PROSITE entry PS50014
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS50014
Direct ScanProsite submission
General information about the entry
Entry name [info] | BROMODOMAIN_2 |
Accession [info] | PS50014 |
Entry type [info] | MATRIX |
Date [info] |
01-NOV-1995 CREATED;
18-JUN-2025 DATA UPDATE; 18-JUN-2025 INFO UPDATE. |
PROSITE Doc. [info] | PDOC00550 |
Associated ProRule [info] | PRU00035 |
Name and characterization of the entry
Description [info] | Bromodomain (BrD) profile. |
Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=106; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=101; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9910014; R2=0.0061618; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1300; N_SCORE=10.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=732; N_SCORE=6.5; MODE=1; TEXT='RR'; /DEFAULT: M0=-22; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='R'; M= -4, -18, -41, 5, -34, -46, -23, -25, 40, -22, -61, -37, -8, 3, 49, 20, -25, -26, 24, 8; /M: SY='M'; M= -29, -73, 1, 0, -61, -9, 23, -3, 6, 21, 43, 15, 1, 1, -1, -2, -30, 9, -77, -20; /M: SY='S'; M= -12, -27, -5, 5, -34, -69, -61, -6, 23, 17, 19, -20, -2, 20, 5, 23, 7, 3, -77, -39; /M: SY='N'; M= -37, -76, 33, 26, -78, -13, 3, -54, 21, -59, 0, 50, 37, 34, -24, -2, -2, -31, -83, -68; /M: SY='E'; M= 5, -27, 15, 35, -42, -68, -61, 0, 33, -20, -32, -1, 28, 30, -37, -2, -17, 2, -78, -39; /M: SY='L'; M= -40, -17, 2, -5, 22, -18, -64, 8, -51, 48, 39, -2, 4, -21, -15, -48, -5, -19, -10, -55; /M: SY='Q'; M= -48, -77, -21, 5, -3, -71, 16, -19, 48, -22, 36, -30, -20, 54, 21, -12, -6, -47, -6, 24; /M: SY='K'; M= -8, -75, 2, 16, -68, -45, 15, -5, 41, -17, -2, -38, -68, 36, 36, -26, 1, 8, -77, -20; /M: SY='K'; M= -18, -40, -37, -4, 14, -28, -35, 6, 51, 10, -23, -32, -31, 29, -8, -7, -12, 7, -71, -23; /M: SY='C'; M= -23, 105, -45, -56, 9, -78, -70, 15, -49, 45, 45, -71, -81, -27, -48, -32, -60, -39, -76, -33; /M: SY='K'; M= -37, -74, 11, 24, -17, -19, 4, -50, 40, -30, -17, 31, -67, 15, 21, 34, -36, -69, -73, 18; /M: SY='E'; M= 5, -73, -28, 51, 20, -18, -58, -25, -1, -46, -10, -6, -44, 27, 8, 15, 10, -15, -72, -5; /M: SY='V'; M= -22, -70, -80, -48, 14, -81, -74, 50, -72, 27, 43, -74, -76, -71, -43, -34, -18, 58, -73, -23; /I: I=-9; MD=-22; /M: SY='L'; M= -68, -73, -23, -22, -21, -86, -69, 20, -75, 75, 9, -79, -82, -70, -50, -76, -64, -7, -71, 6; D=-9; /I: I=-9; MD=-22; /M: SY='D'; M= -47, -79, 47, 44, -76, -49, -12, -75, 22, -23, -68, 8, -28, 13, 23, 10, -1, -54, -9, -28; D=-9; /I: I=-9; MD=-22; /M: SY='Q'; M= 13, -29, -27, 10, 2, -5, -63, -63, 0, 6, 13, 7, -73, 30, 14, 4, -12, -21, -77, -30; D=-9; /I: I=-9; MD=-22; /M: SY='L'; M= -21, -76, -88, -81, 1, -88, -77, 39, -78, 56, 27, -83, -85, -75, -22, -77, -65, 20, -76, -34; D=-9; /I: I=-9; MD=-22; /M: SY='F'; M= -36, -95, -11, -58, 16, -93, -19, 1, -24, -36, -25, -14, -95, -82, -10, 2, -51, -4, -25, -10; D=-9; /I: I=-9; MI=0; MD=-22; IM=0; DM=-22; /M: SY='K'; M= -17, -90, 17, -22, -91, -57, -73, -86, 36, -37, 16, -17, -83, 22, -17, 17, -32, -83, -95, -81; D=-9; /I: I=-9; DM=-22; /M: SY='H'; M= -18, -6, -12, -30, -74, 24, 32, -56, 25, -36, -30, 24, -78, 0, 0, -16, -28, -61, -81, 22; D=-9; /I: I=-9; DM=-22; /M: SY='H'; M= -59, -8, 2, -23, -46, -79, 73, -21, 16, -16, -62, -23, -78, 32, 40, -39, -35, -11, -83, 3; D=-9; /I: I=-9; DM=-22; /M: SY='P'; M= -34, -30, 26, 24, -37, -34, -63, -76, 25, -13, -68, -16, 48, 6, 27, -16, -26, -75, -82, -30; D=-9; /I: I=-9; DM=-22; /M: SY='H'; M= -38, -8, 3, -38, 20, -24, 26, 16, -2, 16, 14, -9, 4, -63, 23, -27, -49, -21, 11, -10; D=-9; /I: I=-9; DM=-22; /M: SY='S'; M= 39, 19, -40, -44, 5, -24, -63, -52, -63, -69, -31, 8, -70, -18, -67, 59, 25, -46, -75, 18; D=-9; /I: I=-9; DM=-22; /M: SY='W'; M= 5, -79, 29, 1, -3, -12, -14, -69, 11, -3, -64, -37, -26, -34, 19, -1, -33, -37, 95, -25; D=-9; /I: I=-9; DM=-22; /M: SY='P'; M= -5, -29, -41, -38, -18, -74, -69, 13, -3, 7, -17, -69, 80, 19, -33, -45, -14, -2, -76, -26; D=-9; /I: I=-9; DM=-22; /M: SY='F'; M= -48, -72, -86, -82, 112, -45, -69, -49, -48, -1, -51, -76, -85, -85, -75, -73, -30, -35, -46, -6; D=-9; /I: I=-9; DM=-22; /M: SY='H'; M= -2, -73, -62, 13, -25, -72, 38, -12, -2, 29, 10, -14, -71, 28, 30, 3, 0, -16, -76, -28; D=-9; /I: I=-9; DM=-22; /M: SY='Q'; M= -37, -75, -28, 36, -29, -29, 30, -70, 44, -57, -62, 21, -66, 46, 17, 7, 13, -14, -76, -10; /I: I=-11; MD=-27; /M: SY='P'; M= -29, -82, -70, -60, -70, -43, -69, -36, -1, 27, -56, -30, 104, -65, -21, -65, -60, -23, -78, -72; D=-11; /I: I=-11; MD=-27; /M: SY='V'; M= -40, -74, -77, -69, -37, -42, -77, 11, -71, 2, -10, -75, 70, -32, -75, -19, -55, 70, -82, -65; D=-11; /I: I=-11; MD=-27; /M: SY='D'; M= -59, -74, 79, -14, -78, -39, -57, -6, -33, -52, -70, 41, 8, -54, -44, 44, 10, -68, -91, -69; D=-11; /I: I=-11; MD=-27; /M: SY='K'; M= -10, -76, 26, -40, -70, -44, -13, -61, 46, 15, -58, -6, 42, -24, 26, -15, -22, -4, -80, -66; D=-11; /I: I=-11; MD=-27; /M: SY='K'; M= -49, 6, 12, 21, -43, -25, -24, -12, 51, -43, -64, 20, -70, -1, 11, 10, -58, 11, -82, -43; D=-11; /I: I=-11; MI=0; MD=-27; IM=0; DM=-27; /M: SY='E'; M= -43, 2, 25, 44, 3, 5, -61, -35, 7, 2, 3, 28, -72, -8, -40, -61, -15, -46, -77, 1; D=-11; /I: I=-11; DM=-27; /M: SY='Y'; M= 17, -40, -45, -48, 2, -29, 14, 27, -17, 16, -48, -38, -33, -39, -68, -8, -59, 26, -65, 55; D=-11; /I: I=-11; DM=-27; /M: SY='P'; M= -35, -84, -3, -3, -79, -70, 9, -69, -20, -26, -66, -65, 106, -25, -20, -38, 5, -33, -82, -75; D=-11; /I: I=-11; DM=-27; /M: SY='D'; M= -20, -77, 93, -10, -27, 1, -28, -24, -17, -29, -23, 25, -69, -27, -35, -31, -39, -44, -89, -67; D=-11; /I: I=-11; DM=-27; /M: SY='Y'; M= -67, -79, -69, -38, -9, -47, -42, -31, -20, -25, -50, -69, -80, -60, -62, -20, -16, -14, -35, 123; /M: SY='Y'; M= -33, 15, -14, -51, 19, -48, 35, -38, -10, -29, -54, -18, -2, -36, -14, -61, 8, -34, 37, 99; /M: SY='E'; M= -20, -75, 40, 43, -74, -54, -55, -38, 39, -44, 23, -10, -27, 36, 3, 17, 1, -67, -78, -14; /M: SY='I'; M= -47, -74, -76, -70, 17, -81, -35, 65, -8, -1, 22, -14, -35, 10, -20, -66, -39, 43, -70, 5; /M: SY='I'; M= -41, -74, -80, -76, -10, -82, -20, 86, -22, -26, -41, -71, -13, -71, -74, 0, -55, 43, -76, -57; /I: I=-12; MI=0; MD=-31; IM=0; DM=-31; /M: SY='K'; M= -23, -74, -23, 17, 3, -16, 1, -70, 63, -57, -63, -20, -4, 30, -21, 23, 16, -33, -73, -21; /M: SY='N'; M= -49, -76, 8, 23, -24, -27, 36, -33, 34, -72, -30, 47, -7, 40, 19, 10, -2, -71, -78, -15; /M: SY='P'; M= -30, -86, -65, -56, -82, -42, -68, -71, -16, -50, -3, -29, 118, -63, -70, -11, -33, -74, -79, -79; /M: SY='M'; M= -61, -14, -82, -74, -6, -79, -62, 32, -69, 14, 121, -72, -73, -24, -69, -69, -18, 17, -74, -51; /M: SY='D'; M= -6, 37, 96, -6, -80, -62, -58, -78, -57, -78, -75, -6, -67, -55, -64, 33, -7, -43, 21, -68; /M: SY='L'; M= -68, -70, -85, -78, 51, -85, -69, 17, -77, 75, 18, -80, -83, -73, -75, -75, -42, -26, -64, -23; /M: SY='S'; M= -29, -24, 24, 15, -73, 8, -57, -70, 24, -50, -11, 12, -32, 30, 13, 38, 12, -25, -78, -9; /M: SY='T'; M= -29, -68, 18, 6, -67, -42, -64, 14, -6, -22, -10, -33, -63, -11, -41, 23, 80, -39, -83, -65; /M: SY='I'; M= -63, -74, -85, -81, -49, -86, -76, 88, -76, 7, 75, -76, -75, -71, -77, -73, -58, 25, -75, -55; /M: SY='K'; M= -32, -77, -5, 40, -74, -44, -55, -33, 56, -14, -20, 5, -66, 38, 48, -17, -32, -68, -77, -65; /M: SY='K'; M= -9, -75, -11, 38, -55, -41, 6, -74, 61, -47, -5, 16, -64, 41, 6, 17, -19, -71, -77, -65; /M: SY='K'; M= -63, -13, -55, -47, -77, -69, 5, -78, 77, -75, -15, 37, -68, 0, 69, -27, -40, -74, -77, -64; /M: SY='L'; M= -24, -2, -46, -76, 15, -82, -37, 52, -75, 52, 21, -27, -78, -71, -75, -49, -38, 33, -73, -53; /M: SY='W'; M= 4, -76, 17, 49, -72, -67, -58, -21, 42, -53, -16, 20, -34, 9, 17, -6, -25, -46, 57, -30; /I: I=-33; MD=-84; /M: SY='N'; M= -11, -25, -31, 28, -74, -12, -18, -34, 25, -48, -31, 51, -67, 8, -12, 45, 12, -68, -81, -27; D=-33; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='G'; M= -58, 8, -19, -27, -22, 63, 25, -55, -17, -28, -66, 39, -33, 8, 7, -13, -9, -74, 13, -43; D=-33; /I: I=-33; DM=-84; /M: SY='E'; M= 6, -24, -54, 45, -24, -26, 9, -52, 25, -17, 14, 1, -6, 35, 11, -8, -30, -51, -70, 31; /M: SY='Y'; M= -71, -82, -36, -72, -20, -77, -38, -22, -65, -53, -50, -26, -83, -61, -63, -66, -65, -60, -29, 132; /I: I=-33; MD=-84; /M: SY='K'; M= -28, 12, 13, 15, -70, -24, 10, -69, 33, -23, -62, -7, -2, 20, 29, 15, 14, -19, -22, 0; D=-33; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='S'; M= -51, -2, 