PROSITE entry PS50020
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PURL: https://purl.expasy.org/prosite/signature/PS50020
Direct ScanProsite submission
General information about the entry
| Entry name [info] | WW_DOMAIN_2 |
| Accession [info] | PS50020 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-1995 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50020 |
| Associated ProRule [info] | PRU00224 |
Name and characterization of the entry
| Description [info] | WW/rsp5/WWP domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=31; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2776000; R2=0.0197000; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1518.2681885; R2=1.0788643; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=418; H_SCORE=1969; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=316; H_SCORE=1859; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='S'; M= -5, -9,-25,-10, -3,-21, -5,-13,-15, -7,-16, -9, -6, -1, 0, -5, 2, 1,-13,-26,-17, -3; /M: SY='P'; M= -7, -5,-30, -1, -1,-24, -5,-13,-22, -9,-24,-17, -4, 27, -6,-13, 0, -5,-24,-29,-22, -5; /M: SY='L'; M= -8,-23,-19,-24,-18, 2,-27,-18, 15,-22, 29, 12,-22,-24,-16,-14,-21, -7, 12,-24, -5,-18; /M: SY='P'; M= -9,-10,-34, -5, 7,-27,-18,-12,-18, -6,-23,-13,-10, 49, 1,-13, -5, -8,-26,-29,-23, 1; /M: SY='P'; M= -1, -1,-24, 1, -2,-22, -6,-11,-21, -5,-24,-17, 2, 12, -5,-10, 8, 1,-19,-29,-17, -5; /M: SY='G'; M= -4, -9,-31, -7,-11,-29, 34,-14,-30,-16,-27,-18, -3, 4,-12,-18, -1,-14,-27,-24,-25,-13; /M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20; /M: SY='E'; M= -8, 0,-25, 3, 24,-20,-20, -7,-21, 15,-18,-10, -3, -8, 9, 5, -2, -3,-16,-25,-12, 16; /M: SY='E'; M= -1, -8,-15, -8, 7,-19,-15,-11,-13, 1,-11, -5, -9,-15, 1, 1, -3, -5, -6,-26,-15, 3; /M: SY='R'; M= -2,-16,-23,-18,-12, -7,-20, -4, -7, -1, -7, -3,-12,-21, -7, 6, -9, -8, -2,-10, 2,-11; /M: SY='Y'; M=-11,-14,-24,-18, -8, 4,-25,-10, -5, -4, -4, 1,-12,-19, -4, -5,-10, -2, -5, -7, 5, -6; /M: SY='D'; M= -5, 17,-20, 19, 3,-23,-11, 1,-22, -6,-20,-14, 10,-12, -2, -9, 10, 10,-15,-34,-13, 0; /M: SY='B'; M= -2, 6,-25, 6, 3,-26, -6, -8,-23, -1,-23,-16, 4, 3, -3, -8, 3, 0,-19,-29,-18, -1; /M: SY='N'; M= -7, 10,-22, 10, 8,-21,-13, -6,-22, 6,-22,-15, 11,-13, 1, 2, 7, 2,-16,-31,-15, 5; /I: MD=-27; /M: SY='G'; M= -3, -5,-26, -7,-11,-23, 30,-13,-28, -3,-23,-12, 