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| Entry: PS50020 |
General information about the entry
| Entry name [info] | WW_DOMAIN_2 |
| Accession [info] | PS50020 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-1995 CREATED;
10-MAY-2017 DATA UPDATE; 07-OCT-2020 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50020 |
| Associated ProRule [info] | PRU00224 |
Name and characterization of the entry
| Description [info] | WW/rsp5/WWP domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=31; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2776000; R2=0.0197000; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1518.2681885; R2=1.0788643; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=418; H_SCORE=1969; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=316; H_SCORE=1859; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='S'; M= -5, -9,-25,-10, -3,-21, -5,-13,-15, -7,-16, -9, -6, -1, 0, -5, 2, 1,-13,-26,-17, -3; /M: SY='P'; M= -7, -5,-30, -1, -1,-24, -5,-13,-22, -9,-24,-17, -4, 27, -6,-13, 0, -5,-24,-29,-22, -5; /M: SY='L'; M= -8,-23,-19,-24,-18, 2,-27,-18, 15,-22, 29, 12,-22,-24,-16,-14,-21, -7, 12,-24, -5,-18; /M: SY='P'; M= -9,-10,-34, -5, 7,-27,-18,-12,-18, -6,-23,-13,-10, 49, 1,-13, -5, -8,-26,-29,-23, 1; /M: SY='P'; M= -1, -1,-24, 1, -2,-22, -6,-11,-21, -5,-24,-17, 2, 12, -5,-10, 8, 1,-19,-29,-17, -5; /M: SY='G'; M= -4, -9,-31, -7,-11,-29, 34,-14,-30,-16,-27,-18, -3, 4,-12,-18, -1,-14,-27,-24,-25,-13; /M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20; /M: SY='E'; M= -8, 0,-25, 3, 24,-20,-20, -7,-21, 15,-18,-10, -3, -8, 9, 5, -2, -3,-16,-25,-12, 16; /M: SY='E'; M= -1, -8,-15, -8, 7,-19,-15,-11,-13, 1,-11, -5, -9,-15, 1, 1, -3, -5, -6,-26,-15, 3; /M: SY='R'; M= -2,-16,-23,-18,-12, -7,-20, -4, -7, -1, -7, -3,-12,-21, -7, 6, -9, -8, -2,-10, 2,-11; /M: SY='Y'; M=-11,-14,-24,-18, -8, 4,-25,-10, -5, -4, -4, 1,-12,-19, -4, -5,-10, -2, -5, -7, 5, -6; /M: SY='D'; M= -5, 17,-20, 19, 3,-23,-11, 1,-22, -6,-20,-14, 10,-12, -2, -9, 10, 10,-15,-34,-13, 0; /M: SY='B'; M= -2, 6,-25, 6, 3,-26, -6, -8,-23, -1,-23,-16, 4, 3, -3, -8, 3, 0,-19,-29,-18, -1; /M: SY='N'; M= -7, 10,-22, 10, 8,-21,-13, -6,-22, 6,-22,-15, 11,-13, 1, 2, 7, 2,-16,-31,-15, 5; /I: MD=-27; /M: SY='G'; M= -3, -5,-26, -7,-11,-23, 