PROSITE entry PS01259

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General information about the entry

Entry name [info]	BH3
Accession [info]	PS01259
Entry type [info]	PATTERN
Date [info]	01-NOV-1997 CREATED; 01-JUL-1998 DATA UPDATE; 03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC00829

Name and characterization of the entry

Description [info]	Apoptosis regulator, Bcl-2 family BH3 motif signature.
Pattern [info]	[LIVAT]-x(3)-L-[KARQ]-x-[IVAL]-G-D-[DESG]-[LIMFV]-[DENSHQ]-[LVSHRQ]- [NSR].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.

Total number of hits	30 in 30 different sequences
Number of true positive hits	30 in 30 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	38
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	44.12 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

30 sequences

B2CL1_CHICK (Q07816    ), B2CL1_HUMAN (Q07817    ), B2CL1_MOUSE (Q64373    ),

B2CL1_PIG   (O77737    ), B2CL1_RAT   (P53563    ), BAK_HUMAN   (Q16611    ), 
BAK_MOUSE   (O08734    ), BAX_BOVIN   (O02703    ), BAX_HUMAN   (Q07812    ), 
BAX_MOUSE   (Q07813    ), BAX_RAT     (Q63690    ), BCL2_BOVIN  (O02718    ), 
BCL2_CANLF  (Q6R755    ), BCL2_CHICK  (Q00709    ), BCL2_CRIGR  (Q9JJV8    ), 
BCL2_HUMAN  (P10415    ), BCL2_MOUSE  (P10417    ), BCL2_RAT    (P49950    ), 
BID_HUMAN   (P55957    ), BID_MOUSE   (P70444    ), BID_RAT     (Q9JLT6    ), 
BIK_HUMAN   (Q13323    ), HRK_HUMAN   (O00198    ), HRK_MOUSE   (P62816    ), 
HRK_RAT     (P62817    ), MCL1_CANLF  (Q8HYS5    ), MCL1_FELCA  (Q7YRZ9    ), 
MCL1_HUMAN  (Q07820    ), MCL1_MOUSE  (P97287    ), MCL1_RAT    (Q9Z1P3    )

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

38 sequences

APR_CANLF   (Q1PCT2    ), APR_HUMAN   (Q13794    ), APR_MOUSE   (Q9JM54    ),

APR_RAT     (Q5U777    ), B2L11_HUMAN (O43521    ), B2L11_MOUSE (O54918    ), 
B2L11_RAT   (O88498    ), B2L13_HUMAN (Q9BXK5    ), B2L13_MOUSE (P59017    ), 
B2L14_BOVIN (Q5E9L4    ), B2L14_HUMAN (Q9BZR8    ), B2L14_MOUSE (Q9CPT0    ), 
B2L14_RAT   (Q6AYK4    ), BAD_HUMAN   (Q92934    ), BAD_MOUSE   (Q61337    ), 
BAD_RAT     (O35147    ), BBC3_HUMAN  (Q9BXH1    ), BBC3_MOUSE  (Q99ML1    ), 
BBC3_RAT    (Q80ZG6    ), BID_CHICK   (Q8JGM8    ), BID_PIG     (Q4JHS0    ), 
BMF_HUMAN   (Q96LC9    ), BMF_MOUSE   (Q91ZE9    ), BMF_RAT     (Q8K589    ), 
BNI3L_BOVIN (Q3T013    ), BNI3L_HUMAN (O60238    ), BNI3L_MOUSE (Q9Z2F7    ), 
BNIP3_BOVIN (Q32KN2    ), BNIP3_HUMAN (Q12983    ), BNIP3_MOUSE (O55003    ), 
BOKA_DANRE  (Q6DC66    ), BOKB_DANRE  (Q7T381    ), BOK_CHICK   (Q9I8I2    ), 
BOK_HUMAN   (Q9UMX3    ), BOK_MOUSE   (O35425    ), BOK_RAT     (Q792S6    ), 
BOP_HUMAN   (Q7L3V2    ), BOP_PONAB   (Q5R6M8    )

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PDB
[Detailed view]