2,-17,-10, -7, -2,-11,-22,-18,-17,-11; D=-5; /I: I=-10; MI=-5; MD=-27; IM=-5; DM=-27; /M: SY='R'; M=-13,-10,-25,-12, -3,-14,-17, -7,-18, 14,-14, -7, -4,-18, 3, 34, -7, -4,-11,-20, -8, -3; D=-5; /I: DM=-27; /M: SY='P'; M= -7,-15,-25,-16, -9, -8,-23,-17, -5, -7,-11, -7,-13, 5,-11, -9, -5, 3, -4,-14, -5,-12; /M: SY='Y'; M=-19,-24,-26,-27,-24, 40,-30, 5, 4,-17, 4, 1,-20,-30,-19,-14,-20,-10, -3, 20, 59,-24; /M: SY='Y'; M=-20,-24,-26,-28,-24, 50,-30, 4, 0,-18, 4, 0,-20,-30,-22,-14,-20,-10, -6, 22, 60,-24; /M: SY='Y'; M=-12,-26,-25,-29,-24, 10,-29, -9, 13,-21, 7, 5,-22,-26,-19,-18,-18, -8, 10, 6, 14,-23; /M: SY='N'; M=-12, 40,-22, 29, 4,-24, -3, 12,-24, 0,-30,-21, 51,-18, 0, -2, 7, -3,-30,-40,-18, 2; /M: SY='H'; M=-12, -5,-28, -5, -3,-18,-20, 39,-19, -8,-12, -3, -1, -5, 0, -4, -9,-10,-19,-28, 2, -5; /M: SY='E'; M= -5, 2,-23, 0, 9,-19,-17, -8,-12, 2,-13, -9, 5,-10, 2, -3, -1, -3,-11,-29,-15, 5; /M: SY='T'; M= -1, 3,-13, -5, -8,-12,-17,-16,-10,-10,-11,-11, 5,-12, -8,-11, 17, 34, -3,-32,-12, -8; /M: SY='K'; M=-11, 1,-29, -1, 4,-28, -7, 1,-29, 25,-27,-10, 6,-14, 11, 22, -6,-11,-24,-22,-12, 7; /M: SY='E'; M= -7, 5,-23, 5, 17,-23,-19, -4,-23, 10,-20,-13, 2, -8, 7, 5, 5, 10,-17,-28,-12, 12; /M: SY='T'; M= 3, 0,-10, -7, -7,-13,-14,-17,-13,-10,-16,-13, 3,-10, -7,-10, 26, 40, -3,-33,-13, -7; /M: SY='Q'; M= -6, -5,-11, -8, 0,-19,-19, -5,-16, -3,-14, -7, -3,-15, 14, 1, 7, 11,-14,-25, -7, 6; /M: SY='W'; M=-19,-36,-45,-37,-28, 14,-21,-24,-17,-19,-16,-17,-35,-29,-20,-19,-34,-24,-25,124, 33,-20; /M: SY='E'; M= -9, 4,-25, 9, 19,-22,-20, -6,-15, 0,-14,-11, -2,-10, 8, -5, 0, -2,-14,-27,-10, 13; /M: SY='D'; M=-15, 5,-32, 12, 8,-29,-18, 4,-27, 10,-25,-15, 1, 11, 2, 8, -8,-11,-24,-29,-14, 2; /M: SY='P'; M=-10,-20,-40,-10, 0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10; /M: SY='R'; M= -9, 1,-23, 0, 1,-20,-14, -8,-21, 10,-16,-11, 2,-16, 0, 19, -1, 0,-13,-27,-13, -1; /M: SY='M'; M=-10,-15,-24,-17, -8, -2,-13,-10, -6,-11, -1, 2,-12,-11,-11, -8,-11, -6, -6,-20, -6,-10; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 392 in 227 different sequences |
| Number of true positive hits | 392 in 227 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 17 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 95.84 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 4 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Feature key [info] | DOMAIN |