13, -3, -73, 1, -18, -69, -23, -48, -66, 21, -65, -4, -17, 62, 58, -40, -84, -44; /M: SY='P'; M= -3, -27, -74, -48, 7, -76, -71, 24, -15, 28, -2, -71, 50, -66, -5, -63, 3, 39, -74, -25; /M: SY='E'; M= 6, -75, 40, 50, -48, -27, 19, -51, 13, -29, -11, -16, -65, 43, -39, 12, -7, -68, -20, -6; /M: SY='E'; M= 11, -77, 38, 77, -79, -38, -24, -76, -10, -36, -36, -11, -36, 45, -53, -10, -39, -72, 1, -68; /M: SY='F'; M= -71, 12, -86, -81, 107, -83, -68, -21, -77, 17, 14, -77, -84, -83, -75, -73, -46, -9, -48, -4; /M: SY='V'; M= -2, -27, -16, 6, -54, -60, -63, 19, -20, 30, 20, 0, -73, 8, -15, -12, -29, 33, -72, 23; /M: SY='D'; M= 27, -29, 46, 29, -37, -64, 24, -50, 22, -37, -64, 6, -67, 20, 8, 11, -56, -68, -1, 11; /M: SY='D'; M= -36, -80, 114, 3, -86, -65, 25, -85, -54, -83, -80, -37, -66, -53, -62, -55, -58, -82,-101, -68; /M: SY='M'; M= -7, -34, -84, -77, 53, -80, -72, 43, -74, 10, 74, -75, -77, -73, -74, -69, -58, 50, -68, -47; /M: SY='K'; M= -41, -75, -1, 12, -33, -45, -26, -62, 44, -13, 36, 36, -69, 38, 39, -17, -44, -4, 8, -61; /M: SY='L'; M= -43, -72, -72, -16, -49, -79, -62, -43, -10, 70, 4, -70, -76, 44, -5, -66, -1, -49, 28, 2; /M: SY='M'; M= -61, -71, -84, -77, -49, -83, -69, 65, -73, 15, 103, -74, -74, -68, -73, -71, -31, 34, -76, -54; /M: SY='F'; M= -54, 27, -81, -47, 88, -81, -69, 12, -32, 27, -13, -75, -41, -11, -71, -70, -39, 4, 32, 2; /M: SY='Q'; M= -16, -74, 16, 13, -72, -47, 44, -6, 12, -68, -17, 13, -67, 45, 29, 27, 15, -38, -4, -23; /M: SY='N'; M= -40, -69, 11, -28, -77, -31, -46, -42, -48, -80, -69, 113, -71, 12, -14, -24, -27, -75, -92, -71; /M: SY='C'; M= 68, 96, -70, -66, -11, -59, 15, -34, -66, -43, -61, -61, -73, -65, -70, 15, -20, -19, -81, -67; /M: SY='R'; M= -26, -28, -62, -10, 2, -72, -4, -2, 43, -2, 39, 15, -71, 9, 44, -36, -27, -15, -18, 25; /I: I=-21; MD=-53; /M: SY='T'; M= -1, -71, -62, 11, -39, -72, 2, 12, 3, 1, 25, -17, -68, 19, 3, -21, 58, -13, -80, -41; D=-21; /I: I=-21; MD=-53; /M: SY='Y'; M= -70, -78, -74, -42, 57, -79, -48, -30, -69, -5, 12, -72, -82, -22, -67, -9, -64, -38, -39, 109; D=-21; /I: I=-21; MD=-53; /M: SY='N'; M= -65, -73, -7, -40, -62, -12, 44, -75, -54, -77, -66, 105, -75, -53, -60, -50, -20, -77, -76, 55; D=-21; /I: I=-21; MD=-53; /M: SY='P'; M= -10, -81, -8, 38, -82, 40, -66, -60, 13, -59, -4, -25, 44, -34, -6, -4, -19, -56, -82, -76; D=-21; /I: I=-21; MD=-53; /M: SY='P'; M= -26, -86, 29, 33, -34, 0, -67, -81, -2, -83, -76, -38, 61, -9, -10, 2, -26, -38, -85, -35; D=-21; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='D'; M= -25, 13, 65, 20, -43, 43, -13, -81, -17, -79, -73, 35, -23, 0, -41, 7, -32, -77, -83, -37; /M: SY='S'; M= -13, -69, 21, -20, -74, -58, 46, -72, -16, -74, -66, 20, 4, -14, -18, 69, 41, -44, -86, -64; /M: SY='E'; M= -27, -77, 28, 