30,-13,-28, -3,-23,-12, 2,-17,-10, -7, -2,-11,-22,-18,-17,-11; D=-5; /I: I=-10; MI=-5; MD=-27; IM=-5; DM=-27; /M: SY='R'; M=-13,-10,-25,-12, -3,-14,-17, -7,-18, 14,-14, -7, -4,-18, 3, 34, -7, -4,-11,-20, -8, -3; D=-5; /I: DM=-27; /M: SY='P'; M= -7,-15,-25,-16, -9, -8,-23,-17, -5, -7,-11, -7,-13, 5,-11, -9, -5, 3, -4,-14, -5,-12; /M: SY='Y'; M=-19,-24,-26,-27,-24, 40,-30, 5, 4,-17, 4, 1,-20,-30,-19,-14,-20,-10, -3, 20, 59,-24; /M: SY='Y'; M=-20,-24,-26,-28,-24, 50,-30, 4, 0,-18, 4, 0,-20,-30,-22,-14,-20,-10, -6, 22, 60,-24; /M: SY='Y'; M=-12,-26,-25,-29,-24, 10,-29, -9, 13,-21, 7, 5,-22,-26,-19,-18,-18, -8, 10, 6, 14,-23; /M: SY='N'; M=-12, 40,-22, 29, 4,-24, -3, 12,-24, 0,-30,-21, 51,-18, 0, -2, 7, -3,-30,-40,-18, 2; /M: SY='H'; M=-12, -5,-28, -5, -3,-18,-20, 39,-19, -8,-12, -3, -1, -5, 0, -4, -9,-10,-19,-28, 2, -5; /M: SY='E'; M= -5, 2,-23, 0, 9,-19,-17, -8,-12, 2,-13, -9, 5,-10, 2, -3, -1, -3,-11,-29,-15, 5; /M: SY='T'; M= -1, 3,-13, -5, -8,-12,-17,-16,-10,-10,-11,-11, 5,-12, -8,-11, 17, 34, -3,-32,-12, -8; /M: SY='K'; M=-11, 1,-29, -1, 4,-28, -7, 1,-29, 25,-27,-10, 6,-14, 11, 22, -6,-11,-24,-22,-12, 7; /M: SY='E'; M= -7, 5,-23, 5, 17,-23,-19, -4,-23, 10,-20,-13, 2, -8, 7, 5, 5, 10,-17,-28,-12, 12; /M: SY='T'; M= 3, 0,-10, -7, -7,-13,-14,-17,-13,-10,-16,-13, 3,-10, -7,-10, 26, 40, -3,-33,-13, -7; /M: SY='Q'; M= -6, -5,-11, -8, 0,-19,-19, -5,-16, -3,-14, -7, -3,-15, 14, 1, 7, 11,-14,-25, -7, 6; /M: SY='W'; M=-19,-36,-45,-37,-28, 14,-21,-24,-17,-19,-16,-17,-35,-29,-20,-19,-34,-24,-25,124, 33,-20; /M: SY='E'; M= -9, 4,-25, 9, 19,-22,-20, -6,-15, 0,-14,-11, -2,-10, 8, -5, 0, -2,-14,-27,-10, 13; /M: SY='D'; M=-15, 5,-32, 12, 8,-29,-18, 4,-27, 10,-25,-15, 1, 11, 2, 8, -8,-11,-24,-29,-14, 2; /M: SY='P'; M=-10,-20,-40,-10, 0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10; /M: SY='R'; M= -9, 1,-23, 0, 1,-20,-14, -8,-21, 10,-16,-11, 2,-16, 0, 19, -1, 0,-13,-27,-13, -1; /M: SY='M'; M=-10,-15,-24,-17, -8, -2,-13,-10, -6,-11, -1, 2,-12,-11,-11, -8,-11, -6, -6,-20, -6,-10; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 382 in 222 different sequences |
| Number of true positive hits | 382 in 222 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 13 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 96.71 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 4 |