| Feature description [info] | WW |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
227 sequences
APBB1_HUMAN (O00213), APBB1_MOUSE (Q9QXJ1), APBB1_RAT (P46933), APBB2_HUMAN (Q92870), APBB2_MOUSE (Q9DBR4), APBB3_HUMAN (O95704), APBB3_MOUSE (Q8R1C9), APBB3_RAT (O35827), BAG3_HUMAN (O95817), BAG3_MOUSE (Q9JLV1), CAPAM_DANRE (A0A0R4IKJ1), CAPAM_HUMAN (Q9H4Z3), CAPAM_MOUSE (P59114), CE164_HUMAN (Q9UPV0), CE164_MOUSE (Q5DU05), CMTR1_BOVIN (A2VE39), CMTR1_DANRE (Q803R5), CMTR1_MOUSE (Q9DBC3), CMTR1_XENLA (Q6GQ76), DB10_NICSY (P46942), DGCR8_BOVIN (A6QR44), DGCR8_HUMAN (Q8WYQ5), DGCR8_MOUSE (Q9EQM6), DMDA_DROME (Q9VDW6), DMDB_DROME (Q9VDW3), DMDD_DROME (Q0KI50), DMDE_DROME (Q7YU29), DMD_CAEEL (Q9TW65), DMD_CANLF (O97592), DMD_CHICK (P11533), DMD_HUMAN (P11532), DMD_MOUSE (P11531), DMD_PIG (Q5GN48), DMD_RAT (P11530), DOD_DROME (P54353), DRE4_SCHPO (Q09685), DRP2_HUMAN (Q13474), DRP2_MOUSE (Q05AA6), DRP2_RAT(Q9EPA0), DWWA_DICDI (Q54T86), ESS1_YEAST (P22696), FCA_ARATH (O04425), FCA_ORYSI (B8BCZ8), FCA_ORYSJ (Q6K271), FEH1_CAEEL (Q9BKZ9), FNBP4_HUMAN (Q8N3X1), FNBP4_MOUSE (Q6ZQ03), FRPD4_HUMAN (Q14CM0), FRPD4_MOUSE (A2AFR3), GAS7_HUMAN (O60861), GAS7_MOUSE (Q60780), GAS7_RAT(O55148), HECW1_CAEEL (Q09291), HECW1_HUMAN (Q76N89), HECW1_MOUSE (Q8K4P8), HECW2_HUMAN (Q9P2P5), HECW2_MOUSE (Q6I6G8), IQGA1_HUMAN (P46940), IQGA2_HUMAN (Q13576), IQGA2_MOUSE (Q3UQ44), ITCH_HUMAN (Q96J02), ITCH_MOUSE (Q8C863), KIBRA_DROAN (B3LWS4), KIBRA_DROER (B3P3M8), KIBRA_DROME (Q9VFG8), KIBRA_DROMO (B4K6I9), KIBRA_DROSE (B4HEJ6), KIBRA_DROVI (B4M5X4), KIBRA_DROWI (B4NAD3), KIBRA_DROYA (B4PSQ2), KIBRA_HUMAN (Q8IX03), KIBRA_MOUSE (Q5SXA9), KIBRA_XENTR (A4IIJ3), MAGI1_HUMAN (Q96QZ7), MAGI1_MOUSE (Q6RHR9), MAGI1_RAT (Q4L1J4), MAGI2_HUMAN (Q86UL8), MAGI2_MOUSE (Q9WVQ1), MAGI2_RAT (O88382), MAGI3_CHICK (Q5F488), MAGI3_HUMAN (Q5TCQ9), MAGI3_MOUSE (Q9EQJ9), MAGI3_RAT (Q9JK71), MAGI3_XENTR (A1A5G4), NCFA_DICDI (Q867T7), NED4L_HUMAN (Q96PU5), NED4L_MOUSE (Q8CFI0), NED4L_PONAB (Q5RBF2), NEDD4_DROME (Q9VVI3), NEDD4_HUMAN (P46934), NEDD4_MOUSE (P46935), NEDD4_RAT (Q62940), PIN1_BOVIN (Q5BIN5), PIN1_HUMAN (Q13526), PIN1_MACFA (Q4R383), PIN1_MOUSE (Q9QUR7), PIN1_RHIO9 (P0C1J8), PIN1_SCHPO (O74448), PINL_HUMAN (O15428), PKHA5_HUMAN (Q9HAU0), PKHA7_DANRE (B6RSP1), PKHA7_HUMAN (Q6IQ23), PKHA7_MOUSE (Q3UIL6), PQBP1_BOVIN (Q2HJC9), PQBP1_GORGO (A1YFA7), PQBP1_HUMAN (O60828), PQBP1_MOUSE (Q91VJ5), PQBP1_PONPY (A2T806), PQBP1_RAT (Q6PCT5), PR40A_ARATH (B6EUA9), PR40A_HUMAN (O75400), PR40A_MOUSE (Q9R1C7), PR40B_ARATH (F4JCC1), PR40B_HUMAN (Q6NWY9), PR40B_MOUSE (Q80W14), PR40C_ARATH (Q9LT25), PRP40_SCHPO (O14176), PRP40_YEAST (P33203), PUB1_SCHPO (Q92462), PUB2_SCHPO (Q9UTG2), PUB3_SCHPO (O14326), RH14_ARATH (Q8H136), RH14_ORYSJ (Q5VQL1), RH40_ARATH (Q9SQV1), RH40_ORYSJ (Q5JKF2), RH46_ARATH (Q9LYJ9), RHG09_HUMAN (Q9BRR9), RHG12_HUMAN (Q8IWW6), RHG12_MACFA (Q9BE31), RHG12_MOUSE (Q8C0D4), RHG27_HUMAN (Q6ZUM4), RHG27_MOUSE (A2AB59), RHG27_RAT (Q6TLK4), RHG39_HUMAN (Q9C0H5), RHG39_MOUSE (P59281), RSP5_ASPCL (A1CQG2), RSP5_ASPFC (B0XQ72), RSP5_ASPFN (B8N7E5), RSP5_ASPFU (Q4WTF3), RSP5_ASPNC (A2QQ28), RSP5_ASPOR (Q2UBP1), RSP5_ASPTN (Q0CCL1), RSP5_CHATD (G0S9J5), RSP5_EMENI (Q5BDP1), RSP5_NEOFI (A1D3C5), RSP5_YEAST (P39940), SAC9_ARATH (Q7XZU0), SAV1_HUMAN (Q9H4B6), SAV1_MOUSE (Q8VEB2), SAV1_RAT(A4V8B4), SAV_DROME (Q9VCR6), SEC24_CRYNB (P0CR41), SEC24_CRYNJ (P0CR40), SEC24_MYCMD (Q4P9K4), SET2_ASPOR (Q2UTN6), SET2_CANAL (Q59XV0), SET2_CANGA (Q6FX50), SET2_CHAGB (Q2H988), SET2_COCIM (Q1DU03), SET2_DEBHA (Q6BM04), SET2_DROME (Q9VYD1), SET2_EMENI (Q5ASA5), SET2_GIBZE (Q4IB50), SET2_NEUCR (Q7RZU4), SET2_YARLI (Q6C5G5), SETD2_HUMAN (Q9BYW2), SETD2_MOUSE (E9Q5F9), SMUF1_DROME (Q9V853), SMUF1_HUMAN (Q9HCE7), SMUF1_MOUSE (Q9CUN6), SMUF1_XENLA (Q9PUN2), SMUF2_DANRE (A9JRZ0), SMUF2_HUMAN (Q9HAU4), SMUF2_MOUSE (A2A5Z6), SMUF2_XENLA (Q2TAS2), SSP1_NEUCR (O60045), STXB4_HUMAN (Q6ZWJ1), STXB4_MOUSE (Q9WV89), SUDX_DROME (Q9Y0H4), TCRG1_HUMAN (O14776), TCRG1_MOUSE (Q8CGF7), TCRGL_HUMAN (Q5VWI1), TCRGL_MOUSE (Q3B807), TG325_CAEEL (P46941), URN1_YEAST (Q06525), UTRN_HUMAN (P46939), UTRN_RAT(G3V7L1), WAC_DANRE (Q7ZUK7), WAC_DROME (Q9VX88), WAC_HUMAN (Q9BTA9), WAC_MOUSE (Q924H7), WAC_XENTR (Q5U4Q0), WBP4_CHICK (Q5F457), WBP4_HUMAN (O75554), WBP4_MOUSE (Q61048), WBP4_RAT(Q5HZF2), WWC2_HUMAN (Q6AWC2), WWC2_MOUSE (Q6NXJ0), WWC2_XENTR (Q6DJR2), WWC3_HUMAN (Q9ULE0), WWM1_YEAST (P43582), WWOX_CHICK (Q5F389), WWOX_DANRE (Q803A8), WWOX_DROME (Q9VLU5), WWOX_HUMAN (Q9NZC7), WWOX_MOUSE (Q91WL8), WWOX_PONAB (Q5R9W5), WWP1_CAEEL (Q9N2Z7), WWP1_HUMAN (Q9H0M0), WWP1_MOUSE (Q8BZZ3), WWP2_HUMAN (O00308), WWP2_MOUSE (Q9DBH0), WWTR1_CANLF (A0A8I3PQN6), WWTR1_HUMAN (Q9GZV5), WWTR1_MOUSE (Q9EPK5), YAP1A_XENLA (D6C652), YAP1_CAEEL (Q19404), YAP1_CANLF (A0A8C0NGY6), YAP1_CHICK (P46936), YAP1_DANRE (Q1L8J7), YAP1_DROME (Q45VV3), YAP1_HUMAN (P46937), YAP1_MOUSE (P46938), YAP1_ORYLA (H2LBU8), YAP1_RAT(Q2EJA0), YO61_CAEEL (P34600), ZYS3_CHLRE (Q8GSP8)» more