50, -20, -21, -19, -14, -4, -18, -20, -11, 32, 25, -11, -7, -26, -3, 25, -63; /M: SY='I'; M= -61, 15, -22, -22, 5, -81, -68, 52, -36, 11, -44, -16, -76, -15, -35, -46, -19, 49, -68, 42; /M: SY='Y'; M= -8, -75, -13, -17, -5, -2, 7, -18, -21, -22, -54, -44, -74, -59, 8, -12, 5, 10, 29, 88; /M: SY='K'; M= -51, -77, -11, 17, -71, -51, 12, 6, 59, -29, -34, -24, -34, 39, 28, 15, -40, -22, 37, -61; /M: SY='M'; M= 24, 34, 39, -29, -7, -67, 2, 13, -12, -6, 60, 4, -71, -24, -1, -10, -27, -36, -76, -5; /M: SY='A'; M= 69, -9, -66, -64, -68, 22, -67, -24, -64, -33, -29, -27, -68, -60, -68, 32, -17, 2, -75, -2; /M: SY='Q'; M= -36, 24, 12, 19, -69, -69, 32, -3, 39, -5, -20, 7, -68, 44, -6, 6, -8, -14, -79, -33; /M: SY='K'; M= -5, -74, -30, 37, -43, -45, -58, -20, 44, -21, 4, -5, -32, 28, 26, 1, 4, -11, -75, -11; /M: SY='M'; M= -64, 15, -84, -77, 1, -83, -68, 15, -75, 68, 74, -78, -80, -70, -74, -73, -28, 16, -72, -52; /M: SY='E'; M= -26, -76, -54, 52, 15, -53, 23, -43, 15, 10, -55, -9, -68, 48, 5, -11, -23, -20, -11, 8; /M: SY='K'; M= 8, -74, 37, 31, -77, -40, -1, -22, 53, -72, 1, 29, -65, 17, -9, 12, -24, -68, -81, -66; /M: SY='F'; M= -23, -8, -13, 7, 43, -74, -17, -4, -1, 13, 2, -4, -73, 22, -36, -20, 6, 25, -67, 19; /M: SY='F'; M= 9, 38, -77, -73, 83, -29, -65, -13, -71, 8, 2, -69, -78, -5, -71, -12, -11, -14, -5, 27; /M: SY='E'; M= -37, -19, 10, 52, 11, -41, 2, -10, 17, 1, -57, -2, -68, 7, 12, -9, -28, -39, -16, 31; /M: SY='Q'; M= -36, -77, 28, 27, -30, -50, 2, -53, 44, -38, 16, -36, 2, 53, 15, 6, -17, -22, -77, -32; /M: SY='W'; M= -1, -74, -22, 9, -35, -24, -36, -4, 37, 28, -6, -30, -70, 37, 3, -20, -9, -26, 55, -58; /M: SY='W'; M= -26, -73, -78, -30, 28, -80, -67, 36, -17, 44, 49, -74, -77, -65, 8, -40, -61, 3, 58, 6; /M: SY='K'; M= -5, -32, 16, 24, -71, -49, -19, -19, 47, -11, -32, 17, -45, 31, 21, 1, -13, -26, -78, -31; /M: SY='E'; M= -13, -76, 17, 66, -46, -55, -55, -51, 29, -34, 3, 33, 1, 25, 2, -18, -25, -70, -79, -67; /M: SY='M'; M= 9, -71, -40, 26, 16, -71, 6, 25, -30, 17, 33, -17, -70, 3, -17, 8, -10, 9, -73, -34; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
Total number of hits | 243 in 185 different sequences |
Number of true positive hits | 243 in 185 different sequences |
Number of 'unknown' hits | 0 |
Number of false positive hits | 0 |
Number of false negative sequences | 0 |
Number of 'partial' sequences | 0 |
Precision (true positives / (true positives + false positives)) | 100.00 % |
Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
Taxonomic range [info] | Eukaryotes |
Maximum number of repetitions [info] | 6 |
Matrix type [info] | protein_domain |
Scaling database [info] | reversed |
Author [info] | CJA_Sigrist |
Feature key [info] | DOMAIN |
Feature description [info] | Bromo |
Version [info] | 6 |
Cross-references [info]