| Feature key [info] | DOMAIN |
| Feature description [info] | WW |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
222 sequences
APBB1_HUMAN (O00213 ), APBB1_MOUSE (Q9QXJ1 ), APBB1_RAT (P46933 ), APBB2_HUMAN (Q92870 ), APBB2_MOUSE (Q9DBR4 ), APBB3_HUMAN (O95704 ), APBB3_MOUSE (Q8R1C9 ), APBB3_RAT (O35827 ), BAG3_HUMAN (O95817 ), BAG3_MOUSE (Q9JLV1 ), C1716_DROME (Q9VYD1 ), CAPAM_DANRE (A0A0R4IKJ1), CAPAM_HUMAN (Q9H4Z3 ), CAPAM_MOUSE (P59114 ), CE164_HUMAN (Q9UPV0 ), CE164_MOUSE (Q5DU05 ), CMTR1_BOVIN (A2VE39 ), CMTR1_DANRE (Q803R5 ), CMTR1_MOUSE (Q9DBC3 ), CMTR1_XENLA (Q6GQ76 ), DB10_NICSY (P46942 ), DGCR8_BOVIN (A6QR44 ), DGCR8_HUMAN (Q8WYQ5 ), DGCR8_MOUSE (Q9EQM6 ), DMDA_DROME (Q9VDW6 ), DMDB_DROME (Q9VDW3 ), DMDD_DROME (Q0KI50 ), DMDE_DROME (Q7YU29 ), DMD_CAEEL (Q9TW65 ), DMD_CANLF (O97592 ), DMD_CHICK (P11533 ), DMD_HUMAN (P11532 ), DMD_MOUSE (P11531 ), DMD_PIG (Q5GN48 ), DMD_RAT (P11530 ), DOD_DROME (P54353 ), DRE4_SCHPO (Q09685 ), DRP2_HUMAN (Q13474 ), DRP2_MOUSE (Q05AA6 ), DRP2_RAT (Q9EPA0 ), DWWA_DICDI (Q54T86 ), ESS1_YEAST (P22696 ), FCA_ARATH (O04425 ), FCA_ORYSI (B8BCZ8 ), FCA_ORYSJ (Q6K271 ), FEH1_CAEEL (Q9BKZ9 ), FNBP4_HUMAN (Q8N3X1 ), FNBP4_MOUSE (Q6ZQ03 ), FRPD4_HUMAN (Q14CM0 ), FRPD4_MOUSE (A2AFR3 ), GAS7_HUMAN (O60861 ), GAS7_MOUSE (Q60780 ), GAS7_RAT (O55148 ), HECW1_CAEEL (Q09291 ), HECW1_HUMAN (Q76N89 ), HECW1_MOUSE (Q8K4P8 ), HECW2_HUMAN (Q9P2P5 ), HECW2_MOUSE (Q6I6G8 ), IQGA1_HUMAN (P46940 ), IQGA2_HUMAN (Q13576 ), IQGA2_MOUSE (Q3UQ44 ), ITCH_HUMAN (Q96J02 ), ITCH_MOUSE (Q8C863 ), KIBRA_DROAN (B3LWS4 ), KIBRA_DROER (B3P3M8 ), KIBRA_DROME (Q9VFG8 ), KIBRA_DROMO (B4K6I9 ), KIBRA_DROSE (B4HEJ6 ), KIBRA_DROVI (B4M5X4 ), KIBRA_DROWI (B4NAD3 ), KIBRA_DROYA (B4PSQ2 ), KIBRA_HUMAN (Q8IX03 ), KIBRA_MOUSE (Q5SXA9 ), KIBRA_XENTR (A4IIJ3 ), MAGI1_HUMAN (Q96QZ7 ), MAGI1_MOUSE (Q6RHR9 ), MAGI1_RAT (Q4L1J4 ), MAGI2_HUMAN (Q86UL8 ), MAGI2_MOUSE (Q9WVQ1 ), MAGI2_RAT (O88382 ), MAGI3_CHICK (Q5F488 ), MAGI3_HUMAN (Q5TCQ9 ), MAGI3_MOUSE (Q9EQJ9 ), MAGI3_RAT (Q9JK71 ), MAGI3_XENTR (A1A5G4 ), NCFA_DICDI (Q867T7 ), NED4L_HUMAN (Q96PU5 ), NED4L_MOUSE (Q8CFI0 ), NED4L_PONAB (Q5RBF2 ), NEDD4_DROME (Q9VVI3 ), NEDD4_HUMAN (P46934 ), NEDD4_MOUSE (P46935 ), NEDD4_RAT (Q62940 ), PIN1_BOVIN (Q5BIN5 ), PIN1_HUMAN (Q13526 ), PIN1_MACFA (Q4R383 ), PIN1_MOUSE (Q9QUR7 ), PIN1_RHIO9 (P0C1J8 ), PIN1_SCHPO (O74448 ), PINL_HUMAN (O15428 ), PKHA5_HUMAN (Q9HAU0 ), PKHA7_DANRE (B6RSP1 ), PKHA7_HUMAN (Q6IQ23 ), PKHA7_MOUSE (Q3UIL6 ), PQBP1_BOVIN (Q2HJC9 ), PQBP1_GORGO (A1YFA7 ), PQBP1_HUMAN (O60828 ), PQBP1_MOUSE (Q91VJ5 ), PQBP1_PONPY (A2T806 ), PQBP1_RAT (Q6PCT5 ), PR40A_ARATH (B6EUA9 ), PR40A_HUMAN (O75400 ), PR40A_MOUSE (Q9R1C7 ), PR40B_ARATH (F4JCC1 ), PR40B_HUMAN (Q6NWY9 ), PR40B_MOUSE (Q80W14 ), PR40C_ARATH (Q9LT25 ), PRP40_SCHPO (O14176 ), PRP40_YEAST (P33203 ), PUB1_SCHPO (Q92462 ), PUB2_SCHPO (Q9UTG2 ), PUB3_SCHPO (O14326 ), RH14_ARATH (Q8H136 ), RH14_ORYSJ (Q5VQL1 ), RH40_ARATH (Q9SQV1 ), RH40_ORYSJ (Q5JKF2 ), RH46_ARATH (Q9LYJ9 ), RHG09_HUMAN (Q9BRR9 ), RHG12_HUMAN (Q8IWW6 ), RHG12_MACFA (Q9BE31 ), RHG12_MOUSE (Q8C0D4 ), RHG27_HUMAN (Q6ZUM4 ), RHG27_MOUSE (A2AB59 ), RHG27_RAT (Q6TLK4 ), RHG39_HUMAN (Q9C0H5 ), RHG39_MOUSE (P59281 ), RSP5_ASPCL (A1CQG2 ), RSP5_ASPFC (B0XQ72 ), RSP5_ASPFN (B8N7E5 ), RSP5_ASPFU (Q4WTF3 ), RSP5_ASPNC (A2QQ28 ), RSP5_ASPOR (Q2UBP1 ), RSP5_ASPTN (Q0CCL1 ), RSP5_CHATD (G0S9J5 ), RSP5_EMENI (Q5BDP1 ), RSP5_NEOFI (A1D3C5 ), RSP5_YEAST (P39940 ), SAC9_ARATH (Q7XZU0 ), SAV1_HUMAN (Q9H4B6 ), SAV1_MOUSE (Q8VEB2 ), SAV1_RAT (A4V8B4 ), SAV_DROME (Q9VCR6 ), SEC24_CRYNB (P0CR41 ), SEC24_CRYNJ (P0CR40 ), SEC24_USTMA (Q4P9K4 ), SET2_ASPOR (Q2UTN6 ), SET2_CANAL (Q59XV0 ), SET2_CANGA (Q6FX50 ), SET2_CHAGB (Q2H988 ), SET2_COCIM (Q1DU03 ), SET2_DEBHA (Q6BM04 ), SET2_EMENI (Q5ASA5 ), SET2_GIBZE (Q4IB50 ), SET2_NEUCR (Q7RZU4 ), SET2_YARLI (Q6C5G5 ), SETD2_HUMAN (Q9BYW2 ), SETD2_MOUSE (E9Q5F9 ), SMUF1_DROME (Q9V853 ), SMUF1_HUMAN (Q9HCE7 ), SMUF1_MOUSE (Q9CUN6 ), SMUF1_XENLA (Q9PUN2 ), SMUF2_DANRE (A9JRZ0 ), SMUF2_HUMAN (Q9HAU4 ), SMUF2_MOUSE (A2A5Z6 ), SMUF2_XENLA (Q2TAS2 ), SSP1_NEUCR (O60045 ), STXB4_HUMAN (Q6ZWJ1 ), STXB4_MOUSE (Q9WV89 ), SUDX_DROME (Q9Y0H4 ), TCRG1_HUMAN (O14776 ), TCRG1_MOUSE (Q8CGF7 ), TCRGL_HUMAN (Q5VWI1 ), TCRGL_MOUSE (Q3B807 ), TG325_CAEEL (P46941 ), URN1_YEAST (Q06525 ), UTRO_HUMAN (P46939 ), WAC_DANRE (Q7ZUK7 ), WAC_DROME (Q9VX88 ), WAC_HUMAN (Q9BTA9 ), WAC_MOUSE (Q924H7 ), WAC_XENTR (Q5U4Q0 ), WBP4_CHICK (Q5F457 ), WBP4_HUMAN (O75554 ), WBP4_MOUSE (Q61048 ), WBP4_RAT (Q5HZF2 ), WWC2_HUMAN (Q6AWC2 ), WWC2_MOUSE (Q6NXJ0 ), WWC2_XENTR (Q6DJR2 ), WWM1_YEAST (P43582 ), WWOX_CHICK (Q5F389 ), WWOX_DANRE (Q803A8 ), WWOX_DROME (Q9VLU5 ), WWOX_HUMAN (Q9NZC7 ), WWOX_MOUSE (Q91WL8 ), WWOX_PONAB (Q5R9W5 ), WWP1_HUMAN (Q9H0M0 ), WWP1_MOUSE (Q8BZZ3 ), WWP2_HUMAN (O00308 ), WWP2_MOUSE (Q9DBH0 ), WWTR1_HUMAN (Q9GZV5 ), WWTR1_MOUSE (Q9EPK5 ), YAP1A_XENLA (D6C652 ), YAP1_CAEEL (Q19404 ), YAP1_CHICK (P46936 ), YAP1_DANRE (Q1L8J7 ), YAP1_DROME (Q45VV3 ), YAP1_HUMAN (P46937 ), YAP1_MOUSE (P46938 ), YAP1_ORYLA (H2LBU8 ), YAP1_RAT (Q2EJA0 ), YO61_CAEEL (P34600 ), ZYS3_CHLRE (Q8GSP8 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
13 sequences
CMTR1_AILME (D2HRF1 ), CMTR1_HUMAN (Q8N1G2 ), CMTR1_PONAB (Q5R981 ), CMTR1_RAT (Q5U2Z5 ), IQGA1_MOUSE (Q9JKF1 ), SET2_ASHGO (Q757Y8 ), SET2_ASPFU (Q4WTT2 ), SET2_KLULA (Q6CXP5 ), SET2_YEAST (P46995 ), YERE_SCHPO (O14097 ), YHK5_SCHPO (O94425 ), YHK6_SCHPO (O94426 ), YNI8_SCHPO (O13598 )» more |
| PDB [Detailed view] |
189 PDB
1E0L; 1E0N; 1EG3; 1EG4; 1F8A; 1I5H; 1I6C; 1I8G; 1I8H; 1JMQ; 1K5R; 1K9Q; 1K9R; 1NMV; 1O6W; 1PIN; 1TK7; 1WMV; 1WR3; 1WR4; 1WR7; 1YIU; 1YWI; 1YWJ; 1ZCN; 1ZR7; 2DJY; 2DK1; 2DK7; 2DMV; 2DWV; 2DYF; 2E45; 2EZ5; 2F21; 2HO2; 2IDH; 2ITK; 2JMF; 2JO9; 2JOC; 2JUP; 2JX8; 2JXW; 2KBU; 2KCF; 2KPZ; 2KQ0; 2KXQ; 2KYK; 2L5F; 2LAJ; 2LAW; 2LAX; 2LAY; 2LAZ; 2LB0; 2LB1; 2LB2; 2LB3; 2LTV; 2LTW; 2LTX; 2LTY; 2LTZ; 2M3O; 2M8I; 2M8J; 2M9E; 2M9F; 2M9I; 2M9J; 2MDC; 2MDI; 2MDJ; 2MPT; 2MW9; 2MWA; 2MWB; 2MWD; 2MWE; 2MWF; 2N1O; 2N4R; 2N4S; 2N4T; 2N4U; 2N4V; 2N4W; 2N8S; 2N8T; 2N8U; 2NNT; 2OEI; 2OP7; 2Q5A; 2RLY; 2RM0; 2XP3; 2XP4; 2XP5; 2XP6; 2XP7; 2XP8; 2XP9; 2XPA; 2XPB; 2YSB; 2YSC; 2YSD; 2YSE; 2YSF; 2YSG; 2YSH; 2YSI; 2ZAJ; 2ZQS; 2ZQT; 2ZQU; 2ZQV; 2ZR4; 2ZR5; 2ZR6; 3KAB; 3KAD; 3KAF; 3KAG; 3KAH; 3KAI; 3KCE; 3L4H; 3LE4; 3NTP; 3ODK; 3OLM; 3OOB; 3TC5; 3TCZ; 3TDB; 3WH0; 4GWT; 4GWV; 4LCD; 4N7F; 4N7H; 4QIB; 4REX; 4ROF; 4U84; 4U85; 4U86; 5AHT; 5B3Y; 5B3Z; 5CQ2; 5DWS; 5DZD; 5O9Z; 5TJ7; 5TJ8; 5TJQ; 5UY9; 5VTI; 5VTJ; 5VTK; 5XMC; 5YDX; 5YDY; 6AHD; 6IKO; 6J1X; 6J1Y; 6J1Z; 6J68; 6J69; 6JJW; 6JJX; 6JJY; 6JJZ; 6JK0; 6JK1; 6LXD; 6LXE; 6N7P; 6O33; 6O34; 6RSS; 6V5B; 6V5C » more |
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