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| UniProtKB/Swiss-Prot False negative sequences |
17 sequences
CFL1_ARATH (Q5HZ54), CFL1_ORYSI (B8AIM8), CFL1_ORYSJ (Q0E0W7), CFL2_ARATH (Q9C7E6), CMTR1_AILME (D2HRF1), CMTR1_HUMAN (Q8N1G2), CMTR1_PONAB (Q5R981), CMTR1_RAT (Q5U2Z5), IQGA1_MOUSE (Q9JKF1), SET2_ASPFU (Q4WTT2), SET2_EREGS (Q757Y8), SET2_KLULA (Q6CXP5), SET2_YEAST (P46995), YERE_SCHPO (O14097), YHK5_SCHPO (O94425), YHK6_SCHPO (O94426), YNI8_SCHPO (O13598)» more |
| PDB [Detailed view] |
246 PDB
1E0L; 1E0N; 1EG3; 1EG4; 1F8A; 1I5H; 1I6C; 1I8G; 1I8H; 1JMQ; 1K5R; 1K9Q; 1K9R; 1NMV; 1O6W; 1PIN; 1TK7; 1WMV; 1WR3; 1WR4; 1WR7; 1YIU; 1YWI; 1YWJ; 1ZCN; 1ZR7; 2DJY; 2DK1; 2DK7; 2DMV; 2DWV; 2DYF; 2E45; 2EZ5; 2F21; 2HO2; 2IDH; 2ITK; 2JMF; 2JO9; 2JOC; 2JUP; 2JX8; 2JXW; 2KBU; 2KCF; 2KPZ; 2KQ0; 2KXQ; 2KYK; 2L5F; 2LAJ; 2LAW; 2LAX; 2LAY; 2LAZ; 2LB0; 2LB1; 2LB2; 2LB3; 2LTV; 2LTW; 2LTX; 2LTY; 2LTZ; 2M3O; 2M8I; 2M8J; 2M9E; 2M9F; 2M9I; 2M9J; 2MDC; 2MDI; 2MDJ; 2MPT; 2MW9; 2MWA; 2MWB; 2MWD; 2MWE; 2MWF; 2N1O; 2N4R; 2N4S; 2N4T; 2N4U; 2N4V; 2N4W; 2N8S; 2N8T; 2N8U; 2NNT; 2OEI; 2OP7; 2Q5A; 2RLY; 2RM0; 2XP3; 2XP4; 2XP5; 2XP6; 2XP7; 2XP8; 2XP9; 2XPA; 2XPB; 2YSB; 2YSC; 2YSD; 2YSE; 2YSF; 2YSG; 2YSH; 2YSI; 2ZAJ; 2ZQS; 2ZQT; 2ZQU; 2ZQV; 2ZR4; 2ZR5; 2ZR6; 3KAB; 3KAD; 3KAF; 3KAG; 3KAH; 3KAI; 3KCE; 3L4H; 3LE4; 3NTP; 3ODK; 3OLM; 3OOB; 3TC5; 3TCZ; 3TDB; 3WH0; 4GWT; 4GWV; 4LCD; 4N7F; 4N7H; 4QIB; 4REX; 4ROF; 4U84; 4U85; 4U86; 5AHT; 5B3Y; 5B3Z; 5CQ2; 5DWS; 5DZD; 5O9Z; 5TJ7; 5TJ8; 5TJQ; 5UY9; 5VTI; 5VTJ; 5VTK; 5XMC; 5YDX; 5YDY; 6AHD; 6IKO; 6J1X; 6J1Y; 6J1Z; 6J68; 6J69; 6JJW; 6JJX; 6JJY; 6JJZ; 6JK0; 6JK1; 6KKG; 6LXD; 6LXE; 6N7P; 6O33; 6O34; 6RSS; 6SVC; 6SVE; 6SVH; 6V5B; 6V5C; 6VAJ; 7ABF; 7ABG; 7BQF; 7BQG; 7EFJ; 7EFX; 7EKV; 7F0M; 7KKF; 7LP1; 7LP2; 7LP3; 7LP4; 7LP5; 7NMZ; 7NWJ; 7O06; 7O0S; 7O3B; 7OQE; 7SA5; 7SUQ; 7SUR; 8H6K; 8H6L; 8P4E; 8P4F; 8PXW; 8PXX; 8Q7N; 8QO9; 8QPE; 8QZS; 8SG2; 8VJD; 8VJE; 8VJF; 8VJG; 8W8F; 8YT8; 9ASM; 9ASN; 9ASO; 9ASP; 9ASQ; 9EGZ; 9EH0; 9EH2; 9EQH; 9EQK; 9INR; 9IT1 » more |