PROSITE entry PS01260

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General information about the entry

Entry name [info]	BH4_1
Accession [info]	PS01260
Entry type [info]	PATTERN
Date [info]	01-NOV-1997 CREATED; 01-NOV-1997 DATA UPDATE; 03-MAY-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC00829

Name and characterization of the entry

Description [info]	Apoptosis regulator, Bcl-2 family BH4 motif signature.
Pattern [info]	[DS]-[NT]-R-[AE]-[LI]-V-x-[KD]-[FY]-[LIV]-[GHS]-Y-K-L-[SR]-Q-[RK]-G- [HY]-x-[CW].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_02 which contains 569'516 sequence entries.

Total number of hits	16 in 16 different sequences
Number of true positive hits	16 in 16 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	10
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	61.54 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

16 sequences

B2CL1_CHICK (Q07816    ), B2CL1_HUMAN (Q07817    ), B2CL1_MOUSE (Q64373    ),

B2CL1_PIG   (O77737    ), B2CL1_RAT   (P53563    ), B2CL2_BOVIN (Q1RMX3    ), 
B2CL2_CANLF (Q45T69    ), B2CL2_HUMAN (Q92843    ), B2CL2_MOUSE (P70345    ), 
BCL2_BOVIN  (O02718    ), BCL2_CANLF  (Q6R755    ), BCL2_CHICK  (Q00709    ), 
BCL2_CRIGR  (Q9JJV8    ), BCL2_HUMAN  (P10415    ), BCL2_MOUSE  (P10417    ), 
BCL2_RAT    (P49950    )

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

10 sequences

B2L13_HUMAN (Q9BXK5    ), B2L13_MOUSE (P59017    ), BOKA_DANRE  (Q6DC66    ),

BOKB_DANRE  (Q7T381    ), BOK_CHICK   (Q9I8I2    ), BOK_HUMAN   (Q9UMX3    ), 
BOK_MOUSE   (O35425    ), BOK_RAT     (Q792S6    ), CED9_CAEBR  (P41957    ), 
CED9_CAEEL  (P41958    )

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PDB
[Detailed view]

129 PDB

1AF3; 1BXL; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1MK3; 1O0L; 1PQ0; 1PQ1; 1R2D; 1R2E; 1R2G; 1R2H; 1R2I; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 2B48; 2BZW; 2LP8; 2LPC; 2M03; 2M04; 2ME8; 2ME9; 2MEJ; 2O1Y; 2O21; 2O22; 2O2F; 2P1L; 2PON; 2W3L; 2XA0; 2YJ1; 2YQ6; 2YQ7; 2YXJ; 3CVA; 3FDL; 3FDM; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 3INQ; 3IO8; 3PL7; 3QKD; 3R85; 3SP7; 3SPF; 3WIZ; 3ZK6; 3ZLN; 3ZLO; 3ZLR; 4A1U; 4A1W; 4AQ3; 4BPK; 4C52; 4C5D; 4CIN; 4EHR; 4HNJ; 4IEH; 4K5A; 4K5B; 4LVT; 4LXD; 4MAN; 4PPI; 4QNQ; 4QVE; 4QVF; 4TUH; 4YJ4; 4YK9; 4Z9V; 5AGW; 5AGX; 5B1Z; 5C3G; 5FCG; 5FMJ; 5FMK; 5JSN; 5VAU; 5VAX; 5VAY; 5VX3; 6BF2; 6DCN; 6DCO; 6GL8; 6HJL; 6IJQ; 6IWB; 6LHD; 6O0K; 6O0L; 6O0M; 6O0O; 6O0P; 6RNU; 6ST2; 6UVC; 6UVD; 6UVE; 6UVF; 6UVG; 6UVH; 6YLI; 6ZHC; 7CA4; 7JGV; 7JGW; 7LHB; 7WJH; 7XGG
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