_00002lr1; pdb_00002m03; 
				pdb_00002m04; pdb_00002m5b; pdb_00002me8; pdb_00002me9; pdb_00002mej; pdb_00002mhs; pdb_00002nl9; pdb_00002nla; pdb_00002o1y; pdb_00002o21; pdb_00002o22; pdb_00002o2f; 
				pdb_00002o2m; pdb_00002o2n; pdb_00002p1l; pdb_00002pon; pdb_00002pqk; pdb_00002roc; pdb_00002rod; pdb_00002v6q; pdb_00002vm6; pdb_00002vof; pdb_00002vog; pdb_00002voh; 
				pdb_00002voi; pdb_00002w3l; pdb_00002wh6; pdb_00002xa0; pdb_00002xpx; pdb_00002y6w; pdb_00002yj1; pdb_00002yq6; pdb_00002yq7; pdb_00002yv6; pdb_00002yxj; pdb_00003cva; 
				pdb_00003d7v; pdb_00003fdl; pdb_00003fdm; pdb_00003i1h; pdb_00003ihc; pdb_00003ihd; pdb_00003ihe; pdb_00003ihf; pdb_00003iig; pdb_00003iih; pdb_00003ilb; pdb_00003ilc; 
				pdb_00003inq; pdb_00003io8; pdb_00003io9; pdb_00003kj0; pdb_00003kj1; pdb_00003kj2; pdb_00003kz0; pdb_00003mk8; pdb_00003mqp; pdb_00003pk1; pdb_00003pl7; pdb_00003qkd; 
				pdb_00003r85; pdb_00003sp7; pdb_00003spf; pdb_00003wix; pdb_00003wiy; pdb_00003wiz; pdb_00003zk6; pdb_00003zln; pdb_00003zlo; pdb_00003zlr; pdb_00004a1u; pdb_00004a1w; 
				pdb_00004aq3; pdb_00004bd2; pdb_00004bd6; pdb_00004bd7; pdb_00004bd8; pdb_00004bpi; pdb_00004bpj; pdb_00004bpk; pdb_00004c52; pdb_00004c5d; pdb_00004cim; pdb_00004cin; 
				pdb_00004ehr; pdb_00004g35; pdb_00004hnj; pdb_00004hw2; pdb_00004hw3; pdb_00004hw4; pdb_00004ieh; pdb_00004k5a; pdb_00004k5b; pdb_00004lvt; pdb_00004lxd; pdb_00004man; 
				pdb_00004oq5; pdb_00004oq6; pdb_00004oyd; pdb_00004ppi; pdb_00004qnq; pdb_00004qve; pdb_00004qvf; pdb_00004qvx; pdb_00004s0o; pdb_00004s0p; pdb_00004tuh; pdb_00004u2u; 
				pdb_00004wgi; pdb_00004wmr; pdb_00004wms; pdb_00004wmt; pdb_00004wmu; pdb_00004wmv; pdb_00004wmw; pdb_00004wmx; pdb_00004yj4; pdb_00004yk9; pdb_00004z9v; pdb_00004zbf; 
				pdb_00004zbi; pdb_00004zeq; pdb_00004zie; pdb_00004zif; pdb_00004zig; pdb_00004zih; pdb_00004zii; pdb_00005agw; pdb_00005agx; pdb_00005b1z; pdb_00005c3f; pdb_00005c3g; 
				pdb_00005c6h; pdb_00005fc4; pdb_00005fcg; pdb_00005fdo; pdb_00005fdr; pdb_00005fmi; pdb_00005fmj; pdb_00005fmk; pdb_00005iez; pdb_00005if4; pdb_00005jsb; pdb_00005jsn; 
				pdb_00005ku9; pdb_00005lof; pdb_00005mes; pdb_00005mev; pdb_00005ua4; pdb_00005ua5; pdb_00005uuk; pdb_00005uul; pdb_00005uum; pdb_00005uup; pdb_00005vau; pdb_00005vax; 
				pdb_00005vay; pdb_00005vkc; pdb_00005vwv; pdb_00005vww; pdb_00005vwx; pdb_00005vwy; pdb_00005vwz; pdb_00005vx0; pdb_00005vx1; pdb_00005vx2; pdb_00005vx3; pdb_00005w5x; 
				pdb_00005w5z; pdb_00005w60; pdb_00005w61; pdb_00005w62; pdb_00005w89; pdb_00005w8f; pdb_00005whh; pdb_00005whi; pdb_00006b4l; pdb_00006b4u; pdb_00006bf2; pdb_00006bw2; 