313 PDB

1AF3; 1BXL; 1DDB; 1F16; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1PQ0; 1PQ1; 1R2D; 1R2E; 1R2H; 1R2I; 1WSX; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 2B48; 2BID; 2BZW; 2IMS; 2IMT; 2JBY; 2JCN; 2JM6; 2K7W; 2KBW; 2L58; 2LP8; 2LPC; 2LR1; 2M03; 2M04; 2M5B; 2M5I; 2ME8; 2ME9; 2MEJ; 2MHS; 2NL9; 2NLA; 2O1Y; 2O21; 2O22; 2O2F; 2O2M; 2O2N; 2P1L; 2PON; 2PQK; 2ROC; 2ROD; 2VOH; 2VOI; 2W3L; 2XA0; 2XPX; 2YJ1; 2YQ6; 2YQ7; 2YV6; 2YXJ; 3CVA; 3D7V; 3FDL; 3FDM; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 3INQ; 3IO8; 3IO9; 3KJ0; 3KJ1; 3KJ2; 3KZ0; 3MK8; 3PK1; 3PL7; 3QBR; 3QKD; 3R85; 3SP7; 3SPF; 3WIX; 3WIY; 3WIZ; 3ZK6; 3ZLN; 3ZLO; 3ZLR; 4A1U; 4A1W; 4AQ3; 4BD2; 4BD6; 4BD7; 4BD8; 4BDU; 4BPI; 4BPJ; 4BPK; 4C52; 4C5D; 4CIN; 4D2L; 4EHR; 4G35; 4HNJ; 4HW2; 4HW3; 4HW4; 4IEH; 4LVT; 4LXD; 4MAN; 4OQ5; 4OQ6; 4PPI; 4QNQ; 4QVE; 4QVF; 4QVX; 4S0O; 4TUH; 4U2U; 4U2V; 4UF1; 4UF2; 4WGI; 4WMR; 4WMS; 4WMT; 4WMU; 4WMV; 4WMW; 4WMX; 4YJ4; 4YK9; 4Z9V; 4ZBF; 4ZBI; 4ZEQ; 4ZIE; 4ZIF; 4ZIG; 4ZIH; 4ZII; 5AGW; 5AGX; 5AJJ; 5AJK; 5B1Z; 5C3F; 5C3G; 5C6H; 5FC4; 5FCG; 5FDO; 5FDR; 5FMI; 5FMJ; 5FMK; 5IEZ; 5IF4; 5JSB; 5JSN; 5KU9; 5LOF; 5MES; 5MEV; 5UUM; 5VAU; 5VAX; 5VAY; 5VKC; 5VWV; 5VWW; 5VWX; 5VWY; 5VWZ; 5VX0; 5VX1; 5VX2; 5VX3; 5W5X; 5W5Z; 5W60; 5W61; 5W62; 5W89; 5W8F; 6B4L; 6B4U; 6BF2; 6BW2; 6BW8; 6DCN; 6DCO; 6DM8; 6EB6; 6FS0; 6FS1; 6FS2; 6GL8; 6HJL; 6IJQ; 6IWB; 6L8V; 6LHD; 6MBD; 6MBE; 6MCY; 6NE5; 6O0K; 6O0M; 6O4U; 6O6F; 6O6G; 6ODH; 6OQB; 6OQC; 6OQD; 6OQN; 6OVC; 6P3P; 6QB3; 6QB4; 6QB6; 6QFC; 6QFI; 6QFM; 6QFQ; 6QG8; 6QGD; 6QXJ; 6QYK; 6QYL; 6QYN; 6QYO; 6QYP; 6QZ5; 6QZ6; 6QZ7; 6QZ8; 6QZB; 6RNU; 6ST2; 6STJ; 6TRR; 6U63; 6U64; 6U65; 6U67; 6U6F; 6UA3; 6UAB; 6UD2; 6UDI; 6UDT; 6UDU; 6UDV; 6UDX; 6UDY; 6UVC; 6UVD; 6UVE; 6UVF; 6UVG; 6UVH; 6UXM; 6UXN; 6UXO; 6UXP; 6UXQ; 6UXR; 6VBX; 6VWC; 6XY4; 6XY6; 6YBG; 6YBJ; 6YBK; 6YBL; 6YLI; 6ZHC; 6ZIE; 7ADT; 7CA4; 7JGV; 7JGW; 7K02; 7LH7; 7LHB; 7LK4; 7M5A; 7M5B; 7NB4; 7NB7; 7P0U; 7P33; 7WJH; 7XGE; 7XGG
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