PROSITE entry PS01260

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PURL: https://purl.expasy.org/prosite/signature/PS01260

Direct ScanProsite submission

General information about the entry

Entry name [info]	BH4_1
Accession [info]	PS01260
Entry type [info]	PATTERN
Date [info]	01-NOV-1997 CREATED; 01-NOV-1997 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00829

Name and characterization of the entry

Description [info]	Apoptosis regulator, Bcl-2 family BH4 motif signature.
Pattern [info]	[DS]-[NT]-R-[AE]-[LI]-V-x-[KD]-[FY]-[LIV]-[GHS]-Y-K-L-[SR]-Q-[RK]-G- [HY]-x-[CW].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	16 in 16 different sequences
Number of true positive hits	16 in 16 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	10
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	61.54 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

16 sequences

B2CL1_CHICK (Q07816), B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373),

B2CL1_PIG   (O77737), B2CL1_RAT   (P53563), B2CL2_BOVIN (Q1RMX3), 
B2CL2_CANLF (Q45T69), B2CL2_HUMAN (Q92843), B2CL2_MOUSE (P70345), 
BCL2_BOVIN  (O02718), BCL2_CANLF  (Q6R755), BCL2_CHICK  (Q00709), 
BCL2_CRIGR  (Q9JJV8), BCL2_HUMAN  (P10415), BCL2_MOUSE  (P10417), 
BCL2_RAT(P49950)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

10 sequences

B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), BOKA_DANRE  (Q6DC66),

BOKB_DANRE  (Q7T381), BOK_CHICK   (Q9I8I2), BOK_HUMAN   (Q9UMX3), 
BOK_MOUSE   (O35425), BOK_RAT (Q792S6), CED9_CAEBR  (P41957), 
CED9_CAEEL  (P41958)

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PDB
[Detailed view]

156 PDB

pdb_00001af3; pdb_00001bxl; pdb_00001g5j; pdb_00001g5m; pdb_00001gjh; pdb_00001lxl; pdb_00001maz; pdb_00001mk3; pdb_00001o0l; pdb_00001pq0; pdb_00001pq1; pdb_00001r2d; pdb_00001r2e; pdb_00001r2g; pdb_00001r2h; pdb_00001r2i; pdb_00001ysg; pdb_00001ysi; pdb_00001ysn; pdb_00001ysw; pdb_00001zy3; pdb_00002b48; pdb_00002bzw; pdb_00002lp8; pdb_00002lpc; pdb_00002m03; pdb_00002m04; pdb_00002me8; pdb_00002me9; pdb_00002mej; pdb_00002o1y; pdb_00002o21; pdb_00002o22; pdb_00002o2f; pdb_00002p1l; pdb_00002pon; pdb_00002w3l; pdb_00002xa0; pdb_00002yj1; pdb_00002yq6; pdb_00002yq7; pdb_00002yxj; pdb_00003cva; pdb_00003fdl; pdb_00003fdm; pdb_00003ihc; pdb_00003ihd; pdb_00003ihe; pdb_00003ihf; pdb_00003iig; pdb_00003iih; pdb_00003ilb; pdb_00003ilc; pdb_00003inq; pdb_00003io8; pdb_00003pl7; pdb_00003qkd; pdb_00003r85; pdb_00003sp7; pdb_00003spf; pdb_00003wiz; pdb_00003zk6; pdb_00003zln; pdb_00003zlo; pdb_00003zlr; pdb_00004a1u; pdb_00004a1w; pdb_00004aq3; pdb_00004bpk; pdb_00004c52; pdb_00004c5d; pdb_00004cin; pdb_00004ehr; pdb_00004hnj; pdb_00004ieh; pdb_00004k5a; pdb_00004k5b; pdb_00004lvt; pdb_00004lxd; pdb_00004man; pdb_00004ppi; pdb_00004qnq; pdb_00004qve; pdb_00004qvf; pdb_00004tuh; pdb_00004yj4; pdb_00004yk9; pdb_00004z9v; pdb_00005agw; pdb_00005agx; pdb_00005b1z; pdb_00005c3g; pdb_00005fcg; pdb_00005fmj; pdb_00005fmk; pdb_00005jsn; pdb_00005vau; pdb_00005vax; pdb_00005vay; pdb_00005vx3; pdb_00006bf2; pdb_00006dcn; pdb_00006dco; pdb_00006gl8; pdb_00006hjl; pdb_00006ijq; pdb_00006iwb; pdb_00006lhd; pdb_00006o0k; pdb_00006o0l; pdb_00006o0m; pdb_00006o0o; pdb_00006o0p; pdb_00006rnu; pdb_00006st2; pdb_00006uvc; pdb_00006uvd; pdb_00006uve; pdb_00006uvf; pdb_00006uvg; pdb_00006uvh; pdb_00006yli; pdb_00006zhc; pdb_00007ca4; pdb_00007jgv; pdb_00007jgw; pdb_00007lhb; pdb_00007wjh; pdb_00007xgf; pdb_00007xgg; pdb_00007y8d; pdb_00007y90; pdb_00007y99; pdb_00007ya5; pdb_00007yaa; pdb_00008fy0; pdb_00008fy1; pdb_00008fy2; pdb_00008hll; pdb_00008hlm; pdb_00008hln; pdb_00008hog; pdb_00008hoh; pdb_00008hoi; pdb_00008htr; pdb_00008hts; pdb_00008iqk; pdb_00008iql; pdb_00008u27; pdb_00008vwx; pdb_00008vwz; pdb_00008vxm; pdb_00008vxn; pdb_00008wls; pdb_00008xp5; pdb_00008zeb
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