				pdb_00006bw8; pdb_00006dcn; pdb_00006dco; pdb_00006dm8; pdb_00006e3i; pdb_00006e3j; pdb_00006eb6; pdb_00006fs0; pdb_00006fs1; pdb_00006fs2; pdb_00006gl8; pdb_00006hjl; 
				pdb_00006ijq; pdb_00006iwb; pdb_00006lhd; pdb_00006mbb; pdb_00006mbc; pdb_00006mbd; pdb_00006mbe; pdb_00006mcy; pdb_00006ne5; pdb_00006o0k; pdb_00006o0l; pdb_00006o0m; 
				pdb_00006o0o; pdb_00006o0p; pdb_00006o4u; pdb_00006o6f; pdb_00006o6g; pdb_00006oqb; pdb_00006oqc; pdb_00006oqd; pdb_00006oqn; pdb_00006ovc; pdb_00006p3p; pdb_00006qb3; 
				pdb_00006qb4; pdb_00006qb6; pdb_00006qfc; pdb_00006qfi; pdb_00006qfm; pdb_00006qfq; pdb_00006qgd; pdb_00006qxj; pdb_00006qyk; pdb_00006qyl; pdb_00006qyn; pdb_00006qyo; 
				pdb_00006qyp; pdb_00006qz5; pdb_00006qz6; pdb_00006qz7; pdb_00006qz8; pdb_00006qzb; pdb_00006rjp; pdb_00006rnu; pdb_00006st2; pdb_00006stj; pdb_00006tzc; pdb_00006u63; 
				pdb_00006u64; pdb_00006u65; pdb_00006u67; pdb_00006u6f; pdb_00006ua3; pdb_00006uab; pdb_00006ud2; pdb_00006udi; pdb_00006udt; pdb_00006udu; pdb_00006udv; pdb_00006udx; 
				pdb_00006udy; pdb_00006uvc; pdb_00006uvd; pdb_00006uve; pdb_00006uvf; pdb_00006uvg; pdb_00006uvh; pdb_00006vbx; pdb_00006vo4; pdb_00006vwc; pdb_00006ybg; pdb_00006ybj; 
				pdb_00006ybk; pdb_00006ybl; pdb_00006yli; pdb_00006zhc; pdb_00006zie; pdb_00007ca4; pdb_00007jgv; pdb_00007jgw; pdb_00007k02; pdb_00007lh7; pdb_00007lhb; pdb_00007lk4; 
				pdb_00007m5a; pdb_00007m5b; pdb_00007nb4; pdb_00007nb7; pdb_00007p33; pdb_00007p9w; pdb_00007wjh; pdb_00007xge; pdb_00007xgf; pdb_00007xgg; pdb_00007y8d; pdb_00007y90; 
				pdb_00007y99; pdb_00007ya5; pdb_00007yaa; pdb_00008av9; pdb_00008czf; pdb_00008czg; pdb_00008czh; pdb_00008ekx; pdb_00008el0; pdb_00008el1; pdb_00008fy0; pdb_00008fy1; 
				pdb_00008fy2; pdb_00008g3s; pdb_00008g3t; pdb_00008g3u; pdb_00008g3w; pdb_00008g3x; pdb_00008g3y; pdb_00008gsv; pdb_00008h7b; pdb_00008hll; pdb_00008hlm; pdb_00008hln; 
				pdb_00008hog; pdb_00008hoh; pdb_00008hoi; pdb_00008htr; pdb_00008hts; pdb_00008igc; pdb_00008iqk; pdb_00008iql; pdb_00008iqm; pdb_00008ivb; pdb_00008qso; pdb_00008rpo; 
				pdb_00008sm5; pdb_00008svy; pdb_00008t6f; pdb_00008u27; pdb_00008uky; pdb_00008vjp; pdb_00008vwx; pdb_00008vwz; pdb_00008vxm; pdb_00008vxn; pdb_00008wls; pdb_00008xp5; 
				pdb_00008y1y; pdb_00008y1z; pdb_00008y20; pdb_00008zeb; pdb_00009aqz; pdb_00009bcg; pdb_00009ckn; pdb_00009fky; pdb_00009fkz; pdb_00009fl0; pdb_00009gip; pdb_00009giq; 
				pdb_00009gir; pdb_00009gis; pdb_00009git
			
			

			» more